Incidental Mutation 'R1127:Cyp2c66'
ID 96365
Institutional Source Beutler Lab
Gene Symbol Cyp2c66
Ensembl Gene ENSMUSG00000067229
Gene Name cytochrome P450, family 2, subfamily c, polypeptide 66
Synonyms 2010301M18Rik
MMRRC Submission 039200-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.150) question?
Stock # R1127 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 39102342-39175200 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 39151812 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Tyrosine at position 176 (N176Y)
Ref Sequence ENSEMBL: ENSMUSP00000084487 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087234] [ENSMUST00000146494]
AlphaFold Q5GLZ0
Predicted Effect probably damaging
Transcript: ENSMUST00000087234
AA Change: N176Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000084487
Gene: ENSMUSG00000067229
AA Change: N176Y

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:p450 30 487 1e-157 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000146494
SMART Domains Protein: ENSMUSP00000120397
Gene: ENSMUSG00000067229

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
SCOP:d1cpt__ 26 55 4e-9 SMART
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 93.1%
  • 20x: 80.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700088E04Rik T C 15: 79,019,403 (GRCm39) D179G probably benign Het
Aadacl2fm2 G A 3: 59,659,314 (GRCm39) E256K probably benign Het
Adh7 C T 3: 137,927,490 (GRCm39) A12V probably benign Het
Ankhd1 T A 18: 36,767,399 (GRCm39) N1179K probably damaging Het
Ankrd50 T C 3: 38,511,336 (GRCm39) T344A probably benign Het
Aplf T C 6: 87,623,273 (GRCm39) T269A probably benign Het
Cavin4 T C 4: 48,663,637 (GRCm39) S6P probably damaging Het
Ces2g T C 8: 105,694,094 (GRCm39) probably null Het
Dnah3 T A 7: 119,522,253 (GRCm39) D3980V probably damaging Het
Drc7 G T 8: 95,799,416 (GRCm39) E530D probably damaging Het
Dst A G 1: 34,314,358 (GRCm39) T6434A probably damaging Het
Dtx3l A G 16: 35,759,127 (GRCm39) S41P possibly damaging Het
Eef1b2 G A 1: 63,218,616 (GRCm39) probably null Het
Eml3 C T 19: 8,913,672 (GRCm39) T43I probably damaging Het
Fam110b T A 4: 5,799,434 (GRCm39) L284Q probably damaging Het
Gpr33 A C 12: 52,070,252 (GRCm39) H262Q probably damaging Het
Igfals T G 17: 25,099,455 (GRCm39) L182R probably damaging Het
Lamc1 A G 1: 153,126,205 (GRCm39) F496L possibly damaging Het
Muc4 T A 16: 32,569,343 (GRCm39) H134Q possibly damaging Het
Nckap1 C T 2: 80,348,286 (GRCm39) S889N probably benign Het
Nxn A T 11: 76,164,895 (GRCm39) C205* probably null Het
Oga G A 19: 45,740,594 (GRCm39) R914* probably null Het
Or11l3 T C 11: 58,516,284 (GRCm39) E196G probably damaging Het
Or52h9 C A 7: 104,202,293 (GRCm39) H56N possibly damaging Het
Pamr1 A T 2: 102,469,698 (GRCm39) I415F possibly damaging Het
Ppp4r4 G A 12: 103,545,327 (GRCm39) G200E probably damaging Het
Pramel29 G A 4: 143,933,694 (GRCm39) T471I probably damaging Het
Prdm16 C A 4: 154,613,256 (GRCm39) S57I probably damaging Het
Psmd11 A G 11: 80,362,410 (GRCm39) K157R possibly damaging Het
Ptprn2 G A 12: 117,175,628 (GRCm39) probably null Het
Pus7 G A 5: 23,973,793 (GRCm39) H234Y probably benign Het
Rd3l A G 12: 111,946,717 (GRCm39) Y20H probably benign Het
Stk31 A G 6: 49,386,141 (GRCm39) D160G probably damaging Het
Sycp2 C T 2: 178,016,159 (GRCm39) E768K possibly damaging Het
Tango6 T C 8: 107,415,527 (GRCm39) V116A probably benign Het
Ttn C T 2: 76,697,574 (GRCm39) probably benign Het
Vmn2r114 ATTT ATT 17: 23,509,906 (GRCm39) probably null Het
Xylb T C 9: 119,212,443 (GRCm39) I427T probably damaging Het
Zc3h7a T G 16: 10,956,939 (GRCm39) D890A probably damaging Het
Other mutations in Cyp2c66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01145:Cyp2c66 APN 19 39,159,405 (GRCm39) missense probably benign 0.00
