Incidental Mutation 'R1132:Atxn2l'
ID 94723
Institutional Source Beutler Lab
Gene Symbol Atxn2l
Ensembl Gene ENSMUSG00000032637
Gene Name ataxin 2-like
Synonyms A2LG, A2RP, A2lp, A2D
MMRRC Submission 039205-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.937) question?
Stock # R1132 (G1)
Quality Score 110
Status Not validated
Chromosome 7
Chromosomal Location 126090880-126102609 bp(-) (GRCm39)
Type of Mutation small deletion (1 aa in frame mutation)
DNA Base Change (assembly) CCAGCAGCAGCAGCAGCAGC to CCAGCAGCAGCAGCAGC at 126093420 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000146023 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040202] [ENSMUST00000098048] [ENSMUST00000106392] [ENSMUST00000166682] [ENSMUST00000167759] [ENSMUST00000179818] [ENSMUST00000206577] [ENSMUST00000206265] [ENSMUST00000206055] [ENSMUST00000206572]
AlphaFold Q7TQH0
Predicted Effect probably benign
Transcript: ENSMUST00000040202
SMART Domains Protein: ENSMUSP00000035415
Gene: ENSMUSG00000032637

DomainStartEndE-ValueType
low complexity region 4 21 N/A INTRINSIC
low complexity region 36 54 N/A INTRINSIC
low complexity region 56 73 N/A INTRINSIC
Pfam:SM-ATX 119 189 8.5e-21 PFAM
LsmAD 262 331 1.95e-28 SMART
low complexity region 357 382 N/A INTRINSIC
low complexity region 450 470 N/A INTRINSIC
Pfam:PAM2 657 672 5.6e-8 PFAM
low complexity region 681 697 N/A INTRINSIC
low complexity region 764 787 N/A INTRINSIC
low complexity region 920 947 N/A INTRINSIC
low complexity region 979 991 N/A INTRINSIC
low complexity region 997 1008 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000098048
SMART Domains Protein: ENSMUSP00000095656
Gene: ENSMUSG00000073838

DomainStartEndE-ValueType
Pfam:GTP_EFTU 55 249 2e-55 PFAM
Pfam:GTP_EFTU_D2 272 341 1.3e-15 PFAM
Pfam:GTP_EFTU_D3 345 440 1.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106392
SMART Domains Protein: ENSMUSP00000102000
Gene: ENSMUSG00000073838

DomainStartEndE-ValueType
Pfam:GTP_EFTU 55 249 2.7e-57 PFAM
Pfam:GTP_EFTU_D2 272 341 2.1e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000166682
SMART Domains Protein: ENSMUSP00000125881
Gene: ENSMUSG00000032637

DomainStartEndE-ValueType
Pfam:SM-ATX 1 69 1.6e-21 PFAM
LsmAD 142 211 1.95e-28 SMART
low complexity region 237 262 N/A INTRINSIC
low complexity region 330 350 N/A INTRINSIC
Pfam:PAM2 537 553 4.3e-8 PFAM
low complexity region 561 577 N/A INTRINSIC
low complexity region 644 667 N/A INTRINSIC
low complexity region 800 827 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000167759
SMART Domains Protein: ENSMUSP00000132959
Gene: ENSMUSG00000032637

DomainStartEndE-ValueType
Pfam:SM-ATX 33 103 8.1e-23 PFAM
LsmAD 176 245 1.95e-28 SMART
low complexity region 271 296 N/A INTRINSIC
low complexity region 364 384 N/A INTRINSIC
Pfam:PAM2 571 587 4.2e-8 PFAM
low complexity region 595 611 N/A INTRINSIC
low complexity region 678 701 N/A INTRINSIC
low complexity region 834 861 N/A INTRINSIC
low complexity region 893 905 N/A INTRINSIC
low complexity region 911 922 N/A INTRINSIC
low complexity region 944 960 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179818
SMART Domains Protein: ENSMUSP00000137108
Gene: ENSMUSG00000032637

