Incidental Mutation 'R0990:Ank2'
ID |
97602 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Ank2
|
Ensembl Gene |
ENSMUSG00000032826 |
Gene Name |
ankyrin 2, brain |
Synonyms |
Ankyrin-B, Ank-2, Ankyrin-2, Gm4392, ankyrin B |
MMRRC Submission |
039110-MU
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R0990 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
3 |
Chromosomal Location |
126921612-127499350 bp(-) (GRCm38) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 126934666 bp (GRCm38)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Methionine
at position 759
(I759M)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000043765
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044443]
[ENSMUST00000182064]
[ENSMUST00000182078]
|
AlphaFold |
no structure available at present |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000044443
AA Change: I759M
PolyPhen 2
Score 0.640 (Sensitivity: 0.87; Specificity: 0.91)
|
SMART Domains |
Protein: ENSMUSP00000043765 Gene: ENSMUSG00000032826 AA Change: I759M
Domain | Start | End | E-Value | Type |
low complexity region
|
9 |
22 |
N/A |
INTRINSIC |
low complexity region
|
57 |
69 |
N/A |
INTRINSIC |
ZU5
|
128 |
232 |
4.13e-61 |
SMART |
Pfam:ZU5
|
289 |
374 |
2.8e-8 |
PFAM |
low complexity region
|
587 |
597 |
N/A |
INTRINSIC |
DEATH
|
603 |
697 |
1.52e-27 |
SMART |
low complexity region
|
732 |
748 |
N/A |
INTRINSIC |
low complexity region
|
860 |
873 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000182062
|
Predicted Effect |
unknown
Transcript: ENSMUST00000182064
AA Change: I3696M
|
SMART Domains |
Protein: ENSMUSP00000138620 Gene: ENSMUSG00000032826 AA Change: I3696M
Domain | Start | End | E-Value | Type |
ANK
|
9 |
38 |
1e1 |
SMART |
ANK
|
42 |
71 |
8.9e-7 |
SMART |
ANK
|
75 |
104 |
4.4e-9 |
SMART |
ANK
|
108 |
137 |
2.8e-9 |
SMART |
ANK
|
141 |
169 |
5.3e-1 |
SMART |
ANK
|
170 |
199 |
7.3e-1 |
SMART |
ANK
|
211 |
240 |
1.1e-7 |
SMART |
ANK
|
244 |
273 |
4.4e-9 |
SMART |
ANK
|
277 |
306 |
9.3e-8 |
SMART |
ANK
|
310 |
339 |
2.1e-8 |
SMART |
ANK
|
343 |
372 |
1.3e-7 |
SMART |
ANK
|
376 |
405 |
6.2e-9 |
SMART |
ANK
|
409 |
438 |
1.1e-7 |
SMART |
ANK
|
442 |
471 |
2.9e-8 |
SMART |
ANK
|
475 |
504 |
1.1e-5 |
SMART |
ANK
|
508 |
537 |
6.5e-6 |
SMART |
ANK
|
541 |
570 |
2.3e-7 |
SMART |
ANK
|
574 |
603 |
2.4e-7 |
SMART |
ANK
|
607 |
636 |
3.2e-9 |
SMART |
ANK
|
640 |
669 |
5.5e-5 |
SMART |
ANK
|
673 |
702 |
1.9e-8 |
SMART |
ANK
|
706 |
735 |
3.3e-9 |
SMART |
low complexity region
|
755 |
775 |
N/A |
INTRINSIC |
low complexity region
|
793 |
806 |
N/A |
INTRINSIC |
low complexity region
|
841 |
853 |
N/A |
INTRINSIC |
ZU5
|
912 |
1016 |
2e-63 |
SMART |
low complexity region
|
1371 |
1381 |
N/A |
INTRINSIC |
low complexity region
|
1448 |
1463 |
N/A |
INTRINSIC |
low complexity region
|
1490 |
1503 |
N/A |
INTRINSIC |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000182078
AA Change: I3609M
|
SMART Domains |
Protein: ENSMUSP00000138753 Gene: ENSMUSG00000032826 AA Change: I3609M
