Incidental Mutation 'R1120:Irak2'
ID 95493
Institutional Source Beutler Lab
Gene Symbol Irak2
Ensembl Gene ENSMUSG00000060477
Gene Name interleukin-1 receptor-associated kinase 2
Synonyms 6330415L08Rik, IRAK-2
MMRRC Submission 039193-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1120 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 113615428-113671987 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to A at 113652720 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000144848 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059286] [ENSMUST00000089022] [ENSMUST00000089023] [ENSMUST00000204744]
AlphaFold Q8CFA1
Predicted Effect probably benign
Transcript: ENSMUST00000059286
SMART Domains Protein: ENSMUSP00000055073
Gene: ENSMUSG00000060477

DomainStartEndE-ValueType
Pfam:Death 14 94 4.8e-16 PFAM
Pfam:Pkinase 208 473 4.8e-28 PFAM
Pfam:Pkinase_Tyr 208 482 1.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000089022
SMART Domains Protein: ENSMUSP00000086416
Gene: ENSMUSG00000060477

DomainStartEndE-ValueType
Pfam:Death 14 93 3.9e-16 PFAM
Pfam:Pkinase 160 425 1.3e-30 PFAM
Pfam:Pkinase_Tyr 160 436 1e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000089023
SMART Domains Protein: ENSMUSP00000086417
Gene: ENSMUSG00000060477

DomainStartEndE-ValueType
PDB:3MOP|N 2 35 3e-13 PDB
Pfam:Pkinase 147 412 1.2e-30 PFAM
Pfam:Pkinase_Tyr 147 419 9.8e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000113024
SMART Domains Protein: ENSMUSP00000108647
Gene: ENSMUSG00000060477

DomainStartEndE-ValueType
Pfam:Pkinase 65 330 1.4e-30 PFAM
Pfam:Pkinase_Tyr 65 342 1.1e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155554
SMART Domains Protein: ENSMUSP00000117755
Gene: ENSMUSG00000060477

DomainStartEndE-ValueType
SCOP:d1b6cb_ 53 96 8e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203466
Predicted Effect probably benign
Transcript: ENSMUST00000204744
SMART Domains Protein: ENSMUSP00000144848
Gene: ENSMUSG00000060477

