Incidental Mutation 'R1101:Serpinb9e'
ID 98124
Institutional Source Beutler Lab
Gene Symbol Serpinb9e
Ensembl Gene ENSMUSG00000062342
Gene Name serine (or cysteine) peptidase inhibitor, clade B, member 9e
Synonyms NK26, ovalbumin, Spi14
MMRRC Submission 039174-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R1101 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 33433595-33444833 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 33444071 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 364 (T364S)
Ref Sequence ENSEMBL: ENSMUSP00000071769 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071873]
AlphaFold O08806
Predicted Effect probably benign
Transcript: ENSMUST00000071873
AA Change: T364S

PolyPhen 2 Score 0.097 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000071769
Gene: ENSMUSG00000062342
AA Change: T364S

DomainStartEndE-ValueType
SERPIN 13 377 1.82e-168 SMART
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.5%
  • 20x: 91.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034J05Rik T C 6: 146,853,909 (GRCm39) I249M possibly damaging Het
2610021A01Rik C A 7: 41,276,783 (GRCm39) H829N probably damaging Het
4930433I11Rik A T 7: 40,642,480 (GRCm39) T141S probably benign Het
Abi3bp G T 16: 56,426,521 (GRCm39) R512L probably damaging Het
Acot2 T G 12: 84,039,624 (GRCm39) S378A probably benign Het
Akap9 T C 5: 4,096,205 (GRCm39) I2360T probably benign Het
Bank1 T C 3: 135,989,625 (GRCm39) D155G probably benign Het
Bsn A G 9: 107,993,610 (GRCm39) V714A probably damaging Het
Cdh15 G A 8: 123,587,585 (GRCm39) V170I possibly damaging Het
Clcn2 G A 16: 20,522,345 (GRCm39) T787I probably damaging Het
Dapk1 A G 13: 60,864,599 (GRCm39) H131R probably damaging Het
Dct T G 14: 118,274,034 (GRCm39) D291A probably damaging Het
Dhx37 A G 5: 125,492,216 (GRCm39) Y1128H probably damaging Het
Dip2c A T 13: 9,684,780 (GRCm39) I1174F probably damaging Het
Eif3l A G 15: 78,959,467 (GRCm39) Y3C probably damaging Het
Enpp5 A G 17: 44,392,258 (GRCm39) N229S possibly damaging Het
Fam83b A T 9: 76,452,952 (GRCm39) H38Q possibly damaging Het
Fcamr T A 1: 130,742,223 (GRCm39) probably null Het
Hdac2 G A 10: 36,867,805 (GRCm39) V184I probably damaging Het
Igf2bp2 A T 16: 21,981,700 (GRCm39) L5Q probably damaging Het
Iqca1 C A 1: 90,070,453 (GRCm39) G133V probably null Het
Ireb2 T A 9: 54,816,986 (GRCm39) H951Q probably benign Het
Lman1 T A 18: 66,120,969 (GRCm39) M418L probably benign Het
Lrrfip2 C T 9: 111,019,293 (GRCm39) R275W probably damaging Het
Mast3 T A 8: 71,239,307 (GRCm39) I424F probably damaging Het
Mep1a T C 17: 43,802,584 (GRCm39) D147G probably benign Het
Mtr C A 13: 12,204,411 (GRCm39) E1128D possibly damaging Het
Ogfod1 C A 8: 94,790,932 (GRCm39) S534R probably benign Het
Or4c107 A T 2: 88,789,328 (GRCm39) I173F possibly damaging Het
Or4k42 T C 2: 111,319,787 (GRCm39) T239A probably damaging Het
Or5k1 A G 16: 58,617,615 (GRCm39) V198A probably benign Het
Oxtr C T 6: 112,454,138 (GRCm39) R42Q probably benign Het
Pcdh18 T A 3: 49,707,828 (GRCm39) D882V probably damaging Het
Pik3cg C T 12: 32,245,645 (GRCm39) G868S probably null Het
Plppr5 T G 3: 117,456,172 (GRCm39) M231R probably damaging Het
