Incidental Mutation 'R1119:Zfp958'
ID97740
Institutional Source Beutler Lab
Gene Symbol Zfp958
Ensembl Gene ENSMUSG00000058748
Gene Namezinc finger protein 958
SynonymsBC003267
MMRRC Submission 039192-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.084) question?
Stock #R1119 (G1)
Quality Score225
Status Validated
Chromosome8
Chromosomal Location4613167-4630231 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 4626169 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Tyrosine at position 46 (N46Y)
Ref Sequence ENSEMBL: ENSMUSP00000143842 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073201] [ENSMUST00000202692]
Predicted Effect probably benign
Transcript: ENSMUST00000073201
AA Change: N45Y

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000072937
Gene: ENSMUSG00000058748
AA Change: N45Y

DomainStartEndE-ValueType
KRAB 3 65 1.96e-17 SMART
ZnF_C2H2 102 124 2.67e-1 SMART
ZnF_C2H2 130 152 8.47e-4 SMART
ZnF_C2H2 158 180 5.5e-3 SMART
ZnF_C2H2 186 208 1.38e-3 SMART
ZnF_C2H2 214 236 9.96e-1 SMART
ZnF_C2H2 242 264 2.15e-5 SMART
ZnF_C2H2 270 292 3.16e-3 SMART
ZnF_C2H2 298 320 1.69e-3 SMART
ZnF_C2H2 326 348 5.14e-3 SMART
ZnF_C2H2 354 376 2.91e-2 SMART
ZnF_C2H2 382 404 2.27e-4 SMART
ZnF_C2H2 410 432 4.79e-3 SMART
ZnF_C2H2 438 460 6.88e-4 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000202692
AA Change: N46Y

PolyPhen 2 Score 0.505 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000143842
Gene: ENSMUSG00000058748
AA Change: N46Y