DomainStartEndE-ValueType
PDB:3MOP|N 2 55 3e-30 PDB
SCOP:d1d2za_ 4 55 9e-13 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.2%
Validation Efficiency 100% (40/40)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased susceptibility to endotoxin shock. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb8 T G 5: 24,613,818 (GRCm39) probably null Het
Akp3 A T 1: 87,053,159 (GRCm39) Q77L probably damaging Het
Blm A G 7: 80,131,214 (GRCm39) L878S probably damaging Het
Cabin1 A G 10: 75,561,550 (GRCm39) Y984H probably damaging Het
Cadps2 T C 6: 23,838,793 (GRCm39) Q86R probably damaging Het
Cd2 C T 3: 101,194,804 (GRCm39) D95N probably damaging Het
Cd36 A G 5: 17,990,826 (GRCm39) I438T possibly damaging Het
Crhbp G T 13: 95,578,593 (GRCm39) T176K probably benign Het
D630045J12Rik G T 6: 38,171,705 (GRCm39) T821K probably damaging Het
Disp1 T C 1: 182,880,139 (GRCm39) D288G probably benign Het
Dsc3 A G 18: 20,120,034 (GRCm39) V208A probably benign Het
Eef1e1 A T 13: 38,842,910 (GRCm39) N20K probably damaging Het
Ercc5 A G 1: 44,201,001 (GRCm39) D187G probably damaging Het
Etl4 T A 2: 20,811,514 (GRCm39) M1199K probably benign Het
Fnbp1 A T 2: 30,926,606 (GRCm39) Y433N probably damaging Het
Fxyd3 A G 7: 30,770,803 (GRCm39) probably benign Het
Hfm1 A T 5: 107,052,084 (GRCm39) probably benign Het
Jpt2 T C 17: 25,179,585 (GRCm39) M1V probably null Het
Knl1 A G 2: 118,892,856 (GRCm39) R51G probably damaging Het
Krtap8-1 A G 16: 89,284,753 (GRCm39) Y15H probably benign Het
Lrba A T 3: 86,202,499 (GRCm39) D250V probably damaging Het
Mgat4a A G 1: 37,491,662 (GRCm39) S357P probably damaging Het
Nup98 T A 7: 101,809,923 (GRCm39) T536S probably damaging Het
Or4a27 A G 2: 88,559,281 (GRCm39) Y221H probably damaging Het
Or4c109 A G 2: 88,818,423 (GRCm39) M41T possibly damaging Het
Or9k2 A G 10: 129,998,406 (GRCm39) L263P probably damaging Het
Parp14 G A 16: 35,677,130 (GRCm39) A946V probably benign Het
Pnpla8 A G 12: 44,351,730 (GRCm39) T568A possibly damaging Het
Ptprn A G 1: 75,234,825 (GRCm39) I254T probably benign Het
Rab5b A C 10: 128,515,483 (GRCm39) N188K probably benign Het
Samd5 A G 10: 9,504,792 (GRCm39) V154A possibly damaging Het
Smarcb1 A G 10: 75,757,157 (GRCm39) F25L probably benign Het
Smchd1 A T 17: 71,665,141 (GRCm39) Y1847* probably null Het
Smpd4 T C 16: 17,456,350 (GRCm39) probably benign Het
Tex14 T A 11: 87,429,502 (GRCm39) probably benign Het
Tnfrsf26 G A 7: 143,171,651 (GRCm39) R101C probably damaging Het
Trmu A G 15: 85,774,486 (GRCm39) K37E possibly damaging Het
Tsen54 C T 11: 115,705,839 (GRCm39) A52V probably damaging Het
Ubb T C 11: 62,443,009 (GRCm39) I13T possibly damaging Het
Vmn2r101 A T 17: 19,797,723 (GRCm39) probably benign Het
Other mutations in Irak2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Irak2 APN 6 113,655,636 (GRCm39) missense probably benign 0.41
IGL03026:Irak2 APN 6 113,653,612 (GRCm39) missense probably damaging 1.00
R0047:Irak2 UTSW 6 113,655,699 (GRCm39) missense probably benign 0.43
R0047:Irak2 UTSW 6 113,649,914 (GRCm39) splice site probably benign
R0658:Irak2 UTSW 6 113,615,525 (GRCm39) missense probably damaging 1.00
R2143:Irak2 UTSW 6 113,649,788 (GRCm39) missense probably benign 0.03
R2190:Irak2 UTSW 6 113,663,904 (GRCm39) missense probably damaging 1.00
R2342:Irak2 UTSW 6 113,670,632 (GRCm39) missense probably benign 0.08
R2507:Irak2 UTSW 6 113,624,639 (GRCm39) missense probably damaging 1.00
R3160:Irak2 UTSW 6 113,649,721 (GRCm39) missense probably benign 0.18
R3162:Irak2 UTSW 6 113,649,721 (GRCm39) missense probably benign 0.18
R4231:Irak2 UTSW 6 113,667,817 (GRCm39) missense probably damaging 0.98
R4604:Irak2 UTSW 6 113,649,848 (GRCm39) missense probably damaging 1.00
R4772:Irak2 UTSW 6 113,670,683 (GRCm39) missense probably damaging 1.00
R4940:Irak2 UTSW 6 113,670,691 (GRCm39) missense probably benign 0.41
R5082:Irak2 UTSW 6 113,649,805 (GRCm39) missense probably damaging 1.00
R5118:Irak2 UTSW 6 113,642,772 (GRCm39) missense probably benign 0.00
R5194:Irak2 UTSW 6 113,667,751 (GRCm39) missense probably benign 0.00
R5604:Irak2 UTSW 6 113,667,792 (GRCm39) missense possibly damaging 0.91
R5928:Irak2 UTSW 6 113,653,587 (GRCm39) missense probably damaging 1.00
R6479:Irak2 UTSW 6 113,663,902 (GRCm39) missense probably damaging 0.99
R7102:Irak2 UTSW 6 113,663,810 (GRCm39) missense probably damaging 1.00
R7153:Irak2 UTSW 6 113,655,670 (GRCm39) missense probably benign 0.34
R7199:Irak2 UTSW 6 113,650,045 (GRCm39) missense probably damaging 0.99
R7509:Irak2 UTSW 6 113,667,859 (GRCm39) frame shift probably null
R7694:Irak2 UTSW 6 113,667,859 (GRCm39) missense probably damaging 1.00
R7716:Irak2 UTSW 6 113,667,859 (GRCm39) frame shift probably null
R8414:Irak2 UTSW 6 113,663,903 (GRCm39) missense probably benign 0.08
R8750:Irak2 UTSW 6 113,663,783 (GRCm39) missense probably benign 0.01
R8870:Irak2 UTSW 6 113,663,902 (GRCm39) missense probably damaging 0.99
R8959:Irak2 UTSW 6 113,624,702 (GRCm39) missense probably damaging 0.98
R9324:Irak2 UTSW 6 113,615,604 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- CCAGGAAGTGGGGTCTGCCT -3'
(R):5'- GCTCAGCCAGTGTGATGTACTACC -3'

Sequencing Primer
(F):5'- GCCTGTGGCTCTTGCTC -3'
(R):5'- gaagtaaagacaggaggaccag -3'
Posted On 2014-01-05