Incidental Mutation 'R1127:Gpr33'
ID 96329
Institutional Source Beutler Lab
Gene Symbol Gpr33
Ensembl Gene ENSMUSG00000035148
Gene Name G protein-coupled receptor 33
Synonyms
MMRRC Submission 039200-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1127 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 52069786-52074846 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 52070252 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 262 (H262Q)
Ref Sequence ENSEMBL: ENSMUSP00000048059 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040161]
AlphaFold O88416
Predicted Effect probably damaging
Transcript: ENSMUST00000040161
AA Change: H262Q

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000048059
Gene: ENSMUSG00000035148
AA Change: H262Q

DomainStartEndE-ValueType
Pfam:7tm_1 46 299 3.6e-32 PFAM
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 93.1%
  • 20x: 80.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene has been identified as an orphan chemoattractant G-protein-coupled receptors (GPCR) pseudogene. Studies have shown that the inactivated gene is present as the predominant allele in the human population. A small fraction of the human population has been found to harbor an intact allele.[provided by RefSeq, Oct 2010]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700088E04Rik T C 15: 79,019,403 (GRCm39) D179G probably benign Het
Aadacl2fm2 G A 3: 59,659,314 (GRCm39) E256K probably benign Het
Adh7 C T 3: 137,927,490 (GRCm39) A12V probably benign Het
Ankhd1 T A 18: 36,767,399 (GRCm39) N1179K probably damaging Het
Ankrd50 T C 3: 38,511,336 (GRCm39) T344A probably benign Het
Aplf T C 6: 87,623,273 (GRCm39) T269A probably benign Het
Cavin4 T C 4: 48,663,637 (GRCm39) S6P probably damaging Het
Ces2g T C 8: 105,694,094 (GRCm39) probably null Het
Cyp2c66 A T 19: 39,151,812 (GRCm39) N176Y probably damaging Het
Dnah3 T A 7: 119,522,253 (GRCm39) D3980V probably damaging Het
Drc7 G T 8: 95,799,416 (GRCm39) E530D probably damaging Het
Dst A G 1: 34,314,358 (GRCm39) T6434A probably damaging Het
Dtx3l A G 16: 35,759,127 (GRCm39) S41P possibly damaging Het
Eef1b2 G A 1: 63,218,616 (GRCm39) probably null Het
Eml3 C T 19: 8,913,672 (GRCm39) T43I probably damaging Het
Fam110b T A 4: 5,799,434 (GRCm39) L284Q probably damaging Het
Igfals T G 17: 25,099,455 (GRCm39) L182R probably damaging Het
Lamc1 A G 1: 153,126,205 (GRCm39) F496L possibly damaging Het
Muc4 T A 16: 32,569,343 (GRCm39) H134Q possibly damaging Het
Nckap1 C T 2: 80,348,286 (GRCm39) S889N probably benign Het
Nxn A T 11: 76,164,895 (GRCm39) C205* probably null Het
Oga G A 19: 45,740,594 (GRCm39) R914* probably null Het
Or11l3 T C 11: 58,516,284 (GRCm39) E196G probably damaging Het
Or52h9 C A 7: 104,202,293 (GRCm39) H56N possibly damaging Het
Pamr1 A T 2: 102,469,698 (GRCm39) I415F possibly damaging Het
Ppp4r4 G A 12: 103,545,327 (GRCm39) G200E probably damaging Het
Pramel29 G A 4: 143,933,694 (GRCm39) T471I probably damaging Het
Prdm16 C A 4: 154,613,256 (GRCm39) S57I probably damaging Het
Psmd11 A G 11: 80,362,410 (GRCm39) K157R possibly damaging Het
Ptprn2 G A 12: 117,175,628 (GRCm39) probably null Het
Pus7 G A 5: 23,973,793 (GRCm39) H234Y probably benign Het
Rd3l A G 12: 111,946,717 (GRCm39) Y20H probably benign Het
Stk31 A G 6: 49,386,141 (GRCm39) D160G probably damaging Het
Sycp2 C T 2: 178,016,159 (GRCm39) E768K possibly damaging Het
Tango6 T C 8: 107,415,527 (GRCm39) V116A probably benign Het
Ttn C T 2: 76,697,574 (GRCm39) probably benign Het
Vmn2r114 ATTT ATT 17: 23,509,906 (GRCm39) probably null Het
Xylb T C 9: 119,212,443 (GRCm39) I427T probably damaging Het
Zc3h7a T G 16: 10,956,939 (GRCm39) D890A probably damaging Het
Other mutations in Gpr33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01655:Gpr33 APN 12 52,070,343 (GRCm39) missense probably damaging 0.98
IGL02177:Gpr33 APN 12 52,070,863 (GRCm39) missense probably benign 0.00
IGL03090:Gpr33 APN 12 52,070,809 (GRCm39) missense probably damaging 0.99
R0883:Gpr33 UTSW 12 52,070,418 (GRCm39) missense probably benign 0.17
R1112:Gpr33 UTSW 12 52,070,155 (GRCm39) missense probably damaging 1.00
R1742:Gpr33 UTSW 12 52,071,045 (GRCm39) critical splice acceptor site probably null
R1967:Gpr33 UTSW 12 52,070,991 (GRCm39) missense probably benign
R2208:Gpr33 UTSW 12 52,070,236 (GRCm39) missense probably benign 0.00
R2917:Gpr33 UTSW 12 52,070,379 (GRCm39) missense possibly damaging 0.63
R4308:Gpr33 UTSW 12 52,070,423 (GRCm39) nonsense probably null
R4725:Gpr33 UTSW 12 52,070,892 (GRCm39) missense probably damaging 1.00
R5616:Gpr33 UTSW 12 52,070,377 (GRCm39) missense probably damaging 0.99
R7055:Gpr33 UTSW 12 52,071,036 (GRCm39) start codon destroyed probably null 0.99
R7272:Gpr33 UTSW 12 52,070,848 (GRCm39) missense probably damaging 0.99
R7419:Gpr33 UTSW 12 52,070,050 (GRCm39) missense probably benign 0.00
R8313:Gpr33 UTSW 12 52,070,907 (GRCm39) missense probably benign 0.00
R8514:Gpr33 UTSW 12 52,070,181 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- CATACTTCCATCATGGCCCATTGCTT -3'
(R):5'- TCATGCAGCCTGTTTCGTCGG -3'

Sequencing Primer
(F):5'- agccatctctcccaccc -3'
(R):5'- TGGCCACCAAGATGAAAGAG -3'
Posted On 2014-01-05