Incidental Mutation 'R1034:Or7d11'
ID 95424
Institutional Source Beutler Lab
Gene Symbol Or7d11
Ensembl Gene ENSMUSG00000044454
Gene Name olfactory receptor family 7 subfamily D member 11
Synonyms GA_x6K02T2PVTD-13795933-13794938, MOR143-2, Olfr867
MMRRC Submission 039133-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R1034 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 19965762-19966757 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 19966661 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 33 (S33T)
Ref Sequence ENSEMBL: ENSMUSP00000150378 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060780] [ENSMUST00000212098] [ENSMUST00000216538]
AlphaFold Q7TRF3
Predicted Effect probably benign
Transcript: ENSMUST00000060780
AA Change: S33T

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000057469
Gene: ENSMUSG00000044454
AA Change: S33T

Pfam:7tm_4 31 308 2.2e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 301 1.6e-6 PFAM
Pfam:7tm_1 41 290 1.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212098
Predicted Effect probably benign
Transcript: ENSMUST00000216538
AA Change: S33T

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.3%
  • 10x: 92.9%
  • 20x: 82.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh G A 5: 77,024,130 (GRCm39) T174M probably damaging Het
Abca14 T C 7: 119,815,370 (GRCm39) F206S probably damaging Het
Arid2 T C 15: 96,267,386 (GRCm39) V622A probably benign Het
Asic1 T A 15: 99,595,939 (GRCm39) L437Q probably damaging Het
Atp1b1 C T 1: 164,281,057 (GRCm39) probably null Het
B3gnt5 A G 16: 19,588,234 (GRCm39) Y151C probably damaging Het
Cbx4 A G 11: 118,972,533 (GRCm39) S281P probably damaging Het
Dnah5 G A 15: 28,302,617 (GRCm39) V1625I probably damaging Het
Eftud2 A C 11: 102,740,010 (GRCm39) D461E probably benign Het
Epgn A G 5: 91,180,080 (GRCm39) Y74C probably damaging Het
Fcho1 C T 8: 72,165,204 (GRCm39) A418T probably benign Het
Fgf14 C T 14: 124,369,946 (GRCm39) V113I probably damaging Het
Ggcx G A 6: 72,391,814 (GRCm39) R68H probably damaging Het
Gm1110 A G 9: 26,832,646 (GRCm39) S16P probably damaging Het
Gm6729 T C 10: 86,375,890 (GRCm39) noncoding transcript Het
Gpr108 A G 17: 57,542,995 (GRCm39) F522S probably damaging Het
Gpr156 T C 16: 37,825,088 (GRCm39) V435A probably benign Het
Khdrbs2 T C 1: 32,506,872 (GRCm39) L172P probably damaging Het
Kmo C T 1: 175,479,184 (GRCm39) P240L possibly damaging Het
Ltn1 A T 16: 87,194,025 (GRCm39) probably null Het
Nbeal1 T A 1: 60,329,165 (GRCm39) Y2194* probably null Het
Or6c8 T A 10: 128,915,830 (GRCm39) M1L probably benign Het
Rab6b T C 9: 103,044,323 (GRCm39) S172P probably benign Het
Ror1 T A 4: 100,190,817 (GRCm39) L58* probably null Het
Sec23b A G 2: 144,432,258 (GRCm39) D756G possibly damaging Het
Slc24a2 T A 4: 86,950,512 (GRCm39) K428N probably damaging Het
Spen C A 4: 141,203,063 (GRCm39) V1855L probably benign Het
Srgap1 G A 10: 121,621,350 (GRCm39) P1071S possibly damaging Het
Tns1 A G 1: 73,981,128 (GRCm39) C1079R probably damaging Het
Traf3ip1 G T 1: 91,446,041 (GRCm39) probably null Het
Trmt2a T C 16: 18,067,573 (GRCm39) F82S probably damaging Het
Xrn1 A G 9: 95,921,790 (GRCm39) D1401G probably damaging Het
Zfp352 T A 4: 90,112,393 (GRCm39) S178T possibly damaging Het
Zfp758 G T 17: 22,594,740 (GRCm39) E409* probably null Het
Other mutations in Or7d11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02138:Or7d11 APN 9 19,966,196 (GRCm39) missense probably benign 0.01
IGL03130:Or7d11 APN 9 19,966,668 (GRCm39) missense probably benign 0.34
R1238:Or7d11 UTSW 9 19,966,757 (GRCm39) start codon destroyed probably benign 0.12
R1412:Or7d11 UTSW 9 19,966,711 (GRCm39) missense possibly damaging 0.65
R1625:Or7d11 UTSW 9 19,966,678 (GRCm39) missense probably damaging 1.00
R1689:Or7d11 UTSW 9 19,966,422 (GRCm39) missense possibly damaging 0.94
R2060:Or7d11 UTSW 9 19,965,892 (GRCm39) missense probably damaging 1.00
R2204:Or7d11 UTSW 9 19,966,507 (GRCm39) missense possibly damaging 0.74
R2350:Or7d11 UTSW 9 19,966,384 (GRCm39) missense probably damaging 1.00
R3901:Or7d11 UTSW 9 19,966,169 (GRCm39) missense probably benign 0.00
R5637:Or7d11 UTSW 9 19,966,279 (GRCm39) missense possibly damaging 0.80
R6084:Or7d11 UTSW 9 19,966,179 (GRCm39) missense possibly damaging 0.71
R6150:Or7d11 UTSW 9 19,966,170 (GRCm39) missense probably benign 0.22
R6602:Or7d11 UTSW 9 19,966,342 (GRCm39) missense probably benign 0.01
R6902:Or7d11 UTSW 9 19,966,670 (GRCm39) missense possibly damaging 0.47
R6946:Or7d11 UTSW 9 19,966,670 (GRCm39) missense possibly damaging 0.47
R7085:Or7d11 UTSW 9 19,966,232 (GRCm39) missense probably benign 0.37
R7678:Or7d11 UTSW 9 19,965,901 (GRCm39) missense probably damaging 1.00
R8034:Or7d11 UTSW 9 19,966,301 (GRCm39) missense probably benign 0.01
R9194:Or7d11 UTSW 9 19,966,543 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2014-01-05