Incidental Mutation 'R1127:Ces2g'
ID |
96310 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Ces2g
|
Ensembl Gene |
ENSMUSG00000031877 |
Gene Name |
carboxylesterase 2G |
Synonyms |
2210023G05Rik |
MMRRC Submission |
039200-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.047)
|
Stock # |
R1127 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
8 |
Chromosomal Location |
105688350-105696169 bp(+) (GRCm39) |
Type of Mutation |
splice site (6 bp from exon) |
DNA Base Change (assembly) |
T to C
at 105694094 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000049315
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043183]
|
AlphaFold |
E9PV38 |
Predicted Effect |
probably null
Transcript: ENSMUST00000043183
|
SMART Domains |
Protein: ENSMUSP00000049315 Gene: ENSMUSG00000031877
Domain | Start | End | E-Value | Type |
Pfam:COesterase
|
11 |
539 |
1.4e-176 |
PFAM |
Pfam:Abhydrolase_3
|
144 |
245 |
4.9e-11 |
PFAM |
Pfam:Peptidase_S9
|
159 |
331 |
8.1e-7 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212330
|
Meta Mutation Damage Score |
0.9755 |
Coding Region Coverage |
- 1x: 98.7%
- 3x: 97.5%
- 10x: 93.1%
- 20x: 80.6%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 39 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700088E04Rik |
T |
C |
15: 79,019,403 (GRCm39) |
D179G |
probably benign |
Het |
Aadacl2fm2 |
G |
A |
3: 59,659,314 (GRCm39) |
E256K |
probably benign |
Het |
Adh7 |
C |
T |
3: 137,927,490 (GRCm39) |
A12V |
probably benign |
Het |
Ankhd1 |
T |
A |
18: 36,767,399 (GRCm39) |
N1179K |
probably damaging |
Het |
Ankrd50 |
T |
C |
3: 38,511,336 (GRCm39) |
T344A |
probably benign |
Het |
Aplf |
T |
C |
6: 87,623,273 (GRCm39) |
T269A |
probably benign |
Het |
Cavin4 |
T |
C |
4: 48,663,637 (GRCm39) |
S6P |
probably damaging |
Het |
Cyp2c66 |
A |
T |
19: 39,151,812 (GRCm39) |
N176Y |
probably damaging |
Het |
Dnah3 |
T |
A |
7: 119,522,253 (GRCm39) |
D3980V |
probably damaging |
Het |
Drc7 |
G |
T |
8: 95,799,416 (GRCm39) |
E530D |
probably damaging |
Het |
Dst |
A |
G |
1: 34,314,358 (GRCm39) |
T6434A |
probably damaging |
Het |
Dtx3l |
A |
G |
16: 35,759,127 (GRCm39) |
S41P |
possibly damaging |
Het |
Eef1b2 |
G |
A |
1: 63,218,616 (GRCm39) |
|
probably null |
Het |
Eml3 |
C |
T |
19: 8,913,672 (GRCm39) |
T43I |
probably damaging |
Het |
Fam110b |
T |
A |
4: 5,799,434 (GRCm39) |
L284Q |
probably damaging |
Het |
Gpr33 |
A |
C |
12: 52,070,252 (GRCm39) |
H262Q |
probably damaging |
Het |
Igfals |
T |
G |
17: 25,099,455 (GRCm39) |
L182R |
probably damaging |
Het |
Lamc1 |
A |
G |
1: 153,126,205 (GRCm39) |
F496L |
possibly damaging |
Het |
Muc4 |
T |
A |
16: 32,569,343 (GRCm39) |
H134Q |
possibly damaging |
Het |
Nckap1 |
C |
T |
2: 80,348,286 (GRCm39) |
S889N |
probably benign |
Het |
Nxn |
A |
T |
11: 76,164,895 (GRCm39) |
C205* |
probably null |
Het |
Oga |
G |
A |
19: 45,740,594 (GRCm39) |
R914* |
probably null |
Het |
Or11l3 |
T |
C |
11: 58,516,284 (GRCm39) |
E196G |
probably damaging |
Het |
Or52h9 |
C |
A |
7: 104,202,293 (GRCm39) |
H56N |
possibly damaging |
Het |
Pamr1 |
A |
T |
2: 102,469,698 (GRCm39) |
I415F |
possibly damaging |
Het |
Ppp4r4 |
G |
A |
12: 103,545,327 (GRCm39) |
G200E |
probably damaging |
Het |
Pramel29 |
G |
A |
4: 143,933,694 (GRCm39) |
T471I |
probably damaging |
Het |
Prdm16 |
C |
A |
4: 154,613,256 (GRCm39) |
S57I |
probably damaging |
Het |
Psmd11 |
A |
G |
11: 80,362,410 (GRCm39) |
K157R |
possibly damaging |
Het |
Ptprn2 |
G |
A |
12: 117,175,628 (GRCm39) |
|
probably null |
Het |
Pus7 |
G |
A |
5: 23,973,793 (GRCm39) |
H234Y |
probably benign |
Het |
Rd3l |
A |
G |
12: 111,946,717 (GRCm39) |
Y20H |
probably benign |
Het |
Stk31 |
A |
G |
6: 49,386,141 (GRCm39) |
D160G |
probably damaging |
Het |
Sycp2 |
C |
T |
2: 178,016,159 (GRCm39) |
E768K |
possibly damaging |
Het |
Tango6 |
T |
C |
8: 107,415,527 (GRCm39) |
V116A |
probably benign |
Het |
Ttn |
C |
T |
