Incidental Mutation 'R1127:Or11l3'
ID 96321
Institutional Source Beutler Lab
Gene Symbol Or11l3
Ensembl Gene ENSMUSG00000043880
Gene Name olfactory receptor family 11 subfamily L member 3
Synonyms MOR107-1, Olfr323, GA_x6K02T2NKPP-794386-795357
MMRRC Submission 039200-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R1127 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 58515899-58516870 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58516284 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 196 (E196G)
Ref Sequence ENSEMBL: ENSMUSP00000151137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070804] [ENSMUST00000203173] [ENSMUST00000214132]
AlphaFold Q5NCD0
Predicted Effect probably damaging
Transcript: ENSMUST00000070804
AA Change: E196G

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000068147
Gene: ENSMUSG00000043880
AA Change: E196G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.4e-54 PFAM
Pfam:7tm_1 41 290 3.7e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203173
SMART Domains Protein: ENSMUSP00000145459
Gene: ENSMUSG00000043880

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000214132
AA Change: E196G

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 93.1%
  • 20x: 80.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700088E04Rik T C 15: 79,019,403 (GRCm39) D179G probably benign Het
Aadacl2fm2 G A 3: 59,659,314 (GRCm39) E256K probably benign Het
Adh7 C T 3: 137,927,490 (GRCm39) A12V probably benign Het
Ankhd1 T A 18: 36,767,399 (GRCm39) N1179K probably damaging Het
Ankrd50 T C 3: 38,511,336 (GRCm39) T344A probably benign Het
Aplf T C 6: 87,623,273 (GRCm39) T269A probably benign Het
Cavin4 T C 4: 48,663,637 (GRCm39) S6P probably damaging Het
Ces2g T C 8: 105,694,094 (GRCm39) probably null Het
Cyp2c66 A T 19: 39,151,812 (GRCm39) N176Y probably damaging Het
Dnah3 T A 7: 119,522,253 (GRCm39) D3980V probably damaging Het
Drc7 G T 8: 95,799,416 (GRCm39) E530D probably damaging Het
Dst A G 1: 34,314,358 (GRCm39) T6434A probably damaging Het
Dtx3l A G 16: 35,759,127 (GRCm39) S41P possibly damaging Het
Eef1b2 G A 1: 63,218,616 (GRCm39) probably null Het
Eml3 C T 19: 8,913,672 (GRCm39) T43I probably damaging Het
Fam110b T A 4: 5,799,434 (GRCm39) L284Q probably damaging Het
Gpr33 A C 12: 52,070,252 (GRCm39) H262Q probably damaging Het
Igfals T G 17: 25,099,455 (GRCm39) L182R probably damaging Het
Lamc1 A G 1: 153,126,205 (GRCm39) F496L possibly damaging Het
Muc4 T A 16: 32,569,343 (GRCm39) H134Q possibly damaging Het
Nckap1 C T 2: 80,348,286 (GRCm39) S889N probably benign Het
Nxn A T 11: 76,164,895 (GRCm39) C205* probably null Het
Oga G A 19: 45,740,594 (GRCm39) R914* probably null Het
Or52h9 C A 7: 104,202,293 (GRCm39) H56N possibly damaging Het
Pamr1 A T 2: 102,469,698 (GRCm39) I415F possibly damaging Het
Ppp4r4 G A 12: 103,545,327 (GRCm39) G200E probably damaging Het
Pramel29 G A 4: 143,933,694 (GRCm39) T471I probably damaging Het
Prdm16 C A 4: 154,613,256 (GRCm39) S57I probably damaging Het
Psmd11 A G 11: 80,362,410 (GRCm39) K157R possibly damaging Het
Ptprn2 G A 12: 117,175,628 (GRCm39) probably null Het
Pus7 G A 5: 23,973,793 (GRCm39) H234Y probably benign Het
Rd3l A G 12: 111,946,717 (GRCm39) Y20H probably benign Het
Stk31 A G 6: 49,386,141 (GRCm39) D160G probably damaging Het
Sycp2 C T 2: 178,016,159 (GRCm39) E768K possibly damaging Het
Tango6 T C 8: 107,415,527 (GRCm39) V116A probably benign Het
Ttn C T 2: 76,697,574 (GRCm39) probably benign Het
Vmn2r114 ATTT ATT 17: 23,509,906 (GRCm39) probably null Het
Xylb T C 9: 119,212,443 (GRCm39) I427T probably damaging Het
Zc3h7a T G 16: 10,956,939 (GRCm39) D890A probably damaging Het
Other mutations in Or11l3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02995:Or11l3 APN 11 58,516,107 (GRCm39) missense possibly damaging 0.92
IGL03118:Or11l3 APN 11 58,516,269 (GRCm39) missense probably damaging 0.99
R0058:Or11l3 UTSW 11 58,516,494 (GRCm39) missense probably damaging 1.00
R0335:Or11l3 UTSW 11 58,516,566 (GRCm39) missense probably damaging 1.00
R2029:Or11l3 UTSW 11 58,516,319 (GRCm39) missense probably damaging 1.00
R2434:Or11l3 UTSW 11 58,515,937 (GRCm39) missense possibly damaging 0.95
R5483:Or11l3 UTSW 11 58,516,783 (GRCm39) missense possibly damaging 0.95
R6423:Or11l3 UTSW 11 58,516,189 (GRCm39) missense probably damaging 1.00
R6990:Or11l3 UTSW 11 58,516,284 (GRCm39) missense probably damaging 0.98
R7472:Or11l3 UTSW 11 58,516,260 (GRCm39) missense probably damaging 1.00
R7539:Or11l3 UTSW 11 58,516,782 (GRCm39) missense probably damaging 1.00
R7635:Or11l3 UTSW 11 58,515,990 (GRCm39) missense unknown
R7647:Or11l3 UTSW 11 58,516,029 (GRCm39) missense probably damaging 1.00
R8519:Or11l3 UTSW 11 58,516,800 (GRCm39) missense probably damaging 1.00
R8869:Or11l3 UTSW 11 58,515,994 (GRCm39) missense unknown
R9180:Or11l3 UTSW 11 58,516,062 (GRCm39) missense probably benign 0.36
R9262:Or11l3 UTSW 11 58,516,282 (GRCm39) missense probably benign 0.00
R9788:Or11l3 UTSW 11 58,516,692 (GRCm39) missense probably benign 0.03
Z1186:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1186:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1186:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1186:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1186:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1187:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1187:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1187:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1187:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1187:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1188:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1188:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1188:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1188:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1188:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1189:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1189:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1189:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1189:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1189:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1190:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1190:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1190:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1190:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1190:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1191:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1191:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1191:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1191:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1191:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1192:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1192:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1192:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1192:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1192:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TCCCGTAGTAGATGGTGACCACAG -3'
(R):5'- TCCTTGCCGCAATGGCTTATGAC -3'

Sequencing Primer
(F):5'- ATGGTGACCACAGCCAGG -3'
(R):5'- TCATGAGCCCGGACAACTG -3'
Posted On 2014-01-05