Incidental Mutation 'R1118:Mei1'
ID 97609
Institutional Source Beutler Lab
Gene Symbol Mei1
Ensembl Gene ENSMUSG00000068117
Gene Name meiotic double-stranded break formation protein 1
Synonyms mei1
MMRRC Submission 039191-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.351) question?
Stock # R1118 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 81954275-82011018 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to A at 82000068 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000154974 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089178] [ENSMUST00000186125] [ENSMUST00000188048] [ENSMUST00000189540] [ENSMUST00000229119]
AlphaFold Q9D4I2
Predicted Effect probably benign
Transcript: ENSMUST00000089178
SMART Domains Protein: ENSMUSP00000086582
Gene: ENSMUSG00000068117

DomainStartEndE-ValueType
low complexity region 13 30 N/A INTRINSIC
SCOP:d1gw5a_ 123 498 1e-3 SMART
low complexity region 956 966 N/A INTRINSIC
low complexity region 1025 1045 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000186125
Predicted Effect probably benign
Transcript: ENSMUST00000188048
SMART Domains Protein: ENSMUSP00000139689
Gene: ENSMUSG00000068117

DomainStartEndE-ValueType
low complexity region 523 536 N/A INTRINSIC
low complexity region 595 615 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000189540
SMART Domains Protein: ENSMUSP00000140479
Gene: ENSMUSG00000068117

DomainStartEndE-ValueType
low complexity region 523 536 N/A INTRINSIC
low complexity region 595 615 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000229119
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 94.3%
Validation Efficiency 98% (60/61)
MGI Phenotype PHENOTYPE: Homozygous mutant mice of both sexes exhibit meiotic defects and are infertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apcdd1 A G 18: 63,085,095 (GRCm39) T431A probably benign Het
Bcan T A 3: 87,896,534 (GRCm39) I721F probably damaging Het
Card10 T C 15: 78,686,643 (GRCm39) D58G possibly damaging Het
Cd200r2 A G 16: 44,729,969 (GRCm39) N171S probably damaging Het
Celsr1 T C 15: 85,916,248 (GRCm39) D575G probably damaging Het
Ces1f A G 8: 93,993,870 (GRCm39) probably benign Het
Cped1 A T 6: 22,237,698 (GRCm39) H938L probably benign Het
Creld1 A G 6: 113,468,656 (GRCm39) D259G probably benign Het
Cubn T C 2: 13,341,053 (GRCm39) I2223V possibly damaging Het
Dop1a A G 9: 86,397,459 (GRCm39) D921G probably damaging Het
Dusp7 T C 9: 106,250,849 (GRCm39) S325P possibly damaging Het
Fat4 A T 3: 39,037,091 (GRCm39) D3581V possibly damaging Het
Fhl3 T C 4: 124,599,584 (GRCm39) probably null Het
Gap43 T C 16: 42,112,167 (GRCm39) E198G probably benign Het
Garin4 G A 1: 190,896,682 (GRCm39) probably benign Het
Grina T C 15: 76,132,779 (GRCm39) F182S probably damaging Het
Gsk3b T C 16: 38,028,346 (GRCm39) probably benign Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
Haus6 A G 4: 86,503,563 (GRCm39) probably null Het
Hmcn1 C T 1: 150,494,679 (GRCm39) A4137T possibly damaging Het
Itih4 C A 14: 30,618,124 (GRCm39) probably benign Het
Itprid1 T C 6: 55,866,155 (GRCm39) F183L probably damaging Het