Domain | Start | End | E-Value | Type |
low complexity region
|
7 |
18 |
N/A |
INTRINSIC |
low complexity region
|
114 |
125 |
N/A |
INTRINSIC |
low complexity region
|
191 |
209 |
N/A |
INTRINSIC |
low complexity region
|
304 |
312 |
N/A |
INTRINSIC |
low complexity region
|
478 |
493 |
N/A |
INTRINSIC |
low complexity region
|
527 |
544 |
N/A |
INTRINSIC |
DEATH
|
591 |
685 |
1e-29 |
SMART |
low complexity region
|
720 |
736 |
N/A |
INTRINSIC |
low complexity region
|
848 |
861 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000182118
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000182271
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000182571
|
Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.6%
- 10x: 94.1%
- 20x: 86.0%
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Homozygous mutation of this gene results in death by postnatal day 8, although some animals survive to P20. Mutant animals display reduced body size, impaired balance and locomotion, brain structure dysmorphologies, abnormal lens, and optic nerve degeneration. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 27 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adcy7 |
T |
C |
8: 88,325,452 |
V916A |
possibly damaging |
Het |
Arhgap32 |
A |
G |
9: 32,255,381 |
D438G |
probably damaging |
Het |
Arhgef12 |
T |
C |
9: 42,972,381 |
Y1285C |
probably benign |
Het |
Cfap65 |
A |
G |
1: 74,921,519 |
V764A |
possibly damaging |
Het |
Cog8 |
T |
A |
8: 107,052,487 |
|
probably null |
Het |
Extl1 |
TGCGTTGCACCGATACCGGG |
TG |
4: 134,357,677 |
|
probably benign |
Het |
Fam120a |
G |
T |
13: 48,885,743 |
A979E |
possibly damaging |
Het |
Fbxo24 |
T |
C |
5: 137,618,439 |
N394S |
probably damaging |
Het |
Gm9938 |
A |
G |
19: 23,724,592 |
|
probably benign |
Het |
Iars2 |
A |
G |
1: 185,318,627 |
F422L |
probably damaging |
Het |
March3 |
A |
T |
18: 56,807,798 |
C87S |
probably damaging |
Het |
Mettl2 |
T |
A |
11: 105,137,744 |
Y307* |
probably null |
Het |
Mlh3 |
T |
C |
12: 85,267,765 |
D549G |
probably benign |
Het |
Muc4 |
A |
G |
16: 32,752,722 |
T867A |
probably benign |
Het |
Nup210l |
A |
T |
3: 90,211,925 |
T1852S |
probably benign |
Het |
Olfr1110 |
T |
A |
2: 87,135,742 |
H193L |
possibly damaging |
Het |
Pdk4 |
A |
T |
6: 5,485,577 |
S371T |
probably benign |
Het |
Pkm |
A |
G |
9: 59,678,096 |
T454A |
probably damaging |
Het |
Satb2 |
G |
A |
1: 56,850,184 |
S340F |
probably damaging |
Het |
Scel |
G |
A |
14: 103,581,832 |
V354I |
possibly damaging |
Het |
Setdb1 |
T |
C |
3: 95,340,265 |
T440A |
probably benign |
Het |
Sgk1 |
T |
C |
10: 21,997,086 |
F230S |
probably damaging |
Het |
Slc22a23 |
A |
T |
13: 34,195,467 |
I439N |
probably damaging |
Het |
Slc9a5 |
G |
A |
8: 105,359,446 |
R615Q |
probably damaging |
Het |
Smad1 |
T |
A |
8: 79,343,788 |
I374F |
probably damaging |
Het |
Tgm4 |
A |
G |
9: 123,046,511 |
E143G |
probably benign |
Het |
Vmn2r53 |
A |
G |
7: 12,581,502 |
S797P |
probably benign |
Het |
|
Other mutations in Ank2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01298:Ank2
