|Institutional Source||Beutler Lab|
|Gene Name||NMD3 ribosome export adaptor|
|Is this an essential gene?||Probably essential (E-score: 0.966)|
|Stock #||R1136 (G1)|
|Chromosomal Location||69721985-69756373 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to A at 69746716 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000029358 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000029358]|
|Predicted Effect||probably benign
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||100% (52/52)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. [provided by RefSeq, Feb 2016]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Nmd3||
(F):5'- AAGGTCACATGAGGAGGTCGCT -3'
(R):5'- GCTTGCCCCTGAAACTGCTTGTA -3'
(F):5'- CTGTAATGTTTCAAAATGGGCTG -3'
(R):5'- TTGTAAGGGTCCAGGAAAGC -3'