Incidental Mutation 'R1115:Osgin2'
ID 97141
Institutional Source Beutler Lab
Gene Symbol Osgin2
Ensembl Gene ENSMUSG00000041153
Gene Name oxidative stress induced growth inhibitor family member 2
Synonyms C230027H09Rik
MMRRC Submission 039188-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.269) question?
Stock # R1115 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 15997121-16013888 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 15998085 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 512 (D512E)
Ref Sequence ENSEMBL: ENSMUSP00000047473 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037198] [ENSMUST00000149891]
AlphaFold Q3TEE9
Predicted Effect possibly damaging
Transcript: ENSMUST00000037198
AA Change: D512E

PolyPhen 2 Score 0.873 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000047473
Gene: ENSMUSG00000041153
AA Change: D512E

DomainStartEndE-ValueType
SCOP:d1lqta1 315 361 7e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134048
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148819
Predicted Effect probably benign
Transcript: ENSMUST00000149891
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.8%
Validation Efficiency 100% (34/34)
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acly C A 11: 100,370,081 (GRCm39) V994F probably damaging Het
Arfgap3 T C 15: 83,214,741 (GRCm39) T182A probably benign Het
Bcl2l14 T C 6: 134,409,102 (GRCm39) probably benign Het
Cabin1 T C 10: 75,553,511 (GRCm39) M1183V possibly damaging Het
Ccr7 A T 11: 99,036,103 (GRCm39) I273K possibly damaging Het
Cd40 A G 2: 164,912,681 (GRCm39) M211V possibly damaging Het
Coro2b T G 9: 62,338,609 (GRCm39) E208A probably damaging Het
Dennd5a A C 7: 109,517,968 (GRCm39) M556R probably damaging Het
Efcab2 A T 1: 178,265,062 (GRCm39) probably benign Het
Fastkd2 T C 1: 63,787,114 (GRCm39) probably benign Het
Fbxw8 A C 5: 118,215,636 (GRCm39) probably benign Het
Fhip1a T C 3: 85,629,802 (GRCm39) E263G probably benign Het
Frem1 T C 4: 82,939,007 (GRCm39) D25G probably benign Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
Ift52 A G 2: 162,871,702 (GRCm39) K178R probably benign Het
Kit T C 5: 75,810,192 (GRCm39) probably benign Het
Map1a T C 2: 121,137,859 (GRCm39) probably null Het
Mxra7 G T 11: 116,701,696 (GRCm39) probably benign Het
Myt1 C A 2: 181,453,024 (GRCm39) S7* probably null Het
Nphs1 C T 7: 30,180,803 (GRCm39) probably benign Het
Or10h28 C T 17: 33,487,940 (GRCm39) R81* probably null Het
Or1l8 C A 2: 36,817,514 (GRCm39) G204V possibly damaging Het
Pde4b T A 4: 102,399,352 (GRCm39) probably benign Het
Rasef G T 4: 73,666,841 (GRCm39) T146K possibly damaging Het
Ren1 T A 1: 133,284,256 (GRCm39) V207D probably damaging Het
S100a8 A G 3: 90,577,180 (GRCm39) D59G probably damaging Het
Sdcbp G A 4: 6,377,143 (GRCm39) probably null Het
Sdk2 C T 11: 113,729,472 (GRCm39) silent Het
Slamf7 A T 1: 171,466,751 (GRCm39) D151E probably benign Het
Slco1b2 A G 6: 141,628,980 (GRCm39) M561V probably benign Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Stard9 T C 2: 120,523,331 (GRCm39) I662T probably benign Het
Vwf T A 6: 125,632,028 (GRCm39) V20D unknown Het
Znhit6 G T 3: 145,300,440 (GRCm39) probably null Het
Other mutations in Osgin2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00391:Osgin2 APN 4 16,006,439 (GRCm39) missense probably damaging 1.00
IGL00767:Osgin2 APN 4 16,006,377 (GRCm39) missense probably damaging 1.00
IGL03164:Osgin2 APN 4 16,001,938 (GRCm39) missense probably benign 0.03
R1515:Osgin2 UTSW 4 15,998,380 (GRCm39) missense probably benign
R1878:Osgin2 UTSW 4 16,005,493 (GRCm39) missense probably damaging 0.99
R1964:Osgin2 UTSW 4 15,998,358 (GRCm39) missense probably damaging 1.00
R2116:Osgin2 UTSW 4 16,008,648 (GRCm39) missense probably damaging 0.99
R4684:Osgin2 UTSW 4 16,001,946 (GRCm39) missense probably benign
R4890:Osgin2 UTSW 4 16,013,739 (GRCm39) utr 5 prime probably benign
R5628:Osgin2 UTSW 4 15,998,998 (GRCm39) missense probably benign 0.01
R5982:Osgin2 UTSW 4 15,998,908 (GRCm39) missense probably benign
R6418:Osgin2 UTSW 4 16,006,410 (GRCm39) missense probably benign
R7239:Osgin2 UTSW 4 16,008,748 (GRCm39) missense probably benign 0.00
R8502:Osgin2 UTSW 4 16,005,493 (GRCm39) missense probably damaging 0.99
R9489:Osgin2 UTSW 4 15,998,427 (GRCm39) missense probably damaging 1.00
R9605:Osgin2 UTSW 4 15,998,427 (GRCm39) missense probably damaging 1.00
R9700:Osgin2 UTSW 4 16,006,455 (GRCm39) missense probably damaging 0.99
R9789:Osgin2 UTSW 4 15,998,957 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTGGAGGCTCTCCCAGTTAATTC -3'
(R):5'- TGTTTCGCAGACGAGTAACTGATCC -3'

Sequencing Primer
(F):5'- AGTTAATTCAAGCCAATACACTGC -3'
(R):5'- CTACCATATGATGTGTAGTCAGTCC -3'
Posted On 2014-01-05