|
APN |
3 |
126959720 |
missense |
possibly damaging |
0.80 |
IGL01652:Ank2
|
APN |
3 |
126933041 |
missense |
probably benign |
0.00 |
IGL01969:Ank2
|
APN |
3 |
126953223 |
missense |
possibly damaging |
0.47 |
IGL02122:Ank2
|
APN |
3 |
126937874 |
splice site |
probably benign |
|
IGL02537:Ank2
|
APN |
3 |
126955916 |
missense |
probably damaging |
1.00 |
IGL02858:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL02981:Ank2
|
APN |
3 |
126934562 |
missense |
possibly damaging |
0.58 |
IGL02981:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03024:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03074:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03111:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03129:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03174:Ank2
|
APN |
3 |
126940095 |
missense |
probably damaging |
0.98 |
IGL03177:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03185:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03188:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03242:Ank2
|
APN |
3 |
126928805 |
missense |
possibly damaging |
0.90 |
IGL03244:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03248:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03285:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03304:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03358:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03380:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03389:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03400:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
IGL03409:Ank2
|
APN |
3 |
126955870 |
missense |
probably damaging |
1.00 |
ballast
|
UTSW |
3 |
126943133 |
missense |
unknown |
|
Chain
|
UTSW |
3 |
126946938 |
intron |
probably benign |
|
Deadman
|
UTSW |
3 |
126929822 |
missense |
probably benign |
0.19 |
drag
|
UTSW |
3 |
127003982 |
missense |
probably damaging |
1.00 |
mooring
|
UTSW |
3 |
126934577 |
missense |
possibly damaging |
0.73 |
Treasure
|
UTSW |
3 |
126946749 |
missense |
unknown |
|
Windlass
|
UTSW |
3 |
126946149 |
missense |
probably benign |
|
R0033:Ank2
|
UTSW |
3 |
127104748 |
splice site |
probably benign |
|
R0042:Ank2
|
UTSW |
3 |
126936631 |
missense |
probably damaging |
0.99 |
R0042:Ank2
|
UTSW |
3 |
126936631 |
missense |
probably damaging |
0.99 |
R0079:Ank2
|
UTSW |
3 |
126934615 |
missense |
probably benign |
0.01 |
R0423:Ank2
|
UTSW |
3 |
126929860 |
nonsense |
probably null |
|
R0699:Ank2
|
UTSW |
3 |
126929829 |
missense |
probably benign |
0.00 |
R0724:Ank2
|
UTSW |
3 |
126962337 |
missense |
probably damaging |
1.00 |
R1450:Ank2
|
UTSW |
3 |
126957302 |
missense |
possibly damaging |
0.94 |
R1500:Ank2
|
UTSW |
3 |
126932982 |
missense |
probably benign |
|
R1702:Ank2
|
UTSW |
3 |
126955899 |
missense |
probably benign |
0.00 |
R1703:Ank2
|
UTSW |
3 |
126929766 |
missense |
probably damaging |
1.00 |
R1710:Ank2
|
UTSW |
3 |
126933060 |
nonsense |
probably null |
