Incidental Mutation 'R1174:Tas2r140'
ID 99809
Institutional Source Beutler Lab
Gene Symbol Tas2r140
Ensembl Gene ENSMUSG00000071147
Gene Name taste receptor, type 2, member 140
Synonyms TRB5, mt2r64, Tas2r40, Tas2r13, mTRB3, TRB3, T2R40
MMRRC Submission 039247-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R1174 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 133031818-133032756 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 133031834 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 308 (E308G)
Ref Sequence ENSEMBL: ENSMUSP00000093040 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095391]
AlphaFold Q7TQA4
Predicted Effect probably benign
Transcript: ENSMUST00000095391
AA Change: E308G

PolyPhen 2 Score 0.271 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000093040
Gene: ENSMUSG00000071147
AA Change: E308G

DomainStartEndE-ValueType
Pfam:TAS2R 1 301 6.7e-86 PFAM
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.4%
  • 20x: 89.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610318N02Rik T A 16: 16,935,446 (GRCm39) H214L probably benign Het
Actn3 A G 19: 4,914,784 (GRCm39) L477P probably damaging Het
Adamts12 T C 15: 11,071,843 (GRCm39) V129A probably benign Het
Agxt2 T C 15: 10,373,837 (GRCm39) F81S probably damaging Het
Alpk1 T A 3: 127,474,459 (GRCm39) S515C probably damaging Het
Aoc1l3 C A 6: 48,967,173 (GRCm39) P707H probably damaging Het
Bivm A G 1: 44,165,942 (GRCm39) T131A probably benign Het
Borcs5 T A 6: 134,687,096 (GRCm39) N150K probably damaging Het
Cdh20 G A 1: 109,988,862 (GRCm39) V255I probably benign Het
Cox4i1 C A 8: 121,400,789 (GRCm39) N151K probably benign Het
Cpeb4 T C 11: 31,870,472 (GRCm39) L432P probably damaging Het
Dnajb11 T A 16: 22,689,423 (GRCm39) D281E probably damaging Het
Eml6 A G 11: 29,699,824 (GRCm39) S1771P possibly damaging Het
Fes A T 7: 80,027,699 (GRCm39) I815N probably damaging Het
Ghrhr T A 6: 55,365,254 (GRCm39) L416* probably null Het
Glipr1l2 C A 10: 111,919,371 (GRCm39) L31I possibly damaging Het
Gm1818 A G 12: 48,602,982 (GRCm39) noncoding transcript Het
Gpr149 A G 3: 62,511,888 (GRCm39) L37P probably damaging Het
Hdac1-ps A T 17: 78,799,507 (GRCm39) Y166F probably benign Het
Hoxa9 A G 6: 52,202,693 (GRCm39) I131T probably damaging Het
Idh1 G T 1: 65,200,319 (GRCm39) N348K probably benign Het
Klf6 A G 13: 5,911,711 (GRCm39) D25G probably benign Het
Laptm4a T C 12: 8,986,716 (GRCm39) V258A probably damaging Het
Lypd6b C T 2: 49,833,609 (GRCm39) A83V possibly damaging Het
Map3k19 A G 1: 127,751,617 (GRCm39) V578A probably benign Het
Mfsd13a T A 19: 46,363,125 (GRCm39) I511N probably benign Het
Mrm3 T C 11: 76,140,850 (GRCm39) V286A probably damaging Het
Muc6 C T 7: 141,234,368 (GRCm39) G708S probably damaging Het
Neurl4 T C 11: 69,794,547 (GRCm39) probably null Het
Pclo T C 5: 14,727,660 (GRCm39) probably benign Het
Pcnt A T 10: 76,228,878 (GRCm39) probably null Het
Pik3r4 G T 9: 105,540,373 (GRCm39) G754C probably damaging Het
Qtrt1 A G 9: 21,323,782 (GRCm39) T136A probably benign Het
Rgs12 T A 5: 35,123,809 (GRCm39) C531S probably benign Het
Rin1 C A 19: 5,105,231 (GRCm39) Q764K probably benign Het
Robo4 C T 9: 37,324,348 (GRCm39) R959W probably damaging Het
Rxfp2 T C 5: 149,975,021 (GRCm39) V210A probably benign Het
Serpinb9d C T 13: 33,384,608 (GRCm39) P195L probably benign Het
Sos1 A C 17: 80,753,037 (GRCm39) Y323* probably null Het
Spmip4 T A 6: 50,566,121 (GRCm39) K118M probably damaging Het
Ssxb8 T G X: 8,556,062 (GRCm39) H88P probably damaging Het
Tdo2 A T 3: 81,881,683 (GRCm39) S40R probably damaging Het
Tle4 C T 19: 14,445,626 (GRCm39) V207I probably benign Het
Txlnb A G 10: 17,718,504 (GRCm39) N445S probably benign Het
