Incidental Mutation 'R0567:H2ac12'
ID 98905
Institutional Source Beutler Lab
Gene Symbol H2ac12
Ensembl Gene ENSMUSG00000069302
Gene Name H2A clustered histone 12
Synonyms Hist1h2ah
MMRRC Submission 038758-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.270) question?
Stock # R0567 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 22219334-22219738 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 22219734 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000106085 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091742] [ENSMUST00000110455]
AlphaFold Q8CGP6
Predicted Effect probably benign
Transcript: ENSMUST00000091742
SMART Domains Protein: ENSMUSP00000089336
Gene: ENSMUSG00000069302

DomainStartEndE-ValueType
H2A 3 123 8.07e-81 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110455
SMART Domains Protein: ENSMUSP00000106085
Gene: ENSMUSG00000062727

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
H2B 28 124 4.64e-72 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146121
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197533
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl1 A G 4: 86,146,253 (GRCm39) E303G probably damaging Het
Akr1b1 A T 6: 34,281,280 (GRCm39) probably null Het
Alox8 A T 11: 69,082,348 (GRCm39) probably null Het
Apcdd1 G A 18: 63,067,107 (GRCm39) E74K possibly damaging Het
Atr T C 9: 95,747,882 (GRCm39) V388A probably benign Het
AW554918 G A 18: 25,533,092 (GRCm39) E452K possibly damaging Het
C1galt1 A G 6: 7,866,874 (GRCm39) D240G probably damaging Het
Ceacam10 T A 7: 24,477,834 (GRCm39) D116E probably damaging Het
Col15a1 G T 4: 47,293,231 (GRCm39) V912L possibly damaging Het
Cyp3a11 G A 5: 145,805,959 (GRCm39) T136I probably damaging Het
Denr C T 5: 124,046,221 (GRCm39) T17M probably benign Het
Doc2b A G 11: 75,670,950 (GRCm39) F227S probably damaging Het
Dsp A T 13: 38,376,414 (GRCm39) T1400S probably benign Het
Egfr A T 11: 16,822,873 (GRCm39) D412V probably benign Het
Fryl C T 5: 73,222,734 (GRCm39) G1949D possibly damaging Het
Gstp3 A T 19: 4,107,636 (GRCm39) L176Q possibly damaging Het
Heatr5a T A 12: 51,956,872 (GRCm39) N1075I probably damaging Het
Ighv1-69 C T 12: 115,587,169 (GRCm39) probably benign Het
Lama3 A G 18: 12,682,309 (GRCm39) I1092V probably benign Het
Lipg A T 18: 75,090,440 (GRCm39) H36Q probably benign Het
Myh7b T C 2: 155,468,318 (GRCm39) W836R probably damaging Het
Oit3 A T 10: 59,271,800 (GRCm39) C186S probably damaging Het
Or4m1 A T 14: 50,558,115 (GRCm39) M59K probably damaging Het
P2ry2 T C 7: 100,647,748 (GRCm39) T186A probably damaging Het
Pyroxd2 T C 19: 42,724,364 (GRCm39) T300A probably benign Het
Rab26 C A 17: 24,748,556 (GRCm39) V283F probably damaging Het
Rad50 C T 11: 53,545,783 (GRCm39) R1180Q probably damaging Het
Rbpms2 ACTGCTGCTGCTGCTGC ACTGCTGCTGCTGCTGCTGC 9: 65,558,948 (GRCm39) probably benign Het
Shroom3 A G 5: 93,112,312 (GRCm39) D1891G possibly damaging Het
Syne2 G A 12: 75,937,004 (GRCm39) E201K probably damaging Het
Taf6 A T 5: 138,181,988 (GRCm39) probably null Het
Tbc1d32 A T 10: 56,050,059 (GRCm39) M493K possibly damaging Het
Uaca A G 9: 60,778,663 (GRCm39) T1017A probably benign Het
Usp17le C T 7: 104,418,105 (GRCm39) V346I possibly damaging Het
Vmn1r71 T C 7: 10,482,556 (GRCm39) D44G probably damaging Het
Vmn2r80 A G 10: 79,030,665 (GRCm39) I830M possibly damaging Het
Yju2b A G 8: 84,987,294 (GRCm39) L93P probably damaging Het
Zfp994 T C 17: 22,419,449 (GRCm39) Y500C possibly damaging Het
Zscan20 A G 4: 128,483,243 (GRCm39) probably null Het
Other mutations in H2ac12
AlleleSourceChrCoordTypePredicted EffectPPH Score
R6981:H2ac12 UTSW 13 22,219,719 (GRCm39) missense probably benign 0.34
Z1177:H2ac12 UTSW 13 22,219,520 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2014-01-10