Mutagenetix > Incidental Mutation

Incidental Mutation 'R1218:Dmxl1'

99878

Institutional Source

Beutler Lab

Gene Symbol

Dmxl1

Ensembl Gene

ENSMUSG00000037416

Gene Name

Dmx-like 1

Synonyms

C630007L23Rik

MMRRC Submission

039287-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.951) question?

Stock #

R1218 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

49832670-49965473 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 49893611 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 1929 (S1929T)

Ref Sequence

ENSEMBL: ENSMUSP00000137871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041772] [ENSMUST00000180611]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000041772
AA Change: S1929T

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000045559
Gene: ENSMUSG00000037416
AA Change: S1929T

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
Pfam:Rav1p_C	1102	1877	4.3e-84	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2371	2385	N/A	INTRINSIC
low complexity region	2397	2410	N/A	INTRINSIC
low complexity region	2449	2466	N/A	INTRINSIC
WD40	2735	2770	1.07e1	SMART
WD40	2773	2813	3.7e0	SMART
WD40	2825	2867	1.07e0	SMART
WD40	2873	2912	1.05e-2	SMART
WD40	2915	2954	4.51e-7	SMART
Blast:WD40	2957	3005	9e-26	BLAST

Predicted Effect

probably damaging
Transcript: ENSMUST00000180611
AA Change: S1929T

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000137871
Gene: ENSMUSG00000037416
AA Change: S1929T

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
low complexity region	1195	1206	N/A	INTRINSIC
low complexity region	1258	1271	N/A	INTRINSIC
Pfam:Rav1p_C	1287	1876	9.4e-72	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2385	2398	N/A	INTRINSIC
low complexity region	2437	2454	N/A	INTRINSIC
WD40	2723	2758	1.07e1	SMART
WD40	2761	2801	3.7e0	SMART
WD40	2813	2855	1.07e0	SMART
WD40	2861	2900	1.05e-2	SMART
WD40	2903	2942	4.51e-7	SMART
Blast:WD40	2945	2993	9e-26	BLAST

