Incidental Mutation 'R1174:Agxt2'
ID |
99849 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Agxt2
|
Ensembl Gene |
ENSMUSG00000089678 |
Gene Name |
alanine-glyoxylate aminotransferase 2 |
Synonyms |
|
MMRRC Submission |
039247-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.065)
|
Stock # |
R1174 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
15 |
Chromosomal Location |
10358618-10410239 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 10373837 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Phenylalanine to Serine
at position 81
(F81S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000106171
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022858]
[ENSMUST00000110540]
[ENSMUST00000110541]
[ENSMUST00000110542]
|
AlphaFold |
Q3UEG6 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000022858
AA Change: F81S
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000022858 Gene: ENSMUSG00000089678 AA Change: F81S
Domain | Start | End | E-Value | Type |
Pfam:Aminotran_3
|
76 |
228 |
4.5e-36 |
PFAM |
Pfam:Aminotran_3
|
269 |
532 |
5.7e-60 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000110540
|
SMART Domains |
Protein: ENSMUSP00000106169 Gene: ENSMUSG00000089678
Domain | Start | End | E-Value | Type |
Pfam:Aminotran_3
|
86 |
122 |
2.6e-9 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000110541
AA Change: F81S
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000106170 Gene: ENSMUSG00000089678 AA Change: F81S
Domain | Start | End | E-Value | Type |
Pfam:Aminotran_3
|
86 |
219 |
1.7e-35 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000110542
AA Change: F81S
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000106171 Gene: ENSMUSG00000089678 AA Change: F81S
Domain | Start | End | E-Value | Type |
Pfam:Aminotran_3
|
87 |
443 |
1.3e-88 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000157020
|
SMART Domains |
Protein: ENSMUSP00000120297 Gene: ENSMUSG00000094814
Domain | Start | End | E-Value | Type |
transmembrane domain
|
20 |
41 |
N/A |
INTRINSIC |
|
Meta Mutation Damage Score |
0.5701 |
Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.4%
- 20x: 89.3%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] PHENOTYPE: Mice homozygous for a targeted allele exhibit reduced circulating L-citrulline, hypertension under terminal aesthesia and increased vasodilation maximal response following acetylcholine treatment. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 49 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2610318N02Rik |
T |
A |
16: 16,935,446 (GRCm39) |
H214L |
probably benign |
Het |
Actn3 |
A |
G |
19: 4,914,784 (GRCm39) |
L477P |
probably damaging |
Het |
Adamts12 |
T |
C |
15: 11,071,843 (GRCm39) |
V129A |
probably benign |
Het |
Alpk1 |
T |
A |
3: 127,474,459 (GRCm39) |
S515C |
probably damaging |
Het |
Aoc1l3 |
C |
A |
6: 48,967,173 (GRCm39) |
P707H |
probably damaging |
Het |
Bivm |
A |
G |
1: 44,165,942 (GRCm39) |
T131A |
probably benign |
Het |
