Incidental Mutation 'IGL00678:Cdk14'
ID9568
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdk14
Ensembl Gene ENSMUSG00000028926
Gene Namecyclin-dependent kinase 14
SynonymsPftk1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00678
Quality Score
Status
Chromosome5
Chromosomal Location4803391-5420312 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 5249237 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000130895 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030763] [ENSMUST00000115450] [ENSMUST00000115451] [ENSMUST00000115452] [ENSMUST00000131392] [ENSMUST00000167567]
Predicted Effect probably benign
Transcript: ENSMUST00000030763
SMART Domains Protein: ENSMUSP00000030763
Gene: ENSMUSG00000028926

DomainStartEndE-ValueType
low complexity region 119 127 N/A INTRINSIC
S_TKc 135 419 3.63e-85 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115450
SMART Domains Protein: ENSMUSP00000111110
Gene: ENSMUSG00000028926

DomainStartEndE-ValueType
low complexity region 73 81 N/A INTRINSIC
S_TKc 89 373 3.63e-85 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115451
SMART Domains Protein: ENSMUSP00000111111
Gene: ENSMUSG00000028926

DomainStartEndE-ValueType
low complexity region 73 81 N/A INTRINSIC
S_TKc 89 373 3.63e-85 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115452
SMART Domains Protein: ENSMUSP00000111112
Gene: ENSMUSG00000028926

DomainStartEndE-ValueType
low complexity region 101 109 N/A INTRINSIC
S_TKc 117 401 3.63e-85 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131392
SMART Domains Protein: ENSMUSP00000114741
Gene: ENSMUSG00000028926

DomainStartEndE-ValueType
low complexity region 73 81 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132390
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133465
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134867
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137554
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153331
Predicted Effect probably benign
Transcript: ENSMUST00000167567
SMART Domains Protein: ENSMUSP00000130895
Gene: ENSMUSG00000028926

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 149 157 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 14 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Baz2b T C 2: 60,006,183 E2G unknown Het
Bbs2 T A 8: 94,089,167 probably null Het
Cubn A T 2: 13,467,710 I477N possibly damaging Het
Dtl A C 1: 191,546,626 probably null Het
Ercc6l2 T A 13: 63,844,613 V292E probably damaging Het
Eri3 A G 4: 117,564,891 H122R probably benign Het
Glrx3 T A 7: 137,452,713 V75D probably damaging Het
Ifi213 A G 1: 173,594,053 probably benign Het
Ppp1cb T A 5: 32,485,338 probably benign Het
Rb1cc1 A G 1: 6,234,085 T66A probably damaging Het
Slco6d1 A G 1: 98,496,344 S574G probably benign Het
Tas2r136 A T 6: 132,777,198 L322Q probably damaging Het
Tead1 A G 7: 112,841,880 probably null Het
Tsfm G A 10: 127,028,442 Q135* probably null Het
Other mutations in Cdk14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01376:Cdk14 APN 5 5010839 missense probably damaging 1.00
IGL02102:Cdk14 APN 5 5380083 missense probably benign 0.01
IGL02179:Cdk14 APN 5 5103845 missense probably damaging 1.00
IGL02423:Cdk14 APN 5 4888905 missense probably benign 0.00
IGL03081:Cdk14 APN 5 4949527 splice site probably benign
IGL02988:Cdk14 UTSW 5 5036484 missense probably damaging 1.00
R0465:Cdk14 UTSW 5 5093019 missense probably damaging 1.00
R0630:Cdk14 UTSW 5 5135422 splice site probably benign
R1452:Cdk14 UTSW 5 4888927 missense possibly damaging 0.85
R1601:Cdk14 UTSW 5 5135378 missense probably damaging 1.00
R1629:Cdk14 UTSW 5 5103807 missense probably benign 0.18
R1659:Cdk14 UTSW 5 4949571 missense probably benign 0.08
R1809:Cdk14 UTSW 5 5010901 missense probably damaging 0.98
R2013:Cdk14 UTSW 5 5093047 missense probably damaging 1.00
R2015:Cdk14 UTSW 5 5380082 missense probably benign
R2256:Cdk14 UTSW 5 4888924 missense probably benign
R2257:Cdk14 UTSW 5 4888924 missense probably benign
R2908:Cdk14 UTSW 5 5249051 missense probably benign 0.33
R4324:Cdk14 UTSW 5 5036532 nonsense probably null
R4432:Cdk14 UTSW 5 5036427 missense probably damaging 1.00
R4907:Cdk14 UTSW 5 5249140 missense probably damaging 0.96
R5426:Cdk14 UTSW 5 4888975 missense possibly damaging 0.93
R5708:Cdk14 UTSW 5 5266036 intron probably benign
R6006:Cdk14 UTSW 5 5249211 start codon destroyed probably null 0.33
R6120:Cdk14 UTSW 5 4894029 missense probably damaging 0.96
R7048:Cdk14 UTSW 5 5093005 missense probably damaging 1.00
R7104:Cdk14 UTSW 5 5195325 missense possibly damaging 0.92
R7712:Cdk14 UTSW 5 5380061 missense possibly damaging 0.86
R8046:Cdk14 UTSW 5 5249159 missense possibly damaging 0.86
Z1176:Cdk14 UTSW 5 5135322 nonsense probably null
Z1177:Cdk14 UTSW 5 4888894 missense possibly damaging 0.92
Posted On2012-12-06