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181907

Coding Region Coverage

1x: 99.2%
3x: 97.9%
10x: 93.3%
20x: 80.5%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930407I10Rik	C	T	15: 82,064,152 (GRCm38)	T750I	probably benign	Het
5330417H12Rik	T	C	7: 107,624,817 (GRCm38)		probably benign	Het
9230109A22Rik	C	T	15: 25,138,938 (GRCm38)		noncoding transcript	Het
Ahnak	A	G	19: 9,015,619 (GRCm38)	K4756E	probably damaging	Het
Ano5	A	T	7: 51,570,421 (GRCm38)		probably null	Het
Bmp6	ACAGCAGCAGCAGCAGCAGCAGCAGCAGCAG	ACAGCAGCAGCAGCAGCAGCAGCAGCAG	13: 38,346,250 (GRCm38)		probably benign	Het
Car9	G	T	4: 43,512,439 (GRCm38)		probably null	Het
Cbfa2t2	A	T	2: 154,523,919 (GRCm38)	M350L	probably benign	Het
Ceacam20	A	T	7: 19,976,097 (GRCm38)	M349L	probably benign	Het
Cfap91	A	G	16: 38,298,133 (GRCm38)	V768A	probably benign	Het
Chd1	G	T	17: 15,725,312 (GRCm38)	G33C	probably damaging	Het
Dhx40	A	G	11: 86,799,484 (GRCm38)	V237A	probably benign	Het
Dlst	G	T	12: 85,123,864 (GRCm38)	D256Y	probably damaging	Het
Exosc10	T	A	4: 148,570,401 (GRCm38)	I551N	probably damaging	Het
Faap100	T	C	11: 120,378,340 (GRCm38)	D91G	probably benign	Het
Fbn1	T	G	2: 125,412,749 (GRCm38)	Q198P	possibly damaging	Het
Flrt2	A	G	12: 95,778,953 (GRCm38)	I22V	probably benign	Het
Gdf10	G	A	14: 33,932,753 (GRCm38)	A406T	probably benign	Het
H2bc3	A	G	13: 23,747,159 (GRCm38)	Y122C	probably benign	Het
Inava	A	T	1: 136,214,402 (GRCm38)	V653E	probably damaging	Het
Kcnn1	T	C	8: 70,852,688 (GRCm38)	I293V	probably benign	Het
Kifc1	G	A	17: 33,884,711 (GRCm38)	R195C	probably benign	Het
Mcpt9	G	T	14: 56,028,668 (GRCm38)	Y34*	probably null	Het
Mepe	A	T	5: 104,327,073 (GRCm38)	M7L	probably benign	Het
Mprip	A	G	11: 59,743,814 (GRCm38)	Y383C	probably damaging	Het
Mtrex	G	A	13: 112,917,622 (GRCm38)	A159V	probably damaging	Het
Myh2	A	T	11: 67,192,525 (GRCm38)	D1438V	probably damaging	Het
Napb	T	C	2: 148,700,425 (GRCm38)	Y205C	probably damaging	Het
Odf2l	A	G	3: 145,148,932 (GRCm38)	D510G	probably damaging	Het
Olfml2b	A	G	1: 170,649,782 (GRCm38)	D162G	probably damaging	Het
Oscp1	T	C	4: 126,058,739 (GRCm38)	V20A	probably benign	Het
Pcdhb10	T	C	18: 37,413,161 (GRCm38)	L430P	probably damaging	Het
Polq	A	G	16: 37,029,446 (GRCm38)	D354G	possibly damaging	Het
Rims1	C	A	1: 22,483,175 (GRCm38)	V481F	probably damaging	Het
Ryr1	A	G	7: 29,086,109 (GRCm38)	I1719T	possibly damaging	Het
Smtn	T	C	11: 3,530,021 (GRCm38)	H400R	probably benign	Het
Snx33	A	G	9: 56,925,985 (GRCm38)	Y267H	probably damaging	Het
Sstr1	T	A	12: 58,213,620 (GRCm38)	M343K	possibly damaging	Het
Stx6	T	C	1: 155,201,991 (GRCm38)	V248A	probably benign	Het
Tbx5	C	T	5: 119,838,720 (GRCm38)	L58F	probably damaging	Het
Tmem241	A	G	18: 12,064,214 (GRCm38)	Y186H	probably damaging	Het
Tnfaip8l3	T	C	9: 54,027,476 (GRCm38)	K72E	probably damaging	Het
Trrap	T	A	5: 144,816,409 (GRCm38)	I1848N	probably damaging	Het
Xrcc6	G	A	15: 82,022,941 (GRCm38)	V155I	probably benign	Het
Zfp458	T	C	13: 67,256,209 (GRCm38)	E722G	probably damaging	Het
Zfyve1	G	T	12: 83,548,051 (GRCm38)	H722Q	possibly damaging	Het