|
R1743:Ank2
|
UTSW |
3 |
126928675 |
missense |
probably damaging |
0.99 |
R1775:Ank2
|
UTSW |
3 |
126934547 |
missense |
probably benign |
0.00 |
R1852:Ank2
|
UTSW |
3 |
126997851 |
critical splice donor site |
probably null |
|
R2198:Ank2
|
UTSW |
3 |
126934577 |
missense |
possibly damaging |
0.73 |
R2892:Ank2
|
UTSW |
3 |
127248243 |
splice site |
probably null |
|
R2893:Ank2
|
UTSW |
3 |
127248243 |
splice site |
probably null |
|
R2894:Ank2
|
UTSW |
3 |
127248243 |
splice site |
probably null |
|
R3148:Ank2
|
UTSW |
3 |
126933075 |
missense |
probably benign |
0.00 |
R3776:Ank2
|
UTSW |
3 |
126942262 |
intron |
probably benign |
|
R3784:Ank2
|
UTSW |
3 |
126953193 |
missense |
probably damaging |
1.00 |
R3856:Ank2
|
UTSW |
3 |
126929844 |
missense |
probably benign |
0.00 |
R3906:Ank2
|
UTSW |
3 |
127016898 |
missense |
probably damaging |
1.00 |
R3907:Ank2
|
UTSW |
3 |
127016898 |
missense |
probably damaging |
1.00 |
R3953:Ank2
|
UTSW |
3 |
126988160 |
missense |
probably damaging |
1.00 |
R3963:Ank2
|
UTSW |
3 |
126934596 |
missense |
probably benign |
|
R4367:Ank2
|
UTSW |
3 |
126946149 |
missense |
probably benign |
|
R4414:Ank2
|
UTSW |
3 |
127225762 |
critical splice donor site |
probably null |
|
R4432:Ank2
|
UTSW |
3 |
126947806 |
intron |
probably benign |
|
R4433:Ank2
|
UTSW |
3 |
126947806 |
intron |
probably benign |
|
R4579:Ank2
|
UTSW |
3 |
126958963 |
missense |
probably damaging |
1.00 |
R4597:Ank2
|
UTSW |
3 |
126988151 |
missense |
probably damaging |
1.00 |
R4603:Ank2
|
UTSW |
3 |
127032016 |
missense |
probably benign |
0.00 |
R4729:Ank2
|
UTSW |
3 |
126976896 |
nonsense |
probably null |
|
R4815:Ank2
|
UTSW |
3 |
126936761 |
missense |
probably benign |
|
R4826:Ank2
|
UTSW |
3 |
126956001 |
missense |
probably benign |
0.35 |
R4871:Ank2
|
UTSW |
3 |
126959795 |
missense |
probably damaging |
1.00 |
R4880:Ank2
|
UTSW |
3 |
127046826 |
splice site |
probably null |
|
R4915:Ank2
|
UTSW |
3 |
126942671 |
intron |
probably benign |
|
R4935:Ank2
|
UTSW |
3 |
126956064 |
missense |
probably damaging |
1.00 |
R4936:Ank2
|
UTSW |
3 |
126955039 |
missense |
possibly damaging |
0.94 |
R4937:Ank2
|
UTSW |
3 |
126962401 |
missense |
probably damaging |
1.00 |
R4946:Ank2
|
UTSW |
3 |
126941940 |
intron |
probably benign |
|
R4963:Ank2
|
UTSW |
3 |
127032096 |
missense |
probably benign |
0.01 |
R4989:Ank2
|
UTSW |
3 |
126963445 |
missense |
possibly damaging |
0.94 |
R5023:Ank2
|
UTSW |
3 |
126941871 |
intron |
probably benign |
|
R5060:Ank2
|
UTSW |
3 |
126945921 |
intron |
probably benign |
|
R5078:Ank2
|
UTSW |
3 |
126942353 |
intron |
probably benign |
|
R5086:Ank2
|
UTSW |
3 |
126947348 |
intron |
probably benign |
|
R5134:Ank2
|
UTSW |
3 |
126963445 |
missense |
possibly damaging |
0.94 |
R5148:Ank2
|
UTSW |
3 |
127025636 |
splice site |
probably null |
|
R5175:Ank2
|
UTSW |
3 |
127004024 |
missense |
probably damaging |
1.00 |
R5275:Ank2
|
UTSW |
3 |
127032183 |
missense |
probably damaging |
1.00 |
R5295:Ank2
|
UTSW |
3 |
127032183 |
