Mutagenetix > Incidental Mutation

Incidental Mutation 'R1170:Neb'

99270

Institutional Source

Beutler Lab

Gene Symbol

Neb

Ensembl Gene

ENSMUSG00000026950

Gene Name

nebulin

Synonyms

MMRRC Submission

039243-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.818) question?

Stock #

R1170 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

52136647-52378474 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 52196357 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 5235 (Y5235N)

Ref Sequence

ENSEMBL: ENSMUSP00000074773 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028320] [ENSMUST00000036934] [ENSMUST00000075301] [ENSMUST00000148356]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000028320
AA Change: Y1463N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000028320
Gene: ENSMUSG00000026950
AA Change: Y1463N

Domain	Start	End	E-Value	Type
low complexity region	8	26	N/A	INTRINSIC
low complexity region	27	36	N/A	INTRINSIC
NEBU	103	134	9.67e-1	SMART
NEBU	137	167	6.6e-7	SMART
NEBU	172	202	9.7e-5	SMART
NEBU	208	238	3.48e-6	SMART
NEBU	246	276	2.66e-2	SMART
NEBU	281	311	5.32e-2	SMART
NEBU	312	342	2.94e-4	SMART
NEBU	346	377	1.34e1	SMART
NEBU	380	410	2.06e-8	SMART
NEBU	415	445	1.67e-8	SMART
NEBU	450	480	8.57e-6	SMART
NEBU	487	518	8.47e0	SMART
NEBU	523	553	5.2e-5	SMART
NEBU	554	584	1.07e-6	SMART
NEBU	589	619	9.55e-4	SMART
NEBU	622	652	6.21e-3	SMART
NEBU	657	686	4.89e-1	SMART
NEBU	692	722	4.7e-3	SMART
NEBU	730	760	1.16e-2	SMART
NEBU	765	795	5.32e-2	SMART
NEBU	796	826	3.62e-4	SMART
NEBU	831	861	1.88e-2	SMART
NEBU	866	896	1.59e-9	SMART
NEBU	901	931	2.7e-3	SMART
NEBU	937	967	4.93e0	SMART
NEBU	975	1005	2.89e1	SMART
NEBU	1010	1040	1.94e-4	SMART
NEBU	1041	1071	3.2e-5	SMART
NEBU	1076	1106	3.71e-1	SMART
NEBU	1111	1141	1.52e-6	SMART
NEBU	1146	1176	4.56e-1	SMART
NEBU	1182	1212	2.39e-4	SMART
NEBU	1220	1250	1.59e1	SMART
NEBU	1255	1285	4.32e-2	SMART
NEBU	1286	1316	4.39e0	SMART
NEBU	1321	1351	5.04e-3	SMART
NEBU	1356	1386	8.78e-3	SMART
NEBU	1392	1422	6.02e-1	SMART
NEBU	1427	1457	5.24e-1	SMART
NEBU	1463	1493	1.53e-2	SMART
NEBU	1498	1528	1.94e-4	SMART
NEBU	1533	1563	1.16e-2	SMART
NEBU	1568	1598	2.51e1	SMART
NEBU	1603	1633	2.81e-1	SMART
NEBU	1638	1668	7.64e-3	SMART
NEBU	1673	1703	5.62e-1	SMART
NEBU	1708	1738	1.49e-5	SMART
NEBU	1743	1773	3.97e-1	SMART
NEBU	1778	1808	1.47e-4	SMART
NEBU	1813	1843	6.45e-1	SMART
NEBU	1848	1878	1.28e-4	SMART
NEBU	1883	1913	9.33e-7	SMART
NEBU	1918	1948	7.58e-7	SMART
NEBU	1954	1984	1.94e-4	SMART
NEBU	1989	2019	9.93e-2	SMART
NEBU	2024	2054	2.45e-1	SMART
NEBU	2059	2089	8.39e-1	SMART
NEBU	2094	2124	1e-6	SMART
NEBU	2131	2161	7.35e-5	SMART
NEBU	2168	2198	1.37e-4	SMART
NEBU	2202	2232	2.83e-6	SMART
NEBU	2237	2267	1.52e-6	SMART
NEBU	2274	2304	5.21e0	SMART
NEBU	2309	2339	7.53e-2	SMART
NEBU	2344	2374	2.5e-7	SMART
NEBU	2377	2409	1.16e-2	SMART
NEBU	2416	2446	1.47e-4	SMART
NEBU	2453	2483	3.2e-5	SMART
NEBU	2491	2521	8.07e-2	SMART
NEBU	2526	2556	1.92e-8	SMART
NEBU	2561	2591	1.08e-2	SMART
NEBU	2596	2626	7.07e-7	SMART
NEBU	2627	2657	2.39e-4	SMART
NEBU	2658	2688	2.39e-4	SMART
NEBU	2689	2719	5.97e-5	SMART
NEBU	2720	2750	2.08e-4	SMART
NEBU	2751	2781	1.02e-3	SMART
NEBU	2787	2817	2.14e-6	SMART
NEBU	2822	2852	1.66e0	SMART
low complexity region	2902	2916	N/A	INTRINSIC
SH3	2988	3044	5.11e-14	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000036934
AA Change: Y5478N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000047763
Gene: ENSMUSG00000026950
AA Change: Y5478N

Domain	Start	End	E-Value	Type
low complexity region	4	39	N/A	INTRINSIC
low complexity region	47	60	N/A	INTRINSIC
NEBU	71	102	3.88e-4	SMART
NEBU	108	138	4e-6	SMART
NEBU	143	173	2.3e-6	SMART
NEBU	178	208	2.06e-8	SMART
NEBU	213	243	1.58e-4	SMART
NEBU	248	278	6.01e-10	SMART
NEBU	284	313	1.14e-1	SMART
NEBU	319	349	6.5e-6	SMART
NEBU	358	388	4.39e-3	SMART
NEBU	393	423	6.01e0	SMART
NEBU	429	459	5.12e-4	SMART
NEBU	497	527	5.74e-7	SMART
NEBU	532	562	5.83e-8	SMART
NEBU	568	598	7.69e-8	SMART
NEBU	606	636	2.87e-7	SMART
NEBU	676	706	3.1e-3	SMART
NEBU	744	774	4.59e-6	SMART
NEBU	779	809	9.47e-8	SMART
NEBU	815	845	7.69e-8	SMART
NEBU	853	883	1.17e-7	SMART
NEBU	888	918	4.74e-8	SMART
NEBU	919	949	9.47e-8	SMART
NEBU	954	985	2.05e-3	SMART
NEBU	988	1018	2.11e-5	SMART
NEBU	1023	1053	8.7e-7	SMART
NEBU	1059	1089	8.7e-7	SMART
NEBU	1097	1127	8.25e-8	SMART
NEBU	1132	1162	8e-6	SMART
NEBU	1163	1193	3.79e-7	SMART
NEBU	1199	1229	8.65e-2	SMART
NEBU	1232	1262	1.05e-9	SMART
NEBU	1267	1297	1.92e-8	SMART
NEBU	1303	1333	7.35e-5	SMART
NEBU	1341	1371	9.33e-7	SMART
NEBU	1376	1406	1.18e-3	SMART
NEBU	1407	1437	7.88e-5	SMART
NEBU	1443	1473	1.33e-2	SMART
NEBU	1476	1506	9.47e-8	SMART
NEBU	1511	1541	7.18e-8	SMART
NEBU	1547	1577	7.46e-6	SMART
NEBU	1585	1615	1.07e-6	SMART
NEBU	1620	1650	3.56e-3	SMART
NEBU	1651	1681	9.33e-7	SMART
NEBU	1687	1717	5.36e-7	SMART
NEBU	1720	1750	1.4e-1	SMART
NEBU	1755	1785	3.59e-8	SMART
NEBU	1791	1821	8e-6	SMART
NEBU	1829	1859	1.92e-8	SMART
NEBU	1864	1894	1.61e-1	SMART
NEBU	1895	1925	6.15e-7	SMART
NEBU	1931	1961	2.02e-2	SMART
NEBU	1964	1994	1.77e-7	SMART
NEBU	1999	2029	1.02e-7	SMART
NEBU	2035	2065	3.25e-6	SMART
NEBU	2073	2103	1.18e-8	SMART
NEBU	2108	2138	2.7e-3	SMART
NEBU	2139	2169	4.85e-5	SMART
NEBU	2175	2205	1.22e-1	SMART
NEBU	2208	2238	2.94e-4	SMART
NEBU	2243	2273	1.67e-8	SMART
NEBU	2279	2309	5.12e-4	SMART
NEBU	2317	2347	1.36e-8	SMART
NEBU	2352	2382	4.85e-5	SMART
NEBU	2383	2413	8.57e-6	SMART
NEBU	2418	2448	1.24e-2	SMART
NEBU	2451	2481	2.09e-9	SMART
NEBU	2486	2516	4e-6	SMART
NEBU	2522	2552	6.5e-6	SMART
NEBU	2560	2590	4.06e-7	SMART
NEBU	2595	2625	2.39e-4	SMART
NEBU	2626	2656	3.43e-5	SMART
NEBU	2661	2691	1.48e0	SMART
NEBU	2694	2724	1.84e-5	SMART
NEBU	2729	2759	3.53e-7	SMART
NEBU	2765	2795	3.15e-4	SMART
NEBU	2803	2833	1.23e-6	SMART
NEBU	2838	2868	2.39e-4	SMART
NEBU	2869	2899	5.97e-5	SMART
NEBU	2904	2934	1.33e-2	SMART
NEBU	2937	2967	1.21e-5	SMART
NEBU	2972	3002	8.32e-4	SMART
NEBU	3008	3038	1.04e-4	SMART
NEBU	3046	3076	4.06e-7	SMART
NEBU	3081	3111	3.73e-6	SMART
NEBU	3112	3142	1.28e-4	SMART
NEBU	3147	3177	3.76e-2	SMART
NEBU	3180	3210	3.25e-6	SMART
NEBU	3215	3245	5.97e-5	SMART
NEBU	3251	3281	2.39e-4	SMART
NEBU	3289	3319	3.3e-7	SMART
NEBU	3324	3354	3.94e-5	SMART
NEBU	3355	3385	1.28e-4	SMART
NEBU	3390	3420	3.76e-2	SMART
NEBU	3423	3453	3.25e-6	SMART
NEBU	3458	3488	2.94e-4	SMART
NEBU	3494	3524	1.84e-5	SMART
NEBU	3532	3562	5.2e-5	SMART
NEBU	3567	3597	3.53e-7	SMART
NEBU	3598	3628	1.32e-6	SMART
NEBU	3633	3663	2.32e-2	SMART
NEBU	3666	3696	5.2e-5	SMART
NEBU	3701	3731	1.15e-6	SMART
NEBU	3737	3767	1.81e-4	SMART
NEBU	3775	3805	4.06e-7	SMART
NEBU	3810	3840	3.73e-6	SMART
NEBU	3841	3871	1.97e-5	SMART
NEBU	3876	3906	2.66e-2	SMART
NEBU	3909	3939	8.12e-7	SMART
NEBU	3944	3974	1.1e-8	SMART
NEBU	3980	4010	2.99e-5	SMART
NEBU	4018	4048	1.07e-6	SMART
NEBU	4053	4083	3.94e-5	SMART
NEBU	4084	4114	2.42e-5	SMART
NEBU	4118	4149	2.66e-2	SMART
NEBU	4152	4182	3.64e-9	SMART
NEBU	4187	4217	1.44e-7	SMART
NEBU	4223	4253	2.87e-7	SMART
NEBU	4261	4291	2.83e-6	SMART
NEBU	4296	4326	5.66e-6	SMART
NEBU	4327	4357	6.06e-6	SMART
NEBU	4361	4392	1.34e1	SMART
NEBU	4395	4425	2.06e-8	SMART
NEBU	4430	4460	1.67e-8	SMART
NEBU	4465	4495	8.57e-6	SMART
NEBU	4502	4533	8.47e0	SMART
NEBU	4538	4568	5.2e-5	SMART
NEBU	4569	4599	1.07e-6	SMART
NEBU	4604	4634	9.55e-4	SMART
NEBU	4637	4667	6.21e-3	SMART
NEBU	4672	4701	4.89e-1	SMART
NEBU	4707	4737	4.7e-3	SMART
NEBU	4745	4775	1.16e-2	SMART
NEBU	4780	4810	5.32e-2	SMART
NEBU	4811	4841	3.62e-4	SMART
NEBU	4846	4876	1.88e-2	SMART
NEBU	4881	4911	1.59e-9	SMART
NEBU	4916	4946	2.7e-3	SMART
NEBU	4952	4982	4.93e0	SMART
NEBU	4990	5020	2.89e1	SMART
NEBU	5025	5055	1.94e-4	SMART
NEBU	5056	5086	3.2e-5	SMART
NEBU	5091	5121	3.71e-1	SMART
NEBU	5126	5156	1.52e-6	SMART
NEBU	5161	5191	4.56e-1	SMART
NEBU	5197	5227	2.39e-4	SMART
NEBU	5235	5265	1.59e1	SMART
NEBU	5270	5300	4.32e-2	SMART
NEBU	5301	5331	4.39e0	SMART
NEBU	5336	5366	5.04e-3	SMART
NEBU	5371	5401	8.78e-3	SMART
NEBU	5407	5437	6.02e-1	SMART
NEBU	5442	5472	5.24e-1	SMART
NEBU	5478	5508	1.53e-2	SMART
NEBU	5513	5543	1.94e-4	SMART
NEBU	5548	5578	1.16e-2	SMART
NEBU	5583	5613	2.51e1	SMART
NEBU	5618	5648	2.81e-1	SMART
NEBU	5653	5683	7.64e-3	SMART
NEBU	5688	5718	5.62e-1	SMART
NEBU	5723	5753	1.49e-5	SMART
NEBU	5758	5788	3.97e-1	SMART
NEBU	5793	5823	1.47e-4	SMART
NEBU	5828	5858	6.45e-1	SMART
NEBU	5863	5893	1.28e-4	SMART
NEBU	5898	5928	9.33e-7	SMART
NEBU	5933	5963	7.58e-7	SMART
NEBU	5969	5999	1.94e-4	SMART
NEBU	6004	6034	9.93e-2	SMART
NEBU	6039	6069	2.45e-1	SMART
NEBU	6074	6104	8.39e-1	SMART
NEBU	6109	6139	1e-6	SMART
NEBU	6146	6176	7.35e-5	SMART
NEBU	6183	6213	1.37e-4	SMART
NEBU	6217	6247	2.83e-6	SMART
NEBU	6252	6282	1.52e-6	SMART
NEBU	6289	6319	5.21e0	SMART
NEBU	6324	6354	7.53e-2	SMART
NEBU	6359	6389	2.5e-7	SMART
NEBU	6392	6424	1.16e-2	SMART
NEBU	6431	6461	1.47e-4	SMART
NEBU	6468	6498	3.2e-5	SMART
NEBU	6506	6536	8.07e-2	SMART
NEBU	6541	6571	1.92e-8	SMART
NEBU	6576	6606	1.08e-2	SMART
NEBU	6611	6641	7.07e-7	SMART
NEBU	6642	6672	2.39e-4	SMART
NEBU	6673	6703	2.39e-4	SMART
NEBU	6704	6734	5.97e-5	SMART
NEBU	6735	6765	4.46e-4	SMART
NEBU	6766	6796	2.18e-7	SMART
NEBU	6797	6827	2.64e-6	SMART
NEBU	6828	6858	6.96e-6	SMART
NEBU	6859	6889	6.3e-4	SMART
NEBU	6895	6925	2.14e-6	SMART
NEBU	6930	6960	1.66e0	SMART
low complexity region	7010	7024	N/A	INTRINSIC
SH3	7096	7152	5.11e-14	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000075301
AA Change: Y5235N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000074773
Gene: ENSMUSG00000026950
AA Change: Y5235N

