Incidental Mutation 'R0980:Kif23'
ID 97011
Institutional Source Beutler Lab
Gene Symbol Kif23
Ensembl Gene ENSMUSG00000032254
Gene Name kinesin family member 23
Synonyms Knsl5, CHO1, C87313, MKLP-1, 3110001D19Rik, MKLP1
MMRRC Submission 039106-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.972) question?
Stock # R0980 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 61824559-61854078 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 61844046 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 154 (K154N)
Ref Sequence ENSEMBL: ENSMUSP00000149553 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034815] [ENSMUST00000214295]
AlphaFold E9Q5G3
Predicted Effect possibly damaging
Transcript: ENSMUST00000034815
AA Change: K154N

PolyPhen 2 Score 0.717 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000034815
Gene: ENSMUSG00000032254
AA Change: K154N

DomainStartEndE-ValueType
KISc 23 444 6.56e-147 SMART
Blast:KISc 524 607 8e-20 BLAST
low complexity region 661 678 N/A INTRINSIC
low complexity region 681 693 N/A INTRINSIC
low complexity region 715 728 N/A INTRINSIC
Pfam:MKLP1_Arf_bdg 796 899 9.2e-47 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213595
Predicted Effect possibly damaging
Transcript: ENSMUST00000214295
AA Change: K154N

