Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00778:Chil4'

9686

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Chil4

Ensembl Gene

ENSMUSG00000063779

Gene Name

chitinase-like 4

Synonyms

Chi3l4, Ym2

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00778

Quality Score

Status

Chromosome

Chromosomal Location

106108807-106126795 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 106109113 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 397 (S397P)

Ref Sequence

ENSEMBL: ENSMUSP00000080851 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000082219]

AlphaFold

Q91Z98

Predicted Effect

probably benign
Transcript: ENSMUST00000082219
AA Change: S397P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000080851
Gene: ENSMUSG00000063779
AA Change: S397P

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Glyco_18	22	365	1.77e-132	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930503E14Rik	G	A	14: 44,401,391 (GRCm39)	H152Y	probably benign	Het
Abca1	T	C	4: 53,086,132 (GRCm39)	D457G	probably benign	Het
Atp8a1	T	G	5: 67,817,246 (GRCm39)	K913N	possibly damaging	Het
Cd180	G	A	13: 102,841,917 (GRCm39)	S321N	probably benign	Het
Cdc14b	T	C	13: 64,363,470 (GRCm39)	N264D	probably damaging	Het
Cenpf	A	T	1: 189,387,109 (GRCm39)	C1724S	probably benign	Het
Clpb	C	T	7: 101,427,815 (GRCm39)	R387*	probably null	Het
Csgalnact2	A	T	6: 118,103,233 (GRCm39)	M1K	probably null	Het
Enpp3	C	A	10: 24,674,160 (GRCm39)	C380F	probably damaging	Het
Gtf3c1	G	A	7: 125,266,546 (GRCm39)	R967W	probably damaging	Het
Hnrnpr	T	A	4: 136,066,856 (GRCm39)	D472E	unknown	Het
Klhl28	A	T	12: 64,996,840 (GRCm39)	D500E	probably damaging	Het
Lmo7	C	T	14: 102,148,321 (GRCm39)		probably benign	Het
Mphosph8	A	G	14: 56,911,900 (GRCm39)	I308V	probably benign	Het
Myo6	T	A	9: 80,190,868 (GRCm39)		probably null	Het
Nsmaf	C	T	4: 6,435,056 (GRCm39)		probably null	Het
Padi6	T	A	4: 140,454,934 (GRCm39)	I668L	possibly damaging	Het
Pigw	A	G	11: 84,768,150 (GRCm39)	I393T	possibly damaging	Het
Prg3	G	A	2: 84,824,076 (GRCm39)	C212Y	probably damaging	Het
Pwp1	T	C	10: 85,715,752 (GRCm39)	V267A	probably benign	Het
Raver2	C	A	4: 100,953,468 (GRCm39)	Q79K	probably benign	Het
Sdr9c7	T	C	10: 127,745,697 (GRCm39)	S270P	probably damaging	Het
Sfmbt2	A	G	2: 10,406,818 (GRCm39)	E39G	probably damaging	Het
Strada	A	G	11: 106,061,976 (GRCm39)		probably benign	Het
Xrn1	T	C	9: 95,855,500 (GRCm39)		probably benign	Het
Zic3	A	G	X: 57,079,779 (GRCm39)	Y424C	probably damaging	Het