Kif22 A G 7: 126,631,916 (GRCm39) S384P probably benign Het
Lbr A C 1: 181,648,233 (GRCm39) probably benign Het
Misp T C 10: 79,662,969 (GRCm39) V462A probably benign Het
Mrgpra3 A C 7: 47,239,039 (GRCm39) L296V possibly damaging Het
Ndufa9 A T 6: 126,799,031 (GRCm39) L362Q probably damaging Het
Nlrp9c A T 7: 26,083,862 (GRCm39) D572E probably benign Het
Or4f14 T A 2: 111,743,222 (GRCm39) T18S probably benign Het
Otud4 C T 8: 80,379,980 (GRCm39) probably benign Het
P4ha3 T C 7: 99,962,535 (GRCm39) I431T probably damaging Het
Pcdhb15 T A 18: 37,606,815 (GRCm39) F16I probably benign Het
Pcnp A G 16: 55,844,754 (GRCm39) S49P probably damaging Het
Pdxdc1 T A 16: 13,697,278 (GRCm39) probably benign Het
Pgc T A 17: 48,039,828 (GRCm39) probably null Het
Phf11a T C 14: 59,521,778 (GRCm39) D131G probably benign Het
Prdm2 G A 4: 142,858,953 (GRCm39) H1446Y possibly damaging Het
Rad54b T C 4: 11,563,352 (GRCm39) S4P probably damaging Het
Slc52a2 T C 15: 76,423,808 (GRCm39) probably benign Het
Slc9a4 G A 1: 40,623,490 (GRCm39) probably benign Het
Smad4 T C 18: 73,773,333 (GRCm39) D551G probably benign Het
Smg7 A T 1: 152,742,326 (GRCm39) probably benign Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Sspo A G 6: 48,436,352 (GRCm39) Y1234C probably damaging Het
Stab2 A T 10: 86,721,582 (GRCm39) probably null Het
Stk36 A G 1: 74,671,925 (GRCm39) E875G probably benign Het
Stmn4 T G 14: 66,591,844 (GRCm39) probably benign Het
Tagln3 C A 16: 45,544,635 (GRCm39) R12L probably damaging Het
Tex14 A T 11: 87,413,343 (GRCm39) R1031S probably benign Het
Tia1 G A 6: 86,396,091 (GRCm39) V96I probably benign Het
Ticrr C T 7: 79,343,701 (GRCm39) P1189S probably benign Het
Tnxb G A 17: 34,904,017 (GRCm39) V1053M probably damaging Het
Tpp2 T C 1: 44,031,556 (GRCm39) probably null Het
Trpm7 A G 2: 126,664,406 (GRCm39) M991T possibly damaging Het
Ttc3 T A 16: 94,217,127 (GRCm39) probably benign Het
Vcan G A 13: 89,853,782 (GRCm39) P393S probably damaging Het
Vmn2r107 G A 17: 20,576,860 (GRCm39) R286Q probably benign Het
Wdr87-ps G A 7: 29,233,669 (GRCm39) noncoding transcript Het
Wrap73 A T 4: 154,236,884 (GRCm39) probably null Het
Zfp958 A T 8: 4,676,169 (GRCm39) N46Y possibly damaging Het
Other mutations in Mei1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01612:Mei1 APN 15 81,973,753 (GRCm39) missense probably damaging 0.99
IGL01776:Mei1 APN 15 81,980,133 (GRCm39) critical splice donor site probably null
IGL01864:Mei1 APN 15 81,997,218 (GRCm39) splice site probably benign
IGL02030:Mei1 APN 15 81,999,944 (GRCm39) missense probably benign
IGL02148:Mei1 APN 15 81,976,912 (GRCm39) nonsense probably null
R0135:Mei1 UTSW 15 81,956,170 (GRCm39) nonsense probably null
R0212:Mei1 UTSW 15 81,980,132 (GRCm39) critical splice donor site probably null
R0537:Mei1 UTSW 15 81,975,562 (GRCm39) missense possibly damaging 0.93
R0605:Mei1 UTSW 15 81,954,351 (GRCm39) missense probably benign
R0727:Mei1 UTSW 15 81,954,350 (GRCm39) missense probably benign 0.01
R1226:Mei1 UTSW 15 81,964,285 (GRCm39) missense possibly damaging 0.92
R1339:Mei1 UTSW 15 81,966,196 (GRCm39) missense possibly damaging 0.66