IGL01589:Cyp2c66 APN 19 39,172,379 (GRCm39) critical splice donor site probably null
IGL02098:Cyp2c66 APN 19 39,159,473 (GRCm39) missense probably damaging 1.00
IGL02114:Cyp2c66 APN 19 39,159,519 (GRCm39) splice site probably benign
IGL02567:Cyp2c66 APN 19 39,175,084 (GRCm39) utr 3 prime probably benign
IGL03181:Cyp2c66 APN 19 39,130,483 (GRCm39) missense probably benign 0.00
IGL03230:Cyp2c66 APN 19 39,172,302 (GRCm39) missense possibly damaging 0.91
R0007:Cyp2c66 UTSW 19 39,159,402 (GRCm39) nonsense probably null
R0092:Cyp2c66 UTSW 19 39,172,224 (GRCm39) splice site probably benign
R0242:Cyp2c66 UTSW 19 39,130,369 (GRCm39) missense probably damaging 1.00
R0242:Cyp2c66 UTSW 19 39,130,369 (GRCm39) missense probably damaging 1.00
R0324:Cyp2c66 UTSW 19 39,165,135 (GRCm39) missense probably benign 0.27
R0675:Cyp2c66 UTSW 19 39,175,060 (GRCm39) missense possibly damaging 0.93
R1871:Cyp2c66 UTSW 19 39,151,858 (GRCm39) missense possibly damaging 0.66
R3404:Cyp2c66 UTSW 19 39,151,771 (GRCm39) missense probably benign
R3429:Cyp2c66 UTSW 19 39,151,892 (GRCm39) missense probably damaging 0.97
R3896:Cyp2c66 UTSW 19 39,130,722 (GRCm39) missense possibly damaging 0.82
R4115:Cyp2c66 UTSW 19 39,165,003 (GRCm39) missense possibly damaging 0.66
R4116:Cyp2c66 UTSW 19 39,165,003 (GRCm39) missense possibly damaging 0.66
R4667:Cyp2c66 UTSW 19 39,165,100 (GRCm39) missense probably damaging 1.00
R4668:Cyp2c66 UTSW 19 39,165,100 (GRCm39) missense probably damaging 1.00
R4711:Cyp2c66 UTSW 19 39,151,843 (GRCm39) missense possibly damaging 0.74
R4960:Cyp2c66 UTSW 19 39,151,766 (GRCm39) critical splice acceptor site probably null
R5070:Cyp2c66 UTSW 19 39,151,914 (GRCm39) missense probably benign 0.15
R5113:Cyp2c66 UTSW 19 39,151,882 (GRCm39) missense probably benign 0.00
R5125:Cyp2c66 UTSW 19 39,159,473 (GRCm39) missense probably damaging 1.00
R5178:Cyp2c66 UTSW 19 39,159,473 (GRCm39) missense probably damaging 1.00
R5588:Cyp2c66 UTSW 19 39,151,858 (GRCm39) missense possibly damaging 0.66
R6011:Cyp2c66 UTSW 19 39,130,380 (GRCm39) missense probably benign 0.00
R6497:Cyp2c66 UTSW 19 39,151,821 (GRCm39) missense probably damaging 0.96
R6707:Cyp2c66 UTSW 19 39,174,944 (GRCm39) missense probably damaging 1.00
R7173:Cyp2c66 UTSW 19 39,159,401 (GRCm39) missense probably benign 0.01
R7202:Cyp2c66 UTSW 19 39,130,348 (GRCm39) missense probably damaging 1.00
R7469:Cyp2c66 UTSW 19 39,172,307 (GRCm39) missense probably damaging 1.00
R7614:Cyp2c66 UTSW 19 39,159,472 (GRCm39) missense probably damaging 0.98
R7985:Cyp2c66 UTSW 19 39,102,430 (GRCm39) missense probably null 1.00
R8012:Cyp2c66 UTSW 19 39,172,369 (GRCm39) missense probably damaging 1.00
R8056:Cyp2c66 UTSW 19 39,130,485 (GRCm39) missense probably benign 0.00
R8302:Cyp2c66 UTSW 19 39,165,078 (GRCm39) missense probably damaging 1.00
R8329:Cyp2c66 UTSW 19 39,174,906 (GRCm39) nonsense probably null
R8365:Cyp2c66 UTSW 19 39,165,048 (GRCm39) missense probably benign 0.00
R8472:Cyp2c66 UTSW 19 39,165,021 (GRCm39) missense probably benign 0.03
R8502:Cyp2c66 UTSW 19 39,130,773 (GRCm39) missense probably benign 0.01
R8688:Cyp2c66 UTSW 19 39,151,884 (GRCm39) missense probably benign 0.00
R8715:Cyp2c66 UTSW 19 39,159,388 (GRCm39) missense probably benign 0.01
R9199:Cyp2c66 UTSW 19 39,130,800 (GRCm39) missense probably benign 0.16
R9551:Cyp2c66 UTSW 19 39,172,246 (GRCm39) missense probably damaging 0.99
R9552:Cyp2c66 UTSW 19 39,172,246 (GRCm39) missense probably damaging 0.99
R9601:Cyp2c66 UTSW 19 39,175,054 (GRCm39) missense probably benign
R9777:Cyp2c66 UTSW 19 39,102,520 (GRCm39) missense probably benign 0.15
Z1177:Cyp2c66 UTSW 19 39,175,070 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- GGCAAGACTTGCTTAAATTGTGACCAG -3'
(R):5'- CCTTGTGGCTAACAGGTGTCAACAATG -3'

Sequencing Primer
(F):5'- TGACCAGTTTCTTTATCTGTTGAG -3'
(R):5'- caagaagtgggagtgagtagg -3'
Posted On 2014-01-05