Incidental Mutation 'R1173:Psg18'
ID 99698
Institutional Source Beutler Lab
Gene Symbol Psg18
Ensembl Gene ENSMUSG00000003505
Gene Name pregnancy specific beta-1-glycoprotein 18
Synonyms Cea-3, mmCGM6, Cea3
MMRRC Submission 039246-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R1173 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 18079669-18088963 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) T to C at 18088742 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 1 (M1V)
Ref Sequence ENSEMBL: ENSMUSP00000003597 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003597] [ENSMUST00000098783]
AlphaFold B2RSG7
Predicted Effect probably null
Transcript: ENSMUST00000003597
AA Change: M1V

PolyPhen 2 Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000003597
Gene: ENSMUSG00000003505
AA Change: M1V

DomainStartEndE-ValueType
low complexity region 19 30 N/A INTRINSIC
IG 40 140 2.11e-2 SMART
IG 161 262 1.03e0 SMART
IG 281 380 2.15e-3 SMART
IGc2 398 462 1.58e-10 SMART
Predicted Effect probably null
Transcript: ENSMUST00000098783
AA Change: M1V

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000096380
Gene: ENSMUSG00000003505
AA Change: M1V

DomainStartEndE-ValueType
IG 40 141 1.03e0 SMART
IG 160 259 2.15e-3 SMART
Meta Mutation Damage Score 0.9484 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.7%
  • 20x: 87.9%
Validation Efficiency 99% (72/73)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Accsl A T 2: 93,696,589 (GRCm39) probably benign Het
Adam30 G A 3: 98,070,222 (GRCm39) S685N probably benign Het
Adamts12 T C 15: 11,071,843 (GRCm39) V129A probably benign Het
Agxt2 T C 15: 10,373,837 (GRCm39) F81S probably damaging Het
Ahnak2 A T 12: 112,749,409 (GRCm39) I186N probably damaging Het
Amz1 A T 5: 140,737,691 (GRCm39) probably null Het
Anapc5 G A 5: 122,926,481 (GRCm39) A619V possibly damaging Het
Aoc1l3 C A 6: 48,967,173 (GRCm39) P707H probably damaging Het
Bbox1 T C 2: 110,095,956 (GRCm39) D336G probably damaging Het
Bivm A G 1: 44,165,942 (GRCm39) T131A probably benign Het
Bpi A T 2: 158,109,660 (GRCm39) I203F probably benign Het
Cd151 A C 7: 141,050,569 (GRCm39) T241P probably damaging Het
Cdh20 G A 1: 109,988,862 (GRCm39) V255I probably benign Het
Cdh23 G A 10: 60,148,171 (GRCm39) probably benign Het
Cul9 C G 17: 46,833,101 (GRCm39) A1326P probably damaging Het
Dclre1b A C 3: 103,711,192 (GRCm39) S240A probably benign Het
Ddc A C 11: 11,796,634 (GRCm39) probably null Het
Dkk1 T C 19: 30,524,650 (GRCm39) R252G probably damaging Het
Dmrtc2 T A 7: 24,573,738 (GRCm39) M191K possibly damaging Het
Eml6 A G 11: 29,699,824 (GRCm39) S1771P possibly damaging Het
Emx1 T C 6: 85,165,353 (GRCm39) probably benign Het
Fah T C 7: 84,250,344 (GRCm39) M1V probably null Het
Fmo6 A T 1: 162,753,710 (GRCm39) M144K probably damaging Het
