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Phenotypic Mutations
47
mutations affecting
45
genes are currently displayed.
Mutations Mapped and Identified Based on Phenotype
[records 1 to 47 of 47]
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Gene
E Score
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Allele
Chr
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Chr Loc
Coordinate
Mode of Inheritance
Unknown
Autosomal Codominant
Autosomal Dominant
Autosomal Recessive
Autosomal Semidominant
X-linked Recessive
X-linked Dominant
Verification Probability
≥ 90%
≥ 80%
≥ 70%
≥ 60%
≥ 50%
≥ 40%
≥ 30%
≥ 20%
≥ 10%
≥ 0%
< 10%
< 20%
< 30%
< 40%
< 50%
< 60%
< 70%
< 80%
< 90%
No ML probability
Failed Initial Filter
OR is public
OR is verified
Updated
Phenotypic Category
all of
any of
125-03 Response - decreased
125-03 Response - increased
30 min GTT hyperglycemic
30 min GTT hyperglycemic (male)
30 min GTT hyperoglycemic (female)
30 min GTT hypoglycemic
30 min GTT hypoglycemic (female)
30 min GTT hypoglycemic (male)
30 Min. Insulin (Female) - decreased
adenovirus infection of macrophages - decreased
adenovirus infection of macrophages - increased
adipose tissue
anemia
Anophthalmia
Antibody: FACS B cells - decreased
Antibody: FACS B cells - increased
Antibody: FACS B:T cells - decreased
Antibody: FACS B:T cells - increased
Antibody: FACS B1 cells - decreased
Antibody: FACS B1 cells - increased
Antibody: FACS B1a cells - decreased
Antibody: FACS B1a cells - increased
Antibody: FACS B1a cells in B1 cells - decreased
Antibody: FACS B1a cells in B1 cells - increased
Antibody: FACS B1b cells - decreased
Antibody: FACS B1b cells - increased
Antibody: FACS B1b cells in B1 cells - decreased
Antibody: FACS B1b cells in B1 cells - increased
Antibody: FACS B2 cells - decreased
Antibody: FACS B2 cells - increased
Antibody: FACS B220 MFI - decreased
Antibody: FACS B220 MFI - increased
Antibody: FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
Antibody: FACS CD11b+ DCs (gated in CD11c+ cells) - increased
Antibody: FACS CD11c+ DCs - decreased
Antibody: FACS CD11c+ DCs - increased
Antibody: FACS CD4:CD8 - decreased
Antibody: FACS CD4:CD8 - increased
Antibody: FACS CD4+ T cells - decreased
Antibody: FACS CD4+ T cells - increased
Antibody: FACS CD4+ T cells in CD3+ T cells - decreased
Antibody: FACS CD4+ T cells in CD3+ T cells - increased
Antibody: FACS CD44+ CD4 MFI - decreased
Antibody: FACS CD44+ CD4 MFI - increased
Antibody: FACS CD44+ CD4 T cells - decreased
Antibody: FACS CD44+ CD4 T cells - increased
Antibody: FACS CD44+ CD8 MFI - decreased
Antibody: FACS CD44+ CD8 MFI - increased
Antibody: FACS CD44+ CD8 T cells - decreased
Antibody: FACS CD44+ CD8 T cells - increased
Antibody: FACS CD44+ T cells - decreased
Antibody: FACS CD44+ T cells - increased
Antibody: FACS CD44+ T MFI - decreased
Antibody: FACS CD44+ T MFI - increased
Antibody: FACS CD8+ T cells - decreased
Antibody: FACS CD8+ T cells - increased
Antibody: FACS CD8+ T cells in CD3+ T cells - decreased
Antibody: FACS CD8+ T cells in CD3+ T cells - increased
Antibody: FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
Antibody: FACS CD8a+ DCs (gated in CD11c+ cells) - increased
Antibody: FACS central memory CD4 T cells in CD4 T cells - decreased
Antibody: FACS central memory CD4 T cells in CD4 T cells - increased
Antibody: FACS central memory CD8 T cells in CD8 T cells - decreased
Antibody: FACS central memory CD8 T cells in CD8 T cells - increased
Antibody: FACS effector memory CD4 T cells in CD4 T cells - decreased
Antibody: FACS effector memory CD4 T cells in CD4 T cells - increased
Antibody: FACS effector memory CD8 T cells in CD8 T cells - decreased
Antibody: FACS effector memory CD8 T cells in CD8 T cells - increased
Antibody: FACS effector T cells - decreased
Antibody: FACS effector T cells - increased
Antibody: FACS IgD MFI - decreased
Antibody: FACS IgD MFI - increased
Antibody: FACS IgD+ B cell percentage - decreased
Antibody: FACS IgD+ B cell percentage - increased
Antibody: FACS IgM MFI - decreased
Antibody: FACS IgM MFI - increased
Antibody: FACS IgM+ B cells - decreased
Antibody: FACS IgM+ B cells - increased
Antibody: FACS Macrophages - decreased
Antibody: FACS Macrophages - increased
