Incidental Mutation 'R1174:Hdac1-ps'
ID 99857
Institutional Source Beutler Lab
Gene Symbol Hdac1-ps
Ensembl Gene ENSMUSG00000061062
Gene Name histone deacetylase 1, pseudogene
Synonyms EG15181, Gm10093
MMRRC Submission 039247-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.908) question?
Stock # R1174 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 78799011-78800454 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 78799507 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 166 (Y166F)
Ref Sequence ENSEMBL: ENSMUSP00000078339 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079363]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000079363
AA Change: Y166F

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000078339
Gene: ENSMUSG00000061062
AA Change: Y166F

DomainStartEndE-ValueType
Pfam:Hist_deacetyl 18 320 3.2e-84 PFAM
low complexity region 390 402 N/A INTRINSIC
low complexity region 417 430 N/A INTRINSIC
low complexity region 443 471 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.4%
  • 20x: 89.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610318N02Rik T A 16: 16,935,446 (GRCm39) H214L probably benign Het
Actn3 A G 19: 4,914,784 (GRCm39) L477P probably damaging Het
Adamts12 T C 15: 11,071,843 (GRCm39) V129A probably benign Het
Agxt2 T C 15: 10,373,837 (GRCm39) F81S probably damaging Het
Alpk1 T A 3: 127,474,459 (GRCm39) S515C probably damaging Het
Aoc1l3 C A 6: 48,967,173 (GRCm39) P707H probably damaging Het
Bivm A G 1: 44,165,942 (GRCm39) T131A probably benign Het
Borcs5 T A 6: 134,687,096 (GRCm39) N150K probably damaging Het
Cdh20 G A 1: 109,988,862 (GRCm39) V255I probably benign Het
Cox4i1 C A 8: 121,400,789 (GRCm39) N151K probably benign Het
Cpeb4 T C 11: 31,870,472 (GRCm39) L432P probably damaging Het
Dnajb11 T A 16: 22,689,423 (GRCm39) D281E probably damaging Het
Eml6 A G 11: 29,699,824 (GRCm39) S1771P possibly damaging Het
Fes A T 7: 80,027,699 (GRCm39) I815N probably damaging Het
Ghrhr T A 6: 55,365,254 (GRCm39) L416* probably null Het
Glipr1l2 C A 10: 111,919,371 (GRCm39) L31I possibly damaging Het
Gm1818 A G 12: 48,602,982 (GRCm39) noncoding transcript Het
Gpr149 A G 3: 62,511,888 (GRCm39) L37P probably damaging Het
Hoxa9 A G 6: 52,202,693 (GRCm39) I131T probably damaging Het
Idh1 G T 1: 65,200,319 (GRCm39) N348K probably benign Het
Klf6 A G 13: 5,911,711 (GRCm39) D25G probably benign Het
Laptm4a T C 12: 8,986,716 (GRCm39) V258A probably damaging Het
Lypd6b C T 2: 49,833,609 (GRCm39) A83V possibly damaging Het
Map3k19 A G 1: 127,751,617 (GRCm39) V578A probably benign Het
Mfsd13a T A 19: 46,363,125 (GRCm39) I511N probably benign Het
Mrm3 T C 11: 76,140,850 (GRCm39) V286A probably damaging Het
Muc6 C T 7: 141,234,368 (GRCm39) G708S probably damaging Het
Neurl4 T C 11: 69,794,547 (GRCm39) probably null Het
Pclo T C 5: 14,727,660 (GRCm39) probably benign Het
Pcnt A T 10: 76,228,878 (GRCm39) probably null Het
Pik3r4 G T 9: 105,540,373 (GRCm39) G754C probably damaging Het
Qtrt1 A G 9: 21,323,782 (GRCm39) T136A probably benign Het
Rgs12 T A 5: 35,123,809 (GRCm39) C531S probably benign Het
