Incidental Mutation 'R1117:Or9e1'
ID 97438
Institutional Source Beutler Lab
Gene Symbol Or9e1
Ensembl Gene ENSMUSG00000094805
Gene Name olfactory receptor family 9 subfamily E member 1
Synonyms MOR222-1, Olfr311, GA_x6K02T2NKPP-565870-564944
MMRRC Submission 039190-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R1117 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 58731942-58732868 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 58732641 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 234 (K234E)
Ref Sequence ENSEMBL: ENSMUSP00000150870 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071625] [ENSMUST00000216473]
AlphaFold Q5NC59
Predicted Effect possibly damaging
Transcript: ENSMUST00000071625
AA Change: K234E

PolyPhen 2 Score 0.643 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000071553
Gene: ENSMUSG00000094805
AA Change: K234E

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 9e-52 PFAM
Pfam:7TM_GPCR_Srsx 33 215 1.7e-8 PFAM
Pfam:7tm_1 39 288 9.7e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214776
Predicted Effect possibly damaging
Transcript: ENSMUST00000216473
AA Change: K234E

PolyPhen 2 Score 0.643 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 90.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1l2 G A 10: 83,344,487 (GRCm39) T353I probably benign Het
Arpc1b T C 5: 145,062,564 (GRCm39) V226A possibly damaging Het
Casz1 C A 4: 149,019,052 (GRCm39) T451K probably damaging Het
Ccr4 C T 9: 114,321,085 (GRCm39) V327M probably benign Het
Cntrl A G 2: 35,017,985 (GRCm39) E465G probably damaging Het
Cpa1 A G 6: 30,645,260 (GRCm39) D412G probably benign Het
Crispld1 T A 1: 17,819,846 (GRCm39) N281K probably benign Het
Cul3 T C 1: 80,258,641 (GRCm39) Q465R probably damaging Het
Cyp2c68 G A 19: 39,700,903 (GRCm39) T305M probably damaging Het
Elp4 T C 2: 105,672,656 (GRCm39) D143G probably benign Het
Etnppl A G 3: 130,428,212 (GRCm39) I462M probably benign Het
Fmo4 A G 1: 162,631,232 (GRCm39) V245A probably benign Het
Gm4076 A G 13: 85,275,437 (GRCm39) noncoding transcript Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
Kcnj15 G A 16: 95,096,484 (GRCm39) M8I probably benign Het
Klk1b22 A T 7: 43,766,283 (GRCm39) M255L probably benign Het
Mmrn1 T A 6: 60,953,309 (GRCm39) I530K possibly damaging Het
Muc21 T C 17: 35,930,920 (GRCm39) probably benign Het
Nid2 A C 14: 19,813,732 (GRCm39) probably null Het
Or10g6 T C 9: 39,934,058 (GRCm39) F123S probably damaging Het
Or10h28 C T 17: 33,487,940 (GRCm39) R81* probably null Het
Peak1 G A 9: 56,165,702 (GRCm39) T742M probably benign Het
Sel1l3 T A 5: 53,329,949 (GRCm39) T469S probably benign Het
Sez6 A G 11: 77,865,340 (GRCm39) Y659C probably damaging Het
Slc19a2 A T 1: 164,091,025 (GRCm39) I278F possibly damaging Het
Slc36a3 T C 11: 55,037,006 (GRCm39) I100V possibly damaging Het
Tcerg1 A G 18: 42,707,717 (GRCm39) D1079G probably damaging Het
Trim43c T C 9: 88,727,030 (GRCm39) S286P probably benign Het
Umod T C 7: 119,076,529 (GRCm39) N79S possibly damaging Het
Wdr43 A G 17: 71,923,382 (GRCm39) T43A probably benign Het
Other mutations in Or9e1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02367:Or9e1 APN 11 58,732,338 (GRCm39) missense probably benign 0.10
H8786:Or9e1 UTSW 11 58,732,146 (GRCm39) missense probably benign 0.22
R0620:Or9e1 UTSW 11 58,732,269 (GRCm39) missense probably damaging 1.00
R0671:Or9e1 UTSW 11 58,732,681 (GRCm39) missense possibly damaging 0.94
R0827:Or9e1 UTSW 11 58,732,597 (GRCm39) missense probably damaging 1.00
R0839:Or9e1 UTSW 11 58,732,478 (GRCm39) missense probably benign
R0932:Or9e1 UTSW 11 58,732,540 (GRCm39) missense possibly damaging 0.92
R1533:Or9e1 UTSW 11 58,732,792 (GRCm39) missense probably damaging 1.00
R1540:Or9e1 UTSW 11 58,732,477 (GRCm39) missense probably benign 0.01