Domain	Start	End	E-Value	Type
low complexity region	4	39	N/A	INTRINSIC
low complexity region	47	60	N/A	INTRINSIC
NEBU	71	102	3.88e-4	SMART
NEBU	108	138	4e-6	SMART
NEBU	143	173	2.3e-6	SMART
NEBU	178	208	2.06e-8	SMART
NEBU	213	243	1.58e-4	SMART
NEBU	248	278	6.01e-10	SMART
NEBU	284	313	1.14e-1	SMART
NEBU	319	349	6.5e-6	SMART
NEBU	358	388	4.39e-3	SMART
NEBU	393	423	6.01e0	SMART
NEBU	429	459	5.12e-4	SMART
NEBU	497	527	5.74e-7	SMART
NEBU	532	562	5.83e-8	SMART
NEBU	568	598	7.69e-8	SMART
NEBU	606	636	2.87e-7	SMART
NEBU	676	706	3.1e-3	SMART
NEBU	744	774	4.59e-6	SMART
NEBU	779	809	9.47e-8	SMART
NEBU	815	845	7.69e-8	SMART
NEBU	853	883	1.17e-7	SMART
NEBU	888	918	4.74e-8	SMART
NEBU	919	949	9.47e-8	SMART
NEBU	954	985	2.05e-3	SMART
NEBU	988	1018	2.11e-5	SMART
NEBU	1023	1053	8.7e-7	SMART
NEBU	1059	1089	8.7e-7	SMART
NEBU	1097	1127	8.25e-8	SMART
NEBU	1132	1162	8e-6	SMART
NEBU	1163	1193	3.79e-7	SMART
NEBU	1199	1229	8.65e-2	SMART
NEBU	1232	1262	1.05e-9	SMART
NEBU	1267	1297	1.92e-8	SMART
NEBU	1303	1333	7.35e-5	SMART
NEBU	1341	1371	9.33e-7	SMART
NEBU	1376	1406	1.18e-3	SMART
NEBU	1407	1437	7.88e-5	SMART
NEBU	1443	1473	1.33e-2	SMART
NEBU	1476	1506	9.47e-8	SMART
NEBU	1511	1541	7.18e-8	SMART
NEBU	1547	1577	7.46e-6	SMART
NEBU	1585	1615	1.07e-6	SMART
NEBU	1620	1650	3.56e-3	SMART
NEBU	1651	1681	9.33e-7	SMART
NEBU	1687	1717	5.36e-7	SMART
NEBU	1720	1750	1.4e-1	SMART
NEBU	1755	1785	3.59e-8	SMART
NEBU	1791	1821	8e-6	SMART
NEBU	1829	1859	1.92e-8	SMART
NEBU	1864	1894	1.61e-1	SMART
NEBU	1895	1925	6.15e-7	SMART
NEBU	1931	1961	2.02e-2	SMART
NEBU	1964	1994	1.77e-7	SMART
NEBU	1999	2029	1.02e-7	SMART
NEBU	2035	2065	3.25e-6	SMART
NEBU	2073	2103	1.18e-8	SMART
NEBU	2108	2138	2.7e-3	SMART
NEBU	2139	2169	4.85e-5	SMART
NEBU	2175	2205	1.22e-1	SMART
NEBU	2208	2238	2.94e-4	SMART
NEBU	2243	2273	1.67e-8	SMART
NEBU	2279	2309	5.12e-4	SMART
NEBU	2317	2347	1.36e-8	SMART
NEBU	2352	2382	4.85e-5	SMART
NEBU	2383	2413	8.57e-6	SMART
NEBU	2418	2448	1.24e-2	SMART
NEBU	2451	2481	2.09e-9	SMART
NEBU	2486	2516	4e-6	SMART
NEBU	2522	2552	6.5e-6	SMART
NEBU	2560	2590	4.06e-7	SMART
NEBU	2595	2625	2.39e-4	SMART
NEBU	2626	2656	3.43e-5	SMART
NEBU	2661	2691	1.48e0	SMART
NEBU	2694	2724	1.84e-5	SMART
NEBU	2729	2759	3.53e-7	SMART
NEBU	2765	2795	3.15e-4	SMART
NEBU	2803	2833	1.23e-6	SMART
NEBU	2838	2868	2.39e-4	SMART
NEBU	2869	2899	5.97e-5	SMART
NEBU	2904	2934	1.33e-2	SMART
NEBU	2937	2967	1.21e-5	SMART
NEBU	2972	3002	8.32e-4	SMART
NEBU	3008	3038	1.04e-4	SMART
NEBU	3046	3076	4.06e-7	SMART
NEBU	3081	3111	3.73e-6	SMART
NEBU	3112	3142	1.28e-4	SMART
NEBU	3147	3177	3.76e-2	SMART
NEBU	3180	3210	3.25e-6	SMART
NEBU	3215	3245	5.97e-5	SMART
NEBU	3251	3281	2.39e-4	SMART
NEBU	3289	3319	3.3e-7	SMART
NEBU	3324	3354	3.94e-5	SMART
NEBU	3355	3385	1.28e-4	SMART
NEBU	3390	3420	3.76e-2	SMART
NEBU	3423	3453	3.25e-6	SMART
NEBU	3458	3488	2.94e-4	SMART
NEBU	3494	3524	1.84e-5	SMART
NEBU	3532	3562	5.2e-5	SMART
NEBU	3567	3597	3.53e-7	SMART
NEBU	3598	3628	1.32e-6	SMART
NEBU	3633	3663	2.32e-2	SMART
NEBU	3666	3696	5.2e-5	SMART
NEBU	3701	3731	1.15e-6	SMART
NEBU	3737	3767	1.81e-4	SMART
NEBU	3775	3805	4.06e-7	SMART
NEBU	3810	3840	3.73e-6	SMART
NEBU	3841	3871	1.97e-5	SMART
NEBU	3876	3906	2.66e-2	SMART
NEBU	3909	3939	8.12e-7	SMART
NEBU	3944	3974	1.1e-8	SMART
NEBU	3980	4010	2.99e-5	SMART
NEBU	4018	4048	1.07e-6	SMART
NEBU	4053	4083	3.94e-5	SMART
NEBU	4084	4114	2.83e-6	SMART
NEBU	4118	4149	1.34e1	SMART
NEBU	4152	4182	2.06e-8	SMART
NEBU	4187	4217	1.67e-8	SMART
NEBU	4222	4252	8.57e-6	SMART
NEBU	4259	4290	8.47e0	SMART
NEBU	4295	4325	5.2e-5	SMART
NEBU	4326	4356	1.07e-6	SMART
NEBU	4361	4391	9.55e-4	SMART
NEBU	4394	4424	6.21e-3	SMART
NEBU	4429	4458	4.89e-1	SMART
NEBU	4464	4494	4.7e-3	SMART
NEBU	4502	4532	1.16e-2	SMART
NEBU	4537	4567	5.32e-2	SMART
NEBU	4568	4598	3.62e-4	SMART
NEBU	4603	4633	1.88e-2	SMART
NEBU	4638	4668	1.59e-9	SMART
NEBU	4673	4703	2.7e-3	SMART
NEBU	4709	4739	4.93e0	SMART
NEBU	4747	4777	2.89e1	SMART
NEBU	4782	4812	1.94e-4	SMART
NEBU	4813	4843	3.2e-5	SMART
NEBU	4848	4878	3.71e-1	SMART
NEBU	4883	4913	1.52e-6	SMART
NEBU	4918	4948	4.56e-1	SMART
NEBU	4954	4984	2.39e-4	SMART
NEBU	4992	5022	1.59e1	SMART
NEBU	5027	5057	4.32e-2	SMART
NEBU	5058	5088	4.39e0	SMART
NEBU	5093	5123	5.04e-3	SMART
NEBU	5128	5158	8.78e-3	SMART
NEBU	5164	5194	6.02e-1	SMART
NEBU	5199	5229	5.24e-1	SMART
NEBU	5235	5265	1.53e-2	SMART
NEBU	5270	5300	1.94e-4	SMART
NEBU	5305	5335	1.16e-2	SMART
NEBU	5340	5370	2.51e1	SMART
NEBU	5375	5405	2.81e-1	SMART
NEBU	5410	5440	7.64e-3	SMART
NEBU	5445	5475	5.62e-1	SMART
NEBU	5480	5510	1.49e-5	SMART
NEBU	5515	5545	3.97e-1	SMART
NEBU	5550	5580	1.47e-4	SMART
NEBU	5585	5615	6.45e-1	SMART
NEBU	5620	5650	1.28e-4	SMART
NEBU	5655	5685	9.33e-7	SMART
NEBU	5690	5720	7.58e-7	SMART
NEBU	5726	5756	1.94e-4	SMART
NEBU	5761	5791	9.93e-2	SMART
NEBU	5796	5826	2.45e-1	SMART
NEBU	5831	5861	8.39e-1	SMART
NEBU	5866	5896	1e-6	SMART
NEBU	5903	5933	7.35e-5	SMART
NEBU	5940	5970	1.37e-4	SMART
NEBU	5974	6004	2.83e-6	SMART
NEBU	6009	6039	1.52e-6	SMART
NEBU	6046	6076	5.21e0	SMART
NEBU	6081	6111	7.53e-2	SMART
NEBU	6116	6146	2.5e-7	SMART
NEBU	6149	6181	1.16e-2	SMART
NEBU	6188	6218	1.47e-4	SMART
NEBU	6225	6255	3.2e-5	SMART
NEBU	6263	6293	8.07e-2	SMART
NEBU	6298	6328	1.92e-8	SMART
NEBU	6333	6363	1.08e-2	SMART
NEBU	6368	6398	7.07e-7	SMART
NEBU	6399	6429	2.39e-4	SMART
NEBU	6430	6460	2.39e-4	SMART
NEBU	6461	6491	5.97e-5	SMART
NEBU	6492	6522	2.08e-4	SMART
NEBU	6523	6553	2.68e-7	SMART
NEBU	6554	6584	2.64e-6	SMART
NEBU	6585	6615	6.96e-6	SMART
NEBU	6616	6646	6.3e-4	SMART
NEBU	6652	6682	2.14e-6	SMART
NEBU	6687	6717	1.66e0	SMART
low complexity region	6767	6781	N/A	INTRINSIC
SH3	6853	6909	5.11e-14	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000148356

