Incidental Mutation 'R1026:Or14a258'
ID 94967
Institutional Source Beutler Lab
Gene Symbol Or14a258
Ensembl Gene ENSMUSG00000062426
Gene Name olfactory receptor family 14 subfamily A member 258
Synonyms GA_x6K02T2NHDJ-9721756-9722757, MOR219-3P, Olfr304
MMRRC Submission 039128-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R1026 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 86034865-86035866 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 86035467 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 134 (M134L)
Ref Sequence ENSEMBL: ENSMUSP00000076449 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077210]
AlphaFold Q7TS03
Predicted Effect probably damaging
Transcript: ENSMUST00000077210
AA Change: M134L

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000076449
Gene: ENSMUSG00000062426
AA Change: M134L

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 8.9e-38 PFAM
Pfam:7tm_1 39 288 1.1e-21 PFAM
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 94.5%
  • 20x: 87.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 15 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alyref C G 11: 120,486,758 (GRCm39) V168L probably damaging Het
Cdc42bpg T C 19: 6,367,217 (GRCm39) C919R probably damaging Het
Cgnl1 A G 9: 71,624,713 (GRCm39) S620P possibly damaging Het
Fbxw10 A G 11: 62,765,997 (GRCm39) T756A probably benign Het
Fsip2 T C 2: 82,818,805 (GRCm39) I4846T possibly damaging Het
Hebp2 G T 10: 18,420,163 (GRCm39) T90K possibly damaging Het
Map4k5 T C 12: 69,921,062 (GRCm39) K52R possibly damaging Het
Neb T A 2: 52,154,122 (GRCm39) M2330L possibly damaging Het
Or8k21 T C 2: 86,145,558 (GRCm39) Q24R possibly damaging Het
Plekhf1 C A 7: 37,921,065 (GRCm39) A168S probably benign Het
Ppp1r12a A G 10: 108,087,720 (GRCm39) T58A probably benign Het
Prss23 T A 7: 89,159,166 (GRCm39) Y301F probably benign Het
R3hdm1 A G 1: 128,124,742 (GRCm39) Y343C probably damaging Het
Zcchc17 C T 4: 130,223,403 (GRCm39) V128I possibly damaging Het
Zfp960 T A 17: 17,308,518 (GRCm39) C411S probably damaging Het
Other mutations in Or14a258
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01391:Or14a258 APN 7 86,035,208 (GRCm39) missense possibly damaging 0.95
IGL02152:Or14a258 APN 7 86,035,251 (GRCm39) missense probably benign 0.00
IGL02540:Or14a258 APN 7 86,035,386 (GRCm39) missense possibly damaging 0.86
IGL03108:Or14a258 APN 7 86,034,929 (GRCm39) missense possibly damaging 0.95
IGL03374:Or14a258 APN 7 86,035,574 (GRCm39) missense probably damaging 1.00
R0040:Or14a258 UTSW 7 86,035,715 (GRCm39) missense probably benign 0.01
R0130:Or14a258 UTSW 7 86,035,514 (GRCm39) missense probably damaging 1.00
R0194:Or14a258 UTSW 7 86,035,582 (GRCm39) nonsense probably null
R0267:Or14a258 UTSW 7 86,035,475 (GRCm39) missense possibly damaging 0.64
R1865:Or14a258 UTSW 7 86,035,769 (GRCm39) missense probably damaging 1.00
R2090:Or14a258 UTSW 7 86,035,289 (GRCm39) missense probably benign 0.01
R3607:Or14a258 UTSW 7 86,034,903 (GRCm39) missense probably benign
R3861:Or14a258 UTSW 7 86,035,331 (GRCm39) missense possibly damaging 0.60
R3909:Or14a258 UTSW 7 86,035,182 (GRCm39) missense probably benign 0.05
R4113:Or14a258 UTSW 7 86,035,733 (GRCm39) missense possibly damaging 0.83
R5268:Or14a258 UTSW 7 86,034,867 (GRCm39) makesense probably null
R5649:Or14a258 UTSW 7 86,035,521 (GRCm39) missense probably damaging 1.00
R6343:Or14a258 UTSW 7 86,035,059 (GRCm39) nonsense probably null
R7716:Or14a258 UTSW 7 86,035,262 (GRCm39) missense probably benign 0.22
R8118:Or14a258 UTSW 7 86,034,976 (GRCm39) nonsense probably null
R9047:Or14a258 UTSW 7 86,035,248 (GRCm39) missense probably benign 0.05
R9503:Or14a258 UTSW 7 86,035,228 (GRCm39) missense probably benign 0.00
R9528:Or14a258 UTSW 7 86,035,059 (GRCm39) nonsense probably null
X0054:Or14a258 UTSW 7 86,034,938 (GRCm39) missense probably benign 0.00
X0063:Or14a258 UTSW 7 86,035,700 (GRCm39) missense probably damaging 1.00
Z1186:Or14a258 UTSW 7 86,035,487 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTGACATCACTGTTCCTCAGGCTG -3'
(R):5'- TGTGTCCATCCCAATCCCAAAGTTC -3'

Sequencing Primer
(F):5'- GCAAATGCTTTGGACTGACC -3'
(R):5'- AGTTCATCATCAATAACCTAACTCAC -3'
Posted On 2014-01-05