Borcs5 |
T |
A |
6: 134,687,096 (GRCm39) |
N150K |
probably damaging |
Het |
Cdh20 |
G |
A |
1: 109,988,862 (GRCm39) |
V255I |
probably benign |
Het |
Cox4i1 |
C |
A |
8: 121,400,789 (GRCm39) |
N151K |
probably benign |
Het |
Cpeb4 |
T |
C |
11: 31,870,472 (GRCm39) |
L432P |
probably damaging |
Het |
Dnajb11 |
T |
A |
16: 22,689,423 (GRCm39) |
D281E |
probably damaging |
Het |
Eml6 |
A |
G |
11: 29,699,824 (GRCm39) |
S1771P |
possibly damaging |
Het |
Fes |
A |
T |
7: 80,027,699 (GRCm39) |
I815N |
probably damaging |
Het |
Ghrhr |
T |
A |
6: 55,365,254 (GRCm39) |
L416* |
probably null |
Het |
Glipr1l2 |
C |
A |
10: 111,919,371 (GRCm39) |
L31I |
possibly damaging |
Het |
Gm1818 |
A |
G |
12: 48,602,982 (GRCm39) |
|
noncoding transcript |
Het |
Gpr149 |
A |
G |
3: 62,511,888 (GRCm39) |
L37P |
probably damaging |
Het |
Hdac1-ps |
A |
T |
17: 78,799,507 (GRCm39) |
Y166F |
probably benign |
Het |
Hoxa9 |
A |
G |
6: 52,202,693 (GRCm39) |
I131T |
probably damaging |
Het |
Idh1 |
G |
T |
1: 65,200,319 (GRCm39) |
N348K |
probably benign |
Het |
Klf6 |
A |
G |
13: 5,911,711 (GRCm39) |
D25G |
probably benign |
Het |
Laptm4a |
T |
C |
12: 8,986,716 (GRCm39) |
V258A |
probably damaging |
Het |
Lypd6b |
C |
T |
2: 49,833,609 (GRCm39) |
A83V |
possibly damaging |
Het |
Map3k19 |
A |
G |
1: 127,751,617 (GRCm39) |
V578A |
probably benign |
Het |
Mfsd13a |
T |
A |
19: 46,363,125 (GRCm39) |
I511N |
probably benign |
Het |
Mrm3 |
T |
C |
11: 76,140,850 (GRCm39) |
V286A |
probably damaging |
Het |
Muc6 |
C |
T |
7: 141,234,368 (GRCm39) |
G708S |
probably damaging |
Het |
Neurl4 |
T |
C |
11: 69,794,547 (GRCm39) |
|
probably null |
Het |
Pclo |
T |
C |
5: 14,727,660 (GRCm39) |
|
probably benign |
Het |
Pcnt |
A |
T |
10: 76,228,878 (GRCm39) |
|
probably null |
Het |
Pik3r4 |
G |
T |
9: 105,540,373 (GRCm39) |
G754C |
probably damaging |
Het |
Qtrt1 |
A |
G |
9: 21,323,782 (GRCm39) |
T136A |
probably benign |
Het |
Rgs12 |
T |
A |
5: 35,123,809 (GRCm39) |
C531S |
probably benign |
Het |
Rin1 |
C |
A |
19: 5,105,231 (GRCm39) |
Q764K |
probably benign |
Het |
Robo4 |
C |
T |
9: 37,324,348 (GRCm39) |
R959W |
probably damaging |
Het |
Rxfp2 |
T |
C |
5: 149,975,021 (GRCm39) |
V210A |
probably benign |
Het |
Serpinb9d |
C |
T |
13: 33,384,608 (GRCm39) |
P195L |
probably benign |
Het |
Sos1 |
A |
C |
17: 80,753,037 (GRCm39) |
Y323* |
probably null |
Het |
Spmip4 |
T |
A |
6: 50,566,121 (GRCm39) |
K118M |
probably damaging |
Het |
Ssxb8 |
T |
G |
X: 8,556,062 (GRCm39) |
H88P |
probably damaging |
Het |
Tas2r140 |
T |
C |
6: 133,031,834 (GRCm39) |
E308G |
probably benign |
Het |
Tdo2 |
A |
T |
3: 81,881,683 (GRCm39) |
S40R |
probably damaging |
Het |
Tle4 |
C |
T |
19: 14,445,626 (GRCm39) |
V207I |
probably benign |
Het |
Txlnb |
A |
G |
10: 17,718,504 (GRCm39) |
N445S |
probably benign |
Het |
Ubap2l |
A |
T |
3: 89,930,807 (GRCm39) |
S413T |
probably benign |
Het |
Vangl2 |
G |
T |
1: 171,832,353 (GRCm39) |
T501N |
probably damaging |
Het |
Vmn2r12 |
A |
T |