DomainStartEndE-ValueType
Pfam:SM-ATX 62 132 4.3e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000206577
Predicted Effect probably benign
Transcript: ENSMUST00000206265
Predicted Effect probably benign
Transcript: ENSMUST00000206055
Predicted Effect probably benign
Transcript: ENSMUST00000206572
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apba1 T C 19: 23,894,917 (GRCm39) V451A possibly damaging Het
C3 C T 17: 57,514,531 (GRCm39) probably null Het
Car9 G T 4: 43,512,439 (GRCm39) probably null Het
Cd163 G T 6: 124,286,055 (GRCm39) G202* probably null Het
Cdk8 A G 5: 146,236,625 (GRCm39) T347A probably benign Het
Cep170 C A 1: 176,577,603 (GRCm39) R1257L probably damaging Het
Cib1 A G 7: 79,877,778 (GRCm39) F168S probably damaging Het
Cntnap5c G A 17: 58,601,351 (GRCm39) G833D probably damaging Het
Dhx37 A T 5: 125,498,103 (GRCm39) I702N probably damaging Het
Dnah3 T C 7: 119,538,227 (GRCm39) K3586R possibly damaging Het
Fbxo31 ACGGCGCGGCG ACGGCGCGGCGCGGCG 8: 122,279,015 (GRCm39) probably null Het
Fbxo31 CGCGG CGCGGAGCGG 8: 122,279,019 (GRCm39) probably null Het
Fhod3 TGAGGAGGAGGAGGAGGA TGAGGAGGAGGAGGA 18: 25,153,722 (GRCm39) probably benign Het
Gaa T C 11: 119,175,885 (GRCm39) S953P probably damaging Het
Inpp5j T C 11: 3,452,305 (GRCm39) E315G possibly damaging Het
Itsn2 T C 12: 4,708,464 (GRCm39) Y840H probably damaging Het
Kif1a T C 1: 92,983,743 (GRCm39) E653G probably damaging Het
Loxhd1 T C 18: 77,517,639 (GRCm39) V1829A possibly damaging Het
Myh8 C T 11: 67,187,957 (GRCm39) Q910* probably null Het
Or12d12 T C 17: 37,610,423 (GRCm39) R297G probably benign Het
Or14a257 A T 7: 86,138,425 (GRCm39) F111L probably benign Het
Or14j4 G T 17: 37,921,333 (GRCm39) T103K possibly damaging Het
Or2ag17 A T 7: 106,389,758 (GRCm39) I150N possibly damaging Het
Prdm4 A G 10: 85,735,145 (GRCm39) S666P probably damaging Het
Rad50 T C 11: 53,585,788 (GRCm39) K331E possibly damaging Het
Rbbp6 A G 7: 122,599,336 (GRCm39) probably benign Het
Selenbp1 C G 3: 94,844,644 (GRCm39) I100M probably benign Het
Skint6 A G 4: 112,755,296 (GRCm39) probably null Het
Stac3 T C 10: 127,343,128 (GRCm39) S208P probably benign Het
Tfap2a T C 13: 40,874,867 (GRCm39) probably null Het
Trhde T C 10: 114,248,383 (GRCm39) K939E possibly damaging Het
Vmn1r22 T C 6: 57,877,826 (GRCm39) I50M probably benign Het
Vmn1r39 C T 6: 66,781,428 (GRCm39) V260I probably benign Het
Zdhhc25 T C 15: 88,484,926 (GRCm39) L87P probably damaging Het
Zfp202 T C 9: 40,122,318 (GRCm39) L360P probably benign Het
Other mutations in Atxn2l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00325:Atxn2l APN 7 126,097,460 (GRCm39) missense possibly damaging 0.94
IGL00507:Atxn2l APN 7 126,095,756 (GRCm39) missense possibly damaging 0.51
IGL00846:Atxn2l APN 7 126,098,350 (GRCm39) missense probably damaging 1.00
IGL01813:Atxn2l APN 7 126,099,425 (GRCm39) missense probably damaging 1.00