PolyPhen 2 Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215965
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216717
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.1%
  • 20x: 89.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankdd1a T C 9: 65,424,253 (GRCm39) H20R probably damaging Het
Arfgef3 T C 10: 18,467,866 (GRCm39) E1778G possibly damaging Het
Arhgef18 C T 8: 3,439,095 (GRCm39) probably benign Het
Blm A T 7: 80,149,706 (GRCm39) probably null Het
Ccr6 A G 17: 8,474,846 (GRCm39) E17G probably benign Het
Cep126 T C 9: 8,100,720 (GRCm39) T605A probably damaging Het
Cnga4 C A 7: 105,057,213 (GRCm39) P439T probably damaging Het
Col11a1 G A 3: 113,932,414 (GRCm39) R113H unknown Het
Cyp2a5 A G 7: 26,538,431 (GRCm39) probably null Het
D430041D05Rik A G 2: 104,079,690 (GRCm39) V1131A probably damaging Het
Elp3 T C 14: 65,815,402 (GRCm39) T197A probably damaging Het
Etl4 A G 2: 20,806,378 (GRCm39) D1200G probably damaging Het
Gapt G C 13: 110,490,273 (GRCm39) T130R probably damaging Het
Gprin1 T C 13: 54,888,214 (GRCm39) D20G possibly damaging Het
Hltf T C 3: 20,145,665 (GRCm39) S432P probably benign Het
Immt T C 6: 71,851,310 (GRCm39) V54A probably benign Het
Jhy T G 9: 40,856,133 (GRCm39) Y118S possibly damaging Het
Krt79 T C 15: 101,846,442 (GRCm39) T169A probably damaging Het
Llgl2 A G 11: 115,740,827 (GRCm39) E443G probably damaging Het
Ltbp4 A T 7: 27,023,587 (GRCm39) C786S probably damaging Het
Mme A T 3: 63,247,550 (GRCm39) E278D probably benign Het
Nt5c2 G T 19: 46,887,317 (GRCm39) Q162K probably benign Het
Obscn A G 11: 58,888,887 (GRCm39) V2109A possibly damaging Het
Or5p64 GGTAG GG 7: 107,855,229 (GRCm39) probably benign Het
Or8k28 T C 2: 86,285,704 (GRCm39) T304A probably benign Het
Or8k38 T A 2: 86,488,209 (GRCm39) I198L probably benign Het
Osmr G T 15: 6,881,921 (GRCm39) N74K probably benign Het
Pes1 AGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGA 11: 3,927,636 (GRCm39) probably benign Het
Pgd A T 4: 149,238,768 (GRCm39) probably null Het
Pld1 T A 3: 28,178,724 (GRCm39) S873T probably damaging Het
Polk A T 13: 96,620,272 (GRCm39) C664S probably benign Het
Proca1 A C 11: 78,095,773 (GRCm39) H135P probably benign Het
Ptgs2 A C 1: 149,980,061 (GRCm39) D333A probably damaging Het
Rexo5 T C 7: 119,423,035 (GRCm39) V289A probably damaging Het
Rnf125 T A 18: 21,112,117 (GRCm39) C49* probably null Het
Rprd2 C A 3: 95,673,216 (GRCm39) R729L probably damaging Het
Sipa1l1 A G 12: 82,388,994 (GRCm39) S407G possibly damaging Het
Slc35a4 C A 18: 36,815,834 (GRCm39) N221K probably damaging Het
Sorcs1 T C 19: 50,220,761 (GRCm39) D563G probably benign Het
Stk39 G T 2: 68,222,515 (GRCm39) T183K probably damaging Het
Tc2n T A 12: 101,644,835 (GRCm39) K264* probably null Het
Trim23 C T 13: 104,324,635 (GRCm39) R238W probably damaging Het
Trim66 C A 7: 109,054,877 (GRCm39) V1240L probably damaging Het
Ttn T C 2: 76,584,389 (GRCm39) T13913A probably damaging Het
Ubap1 T G 4: 41,379,832 (GRCm39) C349G probably damaging Het
Vmn1r170 A T 7: 23,305,759 (GRCm39) I54F possibly damaging Het
Other mutations in Kif23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00428:Kif23 APN 9 61,833,750 (GRCm39) missense probably benign 0.19
IGL00814:Kif23 APN 9 61,844,389 (GRCm39) missense possibly damaging 0.95
IGL01295:Kif23 APN 9 61,839,411 (GRCm39) missense possibly damaging 0.89
IGL01521:Kif23 APN 9 61,827,182 (GRCm39) missense probably damaging 0.99
IGL01583:Kif23 APN 9 61,842,750 (GRCm39) missense probably damaging 1.00
IGL01680:Kif23 APN 9 61,839,096 (GRCm39) missense probably benign 0.17
IGL02450:Kif23 APN 9 61,831,239 (GRCm39) missense probably benign 0.00
IGL02698:Kif23 APN 9 61,832,283 (GRCm39) missense possibly damaging 0.49
IGL03152:Kif23 APN 9 61,837,058 (GRCm39) splice site probably benign
IGL03233:Kif23 APN 9 61,833,735 (GRCm39) missense probably benign 0.05
H8562:Kif23 UTSW 9 61,831,347 (GRCm39) missense probably benign
R0225:Kif23 UTSW 9 61,832,976 (GRCm39) splice site probably benign
R0419:Kif23 UTSW 9 61,833,687 (GRCm39) nonsense probably null
R0512:Kif23 UTSW 9 61,826,257 (GRCm39) splice site probably benign
R0731:Kif23 UTSW 9 61,832,314 (GRCm39) missense possibly damaging 0.67
R1315:Kif23 UTSW 9 61,831,270 (GRCm39) splice site probably null
R1347:Kif23 UTSW 9 61,834,438 (GRCm39) missense probably damaging 0.99
R1347:Kif23 UTSW 9 61,834,438 (GRCm39) missense probably damaging 0.99
R1451:Kif23 UTSW 9 61,832,084 (GRCm39) missense probably damaging 1.00
R1624:Kif23 UTSW 9 61,832,982 (GRCm39) splice site probably null
R1820:Kif23 UTSW 9 61,833,720 (GRCm39) missense possibly damaging 0.67
R1867:Kif23 UTSW 9 61,826,243 (GRCm39) missense possibly damaging 0.87
R1937:Kif23 UTSW 9 61,853,892 (GRCm39) critical splice donor site probably null
R2001:Kif23 UTSW 9 61,834,666 (GRCm39) nonsense probably null
R2002:Kif23 UTSW 9 61,834,666 (GRCm39) nonsense probably null
R2310:Kif23 UTSW 9 61,831,426 (GRCm39) missense probably damaging 1.00
R2680:Kif23 UTSW 9 61,844,758 (GRCm39) missense probably benign 0.25
R3196:Kif23 UTSW 9 61,839,193 (GRCm39) nonsense probably null
R3774:Kif23 UTSW 9 61,832,274 (GRCm39) missense probably benign 0.00
R3775:Kif23 UTSW 9 61,832,274 (GRCm39) missense probably benign 0.00
R3776:Kif23 UTSW 9 61,832,274 (GRCm39) missense probably benign 0.00
R4349:Kif23 UTSW 9 61,839,396 (GRCm39) missense probably damaging 1.00
R4671:Kif23 UTSW 9 61,852,641 (GRCm39) missense probably benign 0.04
R4981:Kif23 UTSW 9 61,839,153 (GRCm39) missense probably damaging 1.00
R4983:Kif23 UTSW 9 61,843,985 (GRCm39) missense probably benign 0.01
R5685:Kif23 UTSW 9 61,852,691 (GRCm39) missense probably benign 0.12
R5721:Kif23 UTSW 9 61,851,498 (GRCm39) missense probably benign 0.45
R6903:Kif23 UTSW 9 61,834,436 (GRCm39) missense possibly damaging 0.77
R7067:Kif23 UTSW 9 61,832,271 (GRCm39) missense probably benign 0.01
R7103:Kif23 UTSW 9 61,827,174 (GRCm39) missense probably damaging 0.99
R7456:Kif23 UTSW 9 61,844,402 (GRCm39) missense probably benign 0.09
R7468:Kif23 UTSW 9 61,844,457 (GRCm39) nonsense probably null
R8357:Kif23 UTSW 9 61,834,317 (GRCm39) critical splice donor site probably null
R8457:Kif23 UTSW 9 61,834,317 (GRCm39) critical splice donor site probably null
R8716:Kif23 UTSW 9 61,844,477 (GRCm39) missense probably damaging 1.00
R8783:Kif23 UTSW 9 61,834,853 (GRCm39) missense probably benign 0.00
R9028:Kif23 UTSW 9 61,828,341 (GRCm39) missense probably damaging 0.99
R9137:Kif23 UTSW 9 61,834,713 (GRCm39) missense probably damaging 0.97
R9283:Kif23 UTSW 9 61,852,651 (GRCm39) missense probably benign
R9430:Kif23 UTSW 9 61,834,722 (GRCm39) missense probably damaging 1.00
R9457:Kif23 UTSW 9 61,851,507 (GRCm39) missense probably benign 0.02
R9533:Kif23 UTSW 9 61,832,924 (GRCm39) missense probably benign
Z1177:Kif23 UTSW 9 61,831,445 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- CCTGAGCAGTCAAGAACATGCCTC -3'
(R):5'- TACACAATGACAGGGTCTCCAGGG -3'

Sequencing Primer
(F):5'- TTCTGCCCTCATAAAAGTCAGC -3'
(R):5'- tgcacacctgtggtggc -3'
Posted On 2014-01-05