Incidental Mutation 'R1004:Zfp600'
ID 97936
Institutional Source Beutler Lab
Gene Symbol Zfp600
Ensembl Gene ENSMUSG00000066007
Gene Name zinc finger protein 600
Synonyms Gm13164
MMRRC Submission 039114-MU
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.571) question?
Stock # R1004 (G1)
Quality Score 190
Status Validated
Chromosome 4
Chromosomal Location 146156824-146198755 bp(+) (GRCm38)
Type of Mutation unclassified
DNA Base Change (assembly) T to A at 146196533 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000117892 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092750] [ENSMUST00000131932] [ENSMUST00000168483]
AlphaFold A2A7V0
Predicted Effect unknown
Transcript: ENSMUST00000092750
AA Change: S590R
SMART Domains Protein: ENSMUSP00000090425
Gene: ENSMUSG00000066007
AA Change: S590R

DomainStartEndE-ValueType
KRAB 28 90 1.29e-17 SMART
ZnF_C2H2 251 273 7.9e-4 SMART
ZnF_C2H2 279 301 7.9e-4 SMART
ZnF_C2H2 307 329 3.49e-5 SMART
ZnF_C2H2 335 357 1.95e-3 SMART
ZnF_C2H2 363 385 7.9e-4 SMART
ZnF_C2H2 391 413 7.9e-4 SMART
ZnF_C2H2 419 441 3.49e-5 SMART
ZnF_C2H2 447 469 3.89e-3 SMART
ZnF_C2H2 475 497 2.75e-3 SMART
ZnF_C2H2 503 525 3.04e-5 SMART
ZnF_C2H2 531 553 8.34e-3 SMART
ZnF_C2H2 559 581 5.67e-5 SMART
ZnF_C2H2 587 609 1.98e-4 SMART
ZnF_C2H2 615 637 5.29e-5 SMART
ZnF_C2H2 643 665 1.58e-3 SMART
ZnF_C2H2 671 693 1.28e-3 SMART
ZnF_C2H2 699 721 1.6e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131932
SMART Domains Protein: ENSMUSP00000117892
Gene: ENSMUSG00000066007

DomainStartEndE-ValueType
KRAB 28 90 1.29e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152923
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153595
Predicted Effect unknown
Transcript: ENSMUST00000168483
AA Change: S590R
SMART Domains Protein: ENSMUSP00000126879
Gene: ENSMUSG00000066007
AA Change: S590R