SMART Domains

Protein: ENSMUSP00000133401
Gene: ENSMUSG00000026950

Domain	Start	End	E-Value	Type
NEBU	2	26	1.23e1	SMART
NEBU	31	61	1.49e-5	SMART
NEBU	66	96	3.97e-1	SMART
NEBU	101	131	1.47e-4	SMART
NEBU	136	166	6.45e-1	SMART
NEBU	171	201	1.76e0	SMART
NEBU	207	236	2.62e-1	SMART
NEBU	241	271	7.58e-7	SMART
NEBU	277	307	1.94e-4	SMART
NEBU	312	342	9.93e-2	SMART

Meta Mutation Damage Score

0.6702

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.4%
20x: 93.0%

Validation Efficiency

100% (105/105)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes nebulin, a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. In most vertebrates, nebulin accounts for 3 to 4% of the total myofibrillar protein. The encoded protein contains approximately 30-amino acid long modules that can be classified into 7 types and other repeated modules. Protein isoform sizes vary from 600 to 800 kD due to alternative splicing that is tissue-, species-,and developmental stage-specific. Of the 183 exons in the nebulin gene, at least 43 are alternatively spliced, although exons 143 and 144 are not found in the same transcript. Of the several thousand transcript variants predicted for nebulin, the RefSeq Project has decided to create three representative RefSeq records. Mutations in this gene are associated with recessive nemaline myopathy. [provided by RefSeq, Sep 2009]
PHENOTYPE: Homozygous inactivation of this gene leads to stunted growth, altered sarcomere structure, reduced contractility in skeletal muscle, progressive muscle weakness, and postnatal death. Observed phenotypes may include a stiff gait, blepharoptosis, kyphosis, abnormal suckling, and reduced adiposity. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 104 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700025G04Rik	A	G	1: 151,980,412 (GRCm38)		probably benign	Het
4932438A13Rik	T	C	3: 37,044,631 (GRCm38)	S1136P	probably damaging	Het
Akap9	G	A	5: 4,055,671 (GRCm38)	S2914N	probably benign	Het
Alk	T	C	17: 71,900,734 (GRCm38)	D1002G	probably damaging	Het
Ap3d1	A	G	10: 80,732,840 (GRCm38)		probably benign	Het
Asb15	T	C	6: 24,562,487 (GRCm38)		probably benign	Het
Asxl3	C	A	18: 22,524,507 (GRCm38)	P1858Q	probably benign	Het
BC003331	T	A	1: 150,386,391 (GRCm38)	E99D	probably benign	Het
Bud31	T	A	5: 145,142,578 (GRCm38)		probably benign	Het
C1qtnf1	G	T	11: 118,448,269 (GRCm38)	R255L	probably damaging	Het
Cacna2d4	C	T	6: 119,307,286 (GRCm38)	R745W	probably damaging	Het
Cage1	C	T	13: 38,022,880 (GRCm38)	E330K	probably damaging	Het
Catsperz	T	A	19: 6,924,949 (GRCm38)	N59I	probably benign	Het
Ccdc110	G	T	8: 45,941,885 (GRCm38)	S271I	probably benign	Het
Ccdc88b	T	A	19: 6,853,213 (GRCm38)	E787V	probably damaging	Het
Ccna2	A	T	3: 36,568,970 (GRCm38)		probably benign	Het
Cd36	T	A	5: 17,813,088 (GRCm38)	D209V	probably damaging	Het
Cers4	T	A	8: 4,519,475 (GRCm38)	W161R	probably damaging	Het
Ces2f	T	A	8: 104,953,546 (GRCm38)	H442Q	probably damaging	Het
Chchd6	A	C	6: 89,384,687 (GRCm38)	C245G	probably damaging	Het
Cndp1	T	G	18: 84,611,625 (GRCm38)	Q481P	probably benign	Het
Col3a1	A	G	1: 45,327,601 (GRCm38)	R234G	unknown	Het
Col3a1	A	T	1: 45,347,724 (GRCm38)	N232I	probably damaging	Het
Colgalt2	A	T	1: 152,503,017 (GRCm38)	D398V	probably damaging	Het
Cxcl10	TACTCAC	TACTCACTCAC	5: 92,348,082 (GRCm38)		probably null	Het
Dcdc2a	C	A	13: 25,056,307 (GRCm38)	Q13K	probably benign	Het
Dzip3	A	T	16: 48,961,208 (GRCm38)	I240N	probably damaging	Het
Epb41l3	T	A	17: 69,259,180 (GRCm38)	L452*	probably null	Het
Fam193b	C	T	13: 55,541,705 (GRCm38)	A753T	probably damaging	Het
Fam35a	A	T	14: 34,268,491 (GRCm38)	S153T	possibly damaging	Het
Fam47e	G	C	5: 92,565,922 (GRCm38)		probably benign	Het
Fastkd1	A	G	2: 69,708,649 (GRCm38)		probably benign	Het
Fmnl1	G	A	11: 103,197,370 (GRCm38)	G69D	probably benign	Het
Foxn2	A	G	17: 88,473,666 (GRCm38)		probably benign	Het
Fsip2	A	G	2: 82,991,500 (GRCm38)	E5859G	possibly damaging	Het
Gm9894	T	A	13: 67,764,701 (GRCm38)		noncoding transcript	Het
H2-Bl	T	C	17: 36,081,091 (GRCm38)	N44S	possibly damaging	Het
Helz2	T	C	2: 181,229,815 (GRCm38)	Y2668C	probably damaging	Het
Hhipl1	T	A	12: 108,311,693 (GRCm38)	C93*	probably null	Het
Lig1	C	T	7: 13,292,153 (GRCm38)	A278V	probably benign	Het
Lipn	T	A	19: 34,071,758 (GRCm38)	I108K	probably benign	Het
Lsamp	A	G	16: 42,151,229 (GRCm38)		probably benign	Het
Map3k14	A	G	11: 103,238,917 (GRCm38)		probably benign	Het
Mdm4	A	G	1: 133,012,692 (GRCm38)	L33P	probably damaging	Het
Mdm4	A	T	1: 132,991,820 (GRCm38)	C436S	probably damaging	Het
Meiob	T	C	17: 24,836,484 (GRCm38)	W422R	probably damaging	Het
Mppe1	T	C	18: 67,227,706 (GRCm38)	Y254C	probably damaging	Het
Mterf1a	A	T	5: 3,890,964 (GRCm38)	N301K	probably benign	Het
Muc6	C	T	7: 141,644,233 (GRCm38)	S1210N	probably damaging	Het
Mycbp2	A	T	14: 103,200,152 (GRCm38)	Y2091*	probably null	Het
Mylk	G	A	16: 34,874,039 (GRCm38)	R156H	probably benign	Het
Myo15	G	T	11: 60,479,407 (GRCm38)	D998Y	probably benign	Het
Nop58	A	G	1: 59,704,211 (GRCm38)		probably benign	Het
Nr4a3	A	G	4: 48,083,324 (GRCm38)	K619R	probably benign	Het
Nr4a3	A	G	4: 48,051,564 (GRCm38)	H135R	probably damaging	Het
Nrg1	T	C	8: 31,837,667 (GRCm38)		probably benign	Het
Olfr1031	A	T	2: 85,992,696 (GRCm38)	N293I	probably damaging	Het
Olfr1312	A	T	2: 112,042,215 (GRCm38)	D272E	probably benign	Het
Olfr1484	T	C	19: 13,586,213 (GRCm38)	V260A	probably benign	Het
Olfr938	T	A	9: 39,078,229 (GRCm38)	D172V	possibly damaging	Het
Parp3	T	C	9: 106,476,005 (GRCm38)		probably benign	Het
Pde2a	A	G	7: 101,484,543 (GRCm38)	E103G	probably benign	Het
Pds5a	A	T	5: 65,635,302 (GRCm38)		probably benign	Het
Pip4k2c	A	G	10: 127,211,393 (GRCm38)	V40A	unknown	Het
Pitrm1	T	C	13: 6,552,744 (GRCm38)		probably benign	Het
Plk4	A	G	3: 40,801,847 (GRCm38)	I64M	probably damaging	Het
Ppp1r16a	C	T	15: 76,693,669 (GRCm38)	Q328*	probably null	Het
Ppp2r1a	T	C	17: 20,951,331 (GRCm38)		probably benign	Het
Ppp4r3b	T	A	11: 29,209,426 (GRCm38)	N172K	probably damaging	Het
Prkcg	G	A	7: 3,319,661 (GRCm38)	R357Q	probably damaging	Het
Prmt3	T	C	7: 49,848,547 (GRCm38)		probably null	Het
Prx	T	A	7: 27,518,007 (GRCm38)	C644*	probably null	Het
Ptpru	A	G	4: 131,808,527 (GRCm38)		probably benign	Het
Rbm5	A	T	9: 107,742,497 (GRCm38)	D738E	probably damaging	Het
Recql5	A	T	11: 115,897,234 (GRCm38)	Y420N	probably damaging	Het
Rnf17	T	C	14: 56,425,631 (GRCm38)	I152T	probably benign	Het
Rnpepl1	A	G	1: 92,919,195 (GRCm38)	S580G	possibly damaging	Het
Ryr3	C	T	2: 112,946,987 (GRCm38)	G275D	probably damaging	Het
Serpinb9e	T	A	13: 33,257,752 (GRCm38)	Y222*	probably null	Het
Slc10a1	T	A	12: 80,956,028 (GRCm38)	I279F	probably damaging	Het
Slc12a8	G	T	16: 33,662,977 (GRCm38)	G584V	probably damaging	Het
Slc35b3	T	A	13: 38,937,331 (GRCm38)	Y311F	probably benign	Het
Slc44a5	A	G	3: 154,257,720 (GRCm38)		probably null	Het
Slc6a9	A	G	4: 117,864,806 (GRCm38)	E422G	possibly damaging	Het
Smpd2	A	G	10: 41,488,732 (GRCm38)		probably null	Het
Spast	A	G	17: 74,381,968 (GRCm38)		probably null	Het
Spink5	A	T	18: 43,983,563 (GRCm38)	E208V	probably benign	Het
Stag1	T	C	9: 100,888,453 (GRCm38)		probably benign	Het
Stambp	A	G	6: 83,563,821 (GRCm38)		probably null	Het
Sult3a2	A	T	10: 33,777,192 (GRCm38)	M184K	possibly damaging	Het
Tcp11	T	C	17: 28,071,662 (GRCm38)	D162G	probably damaging	Het
Themis	A	C	10: 28,668,748 (GRCm38)	E30A	possibly damaging	Het
Tmc7	G	A	7: 118,551,260 (GRCm38)	S350L	probably benign	Het
Tmem131	A	T	1: 36,834,898 (GRCm38)	Y271*	probably null	Het
Trim35	T	A	14: 66,308,799 (GRCm38)	S338R	probably benign	Het
Trim42	C	A	9: 97,363,620 (GRCm38)	V376F	probably benign	Het
Tshr	A	T	12: 91,538,097 (GRCm38)	K11M	probably damaging	Het
Vps8	A	G	16: 21,459,820 (GRCm38)		probably benign	Het
Wdr11	T	C	7: 129,607,107 (GRCm38)		probably benign	Het
Wdr26	A	T	1: 181,181,294 (GRCm38)		probably benign	Het
Wdtc1	A	G	4: 133,297,546 (GRCm38)	Y447H	probably damaging	Het
Zfp687	C	T	3: 95,008,473 (GRCm38)	C996Y	probably damaging	Het
Zfp984	A	T	4: 147,755,989 (GRCm38)	V135E	probably benign	Het
Zranb2	T	C	3: 157,541,865 (GRCm38)		probably benign	Het

