Incidental Mutation 'R1018:Ankrd36'
ID 96628
Institutional Source Beutler Lab
Gene Symbol Ankrd36
Ensembl Gene ENSMUSG00000020481
Gene Name ankyrin repeat domain 36
Synonyms GC3, 1700012M14Rik, 1700008J08Rik
MMRRC Submission 039122-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R1018 (G1)
Quality Score 178
Status Validated
Chromosome 11
Chromosomal Location 5519684-5639337 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) C to T at 5596876 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000120499 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109856] [ENSMUST00000118112] [ENSMUST00000137933]
AlphaFold D3Z4K0
Predicted Effect probably benign
Transcript: ENSMUST00000109856
SMART Domains Protein: ENSMUSP00000105482
Gene: ENSMUSG00000020481

DomainStartEndE-ValueType
Blast:ANK 29 62 3e-12 BLAST
ANK 66 95 4.5e-3 SMART
ANK 99 128 1.44e-1 SMART
ANK 132 161 4.6e0 SMART
ANK 165 194 2.48e-5 SMART
ANK 198 227 4.67e-1 SMART
internal_repeat_1 449 555 1.04e-5 PROSPERO
internal_repeat_1 891 981 1.04e-5 PROSPERO
low complexity region 1105 1118 N/A INTRINSIC
coiled coil region 1268 1297 N/A INTRINSIC
coiled coil region 1318 1338 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000118112
SMART Domains Protein: ENSMUSP00000122397
Gene: ENSMUSG00000020481

DomainStartEndE-ValueType
Blast:ANK 29 62 3e-12 BLAST
ANK 66 95 2.9e-5 SMART
ANK 99 128 9.4e-4 SMART
ANK 132 161 2.9e-2 SMART
ANK 165 194 1.5e-7 SMART
ANK 198 227 2.9e-3 SMART
internal_repeat_1 255 352 8.15e-5 PROSPERO
internal_repeat_1 438 538 8.15e-5 PROSPERO
low complexity region 1138 1151 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000137933
SMART Domains Protein: ENSMUSP00000120499
Gene: ENSMUSG00000020481

DomainStartEndE-ValueType
low complexity region 463 476 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.7%
Validation Efficiency 100% (50/50)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 G T 10: 79,837,325 (GRCm39) C403F probably damaging Het
Adam20 C T 8: 41,249,146 (GRCm39) Q419* probably null Het
Arl8b T A 6: 108,795,572 (GRCm39) I170K probably damaging Het
Atp5pb A T 3: 105,861,488 (GRCm39) V78E possibly damaging Het
Car9 G T 4: 43,512,439 (GRCm39) probably null Het
Cgnl1 A G 9: 71,633,340 (GRCm39) Y4H probably damaging Het
Cnn2 T C 10: 79,829,397 (GRCm39) C176R probably damaging Het
Dst A G 1: 34,233,174 (GRCm39) D3392G probably damaging Het
Eed T C 7: 89,617,019 (GRCm39) probably benign Het
Efl1 T A 7: 82,412,221 (GRCm39) V870E possibly damaging Het
Epx T C 11: 87,760,129 (GRCm39) N495S probably benign Het
Fbxw20 T A 9: 109,050,404 (GRCm39) Y407F probably benign Het
Gbp9 T A 5: 105,228,126 (GRCm39) Q552L probably benign Het
Hspa13 C A 16: 75,558,164 (GRCm39) V134L possibly damaging Het
Il16 T C 7: 83,323,746 (GRCm39) N268S probably damaging Het
Kif14 G A 1: 136,423,579 (GRCm39) probably benign Het
Lrig1 G A 6: 94,599,583 (GRCm39) probably benign Het
Myo7a T A 7: 97,756,212 (GRCm39) D29V probably damaging Het
Nsd2 A G 5: 34,000,585 (GRCm39) K34R probably damaging Het
Or4a15 C A 2: 89,193,523 (GRCm39) L83F possibly damaging Het
P3h1 C A 4: 119,095,104 (GRCm39) T287K probably damaging Het
Pkhd1 A T 1: 20,271,483 (GRCm39) H3023Q possibly damaging Het
Plxna1 A G 6: 89,319,942 (GRCm39) L535P probably damaging Het