5: 109,240,720 (GRCm39) |
I131N |
probably benign |
Het |
Vwa1 |
C |
T |
4: 155,857,723 (GRCm39) |
G25D |
probably damaging |
Het |
Zfp185 |
A |
T |
X: 72,042,929 (GRCm39) |
E138D |
possibly damaging |
Het |
|
Other mutations in Agxt2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01958:Agxt2
|
APN |
15 |
10,393,794 (GRCm39) |
splice site |
probably null |
|
IGL02434:Agxt2
|
APN |
15 |
10,358,686 (GRCm39) |
missense |
possibly damaging |
0.83 |
IGL02824:Agxt2
|
APN |
15 |
10,393,891 (GRCm39) |
missense |
probably null |
0.96 |
IGL02929:Agxt2
|
APN |
15 |
10,388,379 (GRCm39) |
splice site |
probably benign |
|
IGL03368:Agxt2
|
APN |
15 |
10,388,256 (GRCm39) |
nonsense |
probably null |
|
PIT4810001:Agxt2
|
UTSW |
15 |
10,399,151 (GRCm39) |
missense |
probably benign |
0.00 |
R0179:Agxt2
|
UTSW |
15 |
10,399,134 (GRCm39) |
missense |
possibly damaging |
0.71 |
R0526:Agxt2
|
UTSW |
15 |
10,373,948 (GRCm39) |
missense |
probably damaging |
1.00 |
R1085:Agxt2
|
UTSW |
15 |
10,388,338 (GRCm39) |
missense |
probably benign |
0.00 |
R1173:Agxt2
|
UTSW |
15 |
10,373,837 (GRCm39) |
missense |
probably damaging |
1.00 |
R1387:Agxt2
|
UTSW |
15 |
10,380,696 (GRCm39) |
missense |
probably damaging |
1.00 |
R1642:Agxt2
|
UTSW |
15 |
10,373,917 (GRCm39) |
missense |
probably damaging |
1.00 |
R1938:Agxt2
|
UTSW |
15 |
10,392,021 (GRCm39) |
missense |
probably damaging |
1.00 |
R3439:Agxt2
|
UTSW |
15 |
10,381,511 (GRCm39) |
missense |
probably benign |
0.19 |
R4485:Agxt2
|
UTSW |
15 |
10,378,968 (GRCm39) |
missense |
possibly damaging |
0.89 |
R4698:Agxt2
|
UTSW |
15 |
10,392,130 (GRCm39) |
critical splice donor site |
probably null |
|
R5582:Agxt2
|
UTSW |
15 |
10,399,245 (GRCm39) |
missense |
probably damaging |
1.00 |
R6056:Agxt2
|
UTSW |
15 |
10,378,963 (GRCm39) |
missense |
probably damaging |
1.00 |
R6109:Agxt2
|
UTSW |
15 |
10,377,508 (GRCm39) |
missense |
probably damaging |
1.00 |
R6393:Agxt2
|
UTSW |
15 |
10,393,894 (GRCm39) |
critical splice donor site |
probably null |
|
R6868:Agxt2
|
UTSW |
15 |
10,373,855 (GRCm39) |
missense |
probably damaging |
1.00 |
R7206:Agxt2
|
UTSW |
15 |
10,377,542 (GRCm39) |
missense |
probably damaging |
0.99 |
R7275:Agxt2
|
UTSW |
15 |
10,358,753 (GRCm39) |
missense |
probably benign |
0.00 |
R7475:Agxt2
|
UTSW |
15 |
10,409,623 (GRCm39) |
missense |
probably benign |
|
R7792:Agxt2
|
UTSW |
15 |
10,381,472 (GRCm39) |
missense |
probably damaging |
1.00 |
R8722:Agxt2
|
UTSW |
15 |
10,373,825 (GRCm39) |
missense |
probably benign |
|
R8899:Agxt2
|
UTSW |
15 |
10,378,900 (GRCm39) |
missense |
probably damaging |
1.00 |
R8929:Agxt2
|
UTSW |
15 |
10,393,830 (GRCm39) |
missense |
probably benign |
0.02 |
R9229:Agxt2
|
UTSW |
15 |
10,409,597 (GRCm39) |
missense |
probably damaging |
1.00 |
R9311:Agxt2
|
UTSW |
15 |
10,380,733 (GRCm39) |
missense |
probably damaging |
0.96 |
R9608:Agxt2
|
UTSW |
15 |
10,400,624 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
Predicted Primers |
|
Posted On |
2014-01-15 |