Other mutations in Neb

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00088:Neb	APN	2	52,308,747 (GRCm38)	missense	possibly damaging	0.55
IGL00232:Neb	APN	2	52,235,556 (GRCm38)	missense	possibly damaging	0.83
IGL00501:Neb	APN	2	52,295,344 (GRCm38)	missense	probably benign	0.02
IGL00548:Neb	APN	2	52,243,972 (GRCm38)	missense	probably benign	0.33
IGL00556:Neb	APN	2	52,191,949 (GRCm38)	missense	probably benign	0.16
IGL00561:Neb	APN	2	52,206,105 (GRCm38)	missense	probably benign	0.00
IGL00598:Neb	APN	2	52,208,301 (GRCm38)	missense	possibly damaging	0.62
IGL00788:Neb	APN	2	52,205,732 (GRCm38)	splice site	probably benign
IGL00817:Neb	APN	2	52,243,195 (GRCm38)	missense	probably damaging	1.00
IGL00926:Neb	APN	2	52,270,317 (GRCm38)	splice site	probably benign
IGL00975:Neb	APN	2	52,212,728 (GRCm38)	missense	probably benign	0.01
IGL01012:Neb	APN	2	52,196,361 (GRCm38)	missense	probably benign
IGL01014:Neb	APN	2	52,287,158 (GRCm38)	missense	probably benign	0.11
IGL01419:Neb	APN	2	52,226,533 (GRCm38)	nonsense	probably null
IGL01420:Neb	APN	2	52,157,377 (GRCm38)	missense	probably damaging	1.00
IGL01459:Neb	APN	2	52,176,792 (GRCm38)	missense	probably damaging	1.00
IGL01467:Neb	APN	2	52,159,487 (GRCm38)	missense	possibly damaging	0.55
IGL01474:Neb	APN	2	52,328,905 (GRCm38)	missense	unknown
IGL01506:Neb	APN	2	52,247,190 (GRCm38)	missense	probably damaging	1.00
IGL01544:Neb	APN	2	52,292,905 (GRCm38)	missense	possibly damaging	0.62
IGL01608:Neb	APN	2	52,170,536 (GRCm38)	missense	probably damaging	1.00
IGL01681:Neb	APN	2	52,201,486 (GRCm38)	missense	probably damaging	1.00
IGL01717:Neb	APN	2	52,189,867 (GRCm38)	missense	probably damaging	1.00
IGL01743:Neb	APN	2	52,225,667 (GRCm38)	missense	probably damaging	1.00
IGL01774:Neb	APN	2	52,222,970 (GRCm38)	nonsense	probably null
IGL01787:Neb	APN	2	52,296,355 (GRCm38)	missense	possibly damaging	0.56
IGL01822:Neb	APN	2	52,258,746 (GRCm38)	missense	possibly damaging	0.68
IGL01844:Neb	APN	2	52,170,549 (GRCm38)	missense	probably benign	0.01
IGL01871:Neb	APN	2	52,153,069 (GRCm38)	missense	probably damaging	0.99
IGL01878:Neb	APN	2	52,169,840 (GRCm38)	splice site	probably benign
IGL01886:Neb	APN	2	52,183,845 (GRCm38)	splice site	probably benign
IGL01897:Neb	APN	2	52,280,575 (GRCm38)	missense	possibly damaging	0.88
IGL02025:Neb	APN	2	52,307,739 (GRCm38)	missense	probably benign	0.17
IGL02133:Neb	APN	2	52,212,804 (GRCm38)	splice site	probably null
IGL02143:Neb	APN	2	52,291,199 (GRCm38)	missense	probably damaging	0.99
IGL02212:Neb	APN	2	52,308,311 (GRCm38)	missense	probably damaging	1.00
IGL02216:Neb	APN	2	52,226,490 (GRCm38)	missense	probably benign	0.00
IGL02260:Neb	APN	2	52,205,656 (GRCm38)	missense	probably damaging	1.00
IGL02364:Neb	APN	2	52,296,254 (GRCm38)	nonsense	probably null
IGL02424:Neb	APN	2	52,264,191 (GRCm38)	missense	probably damaging	1.00
IGL02449:Neb	APN	2	52,201,906 (GRCm38)	missense	probably benign	0.00
IGL02465:Neb	APN	2	52,193,165 (GRCm38)	unclassified	probably benign
IGL02475:Neb	APN	2	52,292,819 (GRCm38)	missense	probably damaging	1.00
IGL02486:Neb	APN	2	52,282,603 (GRCm38)	missense	possibly damaging	0.86
IGL02527:Neb	APN	2	52,149,213 (GRCm38)	missense	probably benign	0.36
IGL02527:Neb	APN	2	52,263,947 (GRCm38)	missense	probably damaging	1.00
IGL02547:Neb	APN	2	52,188,730 (GRCm38)	missense	probably damaging	1.00
IGL02648:Neb	APN	2	52,271,081 (GRCm38)	missense	possibly damaging	0.79
IGL02685:Neb	APN	2	52,175,301 (GRCm38)	missense	possibly damaging	0.93
IGL02695:Neb	APN	2	52,211,596 (GRCm38)	splice site	probably benign
IGL02695:Neb	APN	2	52,255,591 (GRCm38)	missense	probably damaging	1.00
IGL02731:Neb	APN	2	52,160,703 (GRCm38)	missense	probably damaging	1.00
IGL02738:Neb	APN	2	52,243,850 (GRCm38)	missense	probably damaging	0.99
IGL02750:Neb	APN	2	52,291,055 (GRCm38)	missense	probably benign	0.00
IGL02879:Neb	APN	2	52,256,685 (GRCm38)	missense	possibly damaging	0.95
IGL02887:Neb	APN	2	52,200,721 (GRCm38)	missense	possibly damaging	0.67
IGL02975:Neb	APN	2	52,298,867 (GRCm38)	missense	probably damaging	0.99
IGL03009:Neb	APN	2	52,179,456 (GRCm38)	splice site	probably benign
IGL03036:Neb	APN	2	52,244,153 (GRCm38)	missense	probably damaging	1.00
IGL03076:Neb	APN	2	52,169,088 (GRCm38)	missense	probably damaging	0.99
IGL03091:Neb	APN	2	52,271,312 (GRCm38)	missense	probably benign	0.08
IGL03095:Neb	APN	2	52,169,088 (GRCm38)	missense	probably damaging	0.99
IGL03096:Neb	APN	2	52,249,472 (GRCm38)	missense	possibly damaging	0.59
IGL03107:Neb	APN	2	52,183,825 (GRCm38)	missense	probably benign	0.41
IGL03171:Neb	APN	2	52,216,364 (GRCm38)	splice site	probably benign
IGL03179:Neb	APN	2	52,176,641 (GRCm38)	missense	probably damaging	1.00
IGL03186:Neb	APN	2	52,210,659 (GRCm38)	splice site	probably benign
IGL03186:Neb	APN	2	52,169,088 (GRCm38)	missense	probably damaging	0.99
IGL03187:Neb	APN	2	52,169,088 (GRCm38)	missense	probably damaging	0.99
IGL03209:Neb	APN	2	52,290,819 (GRCm38)	missense	probably damaging	1.00
IGL03214:Neb	APN	2	52,197,844 (GRCm38)	missense	possibly damaging	0.75
IGL03214:Neb	APN	2	52,159,548 (GRCm38)	missense	probably damaging	1.00
IGL03233:Neb	APN	2	52,308,301 (GRCm38)	missense	possibly damaging	0.93
IGL03287:Neb	APN	2	52,137,323 (GRCm38)	missense	probably damaging	1.00
IGL03349:Neb	APN	2	52,278,952 (GRCm38)	missense	possibly damaging	0.88
IGL03369:Neb	APN	2	52,178,037 (GRCm38)	missense	probably benign
IGL03382:Neb	APN	2	52,325,708 (GRCm38)	missense	probably benign	0.00
IGL03410:Neb	APN	2	52,319,705 (GRCm38)	missense	probably benign	0.00
IGL03411:Neb	APN	2	52,292,878 (GRCm38)	missense	probably benign
Crocque	UTSW	2	52,258,176 (GRCm38)	missense	probably damaging	1.00
Fraulein	UTSW	2	52,298,894 (GRCm38)	missense	probably damaging	1.00
mademoiselle	UTSW	2	52,207,725 (GRCm38)	missense	probably damaging	0.99
monsieur	UTSW	2	52,305,283 (GRCm38)	critical splice donor site	probably null
old_folks	UTSW	2	52,211,556 (GRCm38)	missense	probably damaging	0.96
teenage	UTSW	2	52,271,297 (GRCm38)	critical splice donor site	probably null
wedding	UTSW	2	52,292,695 (GRCm38)	missense	possibly damaging	0.89
G1Funyon:Neb	UTSW	2	52,288,835 (GRCm38)	missense	probably benign	0.04
IGL03054:Neb	UTSW	2	52,271,322 (GRCm38)	missense	probably damaging	1.00
PIT4354001:Neb	UTSW	2	52,245,318 (GRCm38)	missense	probably damaging	0.99
PIT4495001:Neb	UTSW	2	52,212,736 (GRCm38)	missense	probably benign	0.00
PIT4581001:Neb	UTSW	2	52,288,802 (GRCm38)	missense	probably damaging	0.98
R0014:Neb	UTSW	2	52,287,156 (GRCm38)	missense	probably damaging	0.99
R0014:Neb	UTSW	2	52,287,156 (GRCm38)	missense	probably damaging	0.99
R0025:Neb	UTSW	2	52,222,774 (GRCm38)	missense	probably damaging	0.99
R0049:Neb	UTSW	2	52,170,467 (GRCm38)	missense	possibly damaging	0.86
R0049:Neb	UTSW	2	52,170,467 (GRCm38)	missense	possibly damaging	0.86
R0052:Neb	UTSW	2	52,273,980 (GRCm38)	missense	possibly damaging	0.62
R0066:Neb	UTSW	2	52,306,530 (GRCm38)	missense	probably damaging	1.00
R0066:Neb	UTSW	2	52,306,530 (GRCm38)	missense	probably damaging	1.00
