Incidental Mutation 'R1170:Dcdc2a'
ID 99331
Institutional Source Beutler Lab
Gene Symbol Dcdc2a
Ensembl Gene ENSMUSG00000035910
Gene Name doublecortin domain containing 2a
Synonyms RU2, Dcdc2
MMRRC Submission 039243-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.317) question?
Stock # R1170 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 25239987-25394689 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 25240290 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 13 (Q13K)
Ref Sequence ENSEMBL: ENSMUSP00000047641 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036932] [ENSMUST00000069614]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000036932
AA Change: Q13K

PolyPhen 2 Score 0.344 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000047641
Gene: ENSMUSG00000035910
AA Change: Q13K

DomainStartEndE-ValueType
DCX 12 100 2.93e-40 SMART
DCX 134 221 1.76e-34 SMART
low complexity region 286 299 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000069614
AA Change: Q13K

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000063650
Gene: ENSMUSG00000035910
AA Change: Q13K

DomainStartEndE-ValueType
DCX 12 100 2.93e-40 SMART
DCX 134 221 1.76e-34 SMART
low complexity region 286 299 N/A INTRINSIC
low complexity region 325 340 N/A INTRINSIC
coiled coil region 409 437 N/A INTRINSIC
low complexity region 461 475 N/A INTRINSIC
Meta Mutation Damage Score 0.1755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 93.0%
Validation Efficiency 100% (105/105)
MGI Phenotype FUNCTION: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired short term object recognition, impaired visuo-spatial learning and memory and increased anxiety-related response. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 104 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700025G04Rik A G 1: 151,856,163 (GRCm39) probably benign Het
Akap9 G A 5: 4,105,671 (GRCm39) S2914N probably benign Het
Alk T C 17: 72,207,729 (GRCm39) D1002G probably damaging Het
Ap3d1 A G 10: 80,568,674 (GRCm39) probably benign Het
Asb15 T C 6: 24,562,486 (GRCm39) probably benign Het
Asxl3 C A 18: 22,657,564 (GRCm39) P1858Q probably benign Het
Bltp1 T C 3: 37,098,780 (GRCm39) S1136P probably damaging Het
Bud31 T A 5: 145,079,388 (GRCm39) probably benign Het
C1qtnf1 G T 11: 118,339,095 (GRCm39) R255L probably damaging Het
Cacna2d4 C T 6: 119,284,247 (GRCm39) R745W probably damaging Het
Cage1 C T 13: 38,206,856 (GRCm39) E330K probably damaging Het
Catsperz T A 19: 6,902,317 (GRCm39) N59I probably benign Het
Ccdc110 G T 8: 46,394,922 (GRCm39) S271I probably benign Het
Ccdc88b T A 19: 6,830,581 (GRCm39) E787V probably damaging Het
Ccna2 A T 3: 36,623,119 (GRCm39) probably benign Het
Cd36 T A 5: 18,018,086 (GRCm39) D209V probably damaging Het
Cers4 T A 8: 4,569,475 (GRCm39) W161R probably damaging Het
Ces2f T A 8: 105,680,178 (GRCm39) H442Q probably damaging Het