Other mutations in Dmxl1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Dmxl1	APN	18	49,851,467 (GRCm38)	missense	probably damaging	1.00
IGL00668:Dmxl1	APN	18	49,939,553 (GRCm38)	missense	possibly damaging	0.64
IGL00740:Dmxl1	APN	18	49,917,668 (GRCm38)	missense	probably benign	0.00
IGL00969:Dmxl1	APN	18	49,912,725 (GRCm38)	missense	probably benign	0.02
IGL01113:Dmxl1	APN	18	49,912,751 (GRCm38)	missense	probably benign	0.01
IGL01384:Dmxl1	APN	18	49,857,334 (GRCm38)	missense	probably benign
IGL01475:Dmxl1	APN	18	49,871,714 (GRCm38)	missense	probably damaging	1.00
IGL01559:Dmxl1	APN	18	49,920,938 (GRCm38)	missense	probably damaging	0.99
IGL01578:Dmxl1	APN	18	49,962,205 (GRCm38)	missense	probably damaging	1.00
IGL01632:Dmxl1	APN	18	49,863,025 (GRCm38)	missense	probably damaging	0.99
IGL01814:Dmxl1	APN	18	49,864,868 (GRCm38)	missense	probably damaging	1.00
IGL01843:Dmxl1	APN	18	49,878,382 (GRCm38)	nonsense	probably null
IGL01933:Dmxl1	APN	18	49,877,785 (GRCm38)	missense	probably benign	0.17
IGL01952:Dmxl1	APN	18	49,890,654 (GRCm38)	missense	probably benign	0.11
IGL02120:Dmxl1	APN	18	49,894,178 (GRCm38)	missense	possibly damaging	0.83
IGL02162:Dmxl1	APN	18	49,961,163 (GRCm38)	missense	probably benign	0.00
IGL02213:Dmxl1	APN	18	49,877,674 (GRCm38)	splice site	probably benign
IGL02261:Dmxl1	APN	18	49,840,499 (GRCm38)	missense	possibly damaging	0.85
IGL02689:Dmxl1	APN	18	49,864,895 (GRCm38)	missense	probably damaging	1.00
IGL02892:Dmxl1	APN	18	49,859,120 (GRCm38)	missense	probably damaging	0.96
IGL03232:Dmxl1	APN	18	49,878,180 (GRCm38)	missense	probably benign	0.01
IGL03258:Dmxl1	APN	18	49,920,893 (GRCm38)	missense	probably damaging	1.00
IGL03298:Dmxl1	APN	18	49,864,818 (GRCm38)	missense	probably benign
capture	UTSW	18	49,962,261 (GRCm38)	missense	probably damaging	1.00
carnivora	UTSW	18	49,864,383 (GRCm38)	missense	probably damaging	0.99
digestion	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
drowning	UTSW	18	49,878,225 (GRCm38)	missense	possibly damaging	0.55
hibiscus	UTSW	18	49,889,467 (GRCm38)	missense	probably damaging	1.00
impound	UTSW	18	49,893,249 (GRCm38)	missense	probably benign
pitcher	UTSW	18	49,864,148 (GRCm38)	missense	probably damaging	1.00
PIT4810001:Dmxl1	UTSW	18	49,931,963 (GRCm38)	missense	probably damaging	1.00
R0001:Dmxl1	UTSW	18	49,888,897 (GRCm38)	splice site	probably benign
R0027:Dmxl1	UTSW	18	49,957,295 (GRCm38)	splice site	probably benign
R0042:Dmxl1	UTSW	18	49,864,035 (GRCm38)	missense	probably benign	0.03
R0042:Dmxl1	UTSW	18	49,864,035 (GRCm38)	missense	probably benign	0.03
R0046:Dmxl1	UTSW	18	49,878,082 (GRCm38)	missense	probably benign	0.22
R0046:Dmxl1	UTSW	18	49,878,082 (GRCm38)	missense	probably benign	0.22
R0257:Dmxl1	UTSW	18	49,955,803 (GRCm38)	splice site	probably benign
R0349:Dmxl1	UTSW	18	49,879,282 (GRCm38)	missense	probably damaging	0.99