2: 76,697,574 (GRCm39) |
|
probably benign |
Het |
Vmn2r114 |
ATTT |
ATT |
17: 23,509,906 (GRCm39) |
|
probably null |
Het |
Xylb |
T |
C |
9: 119,212,443 (GRCm39) |
I427T |
probably damaging |
Het |
Zc3h7a |
T |
G |
16: 10,956,939 (GRCm39) |
D890A |
probably damaging |
Het |
|
Other mutations in Ces2g |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00832:Ces2g
|
APN |
8 |
105,694,471 (GRCm39) |
splice site |
probably benign |
|
IGL00901:Ces2g
|
APN |
8 |
105,691,761 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02101:Ces2g
|
APN |
8 |
105,691,769 (GRCm39) |
splice site |
probably null |
|
IGL02146:Ces2g
|
APN |
8 |
105,693,576 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL02624:Ces2g
|
APN |
8 |
105,691,380 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03091:Ces2g
|
APN |
8 |
105,691,386 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4810001:Ces2g
|
UTSW |
8 |
105,691,521 (GRCm39) |
missense |
possibly damaging |
0.52 |
R0025:Ces2g
|
UTSW |
8 |
105,692,628 (GRCm39) |
splice site |
probably benign |
|
R0025:Ces2g
|
UTSW |
8 |
105,692,628 (GRCm39) |
splice site |
probably benign |
|
R0122:Ces2g
|
UTSW |
8 |
105,694,932 (GRCm39) |
missense |
probably damaging |
0.96 |
R0494:Ces2g
|
UTSW |
8 |
105,693,199 (GRCm39) |
missense |
probably benign |
|
R1337:Ces2g
|
UTSW |
8 |
105,690,597 (GRCm39) |
missense |
possibly damaging |
0.63 |
R1619:Ces2g
|
UTSW |
8 |
105,693,984 (GRCm39) |
missense |
probably damaging |
1.00 |
R1813:Ces2g
|
UTSW |
8 |
105,693,569 (GRCm39) |
missense |
probably benign |
0.32 |
R2240:Ces2g
|
UTSW |
8 |
105,689,134 (GRCm39) |
missense |
probably benign |
0.11 |
R2255:Ces2g
|
UTSW |
8 |
105,694,046 (GRCm39) |
missense |
probably damaging |
1.00 |
R2307:Ces2g
|
UTSW |
8 |
105,695,044 (GRCm39) |
missense |
probably benign |
0.01 |
R2566:Ces2g
|
UTSW |
8 |
105,692,621 (GRCm39) |
critical splice donor site |
probably null |
|
R4026:Ces2g
|
UTSW |
8 |
105,691,377 (GRCm39) |
missense |
probably damaging |
0.99 |
R4469:Ces2g
|
UTSW |
8 |
105,692,602 (GRCm39) |
missense |
probably benign |
0.14 |
R4631:Ces2g
|
UTSW |
8 |
105,694,094 (GRCm39) |
splice site |
probably null |
|
R4859:Ces2g
|
UTSW |
8 |
105,694,094 (GRCm39) |
splice site |
probably null |
|
R4900:Ces2g
|
UTSW |
8 |
105,693,989 (GRCm39) |
nonsense |
probably null |
|
R4925:Ces2g
|
UTSW |
8 |
105,691,526 (GRCm39) |
missense |
probably benign |
0.27 |
R5524:Ces2g
|
UTSW |
8 |
105,693,527 (GRCm39) |
missense |
probably benign |
0.00 |
R5556:Ces2g
|
UTSW |
8 |
105,694,074 (GRCm39) |
missense |
probably benign |
0.14 |
R6795:Ces2g
|
UTSW |
8 |
105,694,449 (GRCm39) |
missense |
probably damaging |
0.96 |
R6988:Ces2g
|
UTSW |
8 |
105,690,540 (GRCm39) |
missense |
probably benign |
|
R7653:Ces2g
|
UTSW |
8 |
105,689,285 (GRCm39) |
missense |
probably damaging |
1.00 |
R7724:Ces2g
|
UTSW |
8 |
105,693,484 (GRCm39) |
missense |
probably benign |
0.02 |
R7740:Ces2g
|
UTSW |
8 |
105,692,962 (GRCm39) |
missense |
probably damaging |
0.98 |
R7856:Ces2g
|
UTSW |
8 |
105,693,014 (GRCm39) |
missense |
not run |
|
R8123:Ces2g
|
UTSW |
8 |
105,693,555 (GRCm39) |
missense |
probably benign |
0.06 |
R8690:Ces2g
|
UTSW |
8 |
105,693,605 (GRCm39) |
missense |
probably benign |
0.01 |
R8724:Ces2g
|
UTSW |
8 |
105,692,955 (GRCm39) |
missense |
probably benign |
0.01 |
R8732:Ces2g
|
UTSW |
8 |
105,689,195 (GRCm39) |
missense |
possibly damaging |
0.78 |
R8825:Ces2g
|
UTSW |
8 |
105,693,954 (GRCm39) |
missense |
probably benign |
0.13 |
R9441:Ces2g
|
UTSW |
8 |
105,690,623 (GRCm39) |
missense |
possibly damaging |
0.52 |
R9688:Ces2g
|
UTSW |
8 |
105,691,304 (GRCm39) |
missense |
probably benign |
0.42 |
Z1177:Ces2g
|
UTSW |
8 |
105,690,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TTTCAGCGTGAGTACCACTGTGAC -3'
(R):5'- GTTGTCTGGCCTCAAATTATTGGCG -3'
Sequencing Primer
(F):5'- CACTGTGACAACGCTTAGTGG -3'
(R):5'- GGCCTCAAATTATTGGCGTTACTAC -3'
|
Posted On |
2014-01-05 |