Mutagenetix > Incidental Mutation

Incidental Mutation 'R1069:Ncapg'

99191

Institutional Source

Beutler Lab

Gene Symbol

Ncapg

Ensembl Gene

ENSMUSG00000015880

Gene Name

non-SMC condensin I complex, subunit G

Synonyms

5730507H05Rik, MFT.M05.13, Hcapg

MMRRC Submission

039155-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.945) question?

Stock #

R1069 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

45669919-45700546 bp(+) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

T to A at 45675930 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000112871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000117396]

AlphaFold

E9PWG6

Predicted Effect

probably benign
Transcript: ENSMUST00000117396

SMART Domains

Protein: ENSMUSP00000112871
Gene: ENSMUSG00000015880

Domain	Start	End	E-Value	Type
Pfam:Cnd3	557	863	7.4e-87	PFAM
low complexity region	864	874	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129562

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134309

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198274

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.5%
20x: 95.4%

Validation Efficiency

100% (33/33)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610203C20Rik	G	A	9: 41,590,298	R151H	possibly damaging	Het
4921524L21Rik	A	G	18: 6,624,037	N106S	probably benign	Het
Akr1c21	C	A	13: 4,575,334		probably benign	Het
Alpk2	G	A	18: 65,305,014	R1570C	probably benign	Het
Atp8b3	G	A	10: 80,531,018	R249C	probably damaging	Het
Cacnb4	C	A	2: 52,455,611	R252I	probably damaging	Het
Cars	T	C	7: 143,570,107	T480A	probably benign	Het
Ccnf	A	T	17: 24,223,997	C745*	probably null	Het
Ccr8	A	G	9: 120,094,217	I133V	probably benign	Het
Cndp1	G	A	18: 84,634,652		probably benign	Het
Dgkq	T	C	5: 108,656,037		probably benign	Het
Ecd	A	G	14: 20,333,436	C312R	probably damaging	Het
Epp13	A	T	7: 6,255,922		probably null	Het
Gstm1	T	C	3: 108,012,748	S226G	probably damaging	Het
Gtf3c3	C	T	1: 54,417,778	A488T	probably damaging	Het
Hacd4	T	A	4: 88,437,502	I49L	probably damaging	Het
Hid1	T	C	11: 115,356,765	N269S	probably damaging	Het
Ifitm3	A	T	7: 141,009,900		probably benign	Het
Kctd9	C	T	14: 67,729,420		probably benign	Het
Kif20b	T	C	19: 34,950,851	L1131P	probably damaging	Het
Kif2c	T	C	4: 117,178,153	T33A	probably damaging	Het
Lipc	T	C	9: 70,823,537	T38A	probably benign	Het
Lrguk	A	C	6: 34,048,883	I205L	possibly damaging	Het
Ptprd	A	G	4: 75,998,487		probably benign	Het
Ptprd	T	A	4: 76,100,633	K635*	probably null	Het
Sap130	G	A	18: 31,711,629	V898I	probably damaging	Het
Sned1	G	A	1: 93,281,654	V830M	possibly damaging	Het
Svep1	C	T	4: 58,070,239	G2516R	probably damaging	Het
Tas2r131	C	T	6: 132,957,825	R7K	probably benign	Het
Tfpi	A	G	2: 84,453,792		probably benign	Het
Trim80	T	C	11: 115,448,083	C580R	probably damaging	Het
Ttn	T	A	2: 76,969,929	I312F	unknown	Het

