Incidental Mutation 'R1175:Vmn2r66'
ID 99946
Institutional Source Beutler Lab
Gene Symbol Vmn2r66
Ensembl Gene ENSMUSG00000094950
Gene Name vomeronasal 2, receptor 66
Synonyms F830104D24Rik
MMRRC Submission 039248-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R1175 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 84643853-84661228 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 84654799 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 503 (D503E)
Ref Sequence ENSEMBL: ENSMUSP00000122645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000124773]
AlphaFold A0A3B2W842
Predicted Effect probably benign
Transcript: ENSMUST00000124773
AA Change: D503E

PolyPhen 2 Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000122645
Gene: ENSMUSG00000094950
AA Change: D503E

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 463 5e-31 PFAM
Pfam:NCD3G 507 559 6e-21 PFAM
Pfam:7tm_3 589 827 3.8e-52 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.7%
  • 20x: 88.0%
Validation Efficiency 100% (74/74)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610318N02Rik T A 16: 16,935,446 (GRCm39) H214L probably benign Het
Abca17 T C 17: 24,508,325 (GRCm39) E1070G possibly damaging Het
Accsl A T 2: 93,696,589 (GRCm39) probably benign Het
Akp3 G A 1: 87,055,593 (GRCm39) G547R unknown Het
Anapc1 C A 2: 128,522,108 (GRCm39) C150F probably damaging Het
Aoc1l3 C A 6: 48,967,173 (GRCm39) P707H probably damaging Het
Arhgef18 T A 8: 3,439,023 (GRCm39) probably benign Het
Borcs5 T A 6: 134,687,096 (GRCm39) N150K probably damaging Het
C9orf72 C A 4: 35,218,630 (GRCm39) E76D probably damaging Het
Cdh20 G A 1: 109,988,862 (GRCm39) V255I probably benign Het
Cntnap5c C A 17: 58,671,241 (GRCm39) T1143K possibly damaging Het
Col7a1 A C 9: 108,784,402 (GRCm39) T137P unknown Het
Defb8 C T 8: 19,495,910 (GRCm39) G50E probably damaging Het
Dimt1 T A 13: 107,086,193 (GRCm39) probably benign Het
Dnajb11 T A 16: 22,689,423 (GRCm39) D281E probably damaging Het
Eci2 G T 13: 35,177,087 (GRCm39) N24K probably damaging Het
Fbn1 A T 2: 125,236,607 (GRCm39) C358S probably benign Het
Fbxl13 A T 5: 21,825,602 (GRCm39) probably benign Het
Fbxw11 T C 11: 32,661,922 (GRCm39) C121R probably damaging Het
Fsd2 T C 7: 81,209,518 (GRCm39) D108G probably benign Het
Gab1 C A 8: 81,511,471 (GRCm39) R458L probably damaging Het
Ghrhr T A 6: 55,365,254 (GRCm39) L416* probably null Het
Glipr1l2 C A 10: 111,919,371 (GRCm39) L31I possibly damaging Het
Gm1818 A G 12: 48,602,982 (GRCm39) noncoding transcript Het
Gm19965 T A 1: 116,748,550 (GRCm39) probably benign Het
Gpr149 A G 3: 62,511,888 (GRCm39) L37P probably damaging Het
Hoxa9 A G 6: 52,202,693 (GRCm39) I131T probably damaging Het
Itpkc T C 7: 26,927,195 (GRCm39) I240V probably benign Het
Jakmip3 A G 7: 138,629,515 (GRCm39) D552G probably damaging Het
Kank4 T C 4: 98,653,806 (GRCm39) Y874C probably damaging Het
Kdm3a T C 6: 71,577,011 (GRCm39) E768G possibly damaging Het
Klf6 A G 13: 5,911,711 (GRCm39) D25G probably benign Het
Lamc1 T C 1: 153,122,977 (GRCm39) probably benign Het
Laptm4a T C 12: 8,986,716 (GRCm39) V258A probably damaging Het
Map3k19 A G 1: 127,751,617 (GRCm39) V578A probably benign Het
Mast1 T C 8: 85,651,956 (GRCm39) E342G probably benign Het