R0097:Neb	UTSW	2	52,204,894 (GRCm38)	missense	probably damaging	1.00
R0097:Neb	UTSW	2	52,204,894 (GRCm38)	missense	probably damaging	1.00
R0110:Neb	UTSW	2	52,290,743 (GRCm38)	splice site	probably benign
R0147:Neb	UTSW	2	52,249,376 (GRCm38)	missense	probably damaging	0.99
R0148:Neb	UTSW	2	52,249,376 (GRCm38)	missense	probably damaging	0.99
R0173:Neb	UTSW	2	52,243,847 (GRCm38)	missense	probably damaging	1.00
R0201:Neb	UTSW	2	52,206,878 (GRCm38)	splice site	probably benign
R0254:Neb	UTSW	2	52,243,390 (GRCm38)	missense	probably damaging	1.00
R0295:Neb	UTSW	2	52,284,285 (GRCm38)	missense	possibly damaging	0.90
R0314:Neb	UTSW	2	52,243,331 (GRCm38)	missense	probably benign	0.01
R0316:Neb	UTSW	2	52,195,470 (GRCm38)	missense	possibly damaging	0.96
R0380:Neb	UTSW	2	52,232,202 (GRCm38)	missense	probably damaging	1.00
R0389:Neb	UTSW	2	52,161,477 (GRCm38)	critical splice acceptor site	probably null
R0394:Neb	UTSW	2	52,177,559 (GRCm38)	splice site	probably null
R0401:Neb	UTSW	2	52,188,677 (GRCm38)	splice site	probably benign
R0413:Neb	UTSW	2	52,290,739 (GRCm38)	splice site	probably benign
R0427:Neb	UTSW	2	52,244,069 (GRCm38)	missense	probably damaging	0.98
R0427:Neb	UTSW	2	52,243,884 (GRCm38)	missense	possibly damaging	0.83
R0443:Neb	UTSW	2	52,161,477 (GRCm38)	critical splice acceptor site	probably null
R0453:Neb	UTSW	2	52,313,890 (GRCm38)	splice site	probably null
R0468:Neb	UTSW	2	52,211,556 (GRCm38)	missense	probably damaging	0.96
R0510:Neb	UTSW	2	52,290,743 (GRCm38)	splice site	probably benign
R0513:Neb	UTSW	2	52,308,687 (GRCm38)	missense	probably damaging	0.98
R0590:Neb	UTSW	2	52,137,290 (GRCm38)	missense	probably damaging	0.99
R0605:Neb	UTSW	2	52,264,026 (GRCm38)	missense	possibly damaging	0.92
R0608:Neb	UTSW	2	52,326,757 (GRCm38)	missense	probably benign	0.19
R0622:Neb	UTSW	2	52,212,951 (GRCm38)	missense	probably benign	0.09
R0639:Neb	UTSW	2	52,256,124 (GRCm38)	missense	possibly damaging	0.47
R0656:Neb	UTSW	2	52,225,558 (GRCm38)	splice site	probably benign
R0670:Neb	UTSW	2	52,256,124 (GRCm38)	missense	possibly damaging	0.47
R0673:Neb	UTSW	2	52,256,124 (GRCm38)	missense	possibly damaging	0.47
R0732:Neb	UTSW	2	52,291,268 (GRCm38)	missense	probably damaging	1.00
R0732:Neb	UTSW	2	52,258,681 (GRCm38)	missense	probably damaging	1.00
R0736:Neb	UTSW	2	52,192,012 (GRCm38)	missense	probably damaging	1.00
R0764:Neb	UTSW	2	52,216,867 (GRCm38)	unclassified	probably benign
R0811:Neb	UTSW	2	52,292,695 (GRCm38)	missense	possibly damaging	0.89
R0812:Neb	UTSW	2	52,292,695 (GRCm38)	missense	possibly damaging	0.89
R0839:Neb	UTSW	2	52,277,548 (GRCm38)	missense	probably damaging	0.99
R0960:Neb	UTSW	2	52,212,983 (GRCm38)	missense	probably benign	0.17
R1026:Neb	UTSW	2	52,264,110 (GRCm38)	missense	possibly damaging	0.93
R1076:Neb	UTSW	2	52,204,892 (GRCm38)	missense	probably damaging	1.00
R1184:Neb	UTSW	2	52,263,947 (GRCm38)	missense	probably damaging	1.00
R1185:Neb	UTSW	2	52,296,298 (GRCm38)	missense	probably damaging	1.00
R1185:Neb	UTSW	2	52,296,298 (GRCm38)	missense	probably damaging	1.00
R1185:Neb	UTSW	2	52,296,298 (GRCm38)	missense	probably damaging	1.00
R1200:Neb	UTSW	2	52,167,645 (GRCm38)	missense	probably damaging	1.00
R1205:Neb	UTSW	2	52,222,984 (GRCm38)	missense	probably damaging	0.97
R1208:Neb	UTSW	2	52,303,900 (GRCm38)	nonsense	probably null
R1208:Neb	UTSW	2	52,303,900 (GRCm38)	nonsense	probably null
R1229:Neb	UTSW	2	52,243,943 (GRCm38)	missense	probably damaging	1.00
R1240:Neb	UTSW	2	52,296,309 (GRCm38)	missense	possibly damaging	0.92
R1374:Neb	UTSW	2	52,243,389 (GRCm38)	missense	probably damaging	1.00
R1381:Neb	UTSW	2	52,260,532 (GRCm38)	missense	probably damaging	1.00
R1397:Neb	UTSW	2	52,243,943 (GRCm38)	missense	probably damaging	1.00
R1398:Neb	UTSW	2	52,289,646 (GRCm38)	missense	probably damaging	1.00
R1404:Neb	UTSW	2	52,183,275 (GRCm38)	missense	possibly damaging	0.95
R1404:Neb	UTSW	2	52,183,275 (GRCm38)	missense	possibly damaging	0.95
R1452:Neb	UTSW	2	52,271,297 (GRCm38)	critical splice donor site	probably null
R1467:Neb	UTSW	2	52,230,047 (GRCm38)	missense	probably damaging	1.00
R1467:Neb	UTSW	2	52,230,047 (GRCm38)	missense	probably damaging	1.00
R1477:Neb	UTSW	2	52,264,122 (GRCm38)	missense	probably damaging	0.99
R1478:Neb	UTSW	2	52,175,607 (GRCm38)	missense	probably benign	0.29
R1496:Neb	UTSW	2	52,328,734 (GRCm38)	missense	probably damaging	0.99
R1503:Neb	UTSW	2	52,298,620 (GRCm38)	missense	probably damaging	0.96
R1513:Neb	UTSW	2	52,227,244 (GRCm38)	missense	probably damaging	1.00
R1600:Neb	UTSW	2	52,271,604 (GRCm38)	missense	probably damaging	1.00
R1601:Neb	UTSW	2	52,287,252 (GRCm38)	nonsense	probably null
R1638:Neb	UTSW	2	52,249,281 (GRCm38)	missense	probably benign	0.05
R1712:Neb	UTSW	2	52,243,389 (GRCm38)	missense	probably damaging	1.00
R1717:Neb	UTSW	2	52,308,747 (GRCm38)	missense	possibly damaging	0.55
R1720:Neb	UTSW	2	52,207,721 (GRCm38)	missense	probably benign	0.02
R1722:Neb	UTSW	2	52,256,745 (GRCm38)	missense	probably damaging	1.00
R1765:Neb	UTSW	2	52,204,664 (GRCm38)	missense	probably damaging	1.00
R1772:Neb	UTSW	2	52,235,677 (GRCm38)	missense	probably damaging	1.00
R1782:Neb	UTSW	2	52,284,345 (GRCm38)	nonsense	probably null
R1834:Neb	UTSW	2	52,236,895 (GRCm38)	missense	probably damaging	1.00
R1847:Neb	UTSW	2	52,196,295 (GRCm38)	missense	possibly damaging	0.80
R1852:Neb	UTSW	2	52,228,542 (GRCm38)	missense	probably damaging	0.98
R1862:Neb	UTSW	2	52,162,187 (GRCm38)	splice site	probably null
R1864:Neb	UTSW	2	52,212,760 (GRCm38)	nonsense	probably null
R1868:Neb	UTSW	2	52,326,744 (GRCm38)	missense	probably damaging	0.99
R1880:Neb	UTSW	2	52,258,731 (GRCm38)	missense	probably damaging	0.98
R1906:Neb	UTSW	2	52,308,526 (GRCm38)	missense	probably damaging	1.00
R1926:Neb	UTSW	2	52,279,635 (GRCm38)	missense	probably damaging	1.00
R1944:Neb	UTSW	2	52,228,850 (GRCm38)	missense	probably benign	0.23
R1962:Neb	UTSW	2	52,272,937 (GRCm38)	nonsense	probably null
R1970:Neb	UTSW	2	52,263,905 (GRCm38)	missense	possibly damaging	0.77
R1978:Neb	UTSW	2	52,287,345 (GRCm38)	missense	probably damaging	1.00
R1995:Neb	UTSW	2	52,298,732 (GRCm38)	missense	probably damaging	1.00
R2000:Neb	UTSW	2	52,212,970 (GRCm38)	nonsense	probably null
R2006:Neb	UTSW	2	52,199,444 (GRCm38)	missense	probably null	1.00
R2019:Neb	UTSW	2	52,232,276 (GRCm38)	nonsense	probably null
R2034:Neb	UTSW	2	52,280,611 (GRCm38)	missense	possibly damaging	0.78
R2067:Neb	UTSW	2	52,284,263 (GRCm38)	missense	probably benign	0.16
R2104:Neb	UTSW	2	52,271,558 (GRCm38)	missense	probably damaging	1.00
R2104:Neb	UTSW	2	52,256,814 (GRCm38)	missense	probably benign	0.14
R2111:Neb	UTSW	2	52,284,263 (GRCm38)	missense	probably benign	0.16
R2112:Neb	UTSW	2	52,328,764 (GRCm38)	missense	probably damaging	1.00
R2120:Neb	UTSW	2	52,264,064 (GRCm38)	missense	probably damaging	1.00
R2121:Neb	UTSW	2	52,264,064 (GRCm38)	missense	probably damaging	1.00
R2124:Neb	UTSW	2	52,264,064 (GRCm38)	missense	probably damaging	1.00
R2125:Neb	UTSW	2	52,310,638 (GRCm38)	missense	probably damaging	1.00
R2126:Neb	UTSW	2	52,310,638 (GRCm38)	missense	probably damaging	1.00
