Mutagenetix > Incidental Mutation

Incidental Mutation 'R1173:Vmn2r12'

99676

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r12

Ensembl Gene

ENSMUSG00000090688

Gene Name

vomeronasal 2, receptor 12

Synonyms

Gm6769

MMRRC Submission

039246-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R1173 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

109085849-109097864 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 109092854 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 131 (I131N)

Ref Sequence

ENSEMBL: ENSMUSP00000093612 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095922]

AlphaFold

L7N217

Predicted Effect

probably benign
Transcript: ENSMUST00000095922
AA Change: I131N

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000093612
Gene: ENSMUSG00000090688
AA Change: I131N

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	76	466	8.8e-30	PFAM
Pfam:NCD3G	505	559	1.7e-18	PFAM
Pfam:7tm_3	591	827	3.9e-54	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 98.9%
3x: 97.8%
10x: 94.7%
20x: 87.9%

Validation Efficiency

99% (72/73)

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921507P07Rik	T	A	6: 50,589,141	K118M	probably damaging	Het
Accsl	A	T	2: 93,866,244		probably benign	Het
Adam30	G	A	3: 98,162,906	S685N	probably benign	Het
Adamts12	T	C	15: 11,071,757	V129A	probably benign	Het
Agxt2	T	C	15: 10,373,751	F81S	probably damaging	Het
Ahnak2	A	T	12: 112,785,789	I186N	probably damaging	Het
Amz1	A	T	5: 140,751,936		probably null	Het
Anapc5	G	A	5: 122,788,418	A619V	possibly damaging	Het
Bbox1	T	C	2: 110,265,611	D336G	probably damaging	Het
Bivm	A	G	1: 44,126,782	T131A	probably benign	Het
Bpi	A	T	2: 158,267,740	I203F	probably benign	Het
Cd151	A	C	7: 141,470,656	T241P	probably damaging	Het
Cdh23	G	A	10: 60,312,392		probably benign	Het
Cdh7	G	A	1: 110,061,132	V255I	probably benign	Het
Cul9	C	G	17: 46,522,175	A1326P	probably damaging	Het
Dclre1b	A	C	3: 103,803,876	S240A	probably benign	Het
Ddc	A	C	11: 11,846,634		probably null	Het
Dkk1	T	C	19: 30,547,250	R252G	probably damaging	Het
Dmrtc2	T	A	7: 24,874,313	M191K	possibly damaging	Het
Eml6	A	G	11: 29,749,824	S1771P	possibly damaging	Het
Emx1	T	C	6: 85,188,371		probably benign	Het
Fah	T	C	7: 84,601,136	M1V	probably null	Het
Fmo6	A	T	1: 162,926,141	M144K	probably damaging	Het
Frem1	A	G	4: 82,950,352	V1445A	probably benign	Het
Fsd2	T	C	7: 81,559,770	D108G	probably benign	Het
Gfm2	A	G	13: 97,165,200		probably null	Het
Ghrhr	T	A	6: 55,388,269	L416*	probably null	Het
Glipr1l2	C	A	10: 112,083,466	L31I	possibly damaging	Het
Gm19965	T	A	1: 116,820,820		probably benign	Het
Gpr149	A	G	3: 62,604,467	L37P	probably damaging	Het
Hoxa9	A	G	6: 52,225,713	I131T	probably damaging	Het
Htra4	T	C	8: 25,030,619	D342G	possibly damaging	Het
Idh1	G	T	1: 65,161,160	N348K	probably benign	Het
Impdh2	T	C	9: 108,561,829	F99S	probably benign	Het
Kank4	T	C	4: 98,765,569	Y874C	probably damaging	Het
Kazn	A	T	4: 142,159,038		probably benign	Het
Kcnq3	T	A	15: 66,000,042	T593S	probably benign	Het
Lamc1	T	C	1: 153,247,231		probably benign	Het
Magi3	A	G	3: 104,061,630		probably null	Het
Map3k19	A	G	1: 127,823,880	V578A	probably benign	Het
Meox2	T	C	12: 37,109,152	C108R	possibly damaging	Het
Nlrp9c	C	A	7: 26,380,435	C722F	probably damaging	Het
Olfr448	T	C	6: 42,897,351	V300A	probably benign	Het
Pde10a	C	T	17: 8,920,546		probably benign	Het
Ppfia4	A	G	1: 134,332,283		probably benign	Het
Psg18	T	C	7: 18,354,817	M1V	probably null	Het
Qtrt1	A	G	9: 21,412,486	T136A	probably benign	Het
Retsat	T	C	6: 72,603,651		probably benign	Het
Rxfp2	T	C	5: 150,051,556	V210A	probably benign	Het
Sfswap	G	A	5: 129,507,143		probably null	Het
Slc16a7	A	T	10: 125,231,372	L133I	possibly damaging	Het
Slc30a3	A	T	5: 31,086,810	M376K	probably damaging	Het
Srbd1	C	T	17: 86,098,512	C620Y	probably null	Het
Svs1	C	A	6: 48,990,239	P707H	probably damaging	Het
Trip10	T	A	17: 57,253,363	L100Q	probably damaging	Het
Tyrp1	C	T	4: 80,844,868	Q331*	probably null	Het
Vangl2	G	T	1: 172,004,786	T501N	probably damaging	Het
Vdr	A	T	15: 97,869,333	Y185N	probably benign	Het
Vmn1r123	C	T	7: 21,162,332	P50S	probably damaging	Het
Vmn1r158	T	A	7: 22,790,445	H113L	probably benign	Het
Vmn2r72	T	A	7: 85,751,944	E89V	probably damaging	Het
Xrcc6	A	G	15: 82,031,163	D94G	probably damaging	Het
Zbtb32	T	A	7: 30,591,267	E201V	possibly damaging	Het
Zfp185	A	T	X: 72,999,323	E138D	possibly damaging	Het
Zmynd11	T	A	13: 9,689,549	H437L	probably damaging	Het

