Incidental Mutation 'R1213:Or13n4'
ID 99483
Institutional Source Beutler Lab
Gene Symbol Or13n4
Ensembl Gene ENSMUSG00000056863
Gene Name olfactory receptor family 13 subfamily N member 4
Synonyms GA_x6K02T2PBJ9-9202245-9201289, MOR260-4, Olfr702
MMRRC Submission 039282-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R1213 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 106422696-106425950 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 106423404 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 110 (T110S)
Ref Sequence ENSEMBL: ENSMUSP00000146445 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075414] [ENSMUST00000080899] [ENSMUST00000208864] [ENSMUST00000208895] [ENSMUST00000217739] [ENSMUST00000219803]
AlphaFold Q920Z2
Predicted Effect probably benign
Transcript: ENSMUST00000075414
SMART Domains Protein: ENSMUSP00000074868
Gene: ENSMUSG00000036744

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.9e-46 PFAM
Pfam:7tm_1 41 290 2.3e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080899
AA Change: T110S

PolyPhen 2 Score 0.127 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000079704
Gene: ENSMUSG00000056863
AA Change: T110S

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 2.7e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 300 2.9e-8 PFAM
Pfam:7tm_1 41 290 1.5e-26 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000208864
AA Change: T110S

PolyPhen 2 Score 0.480 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect probably benign
Transcript: ENSMUST00000208895
AA Change: T110S

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000217739
Predicted Effect probably benign
Transcript: ENSMUST00000219803
AA Change: T110S

PolyPhen 2 Score 0.127 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.3%
  • 10x: 95.2%
  • 20x: 87.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agfg1 T C 1: 82,853,055 (GRCm39) S142P probably damaging Het
Appl1 G A 14: 26,665,950 (GRCm39) A388V probably benign Het
Atp11a A G 8: 12,892,859 (GRCm39) R70G probably benign Het
Atrnl1 G A 19: 57,626,894 (GRCm39) V167I probably benign Het
Bfar T C 16: 13,505,308 (GRCm39) I106T possibly damaging Het
Cbx8 T C 11: 118,930,359 (GRCm39) probably null Het
Cd80 T C 16: 38,294,245 (GRCm39) S43P probably damaging Het
Fat4 G A 3: 38,944,520 (GRCm39) A1138T probably benign Het
Fcgbpl1 T C 7: 27,857,098 (GRCm39) S2149P probably damaging Het
Fmo3 C A 1: 162,795,392 (GRCm39) G148W probably damaging Het
Ftdc2 A T 16: 58,458,057 (GRCm39) Y81* probably null Het
Krt78 T C 15: 101,860,245 (GRCm39) M224V probably benign Het
Moxd2 A G 6: 40,868,831 (GRCm39) probably benign Het
Or2y14 T A 11: 49,405,421 (GRCm39) *319K probably null Het
Or6d15 A G 6: 116,559,827 (GRCm39) S27P probably benign Het
Pax6 G A 2: 105,516,258 (GRCm39) G179R probably benign Het
Rbm12 G A 2: 155,939,412 (GRCm39) Q287* probably null Het
Rtel1 T A 2: 180,993,128 (GRCm39) H703Q probably benign Het
Spag17 A G 3: 100,002,954 (GRCm39) R1893G probably benign Het
Synpo A G 18: 60,735,525 (GRCm39) V807A possibly damaging Het
Other mutations in Or13n4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01549:Or13n4 APN 7 106,423,236 (GRCm39) missense probably benign 0.01
IGL02120:Or13n4 APN 7 106,422,905 (GRCm39) missense possibly damaging 0.94
R0025:Or13n4 UTSW 7 106,422,963 (GRCm39) missense possibly damaging 0.74
R1830:Or13n4 UTSW 7 106,423,317 (GRCm39) missense probably benign 0.00
R2216:Or13n4 UTSW 7 106,423,205 (GRCm39) missense probably damaging 0.99
R2571:Or13n4 UTSW 7 106,422,933 (GRCm39) missense probably benign 0.09
R2876:Or13n4 UTSW 7 106,423,664 (GRCm39) missense probably benign 0.07
R2920:Or13n4 UTSW 7 106,423,571 (GRCm39) missense probably benign 0.11
R4082:Or13n4 UTSW 7 106,423,245 (GRCm39) missense possibly damaging 0.78
R4130:Or13n4 UTSW 7 106,422,792 (GRCm39) missense probably benign 0.01
R4750:Or13n4 UTSW 7 106,423,514 (GRCm39) missense probably damaging 0.98
R5007:Or13n4 UTSW 7 106,423,364 (GRCm39) missense probably damaging 1.00
R5117:Or13n4 UTSW 7 106,422,869 (GRCm39) missense probably damaging 0.99
R5908:Or13n4 UTSW 7 106,423,404 (GRCm39) missense probably benign 0.09
R6824:Or13n4 UTSW 7 106,423,664 (GRCm39) missense probably benign 0.00
R7193:Or13n4 UTSW 7 106,423,798 (GRCm39) start gained probably benign
R7254:Or13n4 UTSW 7 106,422,777 (GRCm39) makesense probably null
R7827:Or13n4 UTSW 7 106,422,932 (GRCm39) missense probably benign 0.01
R8309:Or13n4 UTSW 7 106,423,620 (GRCm39) missense probably benign 0.00
R8410:Or13n4 UTSW 7 106,423,745 (GRCm39) start gained probably benign
R9353:Or13n4 UTSW 7 106,423,062 (GRCm39) missense probably benign 0.00
R9386:Or13n4 UTSW 7 106,423,707 (GRCm39) missense probably benign
R9562:Or13n4 UTSW 7 106,423,020 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCACTGTCCACTGAACATGCAAA -3'
(R):5'- ACATTGCTTTTCCTTCTGACAACAGGT -3'

Sequencing Primer
(F):5'- ATGCCCCACTGATCCAGG -3'
(R):5'- TCTACTGGGACTCTCAGAGAATC -3'
Posted On 2014-01-15