Frem1 A G 4: 82,868,589 (GRCm39) V1445A probably benign Het
Fsd2 T C 7: 81,209,518 (GRCm39) D108G probably benign Het
Gfm2 A G 13: 97,301,708 (GRCm39) probably null Het
Ghrhr T A 6: 55,365,254 (GRCm39) L416* probably null Het
Glipr1l2 C A 10: 111,919,371 (GRCm39) L31I possibly damaging Het
Gm19965 T A 1: 116,748,550 (GRCm39) probably benign Het
Gpr149 A G 3: 62,511,888 (GRCm39) L37P probably damaging Het
Hoxa9 A G 6: 52,202,693 (GRCm39) I131T probably damaging Het
Htra4 T C 8: 25,520,635 (GRCm39) D342G possibly damaging Het
Idh1 G T 1: 65,200,319 (GRCm39) N348K probably benign Het
Impdh2 T C 9: 108,439,028 (GRCm39) F99S probably benign Het
Kank4 T C 4: 98,653,806 (GRCm39) Y874C probably damaging Het
Kazn A T 4: 141,886,349 (GRCm39) probably benign Het
Kcnq3 T A 15: 65,871,891 (GRCm39) T593S probably benign Het
Lamc1 T C 1: 153,122,977 (GRCm39) probably benign Het
Magi3 A G 3: 103,968,946 (GRCm39) probably null Het
Map3k19 A G 1: 127,751,617 (GRCm39) V578A probably benign Het
Meox2 T C 12: 37,159,151 (GRCm39) C108R possibly damaging Het
Nlrp9c C A 7: 26,079,860 (GRCm39) C722F probably damaging Het
Or2a5 T C 6: 42,874,285 (GRCm39) V300A probably benign Het
Pde10a C T 17: 9,139,378 (GRCm39) probably benign Het
Ppfia4 A G 1: 134,260,021 (GRCm39) probably benign Het
Qtrt1 A G 9: 21,323,782 (GRCm39) T136A probably benign Het
Retsat T C 6: 72,580,634 (GRCm39) probably benign Het
Rxfp2 T C 5: 149,975,021 (GRCm39) V210A probably benign Het
Sfswap G A 5: 129,584,207 (GRCm39) probably null Het
Slc16a7 A T 10: 125,067,241 (GRCm39) L133I possibly damaging Het
Slc30a3 A T 5: 31,244,154 (GRCm39) M376K probably damaging Het
Spmip4 T A 6: 50,566,121 (GRCm39) K118M probably damaging Het
Srbd1 C T 17: 86,405,940 (GRCm39) C620Y probably null Het
Trip10 T A 17: 57,560,363 (GRCm39) L100Q probably damaging Het
Tyrp1 C T 4: 80,763,105 (GRCm39) Q331* probably null Het
Vangl2 G T 1: 171,832,353 (GRCm39) T501N probably damaging Het
Vdr A T 15: 97,767,214 (GRCm39) Y185N probably benign Het
Vmn1r123 C T 7: 20,896,257 (GRCm39) P50S probably damaging Het
Vmn1r158 T A 7: 22,489,870 (GRCm39) H113L probably benign Het
Vmn2r12 A T 5: 109,240,720 (GRCm39) I131N probably benign Het
Vmn2r72 T A 7: 85,401,152 (GRCm39) E89V probably damaging Het
Xrcc6 A G 15: 81,915,364 (GRCm39) D94G probably damaging Het
Zbtb32 T A 7: 30,290,692 (GRCm39) E201V possibly damaging Het
Zfp185 A T X: 72,042,929 (GRCm39) E138D possibly damaging Het
Zmynd11 T A 13: 9,739,585 (GRCm39) H437L probably damaging Het
Other mutations in Psg18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01458:Psg18 APN 7 18,088,741 (GRCm39) start codon destroyed probably null 0.99
IGL01748:Psg18 APN 7 18,087,476 (GRCm39) missense probably benign 0.05
IGL01767:Psg18 APN 7 18,087,322 (GRCm39) missense possibly damaging 0.80