Other mutations in Vmn2r12

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00948:Vmn2r12	APN	5	109097675	missense	possibly damaging	0.47
IGL01096:Vmn2r12	APN	5	109086259	missense	probably damaging	1.00
IGL01538:Vmn2r12	APN	5	109091850	missense	probably damaging	1.00
IGL01548:Vmn2r12	APN	5	109093027	nonsense	probably null
IGL01762:Vmn2r12	APN	5	109086564	missense	probably damaging	0.99
IGL01860:Vmn2r12	APN	5	109092159	missense	probably benign	0.10
IGL02269:Vmn2r12	APN	5	109086477	missense	probably damaging	1.00
IGL02530:Vmn2r12	APN	5	109085992	missense	probably damaging	1.00
IGL02887:Vmn2r12	APN	5	109090485	missense	probably benign	0.03
IGL03265:Vmn2r12	APN	5	109092070	missense	probably benign	0.05
R0396:Vmn2r12	UTSW	5	109092899	missense	probably benign	0.00
R0497:Vmn2r12	UTSW	5	109091889	nonsense	probably null
R0529:Vmn2r12	UTSW	5	109092848	missense	probably benign
R0715:Vmn2r12	UTSW	5	109090507	missense	probably benign	0.10
R0742:Vmn2r12	UTSW	5	109086415	missense	possibly damaging	0.55
R0894:Vmn2r12	UTSW	5	109087850	critical splice donor site	probably null
R1174:Vmn2r12	UTSW	5	109092854	missense	probably benign	0.00
R1259:Vmn2r12	UTSW	5	109091897	missense	probably damaging	0.97
R1349:Vmn2r12	UTSW	5	109086586	missense	probably benign	0.00
R1388:Vmn2r12	UTSW	5	109092974	missense	possibly damaging	0.56
R1549:Vmn2r12	UTSW	5	109092830	missense	probably benign	0.06
R1766:Vmn2r12	UTSW	5	109092044	missense	probably damaging	1.00
R1781:Vmn2r12	UTSW	5	109091728	missense	probably benign	0.00
R1885:Vmn2r12	UTSW	5	109092076	missense	probably damaging	1.00
R2159:Vmn2r12	UTSW	5	109091474	missense	probably benign	0.02
R2420:Vmn2r12	UTSW	5	109086532	missense	probably benign	0.39
R2421:Vmn2r12	UTSW	5	109086532	missense	probably benign	0.39
R2422:Vmn2r12	UTSW	5	109086532	missense	probably benign	0.39
R2937:Vmn2r12	UTSW	5	109091531	missense	probably damaging	1.00
R2938:Vmn2r12	UTSW	5	109091531	missense	probably damaging	1.00
R3898:Vmn2r12	UTSW	5	109090504	missense	probably benign	0.02
R4061:Vmn2r12	UTSW	5	109092192	missense	possibly damaging	0.95
R4063:Vmn2r12	UTSW	5	109092192	missense	possibly damaging	0.95
R4090:Vmn2r12	UTSW	5	109091546	missense	probably benign	0.06
R4297:Vmn2r12	UTSW	5	109091964	missense	probably benign	0.12
R4298:Vmn2r12	UTSW	5	109091964	missense	probably benign	0.12
R4299:Vmn2r12	UTSW	5	109091964	missense	probably benign	0.12
R4304:Vmn2r12	UTSW	5	109086006	missense	probably damaging	1.00
R4306:Vmn2r12	UTSW	5	109086006	missense	probably damaging	1.00