R0390:Dmxl1	UTSW	18	49,879,362 (GRCm38)	missense	probably benign	0.14
R0511:Dmxl1	UTSW	18	49,891,467 (GRCm38)	nonsense	probably null
R0539:Dmxl1	UTSW	18	49,857,430 (GRCm38)	splice site	probably benign
R0542:Dmxl1	UTSW	18	49,893,694 (GRCm38)	missense	probably benign	0.05
R0587:Dmxl1	UTSW	18	49,935,307 (GRCm38)	missense	probably benign	0.39
R0635:Dmxl1	UTSW	18	49,851,423 (GRCm38)	splice site	probably benign
R0744:Dmxl1	UTSW	18	49,833,148 (GRCm38)	missense	probably damaging	1.00
R0836:Dmxl1	UTSW	18	49,833,148 (GRCm38)	missense	probably damaging	1.00
R0845:Dmxl1	UTSW	18	49,893,402 (GRCm38)	missense	probably damaging	1.00
R1278:Dmxl1	UTSW	18	49,893,225 (GRCm38)	missense	probably benign
R1313:Dmxl1	UTSW	18	49,878,483 (GRCm38)	missense	probably damaging	1.00
R1313:Dmxl1	UTSW	18	49,878,483 (GRCm38)	missense	probably damaging	1.00
R1349:Dmxl1	UTSW	18	49,888,853 (GRCm38)	missense	probably damaging	1.00
R1453:Dmxl1	UTSW	18	49,857,249 (GRCm38)	missense	probably benign	0.05
R1522:Dmxl1	UTSW	18	49,852,367 (GRCm38)	missense	probably benign	0.05
R1629:Dmxl1	UTSW	18	49,859,286 (GRCm38)	critical splice donor site	probably null
R1638:Dmxl1	UTSW	18	49,890,767 (GRCm38)	nonsense	probably null
R1646:Dmxl1	UTSW	18	49,962,261 (GRCm38)	missense	probably damaging	1.00
R1719:Dmxl1	UTSW	18	49,934,637 (GRCm38)	missense	probably damaging	1.00
R1732:Dmxl1	UTSW	18	49,902,988 (GRCm38)	missense	probably benign
R1732:Dmxl1	UTSW	18	49,893,444 (GRCm38)	nonsense	probably null
R1886:Dmxl1	UTSW	18	49,859,135 (GRCm38)	missense	probably benign	0.09
R1887:Dmxl1	UTSW	18	49,859,135 (GRCm38)	missense	probably benign	0.09
R1895:Dmxl1	UTSW	18	49,955,914 (GRCm38)	splice site	probably null
R1911:Dmxl1	UTSW	18	49,878,163 (GRCm38)	missense	probably benign	0.00
R2020:Dmxl1	UTSW	18	49,889,558 (GRCm38)	nonsense	probably null
R2116:Dmxl1	UTSW	18	49,878,817 (GRCm38)	missense	probably damaging	1.00
R2196:Dmxl1	UTSW	18	49,917,631 (GRCm38)	missense	probably benign	0.00
R2206:Dmxl1	UTSW	18	49,894,094 (GRCm38)	missense	probably benign	0.12
R2216:Dmxl1	UTSW	18	49,893,923 (GRCm38)	missense	probably benign	0.00
R2255:Dmxl1	UTSW	18	49,846,639 (GRCm38)	missense	probably benign	0.34
R2333:Dmxl1	UTSW	18	49,919,976 (GRCm38)	splice site	probably null
R2343:Dmxl1	UTSW	18	49,890,678 (GRCm38)	missense	probably damaging	1.00
R2496:Dmxl1	UTSW	18	49,880,791 (GRCm38)	missense	possibly damaging	0.51
R3757:Dmxl1	UTSW	18	49,935,317 (GRCm38)	missense	probably damaging	0.98
R3758:Dmxl1	UTSW	18	49,935,317 (GRCm38)	missense	probably damaging	0.98
R3783:Dmxl1	UTSW	18	49,865,122 (GRCm38)	missense	probably damaging	1.00
R3786:Dmxl1	UTSW	18	49,865,122 (GRCm38)	missense	probably damaging	1.00
R3787:Dmxl1	UTSW	18	49,865,122 (GRCm38)	missense	probably damaging	1.00