Antibody: FACS memory T cells - decreased
Antibody: FACS memory T cells - increased
Antibody: FACS naive CD4 T cells in CD4 T cells - decreased
Antibody: FACS naive CD4 T cells in CD4 T cells - increased
Antibody: FACS naive CD8 T cells in CD8 T cells - decreased
Antibody: FACS naive CD8 T cells in CD8 T cells - increased
Antibody: FACS naive T cells - decreased
Antibody: FACS naive T cells - increased
Antibody: FACS Neutrophils - decreased
Antibody: FACS Neutrophils - increased
Antibody: FACS NK cells - decreased
Antibody: FACS NK cells - increased
Antibody: FACS NK1.1+ T cells - decreased
Antibody: FACS NK1.1+ T cells - increased
Antibody: FACS NKT cells (tet) - decreased
Antibody: FACS NKT cells (tet) - increased
Antibody: FACS pDCs - decreased
Antibody: FACS pDCs - increased
Antibody: FACS T cells - decreased
Antibody: FACS T cells - increased
Antibody: MC38 tumor volume (day 13) - decreased
Antibody: MC38 tumor volume (day 13) - increased
Antibody: MC38 tumor volume (day 20) - decreased
Antibody: MC38 tumor volume (day 20) - increased
autoimmunity
behavior/neurological
Blood Analysis EO% - decreased
Blood Analysis EO% - increased
Blood Analysis Hb - decreased
Blood Analysis Hb - increased
Blood Analysis HCT - decreased
Blood Analysis HCT - increased
Blood Analysis LY# - decreased
Blood Analysis LY# - increased
Blood Analysis MCH - decreased
Blood Analysis MCH - increased
Blood Analysis MCHC - decreased
Blood Analysis MCHC - increased
Blood Analysis MCV - decreased
Blood Analysis MCV - increased
Blood Analysis MO# - decreased
Blood Analysis MO# - increased
Blood Analysis NE# - decreased
Blood Analysis NE# - increased
Blood Analysis Platelet Count - decreased
Blood Analysis Platelet Count - increased
Blood Analysis RBC - decreased
Blood Analysis RBC - increased
Blood Analysis RDW - decreased
Blood Analysis RDW - increased
Blood Analysis WBC - decreased
Blood Analysis WBC - increased
Blood Pressure: Pooled HR - decreased
Blood Pressure: Pooled HR - increased
Blood Pressure: Pooled SBP - decreased
Blood Pressure: Pooled SBP - increased
Body Weight - decreased
Body Weight - increased
Body Weight (DSS Female) - decreased
Body Weight (DSS Female) - increased
Body Weight (DSS Male) - decreased
Body Weight (DSS Male) - increased
Body Weight (DSS) - decreased
Body Weight (DSS) - increased
Body Weight (DSS, Day10) - decreased
Body Weight (DSS, Day10) - increased
Body Weight (DSS, Day7) - decreased
Body Weight (DSS, Day7) - increased
Body Weight (DSS, z-score) - decreased
Body Weight (DSS, z-score) - increased
Body Weight (Female) - decreased
Body Weight (Female) - increased
Body Weight (Male) - decreased
Body Weight (Male) - increased
Body Weight (Z-score) - decreased
Body Weight (Z-score) - increased
Bone: Femur Length (AI, residual) - decreased
Bone: Femur Length (AI, residual) - increased
Bone: Femur Length (AI, residual, female) - decreased
Bone: Femur Length (AI, residual, female) - increased
Bone: Femur Length (AI, residual, male) - decreased
Bone: Femur Length (AI, residual, male) - increased
Bone: Pelvis Length (AI, residual) - decreased
Bone: Pelvis Length (AI, residual) - increased
Bone: Pelvis Length (AI, residual, female) - decreased
Bone: Pelvis Length (AI, residual, female) - increased
Bone: Pelvis Length (AI, residual, male) - decreased
Bone: Pelvis Length (AI, residual, male) - increased
Bone: Spine Deformity (female)
Bone: Spine Deformity (male)
Bone: Tibia Length (AI, residual) - decreased
Bone: Tibia Length (AI, residual) - increased
Bone: Tibia Length (AI, residual, female) - decreased
Bone: Tibia Length (AI, residual, female) - increased
Bone: Tibia Length (AI, residual, male) - decreased
Bone: Tibia Length (AI, residual, male) - increased
cardiovascular system
CD8 response - decreased
cellular phenotype
craniofacial
CTL killing - decreased
CTL killing - increased
CTL killing dominant epitope - decreased
CTL killing dominant epitope - increased
CTL killing subdominant epitope - decreased
CTL killing subdominant epitope - increased
digestive/alimentary
dsDNA Antibody - decreased
dsDNA Antibody - increased
dsDNA induced type I IFN production - decreased
dsDNA induced type I IFN production - increased
DSS: resistant