DomainStartEndE-ValueType
KRAB 4 66 1.96e-17 SMART
ZnF_C2H2 103 125 2.67e-1 SMART
ZnF_C2H2 131 153 8.47e-4 SMART
ZnF_C2H2 159 181 5.5e-3 SMART
ZnF_C2H2 187 209 1.38e-3 SMART
ZnF_C2H2 215 237 9.96e-1 SMART
ZnF_C2H2 243 265 2.15e-5 SMART
ZnF_C2H2 271 293 3.16e-3 SMART
ZnF_C2H2 299 321 1.69e-3 SMART
ZnF_C2H2 327 349 5.14e-3 SMART
ZnF_C2H2 355 377 2.91e-2 SMART
ZnF_C2H2 383 405 2.27e-4 SMART
ZnF_C2H2 411 433 4.79e-3 SMART
ZnF_C2H2 439 461 6.88e-4 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.4%
Validation Efficiency 100% (51/51)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik T G 3: 36,987,045 V2524G probably damaging Het
Adamtsl3 A C 7: 82,540,317 E583A probably damaging Het
Aoah T A 13: 20,914,938 probably benign Het
Atf7ip2 A G 16: 10,240,612 K305R possibly damaging Het
Ccdc129 T C 6: 55,889,170 F183L probably damaging Het
Cd200r2 A G 16: 44,909,606 N171S probably damaging Het
Cfap57 G A 4: 118,606,676 Q327* probably null Het
Ckap2l A T 2: 129,272,572 probably benign Het
Cul2 A G 18: 3,419,335 probably benign Het
Ddx60 G A 8: 61,942,544 V172M probably damaging Het
Drp2 T C X: 134,441,322 L545P probably damaging Het
Ezh1 A G 11: 101,210,535 probably benign Het
Gipc2 A G 3: 152,094,196 F299S probably damaging Het
Gsk3b T C 16: 38,207,984 probably benign Het
Gtf3c3 C T 1: 54,417,778 A488T probably damaging Het
Hikeshi A G 7: 89,935,730 S89P probably benign Het
Hmcn1 C T 1: 150,618,928 A4137T possibly damaging Het
Larp1b C A 3: 41,033,528 R62S possibly damaging Het
Lgr5 A T 10: 115,460,811 probably null Het
Lpin1 C A 12: 16,563,721 D449Y probably damaging Het
Macrod2 A T 2: 140,400,906 I31L probably benign Het
Meig1 T C 2: 3,409,274 D63G probably damaging Het
Ndufa9 A T 6: 126,822,068 L362Q probably damaging Het
Nlrp9c A T 7: 26,384,437 D572E probably benign Het
Nxpe5 G A 5: 138,239,396 D61N probably benign Het
Ogdh T A 11: 6,340,544 H376Q probably damaging Het
P4ha3 T C 7: 100,313,328 I431T probably damaging Het
Pcdhb14 G A 18: 37,448,587 V249M probably damaging Het
Pcnp A G 16: 56,024,391 S49P probably damaging Het
Pik3r6 C T 11: 68,545,872 T654I probably benign Het
Rptn A G 3: 93,396,245 Y295C possibly damaging Het
Sec16b A G 1: 157,564,834 D924G possibly damaging Het
Setd1b C A 5: 123,147,716 T275K unknown Het
Sgcb T A 5: 73,644,414 K36I probably damaging Het
Smg7 A T 1: 152,866,575 probably benign Het
Sned1 G A 1: 93,281,654 V830M possibly damaging Het
Stab2 T C 10: 86,859,755 D599G possibly damaging Het
Stk36 A G 1: 74,632,766 E875G probably benign Het
Tagln3 C A 16: 45,724,272 R12L probably damaging Het
Tax1bp1 C A 6: 52,741,948 probably benign Het
Thnsl1 A G 2: 21,213,046 N16S probably damaging Het
Ticrr C T 7: 79,693,953 P1189S probably benign Het
Tnxb G A 17: 34,685,043 V1053M probably damaging Het
Tpp2 T C 1: 43,992,396 probably null Het
Trappc9 G A 15: 73,025,967 R377W probably damaging Het
Vmn2r60 A T 7: 42,194,941 Q576L possibly damaging Het
Zfp62 G T 11: 49,216,690 R536L probably damaging Het
Other mutations in Zfp958
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01950:Zfp958 APN 8 4628917 missense probably damaging 1.00
IGL02185:Zfp958 APN 8 4628990 nonsense probably null
IGL02716:Zfp958 APN 8 4625967 critical splice donor site probably null
R1118:Zfp958 UTSW 8 4626169 missense possibly damaging 0.50
R1478:Zfp958 UTSW 8 4629190 missense probably damaging 1.00
R1816:Zfp958 UTSW 8 4629147 missense possibly damaging 0.89
R1837:Zfp958 UTSW 8 4628590 missense probably damaging 1.00
R1838:Zfp958 UTSW 8 4628590 missense probably damaging 1.00
R3763:Zfp958 UTSW 8 4626226 critical splice donor site probably null
R5257:Zfp958 UTSW 8 4628456 missense probably benign 0.28
R5258:Zfp958 UTSW 8 4628456 missense probably benign 0.28
R5304:Zfp958 UTSW 8 4626196 missense possibly damaging 0.73
R5512:Zfp958 UTSW 8 4625838 critical splice acceptor site probably null
R5907:Zfp958 UTSW 8 4629072 missense probably benign 0.01
R6604:Zfp958 UTSW 8 4628245 missense probably damaging 1.00
R6688:Zfp958 UTSW 8 4628940 missense possibly damaging 0.91
R6727:Zfp958 UTSW 8 4628247 missense probably benign 0.08
R6981:Zfp958 UTSW 8 4626170 missense probably benign 0.00
R7010:Zfp958 UTSW 8 4628377 missense probably benign 0.13
R7140:Zfp958 UTSW 8 4628481 missense probably benign 0.05
Predicted Primers
Posted On2014-01-05