Incidental Mutation 'IGL00160:Zfp488'
ID975
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp488
Ensembl Gene ENSMUSG00000044519
Gene Namezinc finger protein 488
SynonymsLOC382867
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00160
Quality Score
Status
Chromosome14
Chromosomal Location33967070-33978764 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 33971069 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Valine at position 46 (M46V)
Ref Sequence ENSEMBL: ENSMUSP00000132436 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166737]
Predicted Effect probably benign
Transcript: ENSMUST00000166737
AA Change: M46V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000132436
Gene: ENSMUSG00000044519
AA Change: M46V

DomainStartEndE-ValueType
low complexity region 161 175 N/A INTRINSIC
low complexity region 244 270 N/A INTRINSIC
ZnF_C2H2 272 294 2.89e1 SMART
ZnF_C2H2 314 336 5.06e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930563D23Rik T C 16: 92,321,002 K133E possibly damaging Het
4931406P16Rik G A 7: 34,239,006 H1035Y possibly damaging Het
4932414N04Rik C T 2: 68,732,875 A387V probably benign Het
Adamts3 C T 5: 89,861,325 V160I probably damaging Het
Arhgef26 T C 3: 62,340,383 V296A probably benign Het
Bdp1 A T 13: 100,061,198 M893K probably benign Het
Camk2d T A 3: 126,838,272 C407* probably null Het
Casc1 T A 6: 145,175,290 H601L probably benign Het
Ces1h T C 8: 93,357,463 D373G probably benign Het
Ces2f A T 8: 104,949,973 N100Y probably damaging Het
Ces2f A T 8: 104,949,972 Q99H probably damaging Het
Dlg5 T C 14: 24,191,161 T223A probably damaging Het
Dnmt3l A G 10: 78,057,355 D322G probably damaging Het
Fbxl20 C T 11: 98,090,674 G396D possibly damaging Het
Gldc T C 19: 30,115,240 T760A probably damaging Het
Gm6483 T A 8: 19,691,647 noncoding transcript Het
Hcrtr2 A T 9: 76,228,155 V460D possibly damaging Het
Kif14 G A 1: 136,469,018 S354N probably benign Het
Men1 G A 19: 6,337,207 probably null Het
Mrgpra2a A T 7: 47,426,538 M324K probably damaging Het
N4bp3 C T 11: 51,645,316 A230T probably benign Het
Nphs1 T G 7: 30,482,551 W1204G possibly damaging Het
Obscn C A 11: 59,002,057 A6788S probably benign Het
Ofcc1 T C 13: 40,142,804 D518G probably damaging Het
Optc T C 1: 133,902,108 Y188C probably damaging Het
Prss45 C A 9: 110,841,005 A285E probably damaging Het
Rcan2 C T 17: 44,037,069 T223I possibly damaging Het
Snrnp70 A G 7: 45,377,354 probably null Het
Sorbs1 T A 19: 40,318,029 T1064S probably damaging Het
Sptb T C 12: 76,623,169 K462E probably damaging Het
Sstr1 A G 12: 58,212,750 E53G probably benign Het
Stxbp2 A T 8: 3,636,354 probably null Het
Tex35 G A 1: 157,099,756 probably benign Het
Thnsl1 T C 2: 21,212,449 F338S possibly damaging Het
Trpv1 C T 11: 73,260,362 A424V probably damaging Het
Unc80 A T 1: 66,654,395 H2535L possibly damaging Het
Usp46 T C 5: 74,002,686 E333G probably null Het
Vmn1r27 T C 6: 58,215,134 Y245C probably benign Het
Zfp566 G T 7: 30,078,511 Q82K probably benign Het
Znhit6 T C 3: 145,578,160 S62P probably damaging Het
Znrf3 T C 11: 5,289,039 H108R probably damaging Het
Other mutations in Zfp488
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02156:Zfp488 APN 14 33970400 missense possibly damaging 0.83
IGL02668:Zfp488 APN 14 33970820 missense probably benign 0.01
R0504:Zfp488 UTSW 14 33970540 missense probably damaging 0.97
R4021:Zfp488 UTSW 14 33971153 missense probably benign 0.01
R4022:Zfp488 UTSW 14 33971153 missense probably benign 0.01
R4291:Zfp488 UTSW 14 33970894 missense possibly damaging 0.83
R6180:Zfp488 UTSW 14 33970794 missense possibly damaging 0.66
R6927:Zfp488 UTSW 14 33970798 missense probably benign
R7687:Zfp488 UTSW 14 33970400 missense possibly damaging 0.83
Posted On2011-07-12