Other mutations in Chil4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02457:Chil4	APN	3	106,121,715 (GRCm39)	missense	probably benign
R1087:Chil4	UTSW	3	106,117,881 (GRCm39)	missense	probably benign	0.01
R1398:Chil4	UTSW	3	106,126,825 (GRCm39)	splice site	probably null
R1503:Chil4	UTSW	3	106,113,350 (GRCm39)	missense	probably benign
R1553:Chil4	UTSW	3	106,111,006 (GRCm39)	missense	probably benign	0.02
R1806:Chil4	UTSW	3	106,117,959 (GRCm39)	splice site	probably benign
R1873:Chil4	UTSW	3	106,113,414 (GRCm39)	missense	probably benign	0.00
R2069:Chil4	UTSW	3	106,126,771 (GRCm39)	missense	probably benign	0.16
R2100:Chil4	UTSW	3	106,121,663 (GRCm39)	missense	probably benign
R2370:Chil4	UTSW	3	106,121,616 (GRCm39)	nonsense	probably null
R2984:Chil4	UTSW	3	106,111,043 (GRCm39)	missense	possibly damaging	0.95
R2985:Chil4	UTSW	3	106,111,043 (GRCm39)	missense	possibly damaging	0.95
R3522:Chil4	UTSW	3	106,111,056 (GRCm39)	missense	probably benign	0.08
R3919:Chil4	UTSW	3	106,109,848 (GRCm39)	missense	probably benign	0.00
R4033:Chil4	UTSW	3	106,121,765 (GRCm39)	missense	probably damaging	1.00
R4181:Chil4	UTSW	3	106,111,043 (GRCm39)	missense	possibly damaging	0.95
R4184:Chil4	UTSW	3	106,111,043 (GRCm39)	missense	possibly damaging	0.95
R4301:Chil4	UTSW	3	106,111,043 (GRCm39)	missense	possibly damaging	0.95
R4347:Chil4	UTSW	3	106,110,144 (GRCm39)	missense	probably benign
R4391:Chil4	UTSW	3	106,111,043 (GRCm39)	missense	possibly damaging	0.95
R4395:Chil4	UTSW	3	106,111,043 (GRCm39)	missense	possibly damaging	0.95
R4418:Chil4	UTSW	3	106,111,043 (GRCm39)	missense	possibly damaging	0.95
R4483:Chil4	UTSW	3	106,121,678 (GRCm39)	missense	probably damaging	1.00
R4544:Chil4	UTSW	3	106,117,922 (GRCm39)	missense	probably damaging	0.97
R4887:Chil4	UTSW	3	106,111,460 (GRCm39)	missense	probably benign	0.01
R4949:Chil4	UTSW	3	106,113,408 (GRCm39)	missense	possibly damaging	0.83
R5076:Chil4	UTSW	3	106,109,913 (GRCm39)	missense	probably damaging	1.00
R5146:Chil4	UTSW	3	106,110,150 (GRCm39)	missense	probably benign	0.18
R5254:Chil4	UTSW	3	106,126,768 (GRCm39)	missense	probably benign	0.00
R5521:Chil4	UTSW	3	106,111,013 (GRCm39)	missense	possibly damaging	0.50
R5790:Chil4	UTSW	3	106,109,894 (GRCm39)	missense	probably benign	0.00
R5883:Chil4	UTSW	3	106,117,886 (GRCm39)	missense	possibly damaging	0.48
R6010:Chil4	UTSW	3	106,121,711 (GRCm39)	missense	probably damaging	1.00
R6257:Chil4	UTSW	3	106,111,412 (GRCm39)	missense	possibly damaging	0.84
R6269:Chil4	UTSW	3	106,111,487 (GRCm39)	missense	probably damaging	1.00
R6602:Chil4	UTSW	3	106,117,906 (GRCm39)	missense	probably benign	0.00
R7113:Chil4	UTSW	3	106,121,664 (GRCm39)	missense	probably benign
R7113:Chil4	UTSW	3	106,110,083 (GRCm39)	missense	probably damaging	1.00
R7188:Chil4	UTSW	3	106,111,475 (GRCm39)	missense	probably damaging	1.00
R7980:Chil4	UTSW	3	106,110,060 (GRCm39)	missense	probably damaging	1.00
R8810:Chil4	UTSW	3	106,109,121 (GRCm39)	missense	probably damaging	0.99
R9300:Chil4	UTSW	3	106,109,874 (GRCm39)	missense	probably benign	0.10
R9307:Chil4	UTSW	3	106,111,382 (GRCm39)	critical splice donor site	probably null
R9529:Chil4	UTSW	3	106,118,656 (GRCm39)	missense	probably damaging	1.00
X0067:Chil4	UTSW	3	106,113,350 (GRCm39)	missense	probably benign	0.01

Posted On

2012-12-06