Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00778:Chil4'

9686

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Chil4

Ensembl Gene

ENSMUSG00000063779

Gene Name

chitinase-like 4

Synonyms

Ym2, Chi3l4

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00778

Quality Score

Status

Chromosome

Chromosomal Location

106201490-106219507 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 106201797 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 397 (S397P)

Ref Sequence

ENSEMBL: ENSMUSP00000080851 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000082219]

AlphaFold

Q91Z98

Predicted Effect

probably benign
Transcript: ENSMUST00000082219
AA Change: S397P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000080851
Gene: ENSMUSG00000063779
AA Change: S397P

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Glyco_18	22	365	1.77e-132	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930503E14Rik	G	A	14: 44,163,934	H152Y	probably benign	Het
Abca1	T	C	4: 53,086,132	D457G	probably benign	Het
Atp8a1	T	G	5: 67,659,903	K913N	possibly damaging	Het
Cd180	G	A	13: 102,705,409	S321N	probably benign	Het
Cdc14b	T	C	13: 64,215,656	N264D	probably damaging	Het
Cenpf	A	T	1: 189,654,912	C1724S	probably benign	Het
Clpb	C	T	7: 101,778,608	R387*	probably null	Het
Csgalnact2	A	T	6: 118,126,272	M1K	probably null	Het
Enpp3	C	A	10: 24,798,262	C380F	probably damaging	Het
Gtf3c1	G	A	7: 125,667,374	R967W	probably damaging	Het
Hnrnpr	T	A	4: 136,339,545	D472E	unknown	Het
Klhl28	A	T	12: 64,950,066	D500E	probably damaging	Het
Lmo7	C	T	14: 101,910,885		probably benign	Het
Mphosph8	A	G	14: 56,674,443	I308V	probably benign	Het
Myo6	T	A	9: 80,283,586		probably null	Het
Nsmaf	C	T	4: 6,435,056		probably null	Het
Padi6	T	A	4: 140,727,623	I668L	possibly damaging	Het
Pigw	A	G	11: 84,877,324	I393T	possibly damaging	Het
Prg3	G	A	2: 84,993,732	C212Y	probably damaging	Het
Pwp1	T	C	10: 85,879,888	V267A	probably benign	Het
Raver2	C	A	4: 101,096,271	Q79K	probably benign	Het
Sdr9c7	T	C	10: 127,909,828	S270P	probably damaging	Het
Sfmbt2	A	G	2: 10,402,007	E39G	probably damaging	Het
Strada	A	G	11: 106,171,150		probably benign	Het
Xrn1	T	C	9: 95,973,447		probably benign	Het
Zic3	A	G	X: 58,034,419	Y424C	probably damaging	Het

Other mutations in Chil4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02457:Chil4	APN	3	106214399	missense	probably benign
R1087:Chil4	UTSW	3	106210565	missense	probably benign	0.01
R1398:Chil4	UTSW	3	106219509	splice site	probably null
R1503:Chil4	UTSW	3	106206034	missense	probably benign
R1553:Chil4	UTSW	3	106203690	missense	probably benign	0.02
R1806:Chil4	UTSW	3	106210643	splice site	probably benign
R1873:Chil4	UTSW	3	106206098	missense	probably benign	0.00
R2069:Chil4	UTSW	3	106219455	missense	probably benign	0.16
R2100:Chil4	UTSW	3	106214347	missense	probably benign
R2370:Chil4	UTSW	3	106214300	nonsense	probably null
R2984:Chil4	UTSW	3	106203727	missense	possibly damaging	0.95
R2985:Chil4	UTSW	3	106203727	missense	possibly damaging	0.95
R3522:Chil4	UTSW	3	106203740	missense	probably benign	0.08
R3919:Chil4	UTSW	3	106202532	missense	probably benign	0.00
R4033:Chil4	UTSW	3	106214449	missense	probably damaging	1.00
R4181:Chil4	UTSW	3	106203727	missense	possibly damaging	0.95
R4184:Chil4	UTSW	3	106203727	missense	possibly damaging	0.95
R4301:Chil4	UTSW	3	106203727	missense	possibly damaging	0.95
R4347:Chil4	UTSW	3	106202828	missense	probably benign
R4391:Chil4	UTSW	3	106203727	missense	possibly damaging	0.95
R4395:Chil4	UTSW	3	106203727	missense	possibly damaging	0.95
R4418:Chil4	UTSW	3	106203727	missense	possibly damaging	0.95
R4483:Chil4	UTSW	3	106214362	missense	probably damaging	1.00
R4544:Chil4	UTSW	3	106210606	missense	probably damaging	0.97
R4887:Chil4	UTSW	3	106204144	missense	probably benign	0.01
R4949:Chil4	UTSW	3	106206092	missense	possibly damaging	0.83
R5076:Chil4	UTSW	3	106202597	missense	probably damaging	1.00
R5146:Chil4	UTSW	3	106202834	missense	probably benign	0.18
R5254:Chil4	UTSW	3	106219452	missense	probably benign	0.00
R5521:Chil4	UTSW	3	106203697	missense	possibly damaging	0.50
R5790:Chil4	UTSW	3	106202578	missense	probably benign	0.00
R5883:Chil4	UTSW	3	106210570	missense	possibly damaging	0.48
R6010:Chil4	UTSW	3	106214395	missense	probably damaging	1.00
R6257:Chil4	UTSW	3	106204096	missense	possibly damaging	0.84
R6269:Chil4	UTSW	3	106204171	missense	probably damaging	1.00
R6602:Chil4	UTSW	3	106210590	missense	probably benign	0.00
R7113:Chil4	UTSW	3	106202767	missense	probably damaging	1.00
R7113:Chil4	UTSW	3	106214348	missense	probably benign
R7188:Chil4	UTSW	3	106204159	missense	probably damaging	1.00
R7980:Chil4	UTSW	3	106202744	missense	probably damaging	1.00
R8810:Chil4	UTSW	3	106201805	missense	probably damaging	0.99
R9300:Chil4	UTSW	3	106202558	missense	probably benign	0.10
R9307:Chil4	UTSW	3	106204066	critical splice donor site	probably null
R9529:Chil4	UTSW	3	106211340	missense	probably damaging	1.00
X0067:Chil4	UTSW	3	106206034	missense	probably benign	0.01

Posted On

2012-12-06