Chchd6 A C 6: 89,361,669 (GRCm39) C245G probably damaging Het
Cndp1 T G 18: 84,629,750 (GRCm39) Q481P probably benign Het
Col3a1 A G 1: 45,366,761 (GRCm39) R234G unknown Het
Col3a1 A T 1: 45,386,884 (GRCm39) N232I probably damaging Het
Colgalt2 A T 1: 152,378,768 (GRCm39) D398V probably damaging Het
Cxcl10 TACTCAC TACTCACTCAC 5: 92,495,941 (GRCm39) probably null Het
Dzip3 A T 16: 48,781,571 (GRCm39) I240N probably damaging Het
Epb41l3 T A 17: 69,566,175 (GRCm39) L452* probably null Het
Fam193b C T 13: 55,689,518 (GRCm39) A753T probably damaging Het
Fam47e G C 5: 92,713,781 (GRCm39) probably benign Het
Fastkd1 A G 2: 69,538,993 (GRCm39) probably benign Het
Fmnl1 G A 11: 103,088,196 (GRCm39) G69D probably benign Het
Foxn2 A G 17: 88,781,094 (GRCm39) probably benign Het
Fsip2 A G 2: 82,821,844 (GRCm39) E5859G possibly damaging Het
Gm9894 T A 13: 67,912,820 (GRCm39) noncoding transcript Het
H2-T13 T C 17: 36,391,983 (GRCm39) N44S possibly damaging Het
Helz2 T C 2: 180,871,608 (GRCm39) Y2668C probably damaging Het
Hhipl1 T A 12: 108,277,952 (GRCm39) C93* probably null Het
Lig1 C T 7: 13,026,079 (GRCm39) A278V probably benign Het
Lipn T A 19: 34,049,158 (GRCm39) I108K probably benign Het
Lsamp A G 16: 41,971,592 (GRCm39) probably benign Het
Map3k14 A G 11: 103,129,743 (GRCm39) probably benign Het
Mdm4 A T 1: 132,919,558 (GRCm39) C436S probably damaging Het
Mdm4 A G 1: 132,940,430 (GRCm39) L33P probably damaging Het
Meiob T C 17: 25,055,458 (GRCm39) W422R probably damaging Het
Mppe1 T C 18: 67,360,777 (GRCm39) Y254C probably damaging Het
Mterf1a A T 5: 3,940,964 (GRCm39) N301K probably benign Het
Muc6 C T 7: 141,230,500 (GRCm39) S1210N probably damaging Het
Mycbp2 A T 14: 103,437,588 (GRCm39) Y2091* probably null Het
Mylk G A 16: 34,694,409 (GRCm39) R156H probably benign Het
Myo15a G T 11: 60,370,233 (GRCm39) D998Y probably benign Het
Neb A T 2: 52,086,369 (GRCm39) Y5235N probably damaging Het
Nop58 A G 1: 59,743,370 (GRCm39) probably benign Het
Nr4a3 A G 4: 48,083,324 (GRCm39) K619R probably benign Het
Nr4a3 A G 4: 48,051,564 (GRCm39) H135R probably damaging Het
Nrg1 T C 8: 32,327,695 (GRCm39) probably benign Het
Odr4 T A 1: 150,262,142 (GRCm39) E99D probably benign Het
Or4f59 A T 2: 111,872,560 (GRCm39) D272E probably benign Het
Or5b122 T C 19: 13,563,577 (GRCm39) V260A probably benign Het
Or5m8 A T 2: 85,823,040 (GRCm39) N293I probably damaging Het
Or8g24 T A 9: 38,989,525 (GRCm39) D172V possibly damaging Het
Parp3 T C 9: 106,353,204 (GRCm39) probably benign Het
Pde2a A G 7: 101,133,750 (GRCm39) E103G probably benign Het
Pds5a A T 5: 65,792,645 (GRCm39) probably benign Het
Pip4k2c A G 10: 127,047,262 (GRCm39) V40A unknown Het
Pitrm1 T C 13: 6,602,780 (GRCm39) probably benign Het
Plk4 A G 3: 40,756,282 (GRCm39) I64M probably damaging Het
Ppp1r16a C T 15: 76,577,869 (GRCm39) Q328* probably null Het
