Incidental Mutation 'R1033:Or3a1'
ID 95299
Institutional Source Beutler Lab
Gene Symbol Or3a1
Ensembl Gene ENSMUSG00000063116
Gene Name olfactory receptor family 3 subfamily A member 1
Synonyms Olfr410, GA_x6K02T2P1NL-4467421-4466474, MOR255-5
MMRRC Submission 039132-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R1033 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 74225108-74226055 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 74225462 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 198 (N198K)
Ref Sequence ENSEMBL: ENSMUSP00000150291 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052254] [ENSMUST00000213831] [ENSMUST00000214490]
AlphaFold Q8VFX7
Predicted Effect possibly damaging
Transcript: ENSMUST00000052254
AA Change: N198K

PolyPhen 2 Score 0.480 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000050456
Gene: ENSMUSG00000063116
AA Change: N198K

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 5.4e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 253 5e-6 PFAM
Pfam:7tm_1 44 293 7.7e-27 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213831
AA Change: N198K

PolyPhen 2 Score 0.480 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214490
AA Change: N198K

PolyPhen 2 Score 0.480 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 91.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh G A 5: 77,024,130 (GRCm39) T174M probably damaging Het
Akap6 A C 12: 53,116,005 (GRCm39) D1036A probably damaging Het
Alg6 T C 4: 99,650,270 (GRCm39) S497P probably benign Het
Arhgap10 T A 8: 77,983,976 (GRCm39) I700L possibly damaging Het
Atp11a A G 8: 12,878,555 (GRCm39) Y377C probably damaging Het
Atp2b2 A T 6: 113,770,849 (GRCm39) probably null Het
Card14 T A 11: 119,229,196 (GRCm39) V702D probably damaging Het
Ccdc17 C T 4: 116,454,077 (GRCm39) R32* probably null Het
Cdh20 A T 1: 110,012,783 (GRCm39) D372V probably damaging Het
Cfap54 A T 10: 92,675,311 (GRCm39) I2870N probably benign Het
Cped1 G T 6: 22,016,950 (GRCm39) V100F probably damaging Het
Dapk1 T C 13: 60,869,679 (GRCm39) probably null Het
Exoc4 G A 6: 33,242,922 (GRCm39) G45D probably damaging Het
Fam110b A T 4: 5,799,440 (GRCm39) N286I probably benign Het
Fbxo10 A T 4: 45,062,236 (GRCm39) C97S probably damaging Het
Frem3 A T 8: 81,421,786 (GRCm39) H2062L probably benign Het
Frk T C 10: 34,484,454 (GRCm39) C476R probably damaging Het
Gm10542 A G 18: 44,337,668 (GRCm39) T49A probably benign Het
Gm128 A G 3: 95,147,322 (GRCm39) V324A possibly damaging Het
Gpr141 C T 13: 19,935,880 (GRCm39) M298I probably benign Het
Gxylt1 T C 15: 93,142,958 (GRCm39) E369G probably benign Het
Hpse2 A G 19: 42,901,638 (GRCm39) V368A probably benign Het
Ice1 A T 13: 70,754,713 (GRCm39) S458T probably damaging Het
Itgb7 T A 15: 102,131,989 (GRCm39) D198V probably damaging Het
Kcnk10 A G 12: 98,484,929 (GRCm39) V72A possibly damaging Het
Magel2 A G 7: 62,029,798 (GRCm39) M901V unknown Het
Mgam A T 6: 40,657,558 (GRCm39) Y971F probably benign Het
Mib2 C T 4: 155,743,917 (GRCm39) G42S probably damaging Het