missense |
probably damaging |
1.00 |
R5303:Ank2
|
UTSW |
3 |
126945804 |
intron |
probably benign |
|
R5309:Ank2
|
UTSW |
3 |
126959768 |
missense |
probably damaging |
0.99 |
R5312:Ank2
|
UTSW |
3 |
126959768 |
missense |
probably damaging |
0.99 |
R5352:Ank2
|
UTSW |
3 |
127498991 |
utr 5 prime |
probably benign |
|
R5355:Ank2
|
UTSW |
3 |
126944049 |
intron |
probably benign |
|
R5386:Ank2
|
UTSW |
3 |
126981933 |
missense |
probably benign |
0.01 |
R5396:Ank2
|
UTSW |
3 |
126953226 |
missense |
probably damaging |
1.00 |
R5518:Ank2
|
UTSW |
3 |
126959699 |
missense |
probably damaging |
0.98 |
R5534:Ank2
|
UTSW |
3 |
126947298 |
intron |
probably benign |
|
R5554:Ank2
|
UTSW |
3 |
126998973 |
missense |
possibly damaging |
0.78 |
R5582:Ank2
|
UTSW |
3 |
126946305 |
intron |
probably benign |
|
R5747:Ank2
|
UTSW |
3 |
126941751 |
intron |
probably benign |
|
R5794:Ank2
|
UTSW |
3 |
126930020 |
missense |
probably benign |
0.00 |
R5831:Ank2
|
UTSW |
3 |
127339159 |
start gained |
probably benign |
|
R5925:Ank2
|
UTSW |
3 |
126932963 |
missense |
probably benign |
0.18 |
R5954:Ank2
|
UTSW |
3 |
126997861 |
missense |
probably benign |
0.34 |
R5956:Ank2
|
UTSW |
3 |
126942688 |
intron |
probably benign |
|
R5986:Ank2
|
UTSW |
3 |
127012686 |
missense |
possibly damaging |
0.94 |
R5992:Ank2
|
UTSW |
3 |
126959651 |
critical splice donor site |
probably null |
|
R6020:Ank2
|
UTSW |
3 |
126946821 |
intron |
probably benign |
|
R6027:Ank2
|
UTSW |
3 |
126997879 |
missense |
possibly damaging |
0.92 |
R6049:Ank2
|
UTSW |
3 |
126943020 |
missense |
possibly damaging |
0.95 |
R6060:Ank2
|
UTSW |
3 |
126955952 |
missense |
probably damaging |
1.00 |
R6114:Ank2
|
UTSW |
3 |
127011051 |
missense |
probably damaging |
1.00 |
R6124:Ank2
|
UTSW |
3 |
127248151 |
missense |
probably benign |
0.31 |
R6156:Ank2
|
UTSW |
3 |
126944237 |
missense |
probably damaging |
1.00 |
R6173:Ank2
|
UTSW |
3 |
127052746 |
missense |
probably damaging |
1.00 |
R6176:Ank2
|
UTSW |
3 |
126945471 |
missense |
probably benign |
0.05 |
R6184:Ank2
|
UTSW |
3 |
126962398 |
missense |
probably damaging |
1.00 |
R6199:Ank2
|
UTSW |
3 |
127004006 |
missense |
probably damaging |
1.00 |
R6241:Ank2
|
UTSW |
3 |
127052748 |
missense |
probably damaging |
1.00 |
R6254:Ank2
|
UTSW |
3 |
126941804 |
intron |
probably benign |
|
R6259:Ank2
|
UTSW |
3 |
127016986 |
missense |
probably benign |
0.28 |
R6260:Ank2
|
UTSW |
3 |
126943557 |
missense |
probably benign |
|
R6321:Ank2
|
UTSW |
3 |
126946938 |
intron |
probably benign |
|
R6393:Ank2
|
UTSW |
3 |
126929757 |
missense |
probably damaging |
1.00 |
R6406:Ank2
|
UTSW |
3 |
127032225 |
missense |
probably damaging |
1.00 |
R6544:Ank2
|
UTSW |
3 |
126933222 |
missense |
probably damaging |
0.99 |
R6583:Ank2
|
UTSW |
3 |
127016964 |
missense |
probably damaging |
1.00 |
R6739:Ank2
|
UTSW |
3 |
127079994 |
missense |
probably damaging |
1.00 |
R6754:Ank2
|
UTSW |
3 |
127096839 |
intron |
probably benign |
|
R6786:Ank2
|
UTSW |
3 |
126958932 |
missense |