PIT4378001:Atxn2l UTSW 7 126,096,443 (GRCm39) missense probably benign 0.11
R0005:Atxn2l UTSW 7 126,097,446 (GRCm39) missense probably damaging 1.00
R0267:Atxn2l UTSW 7 126,092,379 (GRCm39) missense probably damaging 1.00
R0608:Atxn2l UTSW 7 126,100,588 (GRCm39) splice site probably null
R0749:Atxn2l UTSW 7 126,100,009 (GRCm39) missense possibly damaging 0.50
R0831:Atxn2l UTSW 7 126,098,332 (GRCm39) missense probably damaging 1.00
R0881:Atxn2l UTSW 7 126,095,768 (GRCm39) missense probably damaging 1.00
R1022:Atxn2l UTSW 7 126,096,466 (GRCm39) missense probably benign 0.01
R1024:Atxn2l UTSW 7 126,096,466 (GRCm39) missense probably benign 0.01
R1081:Atxn2l UTSW 7 126,093,384 (GRCm39) missense probably damaging 1.00
R1489:Atxn2l UTSW 7 126,095,639 (GRCm39) missense probably damaging 1.00
R1919:Atxn2l UTSW 7 126,092,340 (GRCm39) missense probably damaging 0.99
R2062:Atxn2l UTSW 7 126,095,038 (GRCm39) missense probably damaging 1.00
R2170:Atxn2l UTSW 7 126,102,411 (GRCm39) start gained probably benign
R3719:Atxn2l UTSW 7 126,097,302 (GRCm39) missense probably damaging 1.00
R3861:Atxn2l UTSW 7 126,101,123 (GRCm39) critical splice donor site probably null
R5061:Atxn2l UTSW 7 126,099,375 (GRCm39) missense probably damaging 1.00
R6022:Atxn2l UTSW 7 126,095,607 (GRCm39) critical splice donor site probably null
R6075:Atxn2l UTSW 7 126,091,689 (GRCm39) missense possibly damaging 0.70
R6131:Atxn2l UTSW 7 126,102,337 (GRCm39) unclassified probably benign
R6460:Atxn2l UTSW 7 126,093,420 (GRCm39) small deletion probably benign
R6552:Atxn2l UTSW 7 126,092,993 (GRCm39) missense possibly damaging 0.70
R7167:Atxn2l UTSW 7 126,098,394 (GRCm39) missense possibly damaging 0.76
R7234:Atxn2l UTSW 7 126,092,373 (GRCm39) missense probably damaging 1.00
R7301:Atxn2l UTSW 7 126,093,383 (GRCm39) nonsense probably null
R7432:Atxn2l UTSW 7 126,093,046 (GRCm39) missense possibly damaging 0.46
R7691:Atxn2l UTSW 7 126,091,782 (GRCm39) critical splice acceptor site probably null
R7711:Atxn2l UTSW 7 126,100,441 (GRCm39) missense probably damaging 1.00
R7849:Atxn2l UTSW 7 126,092,345 (GRCm39) missense possibly damaging 0.48
R7870:Atxn2l UTSW 7 126,091,924 (GRCm39) missense probably benign
R8907:Atxn2l UTSW 7 126,099,425 (GRCm39) missense probably damaging 1.00
R8929:Atxn2l UTSW 7 126,092,928 (GRCm39) splice site probably benign
R8949:Atxn2l UTSW 7 126,091,377 (GRCm39) missense probably damaging 0.99
R8982:Atxn2l UTSW 7 126,093,420 (GRCm39) small deletion probably benign
R9021:Atxn2l UTSW 7 126,094,712 (GRCm39) missense probably benign 0.00
R9127:Atxn2l UTSW 7 126,097,393 (GRCm39) missense probably damaging 1.00
R9769:Atxn2l UTSW 7 126,095,692 (GRCm39) missense probably benign 0.00
RF006:Atxn2l UTSW 7 126,095,063 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCGAGAGCAAAGGTTCAATGTCCTG -3'
(R):5'- AGCCCAAGAAAAGTGCTGATTGTCC -3'

Sequencing Primer
(F):5'- CCTGTTACAGGAATTCAAGTGGAC -3'
(R):5'- GAAAAGTGCTGATTGTCCAGCTC -3'
Posted On 2014-01-05