Ppp2r1a T C 17: 21,171,593 (GRCm39) probably benign Het
Ppp4r3b T A 11: 29,159,426 (GRCm39) N172K probably damaging Het
Prkcg G A 7: 3,368,177 (GRCm39) R357Q probably damaging Het
Prmt3 T C 7: 49,498,295 (GRCm39) probably null Het
Prx T A 7: 27,217,432 (GRCm39) C644* probably null Het
Ptpru A G 4: 131,535,838 (GRCm39) probably benign Het
Rbm5 A T 9: 107,619,696 (GRCm39) D738E probably damaging Het
Recql5 A T 11: 115,788,060 (GRCm39) Y420N probably damaging Het
Rnf17 T C 14: 56,663,088 (GRCm39) I152T probably benign Het
Rnpepl1 A G 1: 92,846,917 (GRCm39) S580G possibly damaging Het
Ryr3 C T 2: 112,777,332 (GRCm39) G275D probably damaging Het
Serpinb9e T A 13: 33,441,735 (GRCm39) Y222* probably null Het
Shld2 A T 14: 33,990,448 (GRCm39) S153T possibly damaging Het
Slc10a1 T A 12: 81,002,802 (GRCm39) I279F probably damaging Het
Slc12a8 G T 16: 33,483,347 (GRCm39) G584V probably damaging Het
Slc35b3 T A 13: 39,121,307 (GRCm39) Y311F probably benign Het
Slc44a5 A G 3: 153,963,357 (GRCm39) probably null Het
Slc6a9 A G 4: 117,722,003 (GRCm39) E422G possibly damaging Het
Smpd2 A G 10: 41,364,728 (GRCm39) probably null Het
Spast A G 17: 74,688,963 (GRCm39) probably null Het
Spink5 A T 18: 44,116,630 (GRCm39) E208V probably benign Het
Stag1 T C 9: 100,770,506 (GRCm39) probably benign Het
Stambp A G 6: 83,540,803 (GRCm39) probably null Het
Sult3a2 A T 10: 33,653,188 (GRCm39) M184K possibly damaging Het
Tcp11 T C 17: 28,290,636 (GRCm39) D162G probably damaging Het
Themis A C 10: 28,544,744 (GRCm39) E30A possibly damaging Het
Tmc7 G A 7: 118,150,483 (GRCm39) S350L probably benign Het
Tmem131 A T 1: 36,873,979 (GRCm39) Y271* probably null Het
Trim35 T A 14: 66,546,248 (GRCm39) S338R probably benign Het
Trim42 C A 9: 97,245,673 (GRCm39) V376F probably benign Het
Tshr A T 12: 91,504,871 (GRCm39) K11M probably damaging Het
Vps8 A G 16: 21,278,570 (GRCm39) probably benign Het
Wdr11 T C 7: 129,208,831 (GRCm39) probably benign Het
Wdr26 A T 1: 181,008,859 (GRCm39) probably benign Het
Wdtc1 A G 4: 133,024,857 (GRCm39) Y447H probably damaging Het
Zfp687 C T 3: 94,915,784 (GRCm39) C996Y probably damaging Het
Zfp984 A T 4: 147,840,446 (GRCm39) V135E probably benign Het
Zranb2 T C 3: 157,247,502 (GRCm39) probably benign Het
Other mutations in Dcdc2a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01160:Dcdc2a APN 13 25,303,312 (GRCm39) missense probably benign 0.00
IGL01314:Dcdc2a APN 13 25,286,587 (GRCm39) missense probably damaging 1.00
IGL02171:Dcdc2a APN 13 25,240,417 (GRCm39) missense probably damaging 1.00
IGL02490:Dcdc2a APN 13 25,291,635 (GRCm39) missense probably damaging 1.00
R0128:Dcdc2a UTSW 13 25,371,655 (GRCm39) splice site probably benign
R0130:Dcdc2a UTSW 13 25,371,655 (GRCm39) splice site probably benign
R0366:Dcdc2a UTSW 13 25,240,417 (GRCm39) missense probably damaging 1.00
R0507:Dcdc2a UTSW 13 25,286,572 (GRCm39) missense probably damaging 0.99