R1595:Or9e1 UTSW 11 58,732,478 (GRCm39) missense probably benign
R1826:Or9e1 UTSW 11 58,732,257 (GRCm39) missense probably benign
R2857:Or9e1 UTSW 11 58,732,708 (GRCm39) missense probably benign 0.42
R2858:Or9e1 UTSW 11 58,732,708 (GRCm39) missense probably benign 0.42
R2859:Or9e1 UTSW 11 58,732,708 (GRCm39) missense probably benign 0.42
R3438:Or9e1 UTSW 11 58,732,698 (GRCm39) nonsense probably null
R3765:Or9e1 UTSW 11 58,732,120 (GRCm39) missense probably damaging 1.00
R3831:Or9e1 UTSW 11 58,732,686 (GRCm39) missense probably damaging 0.99
R4858:Or9e1 UTSW 11 58,732,033 (GRCm39) missense possibly damaging 0.86
R5651:Or9e1 UTSW 11 58,732,317 (GRCm39) nonsense probably null
R5979:Or9e1 UTSW 11 58,732,666 (GRCm39) missense probably damaging 1.00
R6316:Or9e1 UTSW 11 58,732,768 (GRCm39) missense probably damaging 1.00
R6717:Or9e1 UTSW 11 58,732,113 (GRCm39) missense probably damaging 1.00
R7163:Or9e1 UTSW 11 58,732,012 (GRCm39) missense probably benign 0.12
R7605:Or9e1 UTSW 11 58,732,326 (GRCm39) missense probably benign 0.00
R8328:Or9e1 UTSW 11 58,732,460 (GRCm39) missense probably benign 0.00
Z1186:Or9e1 UTSW 11 58,732,032 (GRCm39) missense probably benign
Z1186:Or9e1 UTSW 11 58,732,569 (GRCm39) missense probably benign 0.16
Z1186:Or9e1 UTSW 11 58,731,945 (GRCm39) missense probably benign
Z1186:Or9e1 UTSW 11 58,731,907 (GRCm39) start gained probably benign
Z1186:Or9e1 UTSW 11 58,732,615 (GRCm39) missense probably benign
Z1187:Or9e1 UTSW 11 58,732,032 (GRCm39) missense probably benign
Z1187:Or9e1 UTSW 11 58,732,084 (GRCm39) missense probably benign
Z1187:Or9e1 UTSW 11 58,732,569 (GRCm39) missense probably benign 0.16
Z1187:Or9e1 UTSW 11 58,732,615 (GRCm39) missense probably benign
Z1187:Or9e1 UTSW 11 58,731,907 (GRCm39) start gained probably benign
Z1187:Or9e1 UTSW 11 58,731,945 (GRCm39) missense probably benign
Z1188:Or9e1 UTSW 11 58,731,945 (GRCm39) missense probably benign
Z1188:Or9e1 UTSW 11 58,731,907 (GRCm39) start gained probably benign
Z1188:Or9e1 UTSW 11 58,732,615 (GRCm39) missense probably benign
Z1188:Or9e1 UTSW 11 58,732,569 (GRCm39) missense probably benign 0.16
Z1188:Or9e1 UTSW 11 58,732,084 (GRCm39) missense probably benign
Z1188:Or9e1 UTSW 11 58,732,032 (GRCm39) missense probably benign
Z1189:Or9e1 UTSW 11 58,732,569 (GRCm39) missense probably benign 0.16
Z1189:Or9e1 UTSW 11 58,731,945 (GRCm39) missense probably benign
Z1189:Or9e1 UTSW 11 58,731,907 (GRCm39) start gained probably benign
Z1189:Or9e1 UTSW 11 58,732,615 (GRCm39) missense probably benign
Z1190:Or9e1 UTSW 11 58,731,945 (GRCm39) missense probably benign
Z1190:Or9e1 UTSW 11 58,731,907 (GRCm39) start gained probably benign
Z1190:Or9e1 UTSW 11 58,732,615 (GRCm39) missense probably benign
Z1190:Or9e1 UTSW 11 58,732,569 (GRCm39) missense probably benign 0.16
Z1190:Or9e1 UTSW 11 58,732,084 (GRCm39) missense probably benign
Z1190:Or9e1 UTSW 11 58,732,032 (GRCm39) missense probably benign
Z1191:Or9e1 UTSW 11 58,731,945 (GRCm39) missense probably benign
Z1191:Or9e1 UTSW 11 58,731,907 (GRCm39) start gained probably benign
Z1191:Or9e1 UTSW 11 58,732,615 (GRCm39) missense probably benign
Z1191:Or9e1 UTSW 11 58,732,569 (GRCm39) missense probably benign 0.16
Z1191:Or9e1 UTSW 11 58,732,084 (GRCm39) missense probably benign
Z1191:Or9e1 UTSW 11 58,732,032 (GRCm39) missense probably benign
Z1192:Or9e1 UTSW 11 58,732,032 (GRCm39) missense probably benign
Z1192:Or9e1 UTSW 11 58,731,945 (GRCm39) missense probably benign
Z1192:Or9e1 UTSW 11 58,731,907 (GRCm39) start gained probably benign
Z1192:Or9e1 UTSW 11 58,732,615 (GRCm39) missense probably benign
Z1192:Or9e1 UTSW 11 58,732,569 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- ATGCCACCAGTCATGAGACTGTCC -3'
(R):5'- TCAGAGCCACACACTGTAGGCTTC -3'

Sequencing Primer
(F):5'- AGTCATGAGACTGTCCTGCAC -3'
(R):5'- ACACACTGTAGGCTTCAATGTC -3'
Posted On 2014-01-05