Mutagenetix > Incidental Mutation

Incidental Mutation 'R1101:Fcamr'

98060

Institutional Source

Beutler Lab

Gene Symbol

Fcamr

Ensembl Gene

ENSMUSG00000026415

Gene Name

Fc receptor, IgA, IgM, high affinity

Synonyms

MMRRC Submission

039174-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

R1101 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

130800902-130814740 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 130814486 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000108096 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027670] [ENSMUST00000027670] [ENSMUST00000112477] [ENSMUST00000112477]

AlphaFold

Q2TB54

Predicted Effect

probably null
Transcript: ENSMUST00000027670

SMART Domains

Protein: ENSMUSP00000027670
Gene: ENSMUSG00000026415

Domain	Start	End	E-Value	Type
signal peptide	1	36	N/A	INTRINSIC
IG	87	191	1.19e-5	SMART
low complexity region	208	220	N/A	INTRINSIC
low complexity region	241	253	N/A	INTRINSIC
transmembrane domain	456	475	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000027670

SMART Domains

Protein: ENSMUSP00000027670
Gene: ENSMUSG00000026415

Domain	Start	End	E-Value	Type
signal peptide	1	36	N/A	INTRINSIC
IG	87	191	1.19e-5	SMART
low complexity region	208	220	N/A	INTRINSIC
low complexity region	241	253	N/A	INTRINSIC
transmembrane domain	456	475	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000112477

SMART Domains

Protein: ENSMUSP00000108096
Gene: ENSMUSG00000026415

Domain	Start	End	E-Value	Type
low complexity region	80	87	N/A	INTRINSIC
IG	143	247	1.19e-5	SMART
low complexity region	264	276	N/A	INTRINSIC
low complexity region	297	309	N/A	INTRINSIC
transmembrane domain	512	531	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000112477

SMART Domains

Protein: ENSMUSP00000108096
Gene: ENSMUSG00000026415

Domain	Start	End	E-Value	Type
low complexity region	80	87	N/A	INTRINSIC
IG	143	247	1.19e-5	SMART
low complexity region	264	276	N/A	INTRINSIC
low complexity region	297	309	N/A	INTRINSIC
transmembrane domain	512	531	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000122968

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125056

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136015

Coding Region Coverage

1x: 98.9%
3x: 98.0%
10x: 95.5%
20x: 91.2%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null mice have enhanced germinal center formation, affinity maturation and memory induction of IgG3 producing B cells after immunization with T cell-independent antigens. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700034J05Rik	T	C	6: 146,952,411	I249M	possibly damaging	Het
2610021A01Rik	C	A	7: 41,627,359	H829N	probably damaging	Het
4930433I11Rik	A	T	7: 40,993,056	T141S	probably benign	Het
Abi3bp	G	T	16: 56,606,158	R512L	probably damaging	Het
Acot2	T	G	12: 83,992,850	S378A	probably benign	Het
Akap9	T	C	5: 4,046,205	I2360T	probably benign	Het
Bank1	T	C	3: 136,283,864	D155G	probably benign	Het
Bsn	A	G	9: 108,116,411	V714A	probably damaging	Het
Cdh15	G	A	8: 122,860,846	V170I	possibly damaging	Het
Clcn2	G	A	16: 20,703,595	T787I	probably damaging	Het
Dapk1	A	G	13: 60,716,785	H131R	probably damaging	Het
Dct	T	G	14: 118,036,622	D291A	probably damaging	Het
Dhx37	A	G	5: 125,415,152	Y1128H	probably damaging	Het
Dip2c	A	T	13: 9,634,744	I1174F	probably damaging	Het
Eif3l	A	G	15: 79,075,267	Y3C	probably damaging	Het
Enpp5	A	G	17: 44,081,367	N229S	possibly damaging	Het
Fam83b	A	T	9: 76,545,670	H38Q	possibly damaging	Het
Hdac2	G	A	10: 36,991,809	V184I	probably damaging	Het
Igf2bp2	A	T	16: 22,162,950	L5Q	probably damaging	Het
Iqca	C	A	1: 90,142,731	G133V	probably null	Het
Ireb2	T	A	9: 54,909,702	H951Q	probably benign	Het
Lman1	T	A	18: 65,987,898	M418L	probably benign	Het
Lrrfip2	C	T	9: 111,190,225	R275W	probably damaging	Het
Mast3	T	A	8: 70,786,663	I424F	probably damaging	Het
Mep1a	T	C	17: 43,491,693	D147G	probably benign	Het
Mtr	C	A	13: 12,189,525	E1128D	possibly damaging	Het
Ogfod1	C	A	8: 94,064,304	S534R	probably benign	Het
Olfr1212	A	T	2: 88,958,984	I173F	possibly damaging	Het
Olfr1290	T	C	2: 111,489,442	T239A	probably damaging	Het
Olfr173	A	G	16: 58,797,252	V198A	probably benign	Het
Oxtr	C	T	6: 112,477,177	R42Q	probably benign	Het
Pcdh18	T	A	3: 49,753,379	D882V	probably damaging	Het
Pik3cg	C	T	12: 32,195,646	G868S	probably null	Het
Plppr5	T	G	3: 117,662,523	M231R	probably damaging	Het
Polr2a	T	C	11: 69,748,071	T46A	probably benign	Het
Ppp4r3a	C	A	12: 101,051,571	R440L	probably damaging	Het
Serpinb9e	A	T	13: 33,260,088	T364S	probably benign	Het
Sirt3	A	G	7: 140,869,628	V135A	possibly damaging	Het
Supt16	T	C	14: 52,171,439	N826S	probably null	Het
Tbr1	T	C	2: 61,804,739	I11T	probably benign	Het
Trim72	A	G	7: 128,010,247	E407G	possibly damaging	Het
Vps72	C	A	3: 95,119,176	T144K	probably damaging	Het