DomainStartEndE-ValueType
KRAB 28 90 1.29e-17 SMART
ZnF_C2H2 251 273 7.9e-4 SMART
ZnF_C2H2 279 301 7.9e-4 SMART
ZnF_C2H2 307 329 3.49e-5 SMART
ZnF_C2H2 335 357 1.95e-3 SMART
ZnF_C2H2 363 385 7.9e-4 SMART
ZnF_C2H2 391 413 7.9e-4 SMART
ZnF_C2H2 419 441 3.49e-5 SMART
ZnF_C2H2 447 469 3.89e-3 SMART
ZnF_C2H2 475 497 2.75e-3 SMART
ZnF_C2H2 503 525 3.04e-5 SMART
ZnF_C2H2 531 553 8.34e-3 SMART
ZnF_C2H2 559 581 5.67e-5 SMART
ZnF_C2H2 587 609 1.98e-4 SMART
ZnF_C2H2 615 637 5.29e-5 SMART
ZnF_C2H2 643 665 1.58e-3 SMART
ZnF_C2H2 671 693 1.28e-3 SMART
ZnF_C2H2 699 721 1.6e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181199
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.7%
Validation Efficiency 100% (41/41)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A G 11: 110,151,954 I423T possibly damaging Het
Agbl3 A T 6: 34,803,451 E453V probably damaging Het
Agxt A G 1: 93,135,699 M108V possibly damaging Het
Akap13 T C 7: 75,687,286 I831T probably damaging Het
Anpep C T 7: 79,838,256 E518K probably benign Het
Arid1a A G 4: 133,687,275 M1215T unknown Het
Cd163 G T 6: 124,325,347 D957Y probably damaging Het
Ces2e A G 8: 104,929,738 D200G probably damaging Het
Cfap54 T C 10: 93,066,696 probably benign Het
Col11a1 A G 3: 114,095,022 probably benign Het
Dlx6 C T 6: 6,863,665 Q96* probably null Het
Dpp4 T A 2: 62,332,640 Q754L probably benign Het
Ece1 A G 4: 137,926,239 T100A probably benign Het
Gabbr2 C T 4: 46,677,544 V779M possibly damaging Het
Gatm C T 2: 122,609,660 probably benign Het
Gm20767 T A 13: 120,155,022 D132E probably benign Het
Gpc2 A G 5: 138,278,225 L213P probably damaging Het
Hook1 A C 4: 96,022,287 N713H probably benign Het
Kdm5b T A 1: 134,588,904 I178K possibly damaging Het
Mettl9 G A 7: 121,076,237 V287I probably benign Het
Mroh2a C A 1: 88,242,420 A685D possibly damaging Het
Mycbp2 G A 14: 103,140,917 T3774I probably benign Het
Nupl1 C A 14: 60,247,481 probably benign Het
Nxf1 A T 19: 8,764,317 T119S probably benign Het
Oaz3 T A 3: 94,435,043 H102L probably damaging Het
Olfr971 T C 9: 39,839,980 F182S probably benign Het
Pfpl A T 19: 12,430,425 Q680L probably benign Het
Poli T A 18: 70,525,438 Q75L probably benign Het
Ppp2r3a C T 9: 101,198,630 probably null Het
Prr30 A G 14: 101,199,093 L11P probably damaging Het
Ptchd4 A T 17: 42,377,602 Y345F probably benign Het
Ric1 A G 19: 29,602,357 N1233S probably benign Het
Serpinb9f TA "TTTNA,T" 13: 33,334,242 probably benign Het
Sh3bgrl2 C T 9: 83,577,631 probably benign Het
Skp1a G C 11: 52,237,380 probably benign Het
Slc12a9 T C 5: 137,322,524 K528R probably damaging Het
Slc22a6 A G 19: 8,618,399 N35S probably damaging Het
Xrcc5 A G 1: 72,383,778 probably benign Het
Zfp235 T A 7: 24,140,744 L266Q probably damaging Het
Other mutations in Zfp600
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4131001:Zfp600 UTSW 4 146195232 frame shift probably null
R1323:Zfp600 UTSW 4 146196691 missense probably damaging 1.00
R1323:Zfp600 UTSW 4 146196691 missense probably damaging 1.00
R1702:Zfp600 UTSW 4 146196927 missense probably benign 0.04
R2165:Zfp600 UTSW 4 146196918 nonsense probably null
R5238:Zfp600 UTSW 4 146195171 splice site probably null
R5548:Zfp600 UTSW 4 146196449 missense possibly damaging 0.86
R5646:Zfp600 UTSW 4 146195100 missense probably damaging 1.00
R5948:Zfp600 UTSW 4 146195075 missense probably damaging 0.96
R6112:Zfp600 UTSW 4 146195131 missense probably benign 0.41
R7044:Zfp600 UTSW 4 146195322 nonsense probably null
R7836:Zfp600 UTSW 4 146196953 missense probably benign
R8080:Zfp600 UTSW 4 146196612 missense unknown
R8749:Zfp600 UTSW 4 146196581 missense unknown
R9255:Zfp600 UTSW 4 146195103 missense possibly damaging 0.70
Z1176:Zfp600 UTSW 4 146196639 missense unknown
Z1177:Zfp600 UTSW 4 146196763 missense probably damaging 1.00
Predicted Primers
Posted On 2014-01-05