Incidental Mutation 'R1128:Pglyrp3'
ID 96381
Institutional Source Beutler Lab
Gene Symbol Pglyrp3
Ensembl Gene ENSMUSG00000042244
Gene Name peptidoglycan recognition protein 3
Synonyms LOC242100
MMRRC Submission 039201-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R1128 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 91921890-91938889 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 91935479 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 243 (F243S)
Ref Sequence ENSEMBL: ENSMUSP00000035737 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047660]
AlphaFold A1A547
Predicted Effect probably benign
Transcript: ENSMUST00000047660
AA Change: F243S

PolyPhen 2 Score 0.224 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000035737
Gene: ENSMUSG00000042244
AA Change: F243S

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
PGRP 28 169 2.64e-45 SMART
Ami_2 39 169 1.06e-2 SMART
PGRP 185 326 3.23e-72 SMART
Ami_2 195 332 1.75e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118636
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akp3 G A 1: 87,055,593 (GRCm39) G547R unknown Het
Amhr2 A T 15: 102,361,256 (GRCm39) Q402L probably benign Het
Brip1 A T 11: 85,955,763 (GRCm39) L917M possibly damaging Het
Dennd5a G A 7: 109,520,541 (GRCm39) R415* probably null Het
Eif2ak1 G T 5: 143,835,994 (GRCm39) probably null Het
Golga4 G A 9: 118,377,852 (GRCm39) A458T probably benign Het
H1f6 G T 13: 23,880,307 (GRCm39) K153N possibly damaging Het
Ift88 C T 14: 57,754,476 (GRCm39) R762* probably null Het
Kansl2 A T 15: 98,431,566 (GRCm39) C28* probably null Het
Lct T C 1: 128,229,046 (GRCm39) R816G probably damaging Het
Mzf1 C A 7: 12,786,698 (GRCm39) R124L possibly damaging Het
Obscn T C 11: 58,919,769 (GRCm39) N6809S probably null Het
Pak6 A G 2: 118,526,990 (GRCm39) T662A probably benign Het
Rab44 T C 17: 29,359,435 (GRCm39) V541A possibly damaging Het
Slc39a6 G T 18: 24,718,349 (GRCm39) H569Q probably damaging Het
Slc4a7 T C 14: 14,733,832 (GRCm38) S87P probably damaging Het
Spocd1 T C 4: 129,850,599 (GRCm39) V875A possibly damaging Het
Tspan17 A G 13: 54,942,984 (GRCm39) D146G probably damaging Het
Other mutations in Pglyrp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00335:Pglyrp3 APN 3 91,929,986 (GRCm39) missense probably damaging 0.96
IGL00769:Pglyrp3 APN 3 91,921,929 (GRCm39) utr 5 prime probably benign
IGL02491:Pglyrp3 APN 3 91,921,944 (GRCm39) missense possibly damaging 0.77
IGL03279:Pglyrp3 APN 3 91,933,834 (GRCm39) missense probably damaging 1.00
R0056:Pglyrp3 UTSW 3 91,933,111 (GRCm39) splice site probably benign
R2097:Pglyrp3 UTSW 3 91,935,478 (GRCm39) missense possibly damaging 0.91
R2140:Pglyrp3 UTSW 3 91,933,874 (GRCm39) missense probably benign 0.00
R3697:Pglyrp3 UTSW 3 91,935,481 (GRCm39) missense probably damaging 1.00
R4369:Pglyrp3 UTSW 3 91,935,386 (GRCm39) missense probably damaging 1.00
R4430:Pglyrp3 UTSW 3 91,938,798 (GRCm39) missense probably damaging 1.00
R4775:Pglyrp3 UTSW 3 91,933,037 (GRCm39) missense possibly damaging 0.64
R6020:Pglyrp3 UTSW 3 91,938,841 (GRCm39) missense probably damaging 1.00
R7352:Pglyrp3 UTSW 3 91,921,947 (GRCm39) nonsense probably null
R7437:Pglyrp3 UTSW 3 91,937,985 (GRCm39) missense probably benign 0.00
R8150:Pglyrp3 UTSW 3 91,933,790 (GRCm39) missense probably benign 0.00
R8466:Pglyrp3 UTSW 3 91,921,941 (GRCm39) missense probably benign 0.16
R8695:Pglyrp3 UTSW 3 91,933,762 (GRCm39) missense probably null 1.00
R9413:Pglyrp3 UTSW 3 91,930,106 (GRCm39) missense probably damaging 1.00
R9479:Pglyrp3 UTSW 3 91,935,310 (GRCm39) missense probably benign 0.04
R9592:Pglyrp3 UTSW 3 91,938,859 (GRCm39) missense probably benign 0.22
R9722:Pglyrp3 UTSW 3 91,938,695 (GRCm39) missense possibly damaging 0.67
Z1176:Pglyrp3 UTSW 3 91,935,392 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAATATCACACCACGGTCTGCTTG -3'
(R):5'- AGGCATCATACTTCTTTGGGGTTCG -3'

Sequencing Primer
(F):5'- TCTGCTTGGGAAGCCAGAG -3'
(R):5'- GTGATGTTCCCAATCACAATGG -3'
Posted On 2014-01-05