Incidental Mutation 'R1034:Traf3ip1'
ID 95366
Institutional Source Beutler Lab
Gene Symbol Traf3ip1
Ensembl Gene ENSMUSG00000034292
Gene Name TRAF3 interacting protein 1
Synonyms MIP-T3, 3930402D05Rik
MMRRC Submission 039133-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1034 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 91494647-91529307 bp(+) (GRCm38)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) G to T at 91518319 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140151 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047242] [ENSMUST00000189341] [ENSMUST00000189341]
AlphaFold Q149C2
Predicted Effect probably null
Transcript: ENSMUST00000047242
SMART Domains Protein: ENSMUSP00000042391
Gene: ENSMUSG00000034292

DomainStartEndE-ValueType
Pfam:MIP-T3 49 619 7e-207 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187588
Predicted Effect probably null
Transcript: ENSMUST00000189341
SMART Domains Protein: ENSMUSP00000140151
Gene: ENSMUSG00000034292

DomainStartEndE-ValueType
Pfam:MIP-T3 49 648 7.1e-203 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000189341
SMART Domains Protein: ENSMUSP00000140151
Gene: ENSMUSG00000034292

DomainStartEndE-ValueType
Pfam:MIP-T3 49 648 7.1e-203 PFAM
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.3%
  • 10x: 92.9%
  • 20x: 82.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trap allele exhibit embryonic lethality, cardiac edema, abnormal neural development, polydactyly, and microphthalmia associated with a lack of embryonic lethality. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh G A 5: 76,876,283 T174M probably damaging Het
Abca14 T C 7: 120,216,147 F206S probably damaging Het
Arid2 T C 15: 96,369,505 V622A probably benign Het
Asic1 T A 15: 99,698,058 L437Q probably damaging Het
Atp1b1 C T 1: 164,453,488 probably null Het
B3gnt5 A G 16: 19,769,484 Y151C probably damaging Het
Cbx4 A G 11: 119,081,707 S281P probably damaging Het
Dnah5 G A 15: 28,302,471 V1625I probably damaging Het
Eftud2 A C 11: 102,849,184 D461E probably benign Het
Epgn A G 5: 91,032,221 Y74C probably damaging Het
Fcho1 C T 8: 71,712,560 A418T probably benign Het
Fgf14 C T 14: 124,132,534 V113I probably damaging Het
Ggcx G A 6: 72,414,831 R68H probably damaging Het
Gm1110 A G 9: 26,921,350 S16P probably damaging Het
Gm6729 T C 10: 86,540,026 noncoding transcript Het
Gpr108 A G 17: 57,235,995 F522S probably damaging Het
Gpr156 T C 16: 38,004,726 V435A probably benign Het
Khdrbs2 T C 1: 32,467,791 L172P probably damaging Het
Kmo C T 1: 175,651,618 P240L possibly damaging Het
Ltn1 A T 16: 87,397,137 probably null Het
Nbeal1 T A 1: 60,290,006 Y2194* probably null Het
Olfr767 T A 10: 129,079,961 M1L probably benign Het
Olfr867 A T 9: 20,055,365 S33T probably benign Het
Rab6b T C 9: 103,167,124 S172P probably benign Het
Ror1 T A 4: 100,333,620 L58* probably null Het
Sec23b A G 2: 144,590,338 D756G possibly damaging Het
Slc24a2 T A 4: 87,032,275 K428N probably damaging Het
Spen C A 4: 141,475,752 V1855L probably benign Het
Srgap1 G A 10: 121,785,445 P1071S possibly damaging Het
Tns1 A G 1: 73,941,969 C1079R probably damaging Het
Trmt2a T C 16: 18,249,709 F82S probably damaging Het
Xrn1 A G 9: 96,039,737 D1401G probably damaging Het
Zfp352 T A 4: 90,224,156 S178T possibly damaging Het
Zfp758 G T 17: 22,375,759 E409* probably null Het
Other mutations in Traf3ip1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01355:Traf3ip1 APN 1 91518297 missense probably damaging 0.98
IGL01997:Traf3ip1 APN 1 91507570 critical splice donor site probably null
IGL02431:Traf3ip1 APN 1 91499635 missense unknown
IGL03106:Traf3ip1 APN 1 91522887 missense probably benign 0.26
eclectic UTSW 1 91507736 splice site probably null
R0538:Traf3ip1 UTSW 1 91499619 missense unknown
R1065:Traf3ip1 UTSW 1 91500784 missense unknown
R1757:Traf3ip1 UTSW 1 91522857 missense probably damaging 1.00
R2360:Traf3ip1 UTSW 1 91499652 missense unknown
R2367:Traf3ip1 UTSW 1 91507520 missense possibly damaging 0.90
R3031:Traf3ip1 UTSW 1 91520100 missense probably damaging 1.00
R3752:Traf3ip1 UTSW 1 91500917 splice site probably benign
R3752:Traf3ip1 UTSW 1 91518297 missense probably damaging 0.98
R4690:Traf3ip1 UTSW 1 91520112 missense possibly damaging 0.90
R4747:Traf3ip1 UTSW 1 91527757 missense probably damaging 1.00
R5328:Traf3ip1 UTSW 1 91520069 missense probably damaging 1.00
R5540:Traf3ip1 UTSW 1 91501315 missense probably benign 0.07
R5910:Traf3ip1 UTSW 1 91527745 missense probably damaging 1.00
R6593:Traf3ip1 UTSW 1 91527695 missense possibly damaging 0.82
R6836:Traf3ip1 UTSW 1 91521000 missense probably benign 0.17
R7249:Traf3ip1 UTSW 1 91527639 missense probably damaging 1.00
R7418:Traf3ip1 UTSW 1 91507736 splice site probably null
R7436:Traf3ip1 UTSW 1 91511388 missense probably benign 0.02
R7597:Traf3ip1 UTSW 1 91511445 missense probably damaging 0.97
R7751:Traf3ip1 UTSW 1 91494757 start gained probably benign
R8031:Traf3ip1 UTSW 1 91501419 missense probably damaging 1.00
R8179:Traf3ip1 UTSW 1 91500801 missense unknown
R8919:Traf3ip1 UTSW 1 91516074 intron probably benign
R9002:Traf3ip1 UTSW 1 91505456 missense probably benign 0.05
R9040:Traf3ip1 UTSW 1 91501370 missense probably damaging 0.99
R9055:Traf3ip1 UTSW 1 91501011 nonsense probably null
R9745:Traf3ip1 UTSW 1 91511373 nonsense probably null
Predicted Primers PCR Primer
(F):5'- GTGGCGTAGGTAGTCCTTCACATTC -3'
(R):5'- TGTGTATGGCCCACATACAAAATGGAA -3'

Sequencing Primer
(F):5'- agcctgtctctgcctcc -3'
(R):5'- tggaaacttaaaacacagcaaaatag -3'
Posted On 2014-01-05