Other mutations in Fcamr

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00840:Fcamr	APN	1	130813214	missense	probably benign	0.01
IGL02880:Fcamr	APN	1	130813334	missense	probably benign	0.00
IGL03199:Fcamr	APN	1	130812918	missense	probably damaging	1.00
IGL03392:Fcamr	APN	1	130800948	utr 5 prime	probably benign
IGL03398:Fcamr	APN	1	130803248	missense	probably damaging	0.97
R1312:Fcamr	UTSW	1	130811487	missense	probably damaging	1.00
R1351:Fcamr	UTSW	1	130813020	missense	possibly damaging	0.83
R1387:Fcamr	UTSW	1	130804642	missense	possibly damaging	0.85
R1475:Fcamr	UTSW	1	130814484	splice site	probably null
R1728:Fcamr	UTSW	1	130804569	missense	probably benign	0.06
R1728:Fcamr	UTSW	1	130804627	missense	probably benign	0.00
R1728:Fcamr	UTSW	1	130811580	missense	probably benign
R1728:Fcamr	UTSW	1	130812629	missense	probably benign	0.38
R1728:Fcamr	UTSW	1	130812692	missense	probably benign
R1728:Fcamr	UTSW	1	130812738	missense	probably benign	0.00
R1728:Fcamr	UTSW	1	130812809	missense	probably benign	0.02
R1728:Fcamr	UTSW	1	130812816	missense	probably benign	0.41
R1728:Fcamr	UTSW	1	130814597	missense	probably benign
R1729:Fcamr	UTSW	1	130804627	missense	probably benign	0.00
R1729:Fcamr	UTSW	1	130811580	missense	probably benign
R1729:Fcamr	UTSW	1	130812629	missense	probably benign	0.38
R1729:Fcamr	UTSW	1	130812692	missense	probably benign
R1729:Fcamr	UTSW	1	130812738	missense	probably benign	0.00
R1729:Fcamr	UTSW	1	130812809	missense	probably benign	0.02
R1729:Fcamr	UTSW	1	130812816	missense	probably benign	0.41
R1729:Fcamr	UTSW	1	130814597	missense	probably benign
R1730:Fcamr	UTSW	1	130811580	missense	probably benign
R1730:Fcamr	UTSW	1	130812629	missense	probably benign	0.38
R1730:Fcamr	UTSW	1	130812692	missense	probably benign
R1730:Fcamr	UTSW	1	130812738	missense	probably benign	0.00
R1730:Fcamr	UTSW	1	130812809	missense	probably benign	0.02
R1730:Fcamr	UTSW	1	130812816	missense	probably benign	0.41
R1730:Fcamr	UTSW	1	130814597	missense	probably benign
R1739:Fcamr	UTSW	1	130804627	missense	probably benign	0.00
R1739:Fcamr	UTSW	1	130811580	missense	probably benign
R1739:Fcamr	UTSW	1	130812629	missense	probably benign	0.38
R1739:Fcamr	UTSW	1	130812692	missense	probably benign
R1739:Fcamr	UTSW	1	130812738	missense	probably benign	0.00
R1739:Fcamr	UTSW	1	130812809	missense	probably benign	0.02
R1739:Fcamr	UTSW	1	130812816	missense	probably benign	0.41
R1739:Fcamr	UTSW	1	130814597	missense	probably benign
R1762:Fcamr	UTSW	1	130804627	missense	probably benign	0.00
R1762:Fcamr	UTSW	1	130811580	missense	probably benign
R1762:Fcamr	UTSW	1	130812629	missense	probably benign	0.38
R1762:Fcamr	UTSW	1	130812692	missense	probably benign
R1762:Fcamr	UTSW	1	130812738	missense	probably benign	0.00
R1762:Fcamr	UTSW	1	130812809	missense	probably benign	0.02
R1762:Fcamr	UTSW	1	130812816	missense	probably benign	0.41
R1762:Fcamr	UTSW	1	130814597	missense	probably benign