R3885:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3886:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3887:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3888:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3889:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R4014:Dmxl1	UTSW	18	49,863,962 (GRCm38)	missense	probably benign
R4033:Dmxl1	UTSW	18	49,851,431 (GRCm38)	missense	possibly damaging	0.95
R4096:Dmxl1	UTSW	18	49,961,197 (GRCm38)	missense	probably damaging	1.00
R4366:Dmxl1	UTSW	18	49,878,017 (GRCm38)	nonsense	probably null
R4406:Dmxl1	UTSW	18	49,889,553 (GRCm38)	missense	probably damaging	1.00
R4412:Dmxl1	UTSW	18	49,848,761 (GRCm38)	missense	probably benign
R4454:Dmxl1	UTSW	18	49,893,332 (GRCm38)	missense	probably benign	0.01
R4459:Dmxl1	UTSW	18	49,961,216 (GRCm38)	missense	possibly damaging	0.80
R4569:Dmxl1	UTSW	18	49,852,360 (GRCm38)	missense	probably damaging	1.00
R4570:Dmxl1	UTSW	18	49,852,360 (GRCm38)	missense	probably damaging	1.00
R4606:Dmxl1	UTSW	18	49,962,181 (GRCm38)	missense	probably damaging	0.98
R4649:Dmxl1	UTSW	18	49,878,631 (GRCm38)	missense	probably damaging	0.99
R4683:Dmxl1	UTSW	18	49,878,021 (GRCm38)	missense	probably damaging	1.00
R4782:Dmxl1	UTSW	18	49,862,992 (GRCm38)	missense	probably damaging	1.00
R4878:Dmxl1	UTSW	18	49,851,476 (GRCm38)	missense	probably damaging	1.00
R4879:Dmxl1	UTSW	18	49,889,467 (GRCm38)	missense	probably damaging	1.00
R4881:Dmxl1	UTSW	18	49,957,281 (GRCm38)	intron	probably benign
R4885:Dmxl1	UTSW	18	49,878,795 (GRCm38)	missense	probably damaging	0.99
R4916:Dmxl1	UTSW	18	49,877,697 (GRCm38)	missense	probably damaging	1.00
R5022:Dmxl1	UTSW	18	49,895,127 (GRCm38)	missense	probably damaging	0.99
R5056:Dmxl1	UTSW	18	49,870,923 (GRCm38)	missense	probably benign	0.00
R5177:Dmxl1	UTSW	18	49,893,584 (GRCm38)	missense	probably damaging	0.99
R5342:Dmxl1	UTSW	18	49,951,235 (GRCm38)	missense	probably damaging	0.96
R5421:Dmxl1	UTSW	18	49,863,119 (GRCm38)	critical splice donor site	probably null
R5433:Dmxl1	UTSW	18	49,867,899 (GRCm38)	splice site	probably null
R5484:Dmxl1	UTSW	18	49,889,464 (GRCm38)	missense	probably damaging	1.00
R5598:Dmxl1	UTSW	18	49,864,478 (GRCm38)	missense	probably benign	0.04
R5633:Dmxl1	UTSW	18	49,877,697 (GRCm38)	missense	probably damaging	1.00
R5638:Dmxl1	UTSW	18	49,891,626 (GRCm38)	missense	possibly damaging	0.95
R5694:Dmxl1	UTSW	18	49,894,257 (GRCm38)	missense	probably damaging	1.00
R5696:Dmxl1	UTSW	18	49,931,941 (GRCm38)	nonsense	probably null
R5706:Dmxl1	UTSW	18	49,957,395 (GRCm38)	critical splice donor site	probably null
R5745:Dmxl1	UTSW	18	49,846,586 (GRCm38)	missense	probably benign
R5876:Dmxl1	UTSW	18	49,870,984 (GRCm38)	missense	possibly damaging	0.70
R6054:Dmxl1	UTSW	18	49,857,386 (GRCm38)	missense	probably benign	0.00
R6145:Dmxl1	UTSW	18	49,912,766 (GRCm38)	missense	possibly damaging	0.90
R6189:Dmxl1	UTSW	18	49,893,335 (GRCm38)	missense	probably benign	0.33
R6213:Dmxl1	UTSW	18	49,863,015 (GRCm38)	missense	possibly damaging	0.93
R6219:Dmxl1	UTSW	18	49,902,367 (GRCm38)	missense	probably damaging	0.99
