Incidental Mutation 'R1119:Cd200r2'
ID97796
Institutional Source Beutler Lab
Gene Symbol Cd200r2
Ensembl Gene ENSMUSG00000090176
Gene NameCd200 receptor 2
SynonymsCD200 cell surface glycoprotein receptor isoform 2
MMRRC Submission 039192-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.092) question?
Stock #R1119 (G1)
Quality Score225
Status Validated
Chromosome16
Chromosomal Location44867097-44915840 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 44909606 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 171 (N171S)
Ref Sequence ENSEMBL: ENSMUSP00000099869 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102805]
Predicted Effect probably damaging
Transcript: ENSMUST00000102805
AA Change: N171S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000099869
Gene: ENSMUSG00000090176
AA Change: N171S

DomainStartEndE-ValueType
IG 23 126 1.06e-2 SMART
IG_like 128 249 1.85e2 SMART
Meta Mutation Damage Score 0.7621 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.4%
Validation Efficiency 100% (51/51)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik T G 3: 36,987,045 V2524G probably damaging Het
Adamtsl3 A C 7: 82,540,317 E583A probably damaging Het
Aoah T A 13: 20,914,938 probably benign Het
Atf7ip2 A G 16: 10,240,612 K305R possibly damaging Het
Ccdc129 T C 6: 55,889,170 F183L probably damaging Het
Cfap57 G A 4: 118,606,676 Q327* probably null Het
Ckap2l A T 2: 129,272,572 probably benign Het
Cul2 A G 18: 3,419,335 probably benign Het
Ddx60 G A 8: 61,942,544 V172M probably damaging Het
Drp2 T C X: 134,441,322 L545P probably damaging Het
Ezh1 A G 11: 101,210,535 probably benign Het
Gipc2 A G 3: 152,094,196 F299S probably damaging Het
Gsk3b T C 16: 38,207,984 probably benign Het
Gtf3c3 C T 1: 54,417,778 A488T probably damaging Het
Hikeshi A G 7: 89,935,730 S89P probably benign Het
Hmcn1 C T 1: 150,618,928 A4137T possibly damaging Het
Larp1b C A 3: 41,033,528 R62S possibly damaging Het
Lgr5 A T 10: 115,460,811 probably null Het
Lpin1 C A 12: 16,563,721 D449Y probably damaging Het
Macrod2 A T 2: 140,400,906 I31L probably benign Het
Meig1 T C 2: 3,409,274 D63G probably damaging Het
Ndufa9 A T 6: 126,822,068 L362Q probably damaging Het
Nlrp9c A T 7: 26,384,437 D572E probably benign Het
Nxpe5 G A 5: 138,239,396 D61N probably benign Het
Ogdh T A 11: 6,340,544 H376Q probably damaging Het
P4ha3 T C 7: 100,313,328 I431T probably damaging Het
Pcdhb14 G A 18: 37,448,587 V249M probably damaging Het
Pcnp A G 16: 56,024,391 S49P probably damaging Het
Pik3r6 C T 11: 68,545,872 T654I probably benign Het
Rptn A G 3: 93,396,245 Y295C possibly damaging Het
Sec16b A G 1: 157,564,834 D924G possibly damaging Het
Setd1b C A 5: 123,147,716 T275K unknown Het
Sgcb T A 5: 73,644,414 K36I probably damaging Het
Smg7 A T 1: 152,866,575 probably benign Het
Sned1 G A 1: 93,281,654 V830M possibly damaging Het
Stab2 T C 10: 86,859,755 D599G possibly damaging Het
Stk36 A G 1: 74,632,766 E875G probably benign Het
Tagln3 C A 16: 45,724,272 R12L probably damaging Het
Tax1bp1 C A 6: 52,741,948 probably benign Het
Thnsl1 A G 2: 21,213,046 N16S probably damaging Het
Ticrr C T 7: 79,693,953 P1189S probably benign Het
Tnxb G A 17: 34,685,043 V1053M probably damaging Het
Tpp2 T C 1: 43,992,396 probably null Het
Trappc9 G A 15: 73,025,967 R377W probably damaging Het
Vmn2r60 A T 7: 42,194,941 Q576L possibly damaging Het
Zfp62 G T 11: 49,216,690 R536L probably damaging Het
Zfp958 A T 8: 4,626,169 N46Y possibly damaging Het
Other mutations in Cd200r2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Cd200r2 APN 16 44909288 missense probably damaging 1.00
IGL01019:Cd200r2 APN 16 44909469 splice site probably benign
IGL01480:Cd200r2 APN 16 44909266 missense probably null 1.00
IGL01510:Cd200r2 APN 16 44909311 missense probably benign 0.03
IGL02202:Cd200r2 APN 16 44909360 missense probably damaging 1.00
IGL02492:Cd200r2 APN 16 44909540 missense probably damaging 1.00
IGL02499:Cd200r2 APN 16 44914585 missense possibly damaging 0.47
R0066:Cd200r2 UTSW 16 44909674 missense possibly damaging 0.94
R0066:Cd200r2 UTSW 16 44909674 missense possibly damaging 0.94
R0503:Cd200r2 UTSW 16 44877962 start codon destroyed probably null 0.93
R0526:Cd200r2 UTSW 16 44915047 missense probably damaging 1.00
R1118:Cd200r2 UTSW 16 44909606 missense probably damaging 1.00
R2393:Cd200r2 UTSW 16 44909267 missense probably damaging 1.00
R5450:Cd200r2 UTSW 16 44909571 missense probably benign 0.04
R7466:Cd200r2 UTSW 16 44909174 missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- TTCCTGACCTTCAGATCAGTGCGG -3'
(R):5'- TCAACTTGACACAGCTTAGAGCCAC -3'

Sequencing Primer
(F):5'- AAGTCTATGACCTCCAAGTGCTG -3'
(R):5'- cacagcttagagccaccttag -3'
Posted On2014-01-05