R2139:Neb	UTSW	2	52,212,588 (GRCm38)	missense	probably damaging	0.99
R2207:Neb	UTSW	2	52,211,567 (GRCm38)	nonsense	probably null
R2228:Neb	UTSW	2	52,232,995 (GRCm38)	missense	probably benign	0.19
R2352:Neb	UTSW	2	52,287,336 (GRCm38)	missense	probably damaging	1.00
R2374:Neb	UTSW	2	52,263,657 (GRCm38)	missense	probably damaging	1.00
R2413:Neb	UTSW	2	52,210,632 (GRCm38)	missense	probably damaging	1.00
R2424:Neb	UTSW	2	52,209,659 (GRCm38)	splice site	probably benign
R2426:Neb	UTSW	2	52,169,053 (GRCm38)	splice site	probably null
R2508:Neb	UTSW	2	52,195,521 (GRCm38)	missense	probably benign	0.23
R2512:Neb	UTSW	2	52,210,831 (GRCm38)	missense	probably damaging	0.99
R2518:Neb	UTSW	2	52,249,511 (GRCm38)	nonsense	probably null
R2899:Neb	UTSW	2	52,185,323 (GRCm38)	missense	probably benign
R3500:Neb	UTSW	2	52,325,785 (GRCm38)	missense	probably damaging	1.00
R3690:Neb	UTSW	2	52,137,385 (GRCm38)	missense	probably damaging	1.00
R3716:Neb	UTSW	2	52,277,470 (GRCm38)	missense	probably damaging	1.00
R3717:Neb	UTSW	2	52,277,470 (GRCm38)	missense	probably damaging	1.00
R3718:Neb	UTSW	2	52,277,470 (GRCm38)	missense	probably damaging	1.00
R3786:Neb	UTSW	2	52,201,915 (GRCm38)	missense	probably damaging	1.00
R3809:Neb	UTSW	2	52,256,789 (GRCm38)	missense	possibly damaging	0.73
R3840:Neb	UTSW	2	52,207,660 (GRCm38)	critical splice donor site	probably null
R3841:Neb	UTSW	2	52,207,660 (GRCm38)	critical splice donor site	probably null
R3956:Neb	UTSW	2	52,201,963 (GRCm38)	missense	possibly damaging	0.62
R3958:Neb	UTSW	2	52,263,629 (GRCm38)	missense	probably damaging	1.00
R4057:Neb	UTSW	2	52,206,699 (GRCm38)	missense	possibly damaging	0.89
R4057:Neb	UTSW	2	52,237,108 (GRCm38)	missense	probably benign	0.32
R4110:Neb	UTSW	2	52,244,125 (GRCm38)	missense	probably damaging	1.00
R4110:Neb	UTSW	2	52,148,766 (GRCm38)	missense	probably benign	0.10
R4128:Neb	UTSW	2	52,292,700 (GRCm38)	missense	probably damaging	1.00
R4195:Neb	UTSW	2	52,290,835 (GRCm38)	missense	probably damaging	1.00
R4195:Neb	UTSW	2	52,271,559 (GRCm38)	missense	probably damaging	1.00
R4288:Neb	UTSW	2	52,259,300 (GRCm38)	missense	probably damaging	1.00
R4323:Neb	UTSW	2	52,264,110 (GRCm38)	missense	possibly damaging	0.93
R4394:Neb	UTSW	2	52,187,513 (GRCm38)	nonsense	probably null
R4463:Neb	UTSW	2	52,279,722 (GRCm38)	frame shift	probably null
R4527:Neb	UTSW	2	52,193,237 (GRCm38)	missense	probably benign	0.42
R4561:Neb	UTSW	2	52,286,155 (GRCm38)	missense	probably damaging	1.00
R4612:Neb	UTSW	2	52,287,243 (GRCm38)	missense	probably damaging	0.99
R4621:Neb	UTSW	2	52,271,039 (GRCm38)	nonsense	probably null
R4628:Neb	UTSW	2	52,308,350 (GRCm38)	nonsense	probably null
R4655:Neb	UTSW	2	52,227,299 (GRCm38)	missense	probably damaging	0.98
R4660:Neb	UTSW	2	52,255,588 (GRCm38)	missense	possibly damaging	0.85
R4683:Neb	UTSW	2	52,244,062 (GRCm38)	missense	possibly damaging	0.89
R4687:Neb	UTSW	2	52,304,035 (GRCm38)	missense	possibly damaging	0.95
R4690:Neb	UTSW	2	52,244,075 (GRCm38)	missense	probably benign	0.25
R4710:Neb	UTSW	2	52,260,598 (GRCm38)	missense	probably benign	0.32
R4729:Neb	UTSW	2	52,263,662 (GRCm38)	missense	possibly damaging	0.80
R4732:Neb	UTSW	2	52,279,079 (GRCm38)	missense	probably damaging	1.00
R4733:Neb	UTSW	2	52,279,079 (GRCm38)	missense	probably damaging	1.00
R4738:Neb	UTSW	2	52,187,482 (GRCm38)	missense	probably damaging	1.00
R4744:Neb	UTSW	2	52,150,577 (GRCm38)	missense	probably benign	0.29
R4755:Neb	UTSW	2	52,220,209 (GRCm38)	missense	probably damaging	1.00
R4756:Neb	UTSW	2	52,193,231 (GRCm38)	missense	probably damaging	0.96
R4763:Neb	UTSW	2	52,326,720 (GRCm38)	nonsense	probably null
R4763:Neb	UTSW	2	52,237,040 (GRCm38)	nonsense	probably null
R4770:Neb	UTSW	2	52,149,153 (GRCm38)	missense	probably benign	0.00
R4801:Neb	UTSW	2	52,200,703 (GRCm38)	missense	possibly damaging	0.65
R4802:Neb	UTSW	2	52,200,703 (GRCm38)	missense	possibly damaging	0.65
R4824:Neb	UTSW	2	52,204,879 (GRCm38)	missense	possibly damaging	0.86
R4830:Neb	UTSW	2	52,192,520 (GRCm38)	missense	probably damaging	0.99
R4855:Neb	UTSW	2	52,298,894 (GRCm38)	missense	probably damaging	1.00
R4857:Neb	UTSW	2	52,201,980 (GRCm38)	missense	probably damaging	1.00
R4878:Neb	UTSW	2	52,219,394 (GRCm38)	missense	probably damaging	1.00
R4885:Neb	UTSW	2	52,286,046 (GRCm38)	missense	probably damaging	1.00
R4888:Neb	UTSW	2	52,296,307 (GRCm38)	missense	probably benign	0.17
R4928:Neb	UTSW	2	52,212,975 (GRCm38)	missense	possibly damaging	0.79
R4954:Neb	UTSW	2	52,177,518 (GRCm38)	splice site	probably null
R4974:Neb	UTSW	2	52,246,859 (GRCm38)	missense	probably damaging	1.00
R4979:Neb	UTSW	2	52,189,909 (GRCm38)	missense	probably damaging	1.00
R4983:Neb	UTSW	2	52,216,261 (GRCm38)	missense	probably damaging	0.99
R4990:Neb	UTSW	2	52,255,546 (GRCm38)	missense	probably benign
R5026:Neb	UTSW	2	52,204,880 (GRCm38)	missense	possibly damaging	0.94
R5030:Neb	UTSW	2	52,334,492 (GRCm38)	start gained	probably benign
R5062:Neb	UTSW	2	52,280,501 (GRCm38)	missense	possibly damaging	0.94
R5063:Neb	UTSW	2	52,223,212 (GRCm38)	intron	probably benign
R5099:Neb	UTSW	2	52,195,448 (GRCm38)	missense	probably damaging	1.00
R5102:Neb	UTSW	2	52,226,570 (GRCm38)	missense	possibly damaging	0.70
R5124:Neb	UTSW	2	52,281,498 (GRCm38)	missense	probably damaging	1.00
R5150:Neb	UTSW	2	52,169,118 (GRCm38)	missense	probably benign	0.09
R5217:Neb	UTSW	2	52,162,130 (GRCm38)	nonsense	probably null
R5280:Neb	UTSW	2	52,147,156 (GRCm38)	missense	probably damaging	1.00
R5288:Neb	UTSW	2	52,189,861 (GRCm38)	missense	probably damaging	0.99
R5314:Neb	UTSW	2	52,281,503 (GRCm38)	missense	probably benign	0.22
R5340:Neb	UTSW	2	52,223,048 (GRCm38)	missense	probably damaging	1.00
R5375:Neb	UTSW	2	52,212,584 (GRCm38)	missense	possibly damaging	0.75
R5385:Neb	UTSW	2	52,189,861 (GRCm38)	missense	probably damaging	0.99
R5411:Neb	UTSW	2	52,295,372 (GRCm38)	missense	probably damaging	0.98
R5470:Neb	UTSW	2	52,249,438 (GRCm38)	missense	possibly damaging	0.88
R5500:Neb	UTSW	2	52,162,067 (GRCm38)	critical splice donor site	probably null
R5523:Neb	UTSW	2	52,278,815 (GRCm38)	missense	probably benign
R5527:Neb	UTSW	2	52,334,453 (GRCm38)	missense	unknown
R5622:Neb	UTSW	2	52,270,269 (GRCm38)	missense	probably damaging	0.96
R5625:Neb	UTSW	2	52,177,535 (GRCm38)	nonsense	probably null
R5688:Neb	UTSW	2	52,196,327 (GRCm38)	missense	probably damaging	1.00
R5715:Neb	UTSW	2	52,251,768 (GRCm38)	missense	probably damaging	1.00
R5716:Neb	UTSW	2	52,210,584 (GRCm38)	missense	probably benign
R5760:Neb	UTSW	2	52,183,818 (GRCm38)	missense	probably damaging	1.00
R5779:Neb	UTSW	2	52,245,301 (GRCm38)	missense	probably damaging	0.99
R5782:Neb	UTSW	2	52,264,047 (GRCm38)	nonsense	probably null
R5862:Neb	UTSW	2	52,179,542 (GRCm38)	nonsense	probably null
R5905:Neb	UTSW	2	52,193,231 (GRCm38)	missense	probably damaging	0.99
R5918:Neb	UTSW	2	52,197,894 (GRCm38)	missense	probably damaging	1.00
R5939:Neb	UTSW	2	52,257,594 (GRCm38)	missense	probably benign
R5959:Neb	UTSW	2	52,156,377 (GRCm38)	missense	probably benign	0.22
R5976:Neb	UTSW	2	52,216,916 (GRCm38)	missense	possibly damaging	0.88