DSS: resistant day 10
DSS: resistant day 7
DSS: sensitive day 10
DSS: sensitive day 7
embryogenesis
endocrine/exocrine gland
extracellular cGAMP: high response
extracellular cGAMP: low response
eye: micro-ophthalmia
Eye: SL-OCT BM to ILM thickness - decreased
Eye: SL-OCT BM to ILM thickness - increased
Eye: SL-OCT INL to ILM thickness - decreased
Eye: SL-OCT INL to ILM thickness - increased
Eye: SL-OCT IPL to ILM thickness - decreased
Eye: SL-OCT IPL to ILM thickness - increased
FACS B cells - decreased
FACS B cells - increased
FACS B:T cells - decreased
FACS B:T cells - increased
FACS B1 cells - decreased
FACS B1 cells - increased
FACS B1a cells - decreased
FACS B1a cells - increased
FACS B1a cells in B1 cells - decreased
FACS B1a cells in B1 cells - increased
FACS B1b cells - decreased
FACS B1b cells - increased
FACS B1b cells in B1 cells - decreased
FACS B1b cells in B1 cells - increased
FACS B2 cells - decreased
FACS B2 cells - increased
FACS B220 MFI - decreased
FACS B220 MFI - increased
FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
FACS CD11b+ DCs (gated in CD11c+ cells) - increased
FACS CD11c+ DCs - decreased
FACS CD11c+ DCs - increased
FACS CD4:CD8 - decreased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells - increased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 MFI - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - decreased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 MFI - decreased
FACS CD44+ CD8 MFI - increased
FACS CD44+ CD8 T cells - decreased
FACS CD44+ CD8 T cells - increased
FACS CD44+ T cells - decreased
FACS CD44+ T cells - increased
FACS CD44+ T MFI - decreased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells - increased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - increased
FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
FACS CD8a+ DCs (gated in CD11c+ cells) - increased
FACS central memory CD4 T cells in CD4 T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - decreased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - decreased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - decreased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS effector T cells - decreased
FACS effector T cells - increased
FACS IgD MFI - decreased
FACS IgD MFI - increased
FACS IgD+ B cell percentage - decreased
FACS IgD+ B cell percentage - increased
FACS IgM MFI - decreased
FACS IgM MFI - increased
FACS IgM+ B cells - decreased
FACS IgM+ B cells - increased
FACS macrophages - decreased
FACS macrophages - increased
FACS memory T cells - decreased
FACS memory T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD4 T cells in CD4 T cells - increased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - increased
FACS naive T cells - decreased
FACS naive T cells - increased
FACS neutrophils - decreased
FACS neutrophils - increased
FACS NK cells - decreased
FACS NK cells - increased
FACS NK1.1+ T cells - decreased
FACS NK1.1+ T cells - increased
FACS NKT cells (tet) - decreased
FACS NKT cells (tet) - increased
FACS pDCs - decreased
FACS pDCs - increased
FACS T cells - decreased
FACS T cells - increased
growth/size
hearing/vestibular/ear
hematopoietic competition - disadvantage
hematopoietic system
homeostasis/metabolism
IgA response to 2nd OVA/Alum Challenge (day 7) - decreased
IgA response to 2nd OVA/Alum Challenge (day 7) - increased
IgE response to a Cysteine Protease (Papain) - decreased
IgE response to a Cysteine Protease (Papain) - increased
IgG1 response to a Cysteine Protease (Papain) - decreased
IgG1 response to a Cysteine Protease (Papain) - increased
immune system
impaired response to dsDNA- type I IFN production by macrophages
inflammatory bowel disease phenotype
influenza proliferation in macrophages - decreased
influenza proliferation in macrophages - increased
influenza resistance
iron deficiency
iron excess
LCMV clone 13 resistance
lethality-embryonic/perinatal
lethality-postnatal
life span-post-weaning/aging
limbs/digits/tail phenotype
liver/biliary system
LPS Cachexia: Body Weight (day 0) - decreased
LPS Cachexia: Body Weight (day 0) - increased
LPS Cachexia: Body Weight (day 0, z-score) - decreased
LPS Cachexia: Body Weight (day 0, z-score) - increased