R1558:Mei1 UTSW 15 81,991,334 (GRCm39) missense probably damaging 1.00
R1769:Mei1 UTSW 15 81,996,771 (GRCm39) splice site probably null
R1868:Mei1 UTSW 15 82,009,154 (GRCm39) missense probably damaging 1.00
R1980:Mei1 UTSW 15 81,987,513 (GRCm39) missense probably benign 0.00
R1981:Mei1 UTSW 15 81,987,513 (GRCm39) missense probably benign 0.00
R1982:Mei1 UTSW 15 81,987,513 (GRCm39) missense probably benign 0.00
R2103:Mei1 UTSW 15 81,991,237 (GRCm39) missense probably damaging 0.99
R2103:Mei1 UTSW 15 81,987,405 (GRCm39) missense possibly damaging 0.91
R2207:Mei1 UTSW 15 81,987,450 (GRCm39) missense probably benign 0.08
R2444:Mei1 UTSW 15 81,997,142 (GRCm39) missense probably damaging 1.00
R3009:Mei1 UTSW 15 81,996,726 (GRCm39) missense probably damaging 0.97
R3114:Mei1 UTSW 15 82,009,160 (GRCm39) missense probably benign 0.31
R3546:Mei1 UTSW 15 81,982,243 (GRCm39) missense probably damaging 0.97
R3720:Mei1 UTSW 15 81,987,405 (GRCm39) missense possibly damaging 0.91
R3721:Mei1 UTSW 15 81,987,405 (GRCm39) missense possibly damaging 0.91
R3722:Mei1 UTSW 15 81,987,405 (GRCm39) missense possibly damaging 0.91
R3752:Mei1 UTSW 15 81,970,383 (GRCm39) missense probably damaging 0.97
R3778:Mei1 UTSW 15 81,966,209 (GRCm39) missense probably damaging 1.00
R3848:Mei1 UTSW 15 81,997,218 (GRCm39) splice site probably benign
R3933:Mei1 UTSW 15 81,967,353 (GRCm39) missense possibly damaging 0.75
R4274:Mei1 UTSW 15 82,009,064 (GRCm39) missense possibly damaging 0.66
R4765:Mei1 UTSW 15 81,996,686 (GRCm39) missense possibly damaging 0.96
R5070:Mei1 UTSW 15 81,961,804 (GRCm39) missense possibly damaging 0.66
R5394:Mei1 UTSW 15 81,976,957 (GRCm39) missense possibly damaging 0.83
R6108:Mei1 UTSW 15 81,959,389 (GRCm39) missense possibly damaging 0.66
R6302:Mei1 UTSW 15 81,987,439 (GRCm39) nonsense probably null
R6849:Mei1 UTSW 15 81,964,146 (GRCm39) missense possibly damaging 0.92
R6913:Mei1 UTSW 15 81,973,810 (GRCm39) missense probably benign 0.06
R6919:Mei1 UTSW 15 81,966,131 (GRCm39) missense probably damaging 0.98
R6959:Mei1 UTSW 15 82,009,076 (GRCm39) missense probably benign 0.01
R7007:Mei1 UTSW 15 81,978,200 (GRCm39) missense probably damaging 0.99
R7202:Mei1 UTSW 15 81,976,843 (GRCm39) missense
R7374:Mei1 UTSW 15 81,980,109 (GRCm39) missense
R7438:Mei1 UTSW 15 81,999,682 (GRCm39) missense
R7757:Mei1 UTSW 15 81,966,824 (GRCm39) intron probably benign
R7857:Mei1 UTSW 15 81,976,918 (GRCm39) missense not run
R8265:Mei1 UTSW 15 81,987,508 (GRCm39) nonsense probably null
R8728:Mei1 UTSW 15 81,966,182 (GRCm39) missense
R8902:Mei1 UTSW 15 81,954,212 (GRCm39) missense unknown
R9048:Mei1 UTSW 15 81,969,036 (GRCm39) nonsense probably null
R9233:Mei1 UTSW 15 81,973,752 (GRCm39) missense
R9285:Mei1 UTSW 15 81,985,170 (GRCm39) missense
R9660:Mei1 UTSW 15 81,966,098 (GRCm39) missense
R9689:Mei1 UTSW 15 81,997,129 (GRCm39) missense
R9728:Mei1 UTSW 15 81,966,098 (GRCm39) missense
RF051:Mei1 UTSW 15 81,954,211 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- GCATTGCTTCTCCGCCTGGATAG -3'
(R):5'- GTGAACTCCTGGTCTCCTGCCG -3'

Sequencing Primer
(F):5'- TCTCCGCCTGGATAGAGGAAG -3'
(R):5'- gccacctcccaaatgcc -3'
Posted On 2014-01-05