Mug1 A T 6: 121,857,510 (GRCm39) D1078V probably damaging Het
Myom2 G A 8: 15,158,934 (GRCm39) R870H probably benign Het
Nek8 A T 11: 78,062,111 (GRCm39) L71Q probably null Het
Nox4 T A 7: 87,023,621 (GRCm39) D502E probably damaging Het
Nsmaf G A 4: 6,438,054 (GRCm39) P73S probably damaging Het
Nup205 C T 6: 35,204,377 (GRCm39) A1421V probably benign Het
Nxpe4 T C 9: 48,304,533 (GRCm39) F207L probably damaging Het
Or1p1 A C 11: 74,179,492 (GRCm39) T7P probably damaging Het
Or4k38 A T 2: 111,166,147 (GRCm39) I92N probably damaging Het
Or5al7 A G 2: 85,993,194 (GRCm39) I33T possibly damaging Het
Pals2 T C 6: 50,160,716 (GRCm39) Y326H probably damaging Het
Prkdc T C 16: 15,585,815 (GRCm39) L2451P probably damaging Het
Rad51ap2 C T 12: 11,506,252 (GRCm39) S58F probably damaging Het
Rbbp8 A G 18: 11,875,762 (GRCm39) R892G probably benign Het
Rock1 A G 18: 10,067,535 (GRCm39) S1333P probably benign Het
Rpl7 A G 1: 16,172,728 (GRCm39) I197T probably benign Het
Sar1a C A 10: 61,521,395 (GRCm39) Q81K probably damaging Het
Shank1 A T 7: 44,006,220 (GRCm39) H1979L possibly damaging Het
Slc10a2 C T 8: 5,154,889 (GRCm39) V99M probably damaging Het
Slc22a30 G A 19: 8,313,165 (GRCm39) Q436* probably null Het
Spata31e2 G A 1: 26,721,466 (GRCm39) P1238L probably benign Het
Speer4a2 T C 5: 26,294,125 (GRCm39) K18E probably benign Het
Szt2 C T 4: 118,244,303 (GRCm39) R1305H probably damaging Het
Ubash3a G A 17: 31,427,186 (GRCm39) G32S probably damaging Het
Vmn1r200 G A 13: 22,580,060 (GRCm39) D279N probably damaging Het
Zbtb8a T C 4: 129,248,014 (GRCm39) D419G possibly damaging Het
Other mutations in Or3a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02103:Or3a1 APN 11 74,225,862 (GRCm39) missense probably damaging 1.00
IGL02885:Or3a1 APN 11 74,225,519 (GRCm39) missense possibly damaging 0.95
R0363:Or3a1 UTSW 11 74,225,925 (GRCm39) missense probably damaging 1.00
R1722:Or3a1 UTSW 11 74,225,271 (GRCm39) missense probably damaging 1.00
R1759:Or3a1 UTSW 11 74,225,808 (GRCm39) missense possibly damaging 0.49
R2007:Or3a1 UTSW 11 74,225,212 (GRCm39) missense possibly damaging 0.57
R2278:Or3a1 UTSW 11 74,225,991 (GRCm39) missense probably benign 0.00
R4756:Or3a1 UTSW 11 74,225,402 (GRCm39) missense probably benign
R5382:Or3a1 UTSW 11 74,225,806 (GRCm39) missense probably benign 0.00
R6026:Or3a1 UTSW 11 74,225,914 (GRCm39) missense probably damaging 0.99
R6048:Or3a1 UTSW 11 74,225,961 (GRCm39) missense probably benign 0.13
R8488:Or3a1 UTSW 11 74,225,932 (GRCm39) missense probably benign 0.01
R9134:Or3a1 UTSW 11 74,225,670 (GRCm39) missense probably damaging 1.00
R9368:Or3a1 UTSW 11 74,225,193 (GRCm39) missense probably damaging 1.00
X0067:Or3a1 UTSW 11 74,225,776 (GRCm39) missense probably benign 0.00
Z1088:Or3a1 UTSW 11 74,225,518 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCCAGCACCATAGAATATGGCAAC -3'
(R):5'- TATGGAGACTGCCTCACACAGCTC -3'

Sequencing Primer
(F):5'- CATAGAATATGGCAACCACAGTG -3'
(R):5'- GTTGACTGCTTCCTATTGACAG -3'
Posted On 2014-01-05