Mgat5b T C 11: 116,868,622 (GRCm39) L515P probably damaging Het
Mink1 A G 11: 70,502,166 (GRCm39) D985G probably benign Het
Mphosph9 A G 5: 124,453,739 (GRCm39) V191A possibly damaging Het
Muc6 C T 7: 141,234,368 (GRCm39) G708S probably damaging Het
Pcnt A T 10: 76,228,878 (GRCm39) probably null Het
Psmd8 A T 7: 28,875,598 (GRCm39) Y174N probably damaging Het
Ptgdr2 C A 19: 10,918,292 (GRCm39) R270S possibly damaging Het
Rasal2 A G 1: 156,975,218 (GRCm39) M1172T probably damaging Het
Rif1 A G 2: 51,997,640 (GRCm39) probably benign Het
Rnf123 C T 9: 107,954,572 (GRCm39) R48H probably benign Het
Rsrc1 T C 3: 67,263,551 (GRCm39) probably benign Het
Rxfp2 T C 5: 149,975,021 (GRCm39) V210A probably benign Het
Serpinb9d C T 13: 33,384,608 (GRCm39) P195L probably benign Het
Sis A G 3: 72,865,437 (GRCm39) probably benign Het
Skint4 T C 4: 111,981,793 (GRCm39) M246T probably benign Het
Snrnp200 C A 2: 127,070,997 (GRCm39) R1093S probably damaging Het
Sp100 A G 1: 85,629,141 (GRCm39) N471D possibly damaging Het
Spmip4 T A 6: 50,566,121 (GRCm39) K118M probably damaging Het
Ssxb8 T G X: 8,556,062 (GRCm39) H88P probably damaging Het
Sufu T C 19: 46,389,703 (GRCm39) probably null Het
Synpo2l G A 14: 20,718,235 (GRCm39) T10I possibly damaging Het
Tdo2 A T 3: 81,881,683 (GRCm39) S40R probably damaging Het
Tent4b T A 8: 88,978,635 (GRCm39) F445L probably damaging Het
Terb1 G A 8: 105,210,938 (GRCm39) T363I probably benign Het
Timd4 C T 11: 46,708,498 (GRCm39) P175S probably damaging Het
Tlr3 C A 8: 45,850,171 (GRCm39) V833L probably damaging Het
Tpst2 T A 5: 112,455,911 (GRCm39) M150K probably damaging Het
Trim67 T A 8: 125,543,774 (GRCm39) V378E probably damaging Het
Tyrp1 C T 4: 80,763,105 (GRCm39) Q331* probably null Het
Ubap2l A T 3: 89,930,807 (GRCm39) S413T probably benign Het
Uimc1 G A 13: 55,176,415 (GRCm39) T701I possibly damaging Het
Vangl2 G T 1: 171,832,353 (GRCm39) T501N probably damaging Het
Vmn1r60 A G 7: 5,547,621 (GRCm39) S160P probably benign Het
Vmn2r72 T A 7: 85,401,152 (GRCm39) E89V probably damaging Het
Zfp457 G A 13: 67,441,748 (GRCm39) P180S probably damaging Het
Other mutations in Vmn2r66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00321:Vmn2r66 APN 7 84,656,299 (GRCm39) missense probably benign
IGL01562:Vmn2r66 APN 7 84,656,495 (GRCm39) missense probably benign 0.03
IGL01689:Vmn2r66 APN 7 84,657,033 (GRCm39) missense probably damaging 1.00
IGL02237:Vmn2r66 APN 7 84,643,908 (GRCm39) missense probably benign
IGL02415:Vmn2r66 APN 7 84,656,020 (GRCm39) missense probably damaging 0.97
IGL02439:Vmn2r66 APN 7 84,654,455 (GRCm39) splice site probably benign
IGL02545:Vmn2r66 APN 7 84,655,798 (GRCm39) missense possibly damaging 0.50
IGL02708:Vmn2r66 APN 7 84,655,796 (GRCm39) missense probably benign 0.00
IGL02794:Vmn2r66 APN 7 84,644,623 (GRCm39) missense probably benign 0.00
IGL02885:Vmn2r66 APN 7 84,644,723 (GRCm39) missense probably benign 0.00
IGL02975:Vmn2r66 APN 7 84,656,182 (GRCm39) missense probably damaging 0.98
IGL03027:Vmn2r66 APN 7 84,644,777 (GRCm39) splice site probably benign
IGL03081:Vmn2r66 APN 7 84,657,138 (GRCm39) missense probably benign
PIT4131001:Vmn2r66 UTSW 7 84,644,301 (GRCm39) missense probably damaging 1.00
R0098:Vmn2r66 UTSW 7 84,654,965 (GRCm39) missense probably damaging 1.00