R6221:Dmxl1	UTSW	18	49,871,732 (GRCm38)	missense	probably damaging	0.96
R6276:Dmxl1	UTSW	18	49,846,586 (GRCm38)	missense	probably benign
R6319:Dmxl1	UTSW	18	49,852,300 (GRCm38)	missense	probably benign	0.00
R6426:Dmxl1	UTSW	18	49,864,578 (GRCm38)	missense	probably damaging	0.99
R6567:Dmxl1	UTSW	18	49,859,179 (GRCm38)	missense	probably damaging	0.99
R6739:Dmxl1	UTSW	18	49,878,246 (GRCm38)	missense	probably benign	0.03
R6743:Dmxl1	UTSW	18	49,880,780 (GRCm38)	missense	possibly damaging	0.95
R6776:Dmxl1	UTSW	18	49,893,974 (GRCm38)	missense	probably damaging	1.00
R6827:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6828:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6829:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6830:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6833:Dmxl1	UTSW	18	49,955,823 (GRCm38)	missense	probably damaging	0.99
R6834:Dmxl1	UTSW	18	49,955,823 (GRCm38)	missense	probably damaging	0.99
R6856:Dmxl1	UTSW	18	49,852,288 (GRCm38)	nonsense	probably null
R6857:Dmxl1	UTSW	18	49,864,835 (GRCm38)	missense	probably damaging	0.99
R6881:Dmxl1	UTSW	18	49,935,305 (GRCm38)	missense	probably benign	0.00
R6882:Dmxl1	UTSW	18	49,843,784 (GRCm38)	critical splice acceptor site	probably null
R6892:Dmxl1	UTSW	18	49,920,902 (GRCm38)	missense	probably damaging	0.98
R6897:Dmxl1	UTSW	18	49,863,057 (GRCm38)	missense	possibly damaging	0.51
R6897:Dmxl1	UTSW	18	49,851,495 (GRCm38)	missense	probably null	0.99
R6917:Dmxl1	UTSW	18	49,864,148 (GRCm38)	missense	probably damaging	1.00
R7192:Dmxl1	UTSW	18	49,955,853 (GRCm38)	missense	probably damaging	0.99
R7447:Dmxl1	UTSW	18	49,864,614 (GRCm38)	missense	probably damaging	0.99
R7460:Dmxl1	UTSW	18	49,878,612 (GRCm38)	missense	probably benign	0.00
R7570:Dmxl1	UTSW	18	49,893,957 (GRCm38)	missense	possibly damaging	0.82
R7626:Dmxl1	UTSW	18	49,902,794 (GRCm38)	missense	probably benign
R7629:Dmxl1	UTSW	18	49,859,270 (GRCm38)	missense	probably damaging	1.00
R7644:Dmxl1	UTSW	18	49,893,552 (GRCm38)	missense	probably benign
R7688:Dmxl1	UTSW	18	49,955,871 (GRCm38)	missense	probably benign	0.03
R7689:Dmxl1	UTSW	18	49,846,618 (GRCm38)	missense	probably benign	0.00
R7712:Dmxl1	UTSW	18	49,893,461 (GRCm38)	missense	probably damaging	0.99
R7808:Dmxl1	UTSW	18	49,878,315 (GRCm38)	missense	probably benign	0.00
R7834:Dmxl1	UTSW	18	49,920,977 (GRCm38)	missense	probably damaging	1.00
R7848:Dmxl1	UTSW	18	49,840,490 (GRCm38)	missense	possibly damaging	0.88
R7849:Dmxl1	UTSW	18	49,961,147 (GRCm38)	missense	probably benign	0.00
R7881:Dmxl1	UTSW	18	49,864,383 (GRCm38)	missense	probably damaging	0.99
R7884:Dmxl1	UTSW	18	49,893,407 (GRCm38)	missense	possibly damaging	0.65
R8073:Dmxl1	UTSW	18	49,878,433 (GRCm38)	missense	probably damaging	1.00
R8089:Dmxl1	UTSW	18	49,888,830 (GRCm38)	missense	probably damaging	0.99
R8266:Dmxl1	UTSW	18	49,843,811 (GRCm38)	missense	probably benign	0.17