R5987:Neb	UTSW	2	52,295,294 (GRCm38)	missense	probably benign	0.10
R6020:Neb	UTSW	2	52,257,827 (GRCm38)	missense	probably benign	0.05
R6028:Neb	UTSW	2	52,193,231 (GRCm38)	missense	probably damaging	0.99
R6045:Neb	UTSW	2	52,194,425 (GRCm38)	splice site	probably null
R6062:Neb	UTSW	2	52,185,281 (GRCm38)	missense	probably benign	0.05
R6088:Neb	UTSW	2	52,209,342 (GRCm38)	missense	probably damaging	1.00
R6093:Neb	UTSW	2	52,251,770 (GRCm38)	nonsense	probably null
R6119:Neb	UTSW	2	52,220,931 (GRCm38)	missense	probably benign	0.36
R6167:Neb	UTSW	2	52,147,237 (GRCm38)	missense	probably benign	0.12
R6192:Neb	UTSW	2	52,256,790 (GRCm38)	missense	probably benign	0.00
R6216:Neb	UTSW	2	52,224,552 (GRCm38)	missense	probably benign	0.45
R6220:Neb	UTSW	2	52,270,972 (GRCm38)	missense	probably null	0.00
R6239:Neb	UTSW	2	52,273,988 (GRCm38)	missense	probably benign
R6242:Neb	UTSW	2	52,176,812 (GRCm38)	missense	probably damaging	1.00
R6254:Neb	UTSW	2	52,222,961 (GRCm38)	missense	probably benign	0.01
R6262:Neb	UTSW	2	52,308,687 (GRCm38)	missense	probably damaging	0.98
R6305:Neb	UTSW	2	52,251,763 (GRCm38)	nonsense	probably null
R6319:Neb	UTSW	2	52,163,011 (GRCm38)	critical splice acceptor site	probably null
R6333:Neb	UTSW	2	52,258,263 (GRCm38)	missense	probably damaging	1.00
R6341:Neb	UTSW	2	52,209,474 (GRCm38)	missense	probably damaging	1.00
R6362:Neb	UTSW	2	52,212,692 (GRCm38)	missense	probably benign	0.01
R6378:Neb	UTSW	2	52,293,721 (GRCm38)	missense	probably damaging	1.00
R6385:Neb	UTSW	2	52,185,299 (GRCm38)	missense	probably damaging	0.99
R6404:Neb	UTSW	2	52,207,725 (GRCm38)	missense	probably damaging	0.99
R6416:Neb	UTSW	2	52,185,328 (GRCm38)	missense	probably benign	0.10
R6437:Neb	UTSW	2	52,257,557 (GRCm38)	splice site	probably null
R6448:Neb	UTSW	2	52,148,814 (GRCm38)	missense	probably damaging	1.00
R6450:Neb	UTSW	2	52,194,469 (GRCm38)	nonsense	probably null
R6452:Neb	UTSW	2	52,179,483 (GRCm38)	missense	probably benign	0.00
R6455:Neb	UTSW	2	52,167,644 (GRCm38)	nonsense	probably null
R6474:Neb	UTSW	2	52,280,612 (GRCm38)	missense	probably benign	0.00
R6497:Neb	UTSW	2	52,258,289 (GRCm38)	missense	possibly damaging	0.53
R6502:Neb	UTSW	2	52,291,082 (GRCm38)	missense	probably benign	0.34
R6572:Neb	UTSW	2	52,278,847 (GRCm38)	missense	probably damaging	1.00
R6617:Neb	UTSW	2	52,207,747 (GRCm38)	missense	probably damaging	1.00
R6659:Neb	UTSW	2	52,234,353 (GRCm38)	missense	probably damaging	1.00
R6667:Neb	UTSW	2	52,147,189 (GRCm38)	missense	probably damaging	1.00
R6701:Neb	UTSW	2	52,291,208 (GRCm38)	missense	probably damaging	1.00
R6711:Neb	UTSW	2	52,256,287 (GRCm38)	missense	probably damaging	1.00
R6711:Neb	UTSW	2	52,223,064 (GRCm38)	missense	probably benign	0.22
R6861:Neb	UTSW	2	52,195,720 (GRCm38)	missense	probably damaging	1.00
R6872:Neb	UTSW	2	52,293,645 (GRCm38)	missense	probably damaging	0.99
R6886:Neb	UTSW	2	52,220,224 (GRCm38)	missense	probably damaging	1.00
R6923:Neb	UTSW	2	52,186,064 (GRCm38)	missense	probably damaging	0.97
R7025:Neb	UTSW	2	52,296,273 (GRCm38)	missense	possibly damaging	0.94
R7050:Neb	UTSW	2	52,222,876 (GRCm38)	missense	possibly damaging	0.67
R7091:Neb	UTSW	2	52,256,112 (GRCm38)	missense
R7095:Neb	UTSW	2	52,177,623 (GRCm38)	missense	possibly damaging	0.95
R7102:Neb	UTSW	2	52,304,055 (GRCm38)	missense	probably damaging	1.00
R7114:Neb	UTSW	2	52,192,559 (GRCm38)	missense	probably damaging	1.00
R7152:Neb	UTSW	2	52,263,545 (GRCm38)	missense	probably damaging	1.00
R7156:Neb	UTSW	2	52,305,283 (GRCm38)	critical splice donor site	probably null
R7161:Neb	UTSW	2	52,271,592 (GRCm38)	missense	probably damaging	1.00
R7165:Neb	UTSW	2	52,270,306 (GRCm38)	missense	probably damaging	1.00
R7199:Neb	UTSW	2	52,220,200 (GRCm38)	missense	probably benign	0.01
R7205:Neb	UTSW	2	52,196,356 (GRCm38)	missense	probably damaging	1.00
R7224:Neb	UTSW	2	52,334,659 (GRCm38)	splice site	probably null
R7247:Neb	UTSW	2	52,258,741 (GRCm38)	missense	probably damaging	1.00
R7252:Neb	UTSW	2	52,324,961 (GRCm38)	critical splice donor site	probably null
R7275:Neb	UTSW	2	52,206,944 (GRCm38)	missense	probably benign	0.30
R7284:Neb	UTSW	2	52,258,792 (GRCm38)	missense	probably damaging	0.97
R7316:Neb	UTSW	2	52,271,438 (GRCm38)	missense	possibly damaging	0.80
R7330:Neb	UTSW	2	52,189,703 (GRCm38)	missense	possibly damaging	0.89
R7342:Neb	UTSW	2	52,281,667 (GRCm38)	missense	probably damaging	1.00
R7451:Neb	UTSW	2	52,201,454 (GRCm38)	missense	probably benign
R7464:Neb	UTSW	2	52,193,890 (GRCm38)	missense	probably benign	0.02
R7488:Neb	UTSW	2	52,220,221 (GRCm38)	missense	probably benign
R7498:Neb	UTSW	2	52,258,176 (GRCm38)	missense	probably damaging	1.00
R7513:Neb	UTSW	2	52,209,540 (GRCm38)	missense	possibly damaging	0.83
R7527:Neb	UTSW	2	52,176,623 (GRCm38)	missense	probably damaging	1.00
R7533:Neb	UTSW	2	52,224,566 (GRCm38)	missense
R7535:Neb	UTSW	2	52,165,103 (GRCm38)	splice site	probably null
R7538:Neb	UTSW	2	52,256,575 (GRCm38)	splice site	probably null
R7547:Neb	UTSW	2	52,282,625 (GRCm38)	missense	probably benign	0.00
R7552:Neb	UTSW	2	52,247,190 (GRCm38)	missense
R7582:Neb	UTSW	2	52,334,492 (GRCm38)	start gained	probably benign
R7590:Neb	UTSW	2	52,243,842 (GRCm38)	missense	probably damaging	1.00
R7606:Neb	UTSW	2	52,226,444 (GRCm38)	missense
R7619:Neb	UTSW	2	52,296,426 (GRCm38)	missense	possibly damaging	0.53
R7629:Neb	UTSW	2	52,273,961 (GRCm38)	missense	possibly damaging	0.96
R7660:Neb	UTSW	2	52,249,439 (GRCm38)	missense
R7663:Neb	UTSW	2	52,230,047 (GRCm38)	missense
R7678:Neb	UTSW	2	52,206,702 (GRCm38)	missense	probably damaging	1.00
R7693:Neb	UTSW	2	52,299,569 (GRCm38)	missense	probably damaging	0.96
R7728:Neb	UTSW	2	52,183,299 (GRCm38)	missense	probably damaging	1.00
R7750:Neb	UTSW	2	52,280,716 (GRCm38)	splice site	probably null
R7776:Neb	UTSW	2	52,207,701 (GRCm38)	missense	possibly damaging	0.72
R7784:Neb	UTSW	2	52,235,488 (GRCm38)	missense
R7808:Neb	UTSW	2	52,192,023 (GRCm38)	missense	probably damaging	1.00
R7814:Neb	UTSW	2	52,137,380 (GRCm38)	missense	probably damaging	1.00
R7830:Neb	UTSW	2	52,165,189 (GRCm38)	missense	probably benign	0.04
R7835:Neb	UTSW	2	52,150,577 (GRCm38)	missense	probably benign	0.29
R7836:Neb	UTSW	2	52,223,361 (GRCm38)	splice site	probably null
R7851:Neb	UTSW	2	52,153,064 (GRCm38)	missense	probably benign
R7857:Neb	UTSW	2	52,222,984 (GRCm38)	missense	probably damaging	0.97
R7870:Neb	UTSW	2	52,325,749 (GRCm38)	missense	probably damaging	1.00
R7889:Neb	UTSW	2	52,147,669 (GRCm38)	missense	probably benign	0.00
R7912:Neb	UTSW	2	52,220,985 (GRCm38)	missense	possibly damaging	0.51
R7939:Neb	UTSW	2	52,186,061 (GRCm38)	missense	probably damaging	0.98
R7944:Neb	UTSW	2	52,271,348 (GRCm38)	missense	probably damaging	1.00
R7945:Neb	UTSW	2	52,271,348 (GRCm38)	missense	probably damaging	1.00
R7946:Neb	UTSW	2	52,212,734 (GRCm38)	missense	probably damaging	1.00
R7975:Neb	UTSW	2	52,160,666 (GRCm38)	missense	probably benign	0.01
R8000:Neb	UTSW	2	52,288,844 (GRCm38)	missense	probably damaging	0.99
R8026:Neb	UTSW	2	52,223,048 (GRCm38)	missense
R8050:Neb	UTSW	2	52,221,726 (GRCm38)	missense	probably benign
