Mutagenetix > Incidental Mutations

Incidental Mutation 'R1109:Vmn2r120'

98696

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r120

Ensembl Gene

ENSMUSG00000090655

Gene Name

vomeronasal 2, receptor 120

Synonyms

EG224916

MMRRC Submission

039182-MU

Accession Numbers

Genbank: NM_001104591; MGI: 3644483

Is this an essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

R1109 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

57508783-57545314 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 57525829 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 117 (T117A)

Ref Sequence

ENSEMBL: ENSMUSP00000129296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165781]

Predicted Effect

probably benign
Transcript: ENSMUST00000165781
AA Change: T117A

PolyPhen 2 Score 0.088 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000129296
Gene: ENSMUSG00000090655
AA Change: T117A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	80	474	5.9e-42	PFAM
Pfam:NCD3G	517	570	7.5e-22	PFAM
Pfam:7tm_3	598	836	1.3e-54	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 98.9%
3x: 98.0%
10x: 95.3%
20x: 88.9%

Validation Efficiency

100% (80/80)

Allele List at MGI

Other mutations in this stock

Total: 78 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9030624J02Rik	A	T	7: 118,775,329	I351F	probably damaging	Het
Abcd3	T	G	3: 121,779,596	E262D	probably damaging	Het
Abcg1	G	A	17: 31,111,236	A504T	probably benign	Het
Acot11	T	C	4: 106,749,348	T515A	probably benign	Het
Alg8	A	T	7: 97,383,684		probably null	Het
Arhgap44	T	A	11: 65,026,816	H375L	probably benign	Het
Aspm	A	T	1: 139,456,758	I98F	probably damaging	Het
Atp8b5	T	C	4: 43,305,719		probably benign	Het
Ccdc129	G	T	6: 55,968,260	K655N	probably damaging	Het
Coa3	T	C	11: 101,278,785	K48R	probably damaging	Het
Col12a1	A	G	9: 79,699,723	S473P	probably damaging	Het
Dnmt1	A	T	9: 20,922,388	Y451N	probably damaging	Het
Dock5	A	G	14: 67,806,478	Y819H	possibly damaging	Het
Dtx1	G	A	5: 120,710,419		probably benign	Het
Dus2	T	A	8: 106,053,482	F479I	probably benign	Het
Esrp1	T	C	4: 11,365,205	E262G	probably damaging	Het
Exoc4	A	G	6: 33,442,016	Y466C	probably damaging	Het
Fasn	A	G	11: 120,812,324	F1625S	possibly damaging	Het
Fbxw25	A	T	9: 109,650,060	H374Q	probably benign	Het
Focad	T	C	4: 88,196,747		probably benign	Het
Gad2	G	T	2: 22,681,394	R448L	probably damaging	Het
Gad2	G	A	2: 22,690,159		probably benign	Het
Galnt16	G	T	12: 80,590,631	E377D	probably benign	Het
Gcc1	A	C	6: 28,419,167	L389R	probably damaging	Het
Ggct	A	T	6: 54,989,569		probably benign	Het
Gm7052	G	A	17: 22,040,152		probably benign	Het
Gps2	T	A	11: 69,915,681	H177Q	possibly damaging	Het