R0514:Dcdc2a UTSW 13 25,303,369 (GRCm39) missense probably benign 0.04
R1055:Dcdc2a UTSW 13 25,286,593 (GRCm39) missense probably damaging 0.99
R1301:Dcdc2a UTSW 13 25,286,569 (GRCm39) missense possibly damaging 0.93
R1514:Dcdc2a UTSW 13 25,245,237 (GRCm39) missense probably benign 0.05
R1842:Dcdc2a UTSW 13 25,291,585 (GRCm39) missense probably damaging 1.00
R2060:Dcdc2a UTSW 13 25,291,693 (GRCm39) missense possibly damaging 0.59
R2121:Dcdc2a UTSW 13 25,303,268 (GRCm39) missense possibly damaging 0.93
R2122:Dcdc2a UTSW 13 25,303,268 (GRCm39) missense possibly damaging 0.93
R2900:Dcdc2a UTSW 13 25,304,481 (GRCm39) missense probably benign 0.01
R3153:Dcdc2a UTSW 13 25,286,340 (GRCm39) missense probably benign 0.03
R3154:Dcdc2a UTSW 13 25,286,340 (GRCm39) missense probably benign 0.03
R4353:Dcdc2a UTSW 13 25,240,474 (GRCm39) missense probably damaging 1.00
R4608:Dcdc2a UTSW 13 25,245,223 (GRCm39) nonsense probably null
R5099:Dcdc2a UTSW 13 25,291,681 (GRCm39) missense probably benign 0.12
R5128:Dcdc2a UTSW 13 25,286,512 (GRCm39) missense probably damaging 1.00
R5181:Dcdc2a UTSW 13 25,386,347 (GRCm39) missense possibly damaging 0.94
R5271:Dcdc2a UTSW 13 25,371,671 (GRCm39) missense probably benign 0.35
R5869:Dcdc2a UTSW 13 25,291,713 (GRCm39) missense probably benign 0.05
R6058:Dcdc2a UTSW 13 25,240,354 (GRCm39) missense possibly damaging 0.82
R6146:Dcdc2a UTSW 13 25,389,440 (GRCm39) missense probably benign 0.35
R6892:Dcdc2a UTSW 13 25,240,443 (GRCm39) missense probably damaging 1.00
R6956:Dcdc2a UTSW 13 25,303,349 (GRCm39) missense probably benign 0.02
R6972:Dcdc2a UTSW 13 25,304,372 (GRCm39) intron probably benign
R6973:Dcdc2a UTSW 13 25,304,372 (GRCm39) intron probably benign
R7097:Dcdc2a UTSW 13 25,291,681 (GRCm39) missense probably benign 0.12
R7247:Dcdc2a UTSW 13 25,286,374 (GRCm39) missense probably benign 0.00
R7390:Dcdc2a UTSW 13 25,291,600 (GRCm39) missense possibly damaging 0.89
R7570:Dcdc2a UTSW 13 25,303,356 (GRCm39) missense probably benign
R7636:Dcdc2a UTSW 13 25,286,605 (GRCm39) missense probably damaging 1.00
R7644:Dcdc2a UTSW 13 25,291,674 (GRCm39) missense probably damaging 1.00
R7898:Dcdc2a UTSW 13 25,286,361 (GRCm39) missense possibly damaging 0.67
R8070:Dcdc2a UTSW 13 25,386,180 (GRCm39) missense probably benign 0.00
R8183:Dcdc2a UTSW 13 25,291,633 (GRCm39) missense possibly damaging 0.95
R8829:Dcdc2a UTSW 13 25,294,051 (GRCm39) nonsense probably null
R8865:Dcdc2a UTSW 13 25,386,266 (GRCm39) missense probably benign 0.00
R8867:Dcdc2a UTSW 13 25,386,266 (GRCm39) missense probably benign 0.00
R8868:Dcdc2a UTSW 13 25,386,266 (GRCm39) missense probably benign 0.00
R9290:Dcdc2a UTSW 13 25,386,313 (GRCm39) missense probably benign
R9694:Dcdc2a UTSW 13 25,286,340 (GRCm39) missense probably benign 0.27
R9760:Dcdc2a UTSW 13 25,389,443 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2014-01-15