R8053:Neb	UTSW	2	52,286,017 (GRCm38)	missense	possibly damaging	0.82
R8114:Neb	UTSW	2	52,325,722 (GRCm38)	missense	possibly damaging	0.88
R8138:Neb	UTSW	2	52,175,695 (GRCm38)	missense	possibly damaging	0.63
R8140:Neb	UTSW	2	52,209,540 (GRCm38)	missense	possibly damaging	0.83
R8152:Neb	UTSW	2	52,183,836 (GRCm38)	missense	probably benign	0.00
R8203:Neb	UTSW	2	52,149,247 (GRCm38)	nonsense	probably null
R8231:Neb	UTSW	2	52,235,479 (GRCm38)	critical splice donor site	probably null
R8293:Neb	UTSW	2	52,246,815 (GRCm38)	missense	probably benign	0.30
R8296:Neb	UTSW	2	52,226,589 (GRCm38)	missense
R8297:Neb	UTSW	2	52,308,763 (GRCm38)	missense	possibly damaging	0.78
R8301:Neb	UTSW	2	52,288,835 (GRCm38)	missense	probably benign	0.04
R8306:Neb	UTSW	2	52,209,645 (GRCm38)	missense	probably damaging	1.00
R8320:Neb	UTSW	2	52,296,331 (GRCm38)	missense	probably benign	0.00
R8326:Neb	UTSW	2	52,221,702 (GRCm38)	missense	probably damaging	0.99
R8330:Neb	UTSW	2	52,227,408 (GRCm38)	missense
R8336:Neb	UTSW	2	52,273,890 (GRCm38)	missense	probably damaging	1.00
R8343:Neb	UTSW	2	52,308,271 (GRCm38)	splice site	probably null
R8350:Neb	UTSW	2	52,206,182 (GRCm38)	missense	probably benign	0.31
R8380:Neb	UTSW	2	52,197,811 (GRCm38)	missense	probably benign	0.01
R8395:Neb	UTSW	2	52,257,794 (GRCm38)	missense	probably damaging	0.97
R8395:Neb	UTSW	2	52,175,633 (GRCm38)	missense	probably benign	0.01
R8408:Neb	UTSW	2	52,157,911 (GRCm38)	missense	probably benign	0.32
R8435:Neb	UTSW	2	52,267,717 (GRCm38)	missense	probably benign	0.01
R8442:Neb	UTSW	2	52,287,208 (GRCm38)	missense	probably damaging	0.99
R8450:Neb	UTSW	2	52,206,182 (GRCm38)	missense	probably benign	0.31
R8481:Neb	UTSW	2	52,224,585 (GRCm38)	missense	probably damaging	1.00
R8492:Neb	UTSW	2	52,313,212 (GRCm38)	missense	probably damaging	1.00
R8531:Neb	UTSW	2	52,291,062 (GRCm38)	missense	possibly damaging	0.92
R8550:Neb	UTSW	2	52,298,912 (GRCm38)	missense	probably benign	0.18
R8679:Neb	UTSW	2	52,325,039 (GRCm38)	missense	probably damaging	0.98
R8681:Neb	UTSW	2	52,237,036 (GRCm38)	missense	probably damaging	0.98
R8682:Neb	UTSW	2	52,246,845 (GRCm38)	missense	probably damaging	1.00
R8699:Neb	UTSW	2	52,147,234 (GRCm38)	missense	probably benign
R8699:Neb	UTSW	2	52,212,551 (GRCm38)	missense	probably benign	0.05
R8702:Neb	UTSW	2	52,195,705 (GRCm38)	missense	probably damaging	1.00
R8705:Neb	UTSW	2	52,258,783 (GRCm38)	missense	probably damaging	1.00
R8706:Neb	UTSW	2	52,291,314 (GRCm38)	missense	probably benign
R8717:Neb	UTSW	2	52,183,769 (GRCm38)	missense	probably damaging	0.99
R8746:Neb	UTSW	2	52,282,601 (GRCm38)	missense	probably damaging	1.00
R8749:Neb	UTSW	2	52,290,851 (GRCm38)	missense	probably benign	0.03
R8782:Neb	UTSW	2	52,188,773 (GRCm38)	missense	probably benign	0.00
R8783:Neb	UTSW	2	52,258,632 (GRCm38)	missense	probably damaging	1.00
R8785:Neb	UTSW	2	52,169,890 (GRCm38)	missense	probably damaging	1.00
R8824:Neb	UTSW	2	52,216,911 (GRCm38)	missense	probably damaging	1.00
R8828:Neb	UTSW	2	52,194,426 (GRCm38)	missense	probably damaging	0.99
R8870:Neb	UTSW	2	52,161,469 (GRCm38)	missense	probably damaging	1.00
R8879:Neb	UTSW	2	52,235,580 (GRCm38)	missense
R8881:Neb	UTSW	2	52,206,987 (GRCm38)	missense	possibly damaging	0.93
R8902:Neb	UTSW	2	52,243,210 (GRCm38)	missense	probably damaging	1.00
R8906:Neb	UTSW	2	52,206,247 (GRCm38)	missense	probably benign	0.05
R8919:Neb	UTSW	2	52,237,129 (GRCm38)	missense
R8935:Neb	UTSW	2	52,251,768 (GRCm38)	missense	probably damaging	1.00
R8946:Neb	UTSW	2	52,151,413 (GRCm38)	missense	probably damaging	1.00
R9050:Neb	UTSW	2	52,189,889 (GRCm38)	missense	probably damaging	0.99
R9058:Neb	UTSW	2	52,185,329 (GRCm38)	missense	probably benign	0.02
R9114:Neb	UTSW	2	52,209,587 (GRCm38)	missense	probably benign	0.04
R9133:Neb	UTSW	2	52,193,244 (GRCm38)	missense	possibly damaging	0.80
R9137:Neb	UTSW	2	52,260,490 (GRCm38)	unclassified	probably benign
R9149:Neb	UTSW	2	52,210,866 (GRCm38)	missense	possibly damaging	0.84
R9168:Neb	UTSW	2	52,195,684 (GRCm38)	missense	probably damaging	1.00
R9184:Neb	UTSW	2	52,328,755 (GRCm38)	missense	possibly damaging	0.94
R9187:Neb	UTSW	2	52,206,103 (GRCm38)	missense	probably damaging	0.96
R9192:Neb	UTSW	2	52,313,835 (GRCm38)	missense	probably damaging	0.96
R9211:Neb	UTSW	2	52,245,348 (GRCm38)	missense	probably damaging	1.00
R9218:Neb	UTSW	2	52,293,626 (GRCm38)	critical splice donor site	probably null
R9250:Neb	UTSW	2	52,278,901 (GRCm38)	missense	possibly damaging	0.62
R9265:Neb	UTSW	2	52,199,444 (GRCm38)	missense	probably null	1.00
R9275:Neb	UTSW	2	52,256,178 (GRCm38)	missense	probably damaging	1.00
R9278:Neb	UTSW	2	52,256,178 (GRCm38)	missense	probably damaging	1.00
R9288:Neb	UTSW	2	52,161,391 (GRCm38)	missense	probably damaging	1.00
R9310:Neb	UTSW	2	52,263,696 (GRCm38)	missense	probably benign
R9329:Neb	UTSW	2	52,270,219 (GRCm38)	missense	probably benign
R9357:Neb	UTSW	2	52,179,568 (GRCm38)	critical splice acceptor site	probably null
R9366:Neb	UTSW	2	52,282,687 (GRCm38)	missense	probably benign	0.02
R9377:Neb	UTSW	2	52,149,279 (GRCm38)	critical splice acceptor site	probably null
R9377:Neb	UTSW	2	52,226,534 (GRCm38)	missense
R9378:Neb	UTSW	2	52,247,292 (GRCm38)	missense
R9378:Neb	UTSW	2	52,244,101 (GRCm38)	missense	possibly damaging	0.53
R9382:Neb	UTSW	2	52,232,265 (GRCm38)	missense
R9390:Neb	UTSW	2	52,175,145 (GRCm38)	missense	probably benign	0.17
R9404:Neb	UTSW	2	52,257,776 (GRCm38)	missense	probably damaging	1.00
R9416:Neb	UTSW	2	52,247,203 (GRCm38)	missense
R9424:Neb	UTSW	2	52,151,398 (GRCm38)	missense	probably benign	0.31
R9478:Neb	UTSW	2	52,188,776 (GRCm38)	missense	probably benign	0.09
R9561:Neb	UTSW	2	52,242,056 (GRCm38)	missense
R9567:Neb	UTSW	2	52,175,126 (GRCm38)	missense	probably damaging	1.00
R9604:Neb	UTSW	2	52,292,668 (GRCm38)	missense	probably benign	0.02
R9641:Neb	UTSW	2	52,222,771 (GRCm38)	missense
R9673:Neb	UTSW	2	52,243,841 (GRCm38)	critical splice donor site	probably null
R9676:Neb	UTSW	2	52,170,546 (GRCm38)	missense	possibly damaging	0.87
R9709:Neb	UTSW	2	52,211,495 (GRCm38)	missense	probably damaging	0.98
RF001:Neb	UTSW	2	52,195,421 (GRCm38)	missense	probably damaging	1.00
X0021:Neb	UTSW	2	52,270,300 (GRCm38)	missense	probably benign
X0026:Neb	UTSW	2	52,243,904 (GRCm38)	missense	probably benign	0.34
X0027:Neb	UTSW	2	52,227,314 (GRCm38)	missense	probably damaging	1.00
X0065:Neb	UTSW	2	52,249,304 (GRCm38)	missense	possibly damaging	0.95
Z1088:Neb	UTSW	2	52,223,152 (GRCm38)	missense	probably benign	0.00
Z1088:Neb	UTSW	2	52,169,872 (GRCm38)	missense	possibly damaging	0.68
Z1088:Neb	UTSW	2	52,308,567 (GRCm38)	missense	probably damaging	1.00
Z1176:Neb	UTSW	2	52,279,631 (GRCm38)	critical splice donor site	probably null
Z1176:Neb	UTSW	2	52,267,782 (GRCm38)	missense	probably benign	0.26
Z1177:Neb	UTSW	2	52,162,998 (GRCm38)	missense	probably damaging	1.00
Z1177:Neb	UTSW	2	52,299,502 (GRCm38)	missense	probably damaging	0.99
Z1177:Neb	UTSW	2	52,256,670 (GRCm38)	missense	probably damaging	1.00
Z1177:Neb	UTSW	2	52,209,407 (GRCm38)	missense	possibly damaging	0.89

Predicted Primers

Posted On

2014-01-15