Other mutations in Ncapg

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00662:Ncapg	APN	5	45693160	missense	possibly damaging	0.53
IGL00777:Ncapg	APN	5	45695765	missense	possibly damaging	0.93
IGL00857:Ncapg	APN	5	45676585	splice site	probably null
IGL00916:Ncapg	APN	5	45671192	missense	probably benign	0.37
IGL01293:Ncapg	APN	5	45681854	missense	probably benign	0.01
IGL01360:Ncapg	APN	5	45674385	nonsense	probably null
IGL01462:Ncapg	APN	5	45671135	missense	probably benign	0.02
IGL01527:Ncapg	APN	5	45672384	missense	possibly damaging	0.71
IGL01732:Ncapg	APN	5	45693853	missense	probably damaging	1.00
IGL01788:Ncapg	APN	5	45671081	missense	probably damaging	0.97
IGL01871:Ncapg	APN	5	45688581	missense	probably benign	0.09
IGL03106:Ncapg	APN	5	45695668	missense	probably damaging	1.00
IGL03124:Ncapg	APN	5	45671209	missense	probably benign
R0086:Ncapg	UTSW	5	45676744	splice site	probably null
R0109:Ncapg	UTSW	5	45693748	splice site	probably null
R0110:Ncapg	UTSW	5	45693147	unclassified	probably benign
R0377:Ncapg	UTSW	5	45693817	missense	probably benign
R0432:Ncapg	UTSW	5	45672428	missense	probably damaging	0.99
R0637:Ncapg	UTSW	5	45687324	missense	probably damaging	1.00
R0835:Ncapg	UTSW	5	45681448	missense	probably damaging	0.96
R0894:Ncapg	UTSW	5	45679894	missense	probably null	0.24
R1216:Ncapg	UTSW	5	45699919	missense	possibly damaging	0.68
R1967:Ncapg	UTSW	5	45699910	missense	probably damaging	0.99
R2396:Ncapg	UTSW	5	45678373	missense	probably benign	0.00
R3157:Ncapg	UTSW	5	45676058	missense	probably benign
R3735:Ncapg	UTSW	5	45696127	missense	probably benign	0.00
R3736:Ncapg	UTSW	5	45696127	missense	probably benign	0.00
R3887:Ncapg	UTSW	5	45674363	missense	probably benign
R4371:Ncapg	UTSW	5	45678455	missense	probably benign
R4545:Ncapg	UTSW	5	45671212	missense	probably damaging	1.00
R4546:Ncapg	UTSW	5	45671212	missense	probably damaging	1.00
R4558:Ncapg	UTSW	5	45676644	missense	probably benign	0.00
R4615:Ncapg	UTSW	5	45687399	missense	probably benign	0.00
R4938:Ncapg	UTSW	5	45671209	missense	probably benign
R5839:Ncapg	UTSW	5	45672278	missense	probably damaging	0.99
R5871:Ncapg	UTSW	5	45695697	missense	probably damaging	1.00
R6086:Ncapg	UTSW	5	45693236	missense	probably damaging	1.00
R6418:Ncapg	UTSW	5	45681816	missense	probably damaging	1.00
R6617:Ncapg	UTSW	5	45670132	missense	probably benign	0.03
R7145:Ncapg	UTSW	5	45670030	missense	possibly damaging	0.82
R7408:Ncapg	UTSW	5	45695793	missense	probably benign	0.00
R7443:Ncapg	UTSW	5	45672310	missense	probably benign	0.31
R7463:Ncapg	UTSW	5	45694092	splice site	probably null
R7509:Ncapg	UTSW	5	45696108	missense	probably benign	0.01
R7687:Ncapg	UTSW	5	45699885	missense	probably benign	0.03
R7919:Ncapg	UTSW	5	45696048	missense	probably benign	0.00
R8022:Ncapg	UTSW	5	45681794	missense	probably damaging	1.00
R8177:Ncapg	UTSW	5	45693753	missense	probably benign	0.00
R8261:Ncapg	UTSW	5	45687388	missense	possibly damaging	0.90
R8263:Ncapg	UTSW	5	45691792	missense	probably benign	0.44
R8324:Ncapg	UTSW	5	45695668	missense	probably damaging	1.00
R8333:Ncapg	UTSW	5	45674463	missense	probably damaging	0.96
R8742:Ncapg	UTSW	5	45693874	missense	probably damaging	1.00
R9026:Ncapg	UTSW	5	45695773	missense	probably benign	0.00
R9051:Ncapg	UTSW	5	45695798	missense	probably damaging	1.00
R9076:Ncapg	UTSW	5	45676641	missense	probably benign
R9122:Ncapg	UTSW	5	45688673	missense	possibly damaging	0.95
R9751:Ncapg	UTSW	5	45693853	missense	probably damaging	1.00
R9776:Ncapg	UTSW	5	45672492	missense	probably damaging	0.96
RF019:Ncapg	UTSW	5	45698856	missense	probably benign	0.00
Z1088:Ncapg	UTSW	5	45679880	missense	probably damaging	1.00
Z1177:Ncapg	UTSW	5	45672502	critical splice donor site	probably null

Predicted Primers

Posted On

2014-01-10