R1783:Fcamr	UTSW	1	130804627	missense	probably benign	0.00
R1783:Fcamr	UTSW	1	130811580	missense	probably benign
R1783:Fcamr	UTSW	1	130812629	missense	probably benign	0.38
R1783:Fcamr	UTSW	1	130812692	missense	probably benign
R1783:Fcamr	UTSW	1	130812738	missense	probably benign	0.00
R1783:Fcamr	UTSW	1	130812809	missense	probably benign	0.02
R1783:Fcamr	UTSW	1	130812816	missense	probably benign	0.41
R1783:Fcamr	UTSW	1	130814597	missense	probably benign
R1784:Fcamr	UTSW	1	130804627	missense	probably benign	0.00
R1784:Fcamr	UTSW	1	130811580	missense	probably benign
R1784:Fcamr	UTSW	1	130812629	missense	probably benign	0.38
R1784:Fcamr	UTSW	1	130812692	missense	probably benign
R1784:Fcamr	UTSW	1	130812738	missense	probably benign	0.00
R1784:Fcamr	UTSW	1	130812809	missense	probably benign	0.02
R1784:Fcamr	UTSW	1	130812816	missense	probably benign	0.41
R1784:Fcamr	UTSW	1	130814597	missense	probably benign
R1785:Fcamr	UTSW	1	130804569	missense	probably benign	0.06
R1785:Fcamr	UTSW	1	130804627	missense	probably benign	0.00
R1785:Fcamr	UTSW	1	130811580	missense	probably benign
R1785:Fcamr	UTSW	1	130812629	missense	probably benign	0.38
R1785:Fcamr	UTSW	1	130812692	missense	probably benign
R1785:Fcamr	UTSW	1	130812738	missense	probably benign	0.00
R1785:Fcamr	UTSW	1	130812809	missense	probably benign	0.02
R1785:Fcamr	UTSW	1	130812816	missense	probably benign	0.41
R1785:Fcamr	UTSW	1	130814597	missense	probably benign
R1793:Fcamr	UTSW	1	130811547	missense	probably benign	0.03
R2085:Fcamr	UTSW	1	130811598	missense	probably damaging	1.00
R3937:Fcamr	UTSW	1	130804576	missense	probably damaging	0.97
R4529:Fcamr	UTSW	1	130804576	missense	probably damaging	0.99
R4624:Fcamr	UTSW	1	130803262	missense	probably damaging	0.99
R4822:Fcamr	UTSW	1	130812686	missense	possibly damaging	0.82
R5055:Fcamr	UTSW	1	130811437	missense	probably damaging	1.00
R5514:Fcamr	UTSW	1	130814056	missense	probably damaging	1.00
R5807:Fcamr	UTSW	1	130811526	missense	probably damaging	1.00
R6077:Fcamr	UTSW	1	130812926	missense	probably damaging	1.00
R6200:Fcamr	UTSW	1	130803190	missense	probably benign	0.16
R6653:Fcamr	UTSW	1	130813202	missense	possibly damaging	0.89
R7081:Fcamr	UTSW	1	130813212	missense	probably damaging	1.00
R7362:Fcamr	UTSW	1	130814023	missense	possibly damaging	0.52
R7828:Fcamr	UTSW	1	130811706	missense	probably damaging	1.00
R7861:Fcamr	UTSW	1	130814638	missense	probably benign
R8188:Fcamr	UTSW	1	130802928	splice site	probably null
R8869:Fcamr	UTSW	1	130811598	missense	probably damaging	1.00
R8907:Fcamr	UTSW	1	130812591	missense	probably damaging	1.00
R9568:Fcamr	UTSW	1	130804619	missense	not run
X0012:Fcamr	UTSW	1	130812734	missense	probably benign	0.09

Predicted Primers

PCR Primer
(F):5'- TTTTCCACCCGATAGCCTCAGGAC -3'
(R):5'- TAGCTTCAGAGAATGCCTGGCCTC -3'

Sequencing Primer
(F):5'- GTCCTACAGGTACAGACTCTTGATG -3'
(R):5'- TGAGGCCCAAGCTGGTATG -3'

Posted On

2014-01-05