Candidate Explorer
- Mutagenetix Linkage Analysis
- The Mutagenetix system performs automatic linkage analysis when both screen data and genotype information are available for mice in our pedigrees. Analysis is done within individual pedigrees, pedigrees that share a particular exact mutation, pedigrees that have mutations in the same gene, as well as other combinations of pedigrees. The linkage analysis results correlate various screen results with genotype results of mice in various pedigrees studied at the Beutler Lab. Third generation mice are genotyped against a list of ENU induced mutations found in the first generation mouse through whole exome sequencing. Those mice are then screened for various traits. The screen data and genotype data are then analysed to see if variation in screen results correlate with heterozygous or homozygous occurances of the known mutations.
- Candidate Explorer
- The Candidate Explorer application shows the results of machine learning analysis of various factors that better predict if a high scoring mutation is actually the causative mutation for the phenotype. Candidates are scored based on various criteria, including variance in screen values of the homozygous mice, predicted damage of the mutation, overlap of values of reference mice and homozygous mice, result of Gene Linkage analysis, result of Position Linkage analysis, nearby mutations showing better linkage, result of CRISPR analysis, and various other values.
- Available Screens
- The screens available for searching are listed here.