Polr2a T C 11: 69,638,897 (GRCm39) T46A probably benign Het
Ppp4r3a C A 12: 101,017,830 (GRCm39) R440L probably damaging Het
Sirt3 A G 7: 140,449,541 (GRCm39) V135A possibly damaging Het
Supt16 T C 14: 52,408,896 (GRCm39) N826S probably null Het
Tbr1 T C 2: 61,635,083 (GRCm39) I11T probably benign Het
Trim72 A G 7: 127,609,419 (GRCm39) E407G possibly damaging Het
Vps72 C A 3: 95,026,487 (GRCm39) T144K probably damaging Het
Other mutations in Serpinb9e
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01619:Serpinb9e APN 13 33,439,108 (GRCm39) missense probably damaging 0.97
IGL02352:Serpinb9e APN 13 33,441,803 (GRCm39) splice site probably benign
IGL02359:Serpinb9e APN 13 33,441,803 (GRCm39) splice site probably benign
IGL02604:Serpinb9e APN 13 33,441,742 (GRCm39) missense probably benign 0.00
IGL02859:Serpinb9e APN 13 33,435,633 (GRCm39) missense possibly damaging 0.83
R0257:Serpinb9e UTSW 13 33,441,664 (GRCm39) missense probably benign 0.24
R0751:Serpinb9e UTSW 13 33,443,757 (GRCm39) missense probably benign 0.00
R1170:Serpinb9e UTSW 13 33,441,735 (GRCm39) nonsense probably null
R1184:Serpinb9e UTSW 13 33,443,757 (GRCm39) missense probably benign 0.00
R1253:Serpinb9e UTSW 13 33,439,102 (GRCm39) missense possibly damaging 0.77
R1405:Serpinb9e UTSW 13 33,444,009 (GRCm39) missense probably benign
R1405:Serpinb9e UTSW 13 33,444,009 (GRCm39) missense probably benign
R1463:Serpinb9e UTSW 13 33,439,099 (GRCm39) missense probably benign
R1566:Serpinb9e UTSW 13 33,437,477 (GRCm39) missense probably damaging 1.00
R1924:Serpinb9e UTSW 13 33,437,428 (GRCm39) missense probably benign 0.07
R1964:Serpinb9e UTSW 13 33,437,474 (GRCm39) missense probably benign 0.04
R2153:Serpinb9e UTSW 13 33,436,961 (GRCm39) missense probably damaging 1.00
R2405:Serpinb9e UTSW 13 33,444,063 (GRCm39) missense probably benign
R2972:Serpinb9e UTSW 13 33,439,126 (GRCm39) missense probably benign
R2973:Serpinb9e UTSW 13 33,439,126 (GRCm39) missense probably benign
R2974:Serpinb9e UTSW 13 33,439,126 (GRCm39) missense probably benign
R3854:Serpinb9e UTSW 13 33,439,137 (GRCm39) missense probably benign 0.40
R4173:Serpinb9e UTSW 13 33,439,141 (GRCm39) missense probably damaging 0.97
R4937:Serpinb9e UTSW 13 33,436,935 (GRCm39) missense probably benign 0.11
R4949:Serpinb9e UTSW 13 33,435,591 (GRCm39) missense possibly damaging 0.81
R5347:Serpinb9e UTSW 13 33,441,767 (GRCm39) missense probably damaging 1.00
R5976:Serpinb9e UTSW 13 33,439,112 (GRCm39) missense probably benign
R5979:Serpinb9e UTSW 13 33,439,036 (GRCm39) missense probably benign 0.18
R5991:Serpinb9e UTSW 13 33,443,790 (GRCm39) missense probably damaging 1.00
R6059:Serpinb9e UTSW 13 33,441,757 (GRCm39) missense probably benign 0.29
R6884:Serpinb9e UTSW 13 33,435,609 (GRCm39) missense probably benign 0.33
R8007:Serpinb9e UTSW 13 33,435,605 (GRCm39) missense probably benign 0.27
R8504:Serpinb9e UTSW 13 33,439,092 (GRCm39) missense probably benign
R9802:Serpinb9e UTSW 13 33,439,078 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTTAACAGCCTGGACCAAACCAGAG -3'
(R):5'- CTGTGGTCATCTGTCCTGGCAAAG -3'

Sequencing Primer
(F):5'- TGGAAGCAAAGCTGACTTCTC -3'
(R):5'- ATGTGGGCATCACTAGATCAG -3'
Posted On 2014-01-05