IGL02727:Psg18 APN 7 18,079,875 (GRCm39) missense probably damaging 1.00
IGL02744:Psg18 APN 7 18,083,327 (GRCm39) missense probably benign 0.38
G1Funyon:Psg18 UTSW 7 18,087,302 (GRCm39) missense probably damaging 0.99
PIT4466001:Psg18 UTSW 7 18,083,241 (GRCm39) missense probably benign 0.30
R0331:Psg18 UTSW 7 18,087,233 (GRCm39) missense probably benign 0.03
R1077:Psg18 UTSW 7 18,085,000 (GRCm39) missense possibly damaging 0.84
R1171:Psg18 UTSW 7 18,080,004 (GRCm39) missense probably benign 0.10
R1234:Psg18 UTSW 7 18,083,115 (GRCm39) missense probably damaging 1.00
R1553:Psg18 UTSW 7 18,087,406 (GRCm39) missense probably benign 0.19
R1632:Psg18 UTSW 7 18,084,824 (GRCm39) missense probably benign 0.02
R2108:Psg18 UTSW 7 18,084,799 (GRCm39) missense probably damaging 1.00
R2439:Psg18 UTSW 7 18,080,044 (GRCm39) missense probably benign 0.24
R3032:Psg18 UTSW 7 18,084,904 (GRCm39) missense probably benign 0.01
R3053:Psg18 UTSW 7 18,083,118 (GRCm39) missense probably damaging 1.00
R3432:Psg18 UTSW 7 18,083,096 (GRCm39) missense possibly damaging 0.61
R3725:Psg18 UTSW 7 18,088,748 (GRCm39) start gained probably benign
R4479:Psg18 UTSW 7 18,084,787 (GRCm39) missense probably benign 0.01
R4480:Psg18 UTSW 7 18,084,787 (GRCm39) missense probably benign 0.01
R4846:Psg18 UTSW 7 18,084,711 (GRCm39) nonsense probably null
R4858:Psg18 UTSW 7 18,087,409 (GRCm39) missense possibly damaging 0.49
R5010:Psg18 UTSW 7 18,083,279 (GRCm39) missense probably damaging 1.00
R5225:Psg18 UTSW 7 18,079,874 (GRCm39) missense probably damaging 1.00
R5450:Psg18 UTSW 7 18,087,350 (GRCm39) missense probably benign 0.32
R5526:Psg18 UTSW 7 18,083,273 (GRCm39) missense probably damaging 1.00
R5840:Psg18 UTSW 7 18,080,527 (GRCm39) intron probably benign
R6409:Psg18 UTSW 7 18,087,446 (GRCm39) missense probably benign
R7164:Psg18 UTSW 7 18,084,862 (GRCm39) missense possibly damaging 0.89
R7276:Psg18 UTSW 7 18,079,909 (GRCm39) missense probably damaging 0.99
R7768:Psg18 UTSW 7 18,079,953 (GRCm39) missense probably damaging 1.00
R8301:Psg18 UTSW 7 18,087,302 (GRCm39) missense probably damaging 0.99
R8700:Psg18 UTSW 7 18,087,550 (GRCm39) missense probably damaging 1.00
R8982:Psg18 UTSW 7 18,083,300 (GRCm39) missense probably benign 0.20
R9042:Psg18 UTSW 7 18,083,047 (GRCm39) missense probably benign 0.44
R9054:Psg18 UTSW 7 18,087,450 (GRCm39) missense possibly damaging 0.82
R9442:Psg18 UTSW 7 18,083,185 (GRCm39) nonsense probably null
R9538:Psg18 UTSW 7 18,084,713 (GRCm39) missense probably benign 0.01
R9689:Psg18 UTSW 7 18,084,880 (GRCm39) missense probably benign 0.00
Z1176:Psg18 UTSW 7 18,088,712 (GRCm39) missense probably benign 0.07
Z1177:Psg18 UTSW 7 18,083,123 (GRCm39) missense probably benign 0.10
Z1177:Psg18 UTSW 7 18,083,040 (GRCm39) missense probably benign 0.30
Predicted Primers
Posted On 2014-01-15