Prom1 A T 5: 44,187,056 (GRCm39) S400R probably benign Het
Psap T G 10: 60,136,590 (GRCm39) L523R probably damaging Het
Psme4 C T 11: 30,754,310 (GRCm39) T189I probably damaging Het
Ptpn12 A T 5: 21,234,867 (GRCm39) S39T possibly damaging Het
Qtrt2 T A 16: 43,698,363 (GRCm39) H98L possibly damaging Het
Rad54l2 C A 9: 106,589,589 (GRCm39) C601F probably benign Het
Saxo4 A T 19: 10,456,824 (GRCm39) probably benign Het
Sfswap A G 5: 129,631,640 (GRCm39) K756R possibly damaging Het
Slc24a5 T C 2: 124,910,827 (GRCm39) V86A probably damaging Het
Srrm2 T C 17: 24,041,514 (GRCm39) S2575P probably damaging Het
Stam T C 2: 14,122,185 (GRCm39) probably benign Het
Tbx6 T A 7: 126,382,364 (GRCm39) probably benign Het
Tmem131 A C 1: 36,833,900 (GRCm39) F1727V probably damaging Het
Tpr T A 1: 150,317,934 (GRCm39) H2147Q possibly damaging Het
Trio T A 15: 27,871,257 (GRCm39) H620L probably damaging Het
Uba5 T C 9: 103,927,102 (GRCm39) T292A probably benign Het
Unc5a T A 13: 55,138,765 (GRCm39) V48E possibly damaging Het
Upf1 G T 8: 70,791,556 (GRCm39) H514Q possibly damaging Het
Usp9y A G Y: 1,341,414 (GRCm39) probably benign Het
Vmn2r6 T A 3: 64,464,261 (GRCm39) D191V probably benign Het
Wapl T C 14: 34,413,863 (GRCm39) Y242H possibly damaging Het
Zfp341 A T 2: 154,487,972 (GRCm39) N812Y probably damaging Het
Zfp358 C A 8: 3,546,843 (GRCm39) S475* probably null Het
Zfp957 C A 14: 79,450,182 (GRCm39) C539F probably damaging Het
Other mutations in Ankrd36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Ankrd36 APN 11 5,570,131 (GRCm39) missense probably benign 0.01
IGL01361:Ankrd36 APN 11 5,546,706 (GRCm39) splice site probably benign
IGL01370:Ankrd36 APN 11 5,534,019 (GRCm39) missense probably benign 0.06
IGL01384:Ankrd36 APN 11 5,578,348 (GRCm39) missense probably benign 0.33
IGL01484:Ankrd36 APN 11 5,579,006 (GRCm39) missense possibly damaging 0.90
IGL01524:Ankrd36 APN 11 5,585,092 (GRCm39) missense probably benign
IGL01700:Ankrd36 APN 11 5,582,198 (GRCm39) missense probably benign 0.05
IGL02322:Ankrd36 APN 11 5,564,619 (GRCm39) missense possibly damaging 0.86
IGL02511:Ankrd36 APN 11 5,610,845 (GRCm39) splice site probably null
IGL02824:Ankrd36 APN 11 5,524,246 (GRCm39) missense possibly damaging 0.67
IGL03204:Ankrd36 APN 11 5,534,023 (GRCm39) missense possibly damaging 0.70
PIT4508001:Ankrd36 UTSW 11 5,557,137 (GRCm39) missense possibly damaging 0.53
R0058:Ankrd36 UTSW 11 5,580,691 (GRCm39) splice site probably benign
R0058:Ankrd36 UTSW 11 5,580,691 (GRCm39) splice site probably benign
R0304:Ankrd36 UTSW 11 5,578,981 (GRCm39) missense possibly damaging 0.55
R0504:Ankrd36 UTSW 11 5,579,274 (GRCm39) missense probably damaging 0.99
R0550:Ankrd36 UTSW 11 5,557,429 (GRCm39) critical splice donor site probably null
R0563:Ankrd36 UTSW 11 5,579,322 (GRCm39) missense probably benign 0.33
R0891:Ankrd36 UTSW 11 5,637,316 (GRCm39) missense possibly damaging 0.72
R1468:Ankrd36 UTSW 11 5,525,752 (GRCm39) missense probably damaging 0.99
R1468:Ankrd36 UTSW 11 5,525,752 (GRCm39) missense probably damaging 0.99
R1558:Ankrd36 UTSW 11 5,585,329 (GRCm39) missense probably damaging 0.99
R1663:Ankrd36 UTSW 11 5,570,126 (GRCm39) missense possibly damaging 0.70
R1682:Ankrd36 UTSW 11 5,557,143 (GRCm39) missense possibly damaging 0.84
