Incidental Mutation 'R1127:Stk31'
ID 96296
Institutional Source Beutler Lab
Gene Symbol Stk31
Ensembl Gene ENSMUSG00000023403
Gene Name serine threonine kinase 31
Synonyms C330007K24Rik
MMRRC Submission 039200-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1127 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 49372538-49446435 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 49386141 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 160 (D160G)
Ref Sequence ENSEMBL: ENSMUSP00000132896 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024171] [ENSMUST00000163954] [ENSMUST00000172459]
AlphaFold Q99MW1
Predicted Effect probably damaging
Transcript: ENSMUST00000024171
AA Change: D160G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000024171
Gene: ENSMUSG00000023403
AA Change: D160G

DomainStartEndE-ValueType
TUDOR 81 135 1.34e-8 SMART
coiled coil region 298 345 N/A INTRINSIC
Pfam:Pkinase_Tyr 768 932 4.6e-9 PFAM
Pfam:Pkinase 794 973 3.8e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000163954
AA Change: D160G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000127545
Gene: ENSMUSG00000023403
AA Change: D160G

DomainStartEndE-ValueType
TUDOR 81 135 1.34e-8 SMART
coiled coil region 298 345 N/A INTRINSIC
Pfam:Pkinase_Tyr 784 922 7.4e-9 PFAM
Pfam:Pkinase 794 940 1.8e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000172459
AA Change: D160G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000132896
Gene: ENSMUSG00000023403
AA Change: D160G

DomainStartEndE-ValueType
TUDOR 81 135 1.34e-8 SMART
coiled coil region 298 345 N/A INTRINSIC
Pfam:Pkinase_Tyr 739 890 5.2e-9 PFAM
Pfam:Pkinase 749 917 1.1e-16 PFAM
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 93.1%
  • 20x: 80.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null mutation display normal embryonic development and spermatogenesis. [provided by MGI curators]
Allele List at MGI

All alleles(4) : Targeted, other(1) Gene trapped(3)

Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700088E04Rik T C 15: 79,019,403 (GRCm39) D179G probably benign Het
Aadacl2fm2 G A 3: 59,659,314 (GRCm39) E256K probably benign Het
Adh7 C T 3: 137,927,490 (GRCm39) A12V probably benign Het
Ankhd1 T A 18: 36,767,399 (GRCm39) N1179K probably damaging Het
Ankrd50 T C 3: 38,511,336 (GRCm39) T344A probably benign Het
Aplf T C 6: 87,623,273 (GRCm39) T269A probably benign Het
Cavin4 T C 4: 48,663,637 (GRCm39) S6P probably damaging Het
Ces2g T C 8: 105,694,094 (GRCm39) probably null Het
Cyp2c66 A T 19: 39,151,812 (GRCm39) N176Y probably damaging Het
Dnah3 T A 7: 119,522,253 (GRCm39) D3980V probably damaging Het
Drc7 G T 8: 95,799,416 (GRCm39) E530D probably damaging Het
Dst A G 1: 34,314,358 (GRCm39) T6434A probably damaging Het
Dtx3l A G 16: 35,759,127 (GRCm39) S41P possibly damaging Het
Eef1b2 G A 1: 63,218,616 (GRCm39) probably null Het
Eml3 C T 19: 8,913,672 (GRCm39) T43I probably damaging Het
Fam110b T A 4: 5,799,434 (GRCm39) L284Q probably damaging Het
Gpr33 A C 12: 52,070,252 (GRCm39) H262Q probably damaging Het
Igfals T G 17: 25,099,455 (GRCm39) L182R probably damaging Het
Lamc1 A G 1: 153,126,205 (GRCm39) F496L possibly damaging Het
Muc4 T A 16: 32,569,343 (GRCm39) H134Q possibly damaging Het
Nckap1 C T 2: 80,348,286 (GRCm39) S889N probably benign Het
Nxn A T 11: 76,164,895 (GRCm39) C205* probably null Het
Oga G A 19: 45,740,594 (GRCm39) R914* probably null Het
Or11l3 T C 11: 58,516,284 (GRCm39) E196G probably damaging Het
Or52h9 C A 7: 104,202,293 (GRCm39) H56N possibly damaging Het
Pamr1 A T 2: 102,469,698 (GRCm39) I415F possibly damaging Het
Ppp4r4 G A 12: 103,545,327 (GRCm39) G200E probably damaging Het
Pramel29 G A 4: 143,933,694 (GRCm39) T471I probably damaging Het
Prdm16 C A 4: 154,613,256 (GRCm39) S57I probably damaging Het
Psmd11 A G 11: 80,362,410 (GRCm39) K157R possibly damaging Het
Ptprn2 G A 12: 117,175,628 (GRCm39) probably null Het
Pus7 G A 5: 23,973,793 (GRCm39) H234Y probably benign Het
Rd3l A G 12: 111,946,717 (GRCm39) Y20H probably benign Het
Sycp2 C T 2: 178,016,159 (GRCm39) E768K possibly damaging Het
Tango6 T C 8: 107,415,527 (GRCm39) V116A probably benign Het
Ttn C T 2: 76,697,574 (GRCm39) probably benign Het
Vmn2r114 ATTT ATT 17: 23,509,906 (GRCm39) probably null Het
Xylb T C 9: 119,212,443 (GRCm39) I427T probably damaging Het
Zc3h7a T G 16: 10,956,939 (GRCm39) D890A probably damaging Het
Other mutations in Stk31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00495:Stk31 APN 6 49,414,377 (GRCm39) missense probably benign 0.41
IGL02479:Stk31 APN 6 49,398,622 (GRCm39) missense probably damaging 0.99
IGL02490:Stk31 APN 6 49,394,469 (GRCm39) missense probably benign 0.04
IGL03165:Stk31 APN 6 49,422,198 (GRCm39) missense probably damaging 0.98
3-1:Stk31 UTSW 6 49,394,136 (GRCm39) nonsense probably null
R0016:Stk31 UTSW 6 49,414,311 (GRCm39) missense probably damaging 1.00
R0016:Stk31 UTSW 6 49,414,311 (GRCm39) missense probably damaging 1.00
R0039:Stk31 UTSW 6 49,419,192 (GRCm39) missense probably damaging 1.00
R0616:Stk31 UTSW 6 49,400,419 (GRCm39) missense probably damaging 1.00
R0732:Stk31 UTSW 6 49,394,429 (GRCm39) missense probably benign 0.00
R0975:Stk31 UTSW 6 49,400,343 (GRCm39) missense probably damaging 1.00
R1705:Stk31 UTSW 6 49,400,318 (GRCm39) missense possibly damaging 0.94
R1711:Stk31 UTSW 6 49,446,238 (GRCm39) missense probably benign 0.10
R1892:Stk31 UTSW 6 49,415,408 (GRCm39) missense probably damaging 1.00
R1942:Stk31 UTSW 6 49,416,061 (GRCm39) missense probably damaging 0.98
R1953:Stk31 UTSW 6 49,423,412 (GRCm39) critical splice donor site probably null
R2149:Stk31 UTSW 6 49,416,152 (GRCm39) missense possibly damaging 0.80
R2281:Stk31 UTSW 6 49,394,184 (GRCm39) missense probably damaging 1.00
R3438:Stk31 UTSW 6 49,414,455 (GRCm39) missense probably benign 0.00
R4681:Stk31 UTSW 6 49,414,369 (GRCm39) missense probably benign 0.37
R5333:Stk31 UTSW 6 49,446,086 (GRCm39) missense probably benign 0.00
R5492:Stk31 UTSW 6 49,375,177 (GRCm39) missense probably damaging 1.00
R5782:Stk31 UTSW 6 49,446,070 (GRCm39) missense probably benign 0.00
R5820:Stk31 UTSW 6 49,394,219 (GRCm39) missense probably damaging 0.96
R5931:Stk31 UTSW 6 49,446,236 (GRCm39) missense probably benign 0.05
R6012:Stk31 UTSW 6 49,446,243 (GRCm39) missense probably damaging 0.96
R6254:Stk31 UTSW 6 49,398,631 (GRCm39) missense probably benign 0.08
R6281:Stk31 UTSW 6 49,446,114 (GRCm39) missense possibly damaging 0.93
R6294:Stk31 UTSW 6 49,394,278 (GRCm39) missense probably benign 0.18
R6401:Stk31 UTSW 6 49,400,372 (GRCm39) missense probably damaging 1.00
R7289:Stk31 UTSW 6 49,415,393 (GRCm39) missense probably benign 0.05
R7490:Stk31 UTSW 6 49,416,166 (GRCm39) critical splice donor site probably null
R7659:Stk31 UTSW 6 49,400,340 (GRCm39) missense probably benign 0.00
R7757:Stk31 UTSW 6 49,383,877 (GRCm39) splice site probably null
R8172:Stk31 UTSW 6 49,394,261 (GRCm39) missense possibly damaging 0.79
R8731:Stk31 UTSW 6 49,415,435 (GRCm39) missense probably benign 0.16
R8781:Stk31 UTSW 6 49,383,709 (GRCm39) missense probably damaging 1.00
R8966:Stk31 UTSW 6 49,423,134 (GRCm39) missense possibly damaging 0.67
R9594:Stk31 UTSW 6 49,424,221 (GRCm39) missense possibly damaging 0.90
Z1088:Stk31 UTSW 6 49,394,122 (GRCm39) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- AGGAAGGATCACAATGCTGTATGCTC -3'
(R):5'- TGGTAAGTACCAGGGATCAAACCCAG -3'

Sequencing Primer
(F):5'- TGGTACTCTTGGAAATTAGTCCC -3'
(R):5'- aaacccagggtctgatcatac -3'
Posted On 2014-01-05