R0504:Vmn2r66 UTSW 7 84,656,023 (GRCm39) missense probably damaging 0.99
R0557:Vmn2r66 UTSW 7 84,643,972 (GRCm39) missense probably damaging 1.00
R0617:Vmn2r66 UTSW 7 84,644,484 (GRCm39) missense probably benign 0.02
R0883:Vmn2r66 UTSW 7 84,657,070 (GRCm39) missense probably benign
R1159:Vmn2r66 UTSW 7 84,644,613 (GRCm39) missense probably benign 0.44
R1168:Vmn2r66 UTSW 7 84,656,062 (GRCm39) missense possibly damaging 0.46
R1172:Vmn2r66 UTSW 7 84,654,799 (GRCm39) missense probably benign 0.04
R1538:Vmn2r66 UTSW 7 84,644,166 (GRCm39) missense possibly damaging 0.84
R1658:Vmn2r66 UTSW 7 84,656,955 (GRCm39) missense probably benign 0.07
R1937:Vmn2r66 UTSW 7 84,644,344 (GRCm39) missense probably damaging 0.99
R1989:Vmn2r66 UTSW 7 84,661,201 (GRCm39) missense probably benign 0.01
R2698:Vmn2r66 UTSW 7 84,644,607 (GRCm39) missense probably damaging 1.00
R2890:Vmn2r66 UTSW 7 84,661,027 (GRCm39) splice site probably null
R3686:Vmn2r66 UTSW 7 84,644,397 (GRCm39) missense probably damaging 0.96
R4152:Vmn2r66 UTSW 7 84,654,800 (GRCm39) missense probably benign 0.08
R4500:Vmn2r66 UTSW 7 84,657,162 (GRCm39) missense probably damaging 1.00
R4618:Vmn2r66 UTSW 7 84,644,296 (GRCm39) missense possibly damaging 0.62
R4656:Vmn2r66 UTSW 7 84,661,204 (GRCm39) missense possibly damaging 0.87
R4668:Vmn2r66 UTSW 7 84,643,905 (GRCm39) missense probably damaging 1.00
R4942:Vmn2r66 UTSW 7 84,656,980 (GRCm39) missense probably damaging 1.00
R5163:Vmn2r66 UTSW 7 84,656,017 (GRCm39) missense probably benign 0.01
R5223:Vmn2r66 UTSW 7 84,657,093 (GRCm39) missense probably benign
R5377:Vmn2r66 UTSW 7 84,656,026 (GRCm39) missense probably damaging 0.99
R5512:Vmn2r66 UTSW 7 84,657,149 (GRCm39) missense probably damaging 1.00
R5611:Vmn2r66 UTSW 7 84,654,951 (GRCm39) nonsense probably null
R5749:Vmn2r66 UTSW 7 84,655,979 (GRCm39) nonsense probably null
R6131:Vmn2r66 UTSW 7 84,644,224 (GRCm39) missense probably damaging 1.00
R6183:Vmn2r66 UTSW 7 84,644,766 (GRCm39) missense possibly damaging 0.81
R6509:Vmn2r66 UTSW 7 84,656,054 (GRCm39) missense probably benign 0.12
R6930:Vmn2r66 UTSW 7 84,661,216 (GRCm39) missense possibly damaging 0.80
R6992:Vmn2r66 UTSW 7 84,654,436 (GRCm39) missense possibly damaging 0.90
R7015:Vmn2r66 UTSW 7 84,644,766 (GRCm39) missense possibly damaging 0.81
R7302:Vmn2r66 UTSW 7 84,654,423 (GRCm39) missense probably benign 0.00
R7516:Vmn2r66 UTSW 7 84,661,176 (GRCm39) missense possibly damaging 0.51
R7763:Vmn2r66 UTSW 7 84,654,909 (GRCm39) missense probably benign 0.01
R7814:Vmn2r66 UTSW 7 84,656,472 (GRCm39) missense probably benign 0.02
R8077:Vmn2r66 UTSW 7 84,656,093 (GRCm39) missense probably benign
R8307:Vmn2r66 UTSW 7 84,656,270 (GRCm39) missense probably benign
R8315:Vmn2r66 UTSW 7 84,643,932 (GRCm39) missense possibly damaging 0.90
R8490:Vmn2r66 UTSW 7 84,654,794 (GRCm39) critical splice donor site probably null
R8511:Vmn2r66 UTSW 7 84,656,026 (GRCm39) missense probably damaging 0.99
R8781:Vmn2r66 UTSW 7 84,644,355 (GRCm39) nonsense probably null
R8812:Vmn2r66 UTSW 7 84,654,893 (GRCm39) missense probably damaging 0.99
R9203:Vmn2r66 UTSW 7 84,654,950 (GRCm39) missense probably benign 0.01
R9277:Vmn2r66 UTSW 7 84,661,164 (GRCm39) missense probably benign 0.00
Predicted Primers
Posted On 2014-01-15