Incidental Mutation 'R1212:Vmn1r64'
| ID |
99442 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r64
|
| Ensembl Gene |
ENSMUSG00000058399 |
| Gene Name |
vomeronasal 1 receptor 64 |
| Synonyms |
V1rd11 |
| MMRRC Submission |
039281-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.053)
|
| Stock # |
R1212 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
5886579-5887541 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 5887210 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Asparagine
at position 111
(S111N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000077568
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000078475]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000078475
AA Change: S111N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000077568
Gene: ENSMUSG00000058399
AA Change: S111N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
8 |
296 |
3.3e-13 |
PFAM |
|
Pfam:V1R
|
41 |
296 |
1.5e-19 |
PFAM |
|
| Coding Region Coverage |
- 1x: 98.7%
- 3x: 97.4%
- 10x: 93.2%
- 20x: 82.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 14 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ambra1 |
G |
A |
2: 91,599,381 (GRCm39) |
R167H |
possibly damaging |
Het |
| Ankrd50 |
G |
A |
3: 38,509,836 (GRCm39) |
R844C |
probably damaging |
Het |
| Arfgef1 |
T |
C |
1: 10,286,784 (GRCm39) |
E42G |
probably benign |
Het |
| Arhgap42 |
T |
A |
9: 9,015,313 (GRCm39) |
I444F |
probably damaging |
Het |
| Cspg4b |
G |
A |
13: 113,505,951 (GRCm39) |
|
probably benign |
Het |
| Ift56 |
A |
G |
6: 38,387,728 (GRCm39) |
D393G |
probably damaging |
Het |
| Ift70a2 |
A |
T |
2: 75,806,823 (GRCm39) |
I563N |
probably damaging |
Het |
| Il25 |
G |
A |
14: 55,170,212 (GRCm39) |
|
probably benign |
Het |
| Jak1 |
A |
G |
4: 101,046,291 (GRCm39) |
L105P |
probably damaging |
Het |
| Or2ad1 |
C |
T |
13: 21,326,337 (GRCm39) |
V297I |
probably benign |
Het |
| Ralgapa2 |
A |
G |
2: 146,199,902 (GRCm39) |
V1214A |
probably benign |
Het |
| Shtn1 |
T |
C |
19: 59,039,322 (GRCm39) |
D39G |
probably damaging |
Het |
| Supt16 |
G |
A |
14: 52,411,581 (GRCm39) |
R601* |
probably null |
Het |
| Vmn1r113 |
A |
T |
7: 20,521,356 (GRCm39) |
R49S |
probably benign |
Het |
|
| Other mutations in Vmn1r64 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00161:Vmn1r64
|
APN |
7 |
5,886,827 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01070:Vmn1r64
|
APN |
7 |
5,886,941 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01817:Vmn1r64
|
APN |
7 |
5,887,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02026:Vmn1r64
|
APN |
7 |
5,886,649 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02657:Vmn1r64
|
APN |
7 |
5,886,727 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL03352:Vmn1r64
|
APN |
7 |
5,887,070 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0200:Vmn1r64
|
UTSW |
7 |
5,886,817 (GRCm39) |
missense |
probably benign |
0.38 |
|
R0540:Vmn1r64
|
UTSW |
7 |
5,887,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0655:Vmn1r64
|
UTSW |
7 |
5,887,207 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1579:Vmn1r64
|
UTSW |
7 |
5,886,803 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2034:Vmn1r64
|
UTSW |
7 |
5,886,988 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2221:Vmn1r64
|
UTSW |
7 |
5,887,448 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2240:Vmn1r64
|
UTSW |
7 |
5,887,369 (GRCm39) |
nonsense |
probably null |
|
|
R2305:Vmn1r64
|
UTSW |
7 |
5,887,535 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3019:Vmn1r64
|
UTSW |
7 |
5,887,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4256:Vmn1r64
|
UTSW |
7 |
5,886,895 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4666:Vmn1r64
|
UTSW |
7 |
5,887,357 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4996:Vmn1r64
|
UTSW |
7 |
5,887,052 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5682:Vmn1r64
|
UTSW |
7 |
5,886,622 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5730:Vmn1r64
|
UTSW |
7 |
5,887,522 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7397:Vmn1r64
|
UTSW |
7 |
5,887,013 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9697:Vmn1r64
|
UTSW |
7 |
5,886,859 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0063:Vmn1r64
|
UTSW |
7 |
5,887,349 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGACCCCAGAGATGGAGCATATCC -3'
(R):5'- AGTCTTGACTGACTCCCGACTGAG -3'
Sequencing Primer
(F):5'- CAGAGATGGAGCATATCCAATTGTC -3'
(R):5'- TGAGGCCCATACAGGTCATTC -3'
|
| Posted On |
2014-01-15 |
Incidental Mutation