Mutagenetix > Incidental Mutations

Incidental Mutation 'R1174:Tas2r140'

99809

Institutional Source

Beutler Lab

Gene Symbol

Tas2r140

Ensembl Gene

ENSMUSG00000071147

Gene Name

taste receptor, type 2, member 140

Synonyms

Tas2r40, TRB5, T2R40, TRB3, mTRB3, Tas2r13, mt2r64

MMRRC Submission

039247-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

R1174 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

133054817-133055816 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 133054871 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 308 (E308G)

Ref Sequence

ENSEMBL: ENSMUSP00000093040 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095391]

Predicted Effect

probably benign
Transcript: ENSMUST00000095391
AA Change: E308G

PolyPhen 2 Score 0.271 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000093040
Gene: ENSMUSG00000071147
AA Change: E308G

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	301	6.7e-86	PFAM

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.4%
20x: 89.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610318N02Rik	T	A	16: 17,117,582	H214L	probably benign	Het
4921507P07Rik	T	A	6: 50,589,141	K118M	probably damaging	Het
Actn3	A	G	19: 4,864,756	L477P	probably damaging	Het
Adamts12	T	C	15: 11,071,757	V129A	probably benign	Het
Agxt2	T	C	15: 10,373,751	F81S	probably damaging	Het
Alpk1	T	A	3: 127,680,810	S515C	probably damaging	Het
Bivm	A	G	1: 44,126,782	T131A	probably benign	Het
Borcs5	T	A	6: 134,710,133	N150K	probably damaging	Het
Cdh7	G	A	1: 110,061,132	V255I	probably benign	Het
Cox4i1	C	A	8: 120,674,050	N151K	probably benign	Het
Cpeb4	T	C	11: 31,920,472	L432P	probably damaging	Het
Dnajb11	T	A	16: 22,870,673	D281E	probably damaging	Het
Eml6	A	G	11: 29,749,824	S1771P	possibly damaging	Het
Fes	A	T	7: 80,377,951	I815N	probably damaging	Het
Ghrhr	T	A	6: 55,388,269	L416*	probably null	Het
Glipr1l2	C	A	10: 112,083,466	L31I	possibly damaging	Het
Gm10093	A	T	17: 78,492,078	Y166F	probably benign	Het
Gm1818	A	G	12: 48,556,199		noncoding transcript	Het
Gpr149	A	G	3: 62,604,467	L37P	probably damaging	Het
Hoxa9	A	G	6: 52,225,713	I131T	probably damaging	Het
Idh1	G	T	1: 65,161,160	N348K	probably benign	Het
Klf6	A	G	13: 5,861,712	D25G	probably benign	Het
Laptm4a	T	C	12: 8,936,716	V258A	probably damaging	Het
Lypd6b	C	T	2: 49,943,597	A83V	possibly damaging	Het
Map3k19	A	G	1: 127,823,880	V578A	probably benign	Het
Mfsd13a	T	A	19: 46,374,686	I511N	probably benign	Het
Mrm3	T	C	11: 76,250,024	V286A	probably damaging	Het
Muc6	C	T	7: 141,648,101	G708S	probably damaging	Het
Neurl4	T	C	11: 69,903,721		probably null	Het
Pclo	T	C	5: 14,677,646		probably benign	Het
Pcnt	A	T	10: 76,393,044		probably null	Het
Pik3r4	G	T	9: 105,663,174	G754C	probably damaging	Het
Qtrt1	A	G	9: 21,412,486	T136A	probably benign	Het
Rgs12	T	A	5: 34,966,465	C531S	probably benign	Het
Rin1	C	A	19: 5,055,203	Q764K	probably benign	Het
Robo4	C	T	9: 37,413,052	R959W	probably damaging	Het
Rxfp2	T	C	5: 150,051,556	V210A	probably benign	Het
Serpinb9d	C	T	13: 33,200,625	P195L	probably benign	Het
Sos1	A	C	17: 80,445,608	Y323*	probably null	Het
Ssxb8	T	G	X: 8,689,823	H88P	probably damaging	Het
Svs1	C	A	6: 48,990,239	P707H	probably damaging	Het
Tdo2	A	T	3: 81,974,376	S40R	probably damaging	Het
Tle4	C	T	19: 14,468,262	V207I	probably benign	Het
Txlnb	A	G	10: 17,842,756	N445S	probably benign	Het
Ubap2l	A	T	3: 90,023,500	S413T	probably benign	Het
Vangl2	G	T	1: 172,004,786	T501N	probably damaging	Het
Vmn2r12	A	T	5: 109,092,854	I131N	probably benign	Het
Vwa1	C	T	4: 155,773,266	G25D	probably damaging	Het
Zfp185	A	T	X: 72,999,323	E138D	possibly damaging	Het

Other mutations in Tas2r140

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0244:Tas2r140	UTSW	6	133055327	missense	possibly damaging	0.46
R0666:Tas2r140	UTSW	6	133055442	missense	probably benign	0.22
R1237:Tas2r140	UTSW	6	133055208	missense	probably benign	0.04
R1553:Tas2r140	UTSW	6	133055508	missense	probably damaging	0.99
R2030:Tas2r140	UTSW	6	133055250	missense	probably benign	0.23
R3123:Tas2r140	UTSW	6	133055241	missense	probably benign	0.05
R3124:Tas2r140	UTSW	6	133055241	missense	probably benign	0.05
R4233:Tas2r140	UTSW	6	133054952	missense	probably damaging	1.00
R4234:Tas2r140	UTSW	6	133054952	missense	probably damaging	1.00
R4236:Tas2r140	UTSW	6	133054952	missense	probably damaging	1.00
R4525:Tas2r140	UTSW	6	133055244	missense	possibly damaging	0.66
R4803:Tas2r140	UTSW	6	133055780	missense	possibly damaging	0.77
R4840:Tas2r140	UTSW	6	133055565	missense	probably benign	0.01
R5317:Tas2r140	UTSW	6	133055580	missense	probably benign	0.06
R5937:Tas2r140	UTSW	6	133055273	missense	probably benign	0.01
R6142:Tas2r140	UTSW	6	133055735	missense	probably damaging	1.00
R7127:Tas2r140	UTSW	6	133054959	missense	possibly damaging	0.62
R7143:Tas2r140	UTSW	6	133055519	missense	probably benign	0.00
R7178:Tas2r140	UTSW	6	133055660	missense	probably damaging	1.00

Predicted Primers

Posted On

2014-01-15