probably damaging |
0.99 |
R6798:Ank2
|
UTSW |
3 |
126944264 |
intron |
probably benign |
|
R6882:Ank2
|
UTSW |
3 |
126945757 |
intron |
probably benign |
|
R6940:Ank2
|
UTSW |
3 |
126941972 |
intron |
probably benign |
|
R6949:Ank2
|
UTSW |
3 |
127010884 |
missense |
probably benign |
0.00 |
R7001:Ank2
|
UTSW |
3 |
127077581 |
missense |
probably damaging |
1.00 |
R7033:Ank2
|
UTSW |
3 |
126944850 |
nonsense |
probably null |
|
R7036:Ank2
|
UTSW |
3 |
126946392 |
intron |
probably benign |
|
R7045:Ank2
|
UTSW |
3 |
127012744 |
missense |
probably damaging |
1.00 |
R7048:Ank2
|
UTSW |
3 |
127025618 |
missense |
probably benign |
0.03 |
R7054:Ank2
|
UTSW |
3 |
126943303 |
intron |
probably benign |
|
R7069:Ank2
|
UTSW |
3 |
126946298 |
intron |
probably benign |
|
R7091:Ank2
|
UTSW |
3 |
127023351 |
missense |
probably damaging |
0.98 |
R7107:Ank2
|
UTSW |
3 |
127003982 |
missense |
probably damaging |
1.00 |
R7175:Ank2
|
UTSW |
3 |
126946941 |
missense |
unknown |
|
R7191:Ank2
|
UTSW |
3 |
126946392 |
missense |
unknown |
|
R7272:Ank2
|
UTSW |
3 |
126943133 |
missense |
unknown |
|
R7381:Ank2
|
UTSW |
3 |
126936628 |
missense |
possibly damaging |
0.46 |
R7394:Ank2
|
UTSW |
3 |
126936653 |
missense |
possibly damaging |
0.77 |
R7462:Ank2
|
UTSW |
3 |
126943034 |
missense |
unknown |
|
R7490:Ank2
|
UTSW |
3 |
126958889 |
missense |
probably damaging |
0.99 |
R7514:Ank2
|
UTSW |
3 |
127025603 |
missense |
probably benign |
0.06 |
R7534:Ank2
|
UTSW |
3 |
126934333 |
splice site |
probably null |
|
R7540:Ank2
|
UTSW |
3 |
126988159 |
missense |
possibly damaging |
0.94 |
R7547:Ank2
|
UTSW |
3 |
126945203 |
missense |
unknown |
|
R7579:Ank2
|
UTSW |
3 |
126946398 |
missense |
unknown |
|
R7584:Ank2
|
UTSW |
3 |
126946128 |
nonsense |
probably null |
|
R7625:Ank2
|
UTSW |
3 |
127052800 |
missense |
probably damaging |
1.00 |
R7698:Ank2
|
UTSW |
3 |
127032211 |
missense |
probably benign |
0.35 |
R7716:Ank2
|
UTSW |
3 |
126943166 |
missense |
unknown |
|
R7718:Ank2
|
UTSW |
3 |
126965013 |
missense |
possibly damaging |
0.88 |
R7722:Ank2
|
UTSW |
3 |
127029302 |
missense |
probably benign |
0.01 |
R7738:Ank2
|
UTSW |
3 |
126947622 |
missense |
|
|
R7977:Ank2
|
UTSW |
3 |
126945707 |
missense |
unknown |
|
R7987:Ank2
|
UTSW |
3 |
126945707 |
missense |
unknown |
|
R8007:Ank2
|
UTSW |
3 |
126936447 |
intron |
probably benign |
|
R8150:Ank2
|
UTSW |
3 |
126947513 |
missense |
|
|
R8161:Ank2
|
UTSW |
3 |
127032129 |
missense |
|
|
R8196:Ank2
|
UTSW |
3 |
126929883 |
missense |
probably damaging |
0.99 |
R8248:Ank2
|
UTSW |
3 |
126937785 |
missense |
possibly damaging |
0.78 |
R8255:Ank2
|
UTSW |
3 |
126946749 |
missense |
unknown |
|
R8279:Ank2
|
UTSW |
3 |
126933171 |
missense |
probably benign |
0.04 |
R8300:Ank2
|
UTSW |
3 |
127010906 |
missense |
|
|
R8716:Ank2
|
UTSW |
3 |
126942839 |
nonsense |
probably null |
|
R8724:Ank2
|
UTSW |
3 |
126943756 |
missense |
unknown |
|
R8765:Ank2
|
UTSW |
3 |
127057082 |
missense |
possibly damaging |
0.94 |
R8779:Ank2
|
UTSW |