Heg1	T	A	16: 33,763,591	L1256Q	probably damaging	Het
Ikbkap	T	C	4: 56,786,723	T407A	probably benign	Het
Il1f6	G	A	2: 24,216,590	G62E	probably damaging	Het
Il3ra	C	T	14: 14,349,317	R138W	probably damaging	Het
Kdm4b	T	A	17: 56,399,430	I848N	probably damaging	Het
L3hypdh	A	G	12: 72,073,996	V327A	possibly damaging	Het
Lepr	G	T	4: 101,771,355	L552F	probably damaging	Het
Lpin3	T	C	2: 160,899,021	I449T	probably damaging	Het
Lrrn1	A	G	6: 107,567,264	K8E	probably benign	Het
Mex3a	G	T	3: 88,536,660	D348Y	possibly damaging	Het
Mindy2	G	A	9: 70,631,079	R325*	probably null	Het
Mkrn1	A	T	6: 39,399,334	M382K	probably damaging	Het
Mroh1	G	T	15: 76,446,509		probably benign	Het
Myo15	T	A	11: 60,493,066	D1646E	probably damaging	Het
Neu2	A	G	1: 87,596,728	D145G	probably damaging	Het
Olfr317	T	C	11: 58,732,916	Y83C	probably benign	Het
Olfr718-ps1	A	T	5: 143,137,619	N216K	probably benign	Het
Olfr743	T	C	14: 50,533,702	S97P	possibly damaging	Het
Plekhm2	T	A	4: 141,627,984	I938F	probably benign	Het
Pnmal1	A	T	7: 16,961,467	K416*	probably null	Het
Ppid	T	C	3: 79,598,861	S198P	probably benign	Het
Rabl6	G	T	2: 25,587,526	P304Q	probably damaging	Het
Rasal2	A	T	1: 157,177,638		probably benign	Het
Ripor1	G	T	8: 105,618,928		probably benign	Het
Rnf216	A	T	5: 143,068,369	L658Q	probably damaging	Het
Rnf219	A	T	14: 104,479,764	L391*	probably null	Het
Safb	T	A	17: 56,601,228		probably benign	Het
Sf3b5	T	C	10: 13,008,753	M44T	probably benign	Het
Slc26a9	A	T	1: 131,758,798	M419L	probably benign	Het
Slc38a8	T	C	8: 119,482,655	D393G	probably benign	Het
Slc6a3	A	G	13: 73,557,080	D230G	probably benign	Het
Smc1b	T	C	15: 85,112,815	T535A	probably damaging	Het
Smg7	G	C	1: 152,845,583	P626R	probably damaging	Het
Smu1	C	T	4: 40,755,722	V48M	probably benign	Het
Spag17	T	C	3: 100,027,351	Y650H	possibly damaging	Het
Spata1	C	T	3: 146,475,298	V302I	possibly damaging	Het
Sptb	G	A	12: 76,603,603	A1780V	probably damaging	Het
Srrm2	G	A	17: 23,819,617		probably benign	Het
Sspo	A	C	6: 48,497,443	N4933H	probably damaging	Het
Sult2a2	T	C	7: 13,734,873	I88T	probably benign	Het
Tgfa	G	T	6: 86,270,090		probably benign	Het
Thsd1	T	A	8: 22,243,692	C252S	possibly damaging	Het
Tmem102	T	A	11: 69,804,804	H114L	probably damaging	Het
Tnni3k	T	A	3: 154,792,777	K808N	possibly damaging	Het
Trpm7	G	T	2: 126,797,793	L1628M	probably benign	Het
Ttn	A	G	2: 76,730,737	Y29107H	probably damaging	Het
Upb1	T	C	10: 75,438,165	L342P	probably damaging	Het
Vmn2r16	A	G	5: 109,339,786	D175G	probably damaging	Het
Zfhx4	T	G	3: 5,399,870	M1696R	possibly damaging	Het
Zfp746	A	G	6: 48,064,922	V289A	possibly damaging	Het
Zfyve26	A	C	12: 79,272,127	F1146V	probably damaging	Het