R1898:Ankrd36 UTSW 11 5,525,683 (GRCm39) missense probably benign 0.33
R2019:Ankrd36 UTSW 11 5,639,140 (GRCm39) missense probably benign
R2032:Ankrd36 UTSW 11 5,578,616 (GRCm39) missense possibly damaging 0.86
R2084:Ankrd36 UTSW 11 5,612,378 (GRCm39) nonsense probably null
R4097:Ankrd36 UTSW 11 5,578,703 (GRCm39) missense possibly damaging 0.85
R4572:Ankrd36 UTSW 11 5,639,340 (GRCm39) splice site probably null
R4601:Ankrd36 UTSW 11 5,520,102 (GRCm39) missense probably benign 0.04
R4770:Ankrd36 UTSW 11 5,540,870 (GRCm39) missense possibly damaging 0.73
R4777:Ankrd36 UTSW 11 5,557,120 (GRCm39) missense probably benign
R4894:Ankrd36 UTSW 11 5,585,332 (GRCm39) missense probably damaging 0.98
R5288:Ankrd36 UTSW 11 5,639,340 (GRCm39) unclassified probably benign
R5366:Ankrd36 UTSW 11 5,542,841 (GRCm39) nonsense probably null
R5384:Ankrd36 UTSW 11 5,639,340 (GRCm39) unclassified probably benign
R5385:Ankrd36 UTSW 11 5,639,340 (GRCm39) unclassified probably benign
R6109:Ankrd36 UTSW 11 5,578,941 (GRCm39) missense probably damaging 0.98
R6155:Ankrd36 UTSW 11 5,637,442 (GRCm39) missense probably benign 0.00
R6186:Ankrd36 UTSW 11 5,593,812 (GRCm39) missense possibly damaging 0.81
R6289:Ankrd36 UTSW 11 5,578,837 (GRCm39) missense probably damaging 0.96
R6476:Ankrd36 UTSW 11 5,578,753 (GRCm39) missense probably benign 0.05
R6816:Ankrd36 UTSW 11 5,593,765 (GRCm39) missense possibly damaging 0.66
R6880:Ankrd36 UTSW 11 5,578,748 (GRCm39) missense probably damaging 0.99
R6919:Ankrd36 UTSW 11 5,579,299 (GRCm39) missense probably benign
R7007:Ankrd36 UTSW 11 5,639,168 (GRCm39) missense probably benign 0.00
R7515:Ankrd36 UTSW 11 5,578,905 (GRCm39) missense possibly damaging 0.94
R7617:Ankrd36 UTSW 11 5,637,348 (GRCm39) missense probably benign 0.33
R7684:Ankrd36 UTSW 11 5,520,113 (GRCm39) missense possibly damaging 0.49
R7746:Ankrd36 UTSW 11 5,637,451 (GRCm39) missense possibly damaging 0.96
R7783:Ankrd36 UTSW 11 5,585,359 (GRCm39) missense probably damaging 0.99
R7790:Ankrd36 UTSW 11 5,585,176 (GRCm39) missense possibly damaging 0.80
R8221:Ankrd36 UTSW 11 5,534,016 (GRCm39) missense possibly damaging 0.53
R8671:Ankrd36 UTSW 11 5,579,312 (GRCm39) missense probably benign 0.05
R8732:Ankrd36 UTSW 11 5,578,906 (GRCm39) missense possibly damaging 0.90
R8768:Ankrd36 UTSW 11 5,593,763 (GRCm39) missense probably benign 0.00
R9026:Ankrd36 UTSW 11 5,610,696 (GRCm39) missense probably benign
R9093:Ankrd36 UTSW 11 5,589,132 (GRCm39) missense probably benign
R9211:Ankrd36 UTSW 11 5,612,370 (GRCm39) missense possibly damaging 0.85
R9300:Ankrd36 UTSW 11 5,519,979 (GRCm39) missense possibly damaging 0.84
R9644:Ankrd36 UTSW 11 5,593,835 (GRCm39) missense possibly damaging 0.90
RF004:Ankrd36 UTSW 11 5,612,411 (GRCm39) missense possibly damaging 0.53
U24488:Ankrd36 UTSW 11 5,580,772 (GRCm39) missense probably damaging 0.99
Z1176:Ankrd36 UTSW 11 5,565,538 (GRCm39) missense probably benign
Z1177:Ankrd36 UTSW 11 5,593,738 (GRCm39) missense probably damaging 0.96
Z1177:Ankrd36 UTSW 11 5,579,345 (GRCm39) missense probably benign 0.01
Z1177:Ankrd36 UTSW 11 5,521,117 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- TAATAAACAGGAGGTGTTGACTGGGGTA -3'
(R):5'- GAACCTGAACTCTTCCACGTTCTGTGA -3'

Sequencing Primer
(F):5'- CACCACTTCTGTGCATTTACTGC -3'
(R):5'- CCACGTTCTGTGACTCGG -3'
Posted On 2014-01-05