Ubap2l A T 3: 89,930,807 (GRCm39) S413T probably benign Het
Vangl2 G T 1: 171,832,353 (GRCm39) T501N probably damaging Het
Vmn2r12 A T 5: 109,240,720 (GRCm39) I131N probably benign Het
Vwa1 C T 4: 155,857,723 (GRCm39) G25D probably damaging Het
Zfp185 A T X: 72,042,929 (GRCm39) E138D possibly damaging Het
Other mutations in Tas2r140
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Tas2r140 APN 6 40,468,274 (GRCm39) missense probably benign 0.20
IGL00951:Tas2r140 APN 6 40,468,913 (GRCm39) nonsense probably null
IGL00980:Tas2r140 APN 6 40,468,352 (GRCm39) missense possibly damaging 0.60
IGL02055:Tas2r140 APN 6 40,468,493 (GRCm39) missense probably damaging 1.00
IGL03101:Tas2r140 APN 6 40,468,764 (GRCm39) missense probably benign 0.03
R0149:Tas2r140 UTSW 6 40,468,232 (GRCm39) missense probably benign 0.08
R0244:Tas2r140 UTSW 6 133,032,290 (GRCm39) missense possibly damaging 0.46
R0361:Tas2r140 UTSW 6 40,468,232 (GRCm39) missense probably benign 0.08
R0666:Tas2r140 UTSW 6 133,032,405 (GRCm39) missense probably benign 0.22
R0755:Tas2r140 UTSW 6 40,468,344 (GRCm39) missense probably damaging 0.99
R1237:Tas2r140 UTSW 6 133,032,171 (GRCm39) missense probably benign 0.04
R1553:Tas2r140 UTSW 6 133,032,471 (GRCm39) missense probably damaging 0.99
R2030:Tas2r140 UTSW 6 133,032,213 (GRCm39) missense probably benign 0.23
R2030:Tas2r140 UTSW 6 40,469,154 (GRCm39) missense possibly damaging 0.58
R3123:Tas2r140 UTSW 6 133,032,204 (GRCm39) missense probably benign 0.05
R3124:Tas2r140 UTSW 6 133,032,204 (GRCm39) missense probably benign 0.05
R4233:Tas2r140 UTSW 6 133,031,915 (GRCm39) missense probably damaging 1.00
R4234:Tas2r140 UTSW 6 133,031,915 (GRCm39) missense probably damaging 1.00
R4236:Tas2r140 UTSW 6 133,031,915 (GRCm39) missense probably damaging 1.00
R4525:Tas2r140 UTSW 6 133,032,207 (GRCm39) missense possibly damaging 0.66
R4803:Tas2r140 UTSW 6 133,032,743 (GRCm39) missense possibly damaging 0.77
R4840:Tas2r140 UTSW 6 133,032,528 (GRCm39) missense probably benign 0.01
R4885:Tas2r140 UTSW 6 40,468,334 (GRCm39) missense probably damaging 0.98
R5092:Tas2r140 UTSW 6 40,468,200 (GRCm39) missense probably benign
R5182:Tas2r140 UTSW 6 40,468,866 (GRCm39) missense probably benign 0.01
R5317:Tas2r140 UTSW 6 133,032,543 (GRCm39) missense probably benign 0.06
R5937:Tas2r140 UTSW 6 133,032,236 (GRCm39) missense probably benign 0.01
R5952:Tas2r140 UTSW 6 40,468,476 (GRCm39) missense probably benign 0.43
R6142:Tas2r140 UTSW 6 133,032,698 (GRCm39) missense probably damaging 1.00
R7127:Tas2r140 UTSW 6 133,031,922 (GRCm39) missense possibly damaging 0.62
R7143:Tas2r140 UTSW 6 133,032,482 (GRCm39) missense probably benign 0.00
R7178:Tas2r140 UTSW 6 133,032,623 (GRCm39) missense probably damaging 1.00
R7494:Tas2r140 UTSW 6 40,468,254 (GRCm39) missense probably damaging 0.99
R7513:Tas2r140 UTSW 6 40,469,084 (GRCm39) missense probably damaging 1.00
R7875:Tas2r140 UTSW 6 40,469,097 (GRCm39) missense probably damaging 1.00
R7979:Tas2r140 UTSW 6 40,468,601 (GRCm39) missense probably damaging 1.00
R8804:Tas2r140 UTSW 6 133,032,326 (GRCm39) missense probably damaging 0.98
R9029:Tas2r140 UTSW 6 133,032,181 (GRCm39) missense possibly damaging 0.69
R9055:Tas2r140 UTSW 6 133,032,380 (GRCm39) missense possibly damaging 0.77
R9257:Tas2r140 UTSW 6 40,468,592 (GRCm39) missense probably damaging 0.98
R9385:Tas2r140 UTSW 6 133,032,241 (GRCm39) missense probably benign 0.03
R9530:Tas2r140 UTSW 6 133,032,494 (GRCm39) missense probably benign 0.00
R9760:Tas2r140 UTSW 6 40,469,036 (GRCm39) missense probably benign 0.41
X0022:Tas2r140 UTSW 6 40,468,275 (GRCm39) missense possibly damaging 0.63
Predicted Primers
Posted On 2014-01-15