Other mutations in Vmn2r120

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01335:Vmn2r120	APN	17	57525732	missense	possibly damaging	0.86
IGL01346:Vmn2r120	APN	17	57545232	missense	probably benign	0.11
IGL01996:Vmn2r120	APN	17	57525222	missense	possibly damaging	0.92
IGL02503:Vmn2r120	APN	17	57509385	missense	probably benign	0.40
IGL02582:Vmn2r120	APN	17	57524724	missense	probably damaging	0.99
IGL02747:Vmn2r120	APN	17	57524719	missense	probably benign	0.19
IGL02896:Vmn2r120	APN	17	57509008	missense	probably damaging	1.00
IGL03139:Vmn2r120	APN	17	57524742	missense	probably benign	0.39
IGL03342:Vmn2r120	APN	17	57509372	missense	probably benign	0.03
A4554:Vmn2r120	UTSW	17	57525715	missense	probably benign	0.01
R0207:Vmn2r120	UTSW	17	57525052	missense	probably benign	0.17
R0472:Vmn2r120	UTSW	17	57524518	missense	probably benign	0.03
R0517:Vmn2r120	UTSW	17	57508949	missense	probably damaging	1.00
R1316:Vmn2r120	UTSW	17	57525939	missense	probably benign	0.28
R1543:Vmn2r120	UTSW	17	57522374	missense	probably benign	0.09
R1795:Vmn2r120	UTSW	17	57525038	missense	probably benign	0.35
R1850:Vmn2r120	UTSW	17	57525826	missense	probably benign	0.19
R1920:Vmn2r120	UTSW	17	57524839	missense	probably benign	0.01
R1921:Vmn2r120	UTSW	17	57524839	missense	probably benign	0.01
R1922:Vmn2r120	UTSW	17	57524839	missense	probably benign	0.01
R2063:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2064:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2065:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2067:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2286:Vmn2r120	UTSW	17	57508958	missense	probably damaging	1.00
R2291:Vmn2r120	UTSW	17	57509479	missense	probably damaging	1.00
R3416:Vmn2r120	UTSW	17	57509241	missense	possibly damaging	0.89
R3874:Vmn2r120	UTSW	17	57524954	missense	probably benign	0.40
R4023:Vmn2r120	UTSW	17	57536718	missense	possibly damaging	0.92
R4024:Vmn2r120	UTSW	17	57536718	missense	possibly damaging	0.92
R4348:Vmn2r120	UTSW	17	57522466	missense	possibly damaging	0.47
R4409:Vmn2r120	UTSW	17	57509477	missense	probably damaging	1.00
R4610:Vmn2r120	UTSW	17	57509120	missense	probably damaging	1.00
R4771:Vmn2r120	UTSW	17	57524887	missense	probably damaging	1.00
R4786:Vmn2r120	UTSW	17	57522048	missense	probably benign	0.14
R4927:Vmn2r120	UTSW	17	57509125	missense	probably damaging	1.00
R5285:Vmn2r120	UTSW	17	57536703	missense	probably damaging	1.00
R5566:Vmn2r120	UTSW	17	57545290	missense	possibly damaging	0.95
R5578:Vmn2r120	UTSW	17	57522514	missense	probably benign	0.01
R5643:Vmn2r120	UTSW	17	57524977	missense	probably benign	0.01
R5644:Vmn2r120	UTSW	17	57524977	missense	probably benign	0.01
R5781:Vmn2r120	UTSW	17	57524938	missense	probably benign	0.00
R6084:Vmn2r120	UTSW	17	57525721	missense	probably benign	0.15
R6120:Vmn2r120	UTSW	17	57525973	missense	probably benign	0.02
R6160:Vmn2r120	UTSW	17	57509418	missense	probably benign	0.03
R6248:Vmn2r120	UTSW	17	57545287	missense	probably benign	0.03
R6256:Vmn2r120	UTSW	17	57524700	nonsense	probably null
R6730:Vmn2r120	UTSW	17	57525012	missense	probably benign	0.03
R6821:Vmn2r120	UTSW	17	57536659	missense	probably benign	0.00
R6868:Vmn2r120	UTSW	17	57545218	missense	probably benign	0.00
R6880:Vmn2r120	UTSW	17	57509187	missense	probably damaging	1.00
R6986:Vmn2r120	UTSW	17	57509340	missense	probably damaging	1.00
R7276:Vmn2r120	UTSW	17	57524881	missense	probably benign	0.11
R7373:Vmn2r120	UTSW	17	57509406	missense	probably benign	0.35
R7653:Vmn2r120	UTSW	17	57509258	missense	possibly damaging	0.93
R7667:Vmn2r120	UTSW	17	57536657	missense	probably benign	0.04
R7775:Vmn2r120	UTSW	17	57525942	missense	probably damaging	1.00
R7778:Vmn2r120	UTSW	17	57525942	missense	probably damaging	1.00
R7797:Vmn2r120	UTSW	17	57508874	missense	probably damaging	1.00
R7824:Vmn2r120	UTSW	17	57525942	missense	probably damaging	1.00
R7902:Vmn2r120	UTSW	17	57509244	missense	possibly damaging	0.87
R7922:Vmn2r120	UTSW	17	57524683	missense	probably damaging	0.99
R8508:Vmn2r120	UTSW	17	57525843	missense	probably benign	0.03
RF005:Vmn2r120	UTSW	17	57521991	missense	possibly damaging	0.65
Z1177:Vmn2r120	UTSW	17	57509245	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TGTCCCCAAGAGAAAATTGTTGCACTC -3'
(R):5'- GGTCTGATGAATCCACAAAAGGCTAGG -3'

Sequencing Primer
(F):5'- CAAGAGAAAATTGTTGCACTCTTCAG -3'
(R):5'- GGCAGCCTACCTTATTATGGAAG -3'

Posted On

2014-01-05