R4307:Vmn2r12	UTSW	5	109086006	missense	probably damaging	1.00
R4308:Vmn2r12	UTSW	5	109086006	missense	probably damaging	1.00
R4594:Vmn2r12	UTSW	5	109086435	missense	probably damaging	1.00
R4783:Vmn2r12	UTSW	5	109086513	missense	probably damaging	1.00
R4900:Vmn2r12	UTSW	5	109092986	missense	probably damaging	1.00
R4929:Vmn2r12	UTSW	5	109091678	missense	probably damaging	1.00
R4974:Vmn2r12	UTSW	5	109091506	missense	probably damaging	1.00
R5389:Vmn2r12	UTSW	5	109090395	missense	probably benign	0.00
R5431:Vmn2r12	UTSW	5	109091818	missense	probably damaging	0.99
R5527:Vmn2r12	UTSW	5	109086617	nonsense	probably null
R5639:Vmn2r12	UTSW	5	109092800	missense	probably benign	0.06
R5753:Vmn2r12	UTSW	5	109091804	missense	probably damaging	1.00
R5797:Vmn2r12	UTSW	5	109085870	nonsense	probably null
R6142:Vmn2r12	UTSW	5	109092897	missense	probably benign
R6162:Vmn2r12	UTSW	5	109086564	missense	probably damaging	0.99
R6176:Vmn2r12	UTSW	5	109086000	missense	probably benign	0.43
R6853:Vmn2r12	UTSW	5	109092905	missense	probably damaging	1.00
R7238:Vmn2r12	UTSW	5	109097789	missense	possibly damaging	0.81
R7341:Vmn2r12	UTSW	5	109086247	missense	possibly damaging	0.74
R7341:Vmn2r12	UTSW	5	109091945	missense	possibly damaging	0.95
R7383:Vmn2r12	UTSW	5	109092818	missense	probably benign	0.19
R7740:Vmn2r12	UTSW	5	109091749	missense	probably damaging	1.00
R7749:Vmn2r12	UTSW	5	109086054	missense	probably damaging	0.99
R7861:Vmn2r12	UTSW	5	109087963	missense	probably benign	0.00
R7908:Vmn2r12	UTSW	5	109086441	missense	probably damaging	1.00
R8128:Vmn2r12	UTSW	5	109091881	missense	possibly damaging	0.81
R8175:Vmn2r12	UTSW	5	109090483	missense	probably damaging	0.97
R8234:Vmn2r12	UTSW	5	109086208	missense	probably benign	0.01
R8771:Vmn2r12	UTSW	5	109092086	missense	possibly damaging	0.95
R8947:Vmn2r12	UTSW	5	109086656	missense	possibly damaging	0.64
R8991:Vmn2r12	UTSW	5	109086167	nonsense	probably null
R9116:Vmn2r12	UTSW	5	109086019	missense	probably damaging	1.00
R9122:Vmn2r12	UTSW	5	109093044	missense	probably benign	0.00
R9153:Vmn2r12	UTSW	5	109086337	missense	probably damaging	1.00
R9371:Vmn2r12	UTSW	5	109086586	missense	probably benign	0.00
R9375:Vmn2r12	UTSW	5	109086120	missense	probably damaging	1.00
R9524:Vmn2r12	UTSW	5	109091957	missense	probably damaging	1.00
R9587:Vmn2r12	UTSW	5	109091456	missense	probably damaging	0.99
Z1088:Vmn2r12	UTSW	5	109092780	missense	probably benign
Z1176:Vmn2r12	UTSW	5	109091437	missense	probably benign	0.01

Predicted Primers

Posted On

2014-01-15