3 |
126965102 |
missense |
probably damaging |
0.99 |
R8783:Ank2
|
UTSW |
3 |
127052806 |
missense |
probably damaging |
1.00 |
R8785:Ank2
|
UTSW |
3 |
126997921 |
missense |
probably damaging |
1.00 |
R8826:Ank2
|
UTSW |
3 |
126947302 |
missense |
unknown |
|
R8872:Ank2
|
UTSW |
3 |
126997876 |
missense |
possibly damaging |
0.88 |
R8903:Ank2
|
UTSW |
3 |
127046782 |
missense |
probably damaging |
1.00 |
R8906:Ank2
|
UTSW |
3 |
126933071 |
missense |
probably benign |
0.00 |
R8918:Ank2
|
UTSW |
3 |
126943731 |
missense |
unknown |
|
R8947:Ank2
|
UTSW |
3 |
126942747 |
intron |
probably benign |
|
R8977:Ank2
|
UTSW |
3 |
126944926 |
missense |
unknown |
|
R8990:Ank2
|
UTSW |
3 |
127048180 |
critical splice donor site |
probably null |
|
R8994:Ank2
|
UTSW |
3 |
126929822 |
missense |
probably benign |
0.19 |
R9009:Ank2
|
UTSW |
3 |
126934376 |
unclassified |
probably benign |
|
R9123:Ank2
|
UTSW |
3 |
126940095 |
missense |
probably damaging |
1.00 |
R9125:Ank2
|
UTSW |
3 |
126940095 |
missense |
probably damaging |
1.00 |
R9130:Ank2
|
UTSW |
3 |
127016916 |
missense |
|
|
R9175:Ank2
|
UTSW |
3 |
126928753 |
missense |
possibly damaging |
0.52 |
R9220:Ank2
|
UTSW |
3 |
126943437 |
missense |
unknown |
|
R9225:Ank2
|
UTSW |
3 |
126942462 |
missense |
unknown |
|
R9286:Ank2
|
UTSW |
3 |
127052732 |
missense |
probably damaging |
0.99 |
R9325:Ank2
|
UTSW |
3 |
126981855 |
missense |
probably damaging |
0.98 |
R9367:Ank2
|
UTSW |
3 |
126945029 |
missense |
unknown |
|
R9385:Ank2
|
UTSW |
3 |
126959717 |
missense |
probably benign |
0.00 |
R9391:Ank2
|
UTSW |
3 |
126937745 |
missense |
probably damaging |
0.99 |
R9422:Ank2
|
UTSW |
3 |
127096856 |
missense |
unknown |
|
R9536:Ank2
|
UTSW |
3 |
126942382 |
missense |
unknown |
|
R9647:Ank2
|
UTSW |
3 |
126998974 |
missense |
possibly damaging |
0.93 |
R9650:Ank2
|
UTSW |
3 |
126942180 |
missense |
unknown |
|
R9666:Ank2
|
UTSW |
3 |
126933189 |
nonsense |
probably null |
|
R9686:Ank2
|
UTSW |
3 |
126946901 |
missense |
unknown |
|
R9730:Ank2
|
UTSW |
3 |
127225844 |
missense |
|
|
R9738:Ank2
|
UTSW |
3 |
126943472 |
missense |
unknown |
|
R9743:Ank2
|
UTSW |
3 |
126940145 |
missense |
possibly damaging |
0.81 |
R9747:Ank2
|
UTSW |
3 |
126959018 |
missense |
probably damaging |
1.00 |
R9800:Ank2
|
UTSW |
3 |
126946500 |
missense |
unknown |
|
R9803:Ank2
|
UTSW |
3 |
126959077 |
missense |
possibly damaging |
0.64 |
RF020:Ank2
|
UTSW |
3 |
126945476 |
missense |
unknown |
|
Z1088:Ank2
|
UTSW |
3 |
127029509 |
missense |
possibly damaging |
0.45 |
Z1177:Ank2
|
UTSW |
3 |
126944357 |
missense |
unknown |
|
Z1187:Ank2
|
UTSW |
3 |
126955952 |
missense |
probably damaging |
1.00 |
Z1190:Ank2
|
UTSW |
3 |
126955952 |
missense |
probably damaging |
1.00 |
Z1192:Ank2
|
UTSW |
3 |
126955952 |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TTGGGTAGAATGGCCTCACACAAC -3'
(R):5'- ATGCTCCAATAGCAGGATGTGGAAC -3'
Sequencing Primer
(F):5'- CAGCCTACAGGGCACTATGAG -3'
(R):5'- GGATGTGGAACATAATGACCCTTAAC -3'
|
Posted On |
2014-01-05 |