R8371:Dmxl1	UTSW	18	49,898,714 (GRCm38)	missense	probably benign	0.08
R8402:Dmxl1	UTSW	18	49,878,342 (GRCm38)	missense	probably benign
R8402:Dmxl1	UTSW	18	49,878,326 (GRCm38)	nonsense	probably null
R8402:Dmxl1	UTSW	18	49,878,327 (GRCm38)	missense	probably benign	0.09
R8423:Dmxl1	UTSW	18	49,865,116 (GRCm38)	missense	probably damaging	1.00
R8678:Dmxl1	UTSW	18	49,871,692 (GRCm38)	nonsense	probably null
R8702:Dmxl1	UTSW	18	49,859,135 (GRCm38)	missense	probably benign	0.09
R8749:Dmxl1	UTSW	18	49,955,870 (GRCm38)	missense	probably damaging	1.00
R8813:Dmxl1	UTSW	18	49,957,339 (GRCm38)	missense	probably damaging	0.99
R8877:Dmxl1	UTSW	18	49,878,225 (GRCm38)	missense	possibly damaging	0.55
R8945:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	49,893,674 (GRCm38)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	49,864,508 (GRCm38)	missense	possibly damaging	0.96
R8978:Dmxl1	UTSW	18	49,922,612 (GRCm38)	missense	probably benign	0.37
R8987:Dmxl1	UTSW	18	49,893,852 (GRCm38)	missense
R9011:Dmxl1	UTSW	18	49,864,173 (GRCm38)	missense	probably damaging	1.00
R9124:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9131:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9132:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9156:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9165:Dmxl1	UTSW	18	49,878,925 (GRCm38)	missense	probably damaging	1.00
R9244:Dmxl1	UTSW	18	49,893,249 (GRCm38)	missense	probably benign
R9254:Dmxl1	UTSW	18	49,891,500 (GRCm38)	missense	possibly damaging	0.67
R9262:Dmxl1	UTSW	18	49,843,852 (GRCm38)	missense	probably benign	0.03
R9335:Dmxl1	UTSW	18	49,859,120 (GRCm38)	missense	probably damaging	0.96
R9375:Dmxl1	UTSW	18	49,958,410 (GRCm38)	missense	probably damaging	1.00
R9379:Dmxl1	UTSW	18	49,891,500 (GRCm38)	missense	possibly damaging	0.67
R9434:Dmxl1	UTSW	18	49,877,721 (GRCm38)	missense	probably damaging	0.98
R9470:Dmxl1	UTSW	18	49,893,710 (GRCm38)	missense	possibly damaging	0.69
R9500:Dmxl1	UTSW	18	49,878,204 (GRCm38)	missense	probably damaging	1.00
R9507:Dmxl1	UTSW	18	49,891,500 (GRCm38)	missense	possibly damaging	0.94
R9617:Dmxl1	UTSW	18	49,865,161 (GRCm38)	missense	probably damaging	1.00
R9642:Dmxl1	UTSW	18	49,880,758 (GRCm38)	missense	probably damaging	1.00
RF009:Dmxl1	UTSW	18	49,893,394 (GRCm38)	missense	probably damaging	0.96
X0025:Dmxl1	UTSW	18	49,864,368 (GRCm38)	missense	probably damaging	0.98
X0066:Dmxl1	UTSW	18	49,919,899 (GRCm38)	missense	probably damaging	1.00
Z1088:Dmxl1	UTSW	18	49,920,965 (GRCm38)	missense	probably benign
Z1188:Dmxl1	UTSW	18	49,868,003 (GRCm38)	missense	probably damaging	0.96
Z1189:Dmxl1	UTSW	18	49,868,003 (GRCm38)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- ACTGCTAGTGCTCACCTAAAAGCTG -3'
(R):5'- GTTGGTAACGCAATTTCCCACCATC -3'

Sequencing Primer
(F):5'- CCCAATGTTGGCTTTGGAAG -3'
(R):5'- CGGTGAGAATCTTCAAACATGCTC -3'

Posted On

2014-01-15