Rin1 C A 19: 5,105,231 (GRCm39) Q764K probably benign Het
Robo4 C T 9: 37,324,348 (GRCm39) R959W probably damaging Het
Rxfp2 T C 5: 149,975,021 (GRCm39) V210A probably benign Het
Serpinb9d C T 13: 33,384,608 (GRCm39) P195L probably benign Het
Sos1 A C 17: 80,753,037 (GRCm39) Y323* probably null Het
Spmip4 T A 6: 50,566,121 (GRCm39) K118M probably damaging Het
Ssxb8 T G X: 8,556,062 (GRCm39) H88P probably damaging Het
Tas2r140 T C 6: 133,031,834 (GRCm39) E308G probably benign Het
Tdo2 A T 3: 81,881,683 (GRCm39) S40R probably damaging Het
Tle4 C T 19: 14,445,626 (GRCm39) V207I probably benign Het
Txlnb A G 10: 17,718,504 (GRCm39) N445S probably benign Het
Ubap2l A T 3: 89,930,807 (GRCm39) S413T probably benign Het
Vangl2 G T 1: 171,832,353 (GRCm39) T501N probably damaging Het
Vmn2r12 A T 5: 109,240,720 (GRCm39) I131N probably benign Het
Vwa1 C T 4: 155,857,723 (GRCm39) G25D probably damaging Het
Zfp185 A T X: 72,042,929 (GRCm39) E138D possibly damaging Het
Other mutations in Hdac1-ps
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01936:Hdac1-ps APN 17 78,799,558 (GRCm39) missense probably damaging 1.00
IGL01983:Hdac1-ps APN 17 78,800,282 (GRCm39) missense probably benign
IGL02543:Hdac1-ps APN 17 78,799,303 (GRCm39) missense probably damaging 0.97
buttress UTSW 17 78,800,343 (GRCm39) missense possibly damaging 0.91
Chartre UTSW 17 78,799,969 (GRCm39) missense probably damaging 0.99
R1605:Hdac1-ps UTSW 17 78,799,537 (GRCm39) missense probably damaging 0.98
R2416:Hdac1-ps UTSW 17 78,799,945 (GRCm39) missense probably damaging 1.00
R2919:Hdac1-ps UTSW 17 78,800,275 (GRCm39) missense probably damaging 0.98
R2920:Hdac1-ps UTSW 17 78,800,275 (GRCm39) missense probably damaging 0.98
R3846:Hdac1-ps UTSW 17 78,800,401 (GRCm39) missense possibly damaging 0.91
R4544:Hdac1-ps UTSW 17 78,800,388 (GRCm39) missense probably benign 0.02
R4546:Hdac1-ps UTSW 17 78,800,388 (GRCm39) missense probably benign 0.02
R5223:Hdac1-ps UTSW 17 78,799,867 (GRCm39) missense probably benign 0.02
R5297:Hdac1-ps UTSW 17 78,800,187 (GRCm39) missense probably benign
R6164:Hdac1-ps UTSW 17 78,799,716 (GRCm39) missense probably damaging 0.99
R6568:Hdac1-ps UTSW 17 78,800,017 (GRCm39) missense probably damaging 1.00
R6726:Hdac1-ps UTSW 17 78,800,287 (GRCm39) missense probably damaging 0.99
R6901:Hdac1-ps UTSW 17 78,800,089 (GRCm39) missense probably benign 0.07
R6923:Hdac1-ps UTSW 17 78,800,343 (GRCm39) missense possibly damaging 0.91
R7838:Hdac1-ps UTSW 17 78,799,447 (GRCm39) missense probably damaging 1.00
R8002:Hdac1-ps UTSW 17 78,799,716 (GRCm39) missense probably damaging 0.99
R8728:Hdac1-ps UTSW 17 78,800,332 (GRCm39) missense probably benign 0.01
R8821:Hdac1-ps UTSW 17 78,799,969 (GRCm39) missense probably damaging 0.99
R8920:Hdac1-ps UTSW 17 78,799,171 (GRCm39) missense probably benign 0.37
R9618:Hdac1-ps UTSW 17 78,799,114 (GRCm39) missense probably damaging 1.00
R9649:Hdac1-ps UTSW 17 78,799,075 (GRCm39) missense probably benign 0.03
X0060:Hdac1-ps UTSW 17 78,799,557 (GRCm39) missense probably damaging 0.99
Predicted Primers
Posted On 2014-01-15