LPS Cachexia: Body Weight (day 1) - decreased
LPS Cachexia: Body Weight (day 1) - increased
LPS Cachexia: Body Weight (day 14) - decreased
LPS Cachexia: Body Weight (day 14) - increased
LPS Cachexia: Body Weight (day 2) - decreased
LPS Cachexia: Body Weight (day 2) - increased
LPS Cachexia: Body Weight Change (day 1, g) - decreased
LPS Cachexia: Body Weight Change (day 1, g) - increased
LPS Cachexia: Body Weight Change (day 1, ratio) - decreased
LPS Cachexia: Body Weight Change (day 1, ratio) - increased
LPS Cachexia: Body Weight Change (day 14, g) - decreased
LPS Cachexia: Body Weight Change (day 14, g) - increased
LPS Cachexia: Body Weight Change (day 14, ratio) - decreased
LPS Cachexia: Body Weight Change (day 14, ratio) - increased
LPS Cachexia: Body Weight Change (day 2, g) - decreased
LPS Cachexia: Body Weight Change (day 2, g) - increased
LPS Cachexia: Body Weight Change (day 2, ratio) - decreased
LPS Cachexia: Body Weight Change (day 2, ratio) - increased
LPS Hypersensitivity - decreased
LPS Hypersensitivity - increased
LPS-induced Necroptosis - decreased
LPS-induced Necroptosis - increased
Macrophage necroptosis: high
Macrophage necroptosis: low
MC38 tumor volume (day 22) - decreased
MC38 tumor volume (day 22) - increased
MC38 tumor volume (day 22, early sac sick or found dead, IM injection, dermatitis, trimmed) - decreased
MC38 tumor volume (day 22, early sac sick or found dead, IM injection, dermatitis, trimmed) - increased
MC38 tumor volume (day 22, early sac sick or found dead, trimmed) - decreased
MC38 tumor volume (day 22, early sac sick or found dead, trimmed) - increased
MC38 tumor volume (day 22, IM injection, dermatitis, trimmed) - decreased
MC38 tumor volume (day 22, IM injection, dermatitis, trimmed) - increased
MCMV proliferation in macrophages - decreased
MCMV proliferation in macrophages - increased
MCMV resistance
MCMV susceptibility
MTT dsDNA PECs - decreased
MTT dsDNA PECs - increased
MTT Value of PECs - decreased
MTT Value of PECs - increased
muscle
NALP3 inflammasome signaling defect
nervous system
NK cell response - decreased
NK killing - decreased
NK killing - increased
Nlrc4 inflammasome: high response
Nlrc4 inflammasome: low response
NLRP3 inflammasome: high response
NLRP3 inflammasome: low response
no phenotypic analysis
normal phenotype
other phenotype
OVA-specific IgE - decreased
OVA-specific IgE - increased
OVA-specific IgE after 2nd OVA/Alum - decreased
OVA-specific IgE after 2nd OVA/Alum - increased
Peritoneal exudates B1a cell % - decreased
Peritoneal exudates B1a cell % - increased
Peritoneal exudates B1a cell numbers - decreased
Peritoneal exudates B1a cell numbers - increased
Peritoneal exudates B1b cell % - decreased
Peritoneal exudates B1b cell % - increased
Peritoneal exudates B1b cell numbers - decreased
Peritoneal exudates B1b cell numbers - increased
Peritoneal exudates macrophage % - decreased
Peritoneal exudates macrophage % - increased
Peritoneal exudates macrophage numbers - decreased
Peritoneal exudates macrophage numbers - increased
Peritoneal exudates neutrophil % - decreased
Peritoneal exudates neutrophil % - increased
Peritoneal exudates neutrophil numbers - decreased
Peritoneal exudates neutrophil numbers - increased
phagocytosis in PECs - decreased
phagocytosis in PECs - increased
pigmentation
polycythemia
post-MCMV FACS B cells - decreased
post-MCMV FACS B cells - increased
post-MCMV FACS B:T cells - decreased
post-MCMV FACS B:T cells - increased
post-MCMV FACS B1 cells - decreased
post-MCMV FACS B1 cells - increased
post-MCMV FACS B1a cells - decreased
post-MCMV FACS B1a cells - increased
post-MCMV FACS B1a cells in B1 cells - decreased
post-MCMV FACS B1a cells in B1 cells - increased
post-MCMV FACS B1b cells - decreased
post-MCMV FACS B1b cells - increased
post-MCMV FACS B1b cells in B1 cells - decreased
post-MCMV FACS B1b cells in B1 cells - increased
post-MCMV FACS B2 cells - decreased
post-MCMV FACS B2 cells - increased
post-MCMV FACS B220 MFI - decreased
post-MCMV FACS B220 MFI - increased
post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - increased
post-MCMV FACS CD11c+ DCs - decreased
post-MCMV FACS CD11c+ DCs - increased
post-MCMV FACS CD4:CD8 - decreased
post-MCMV FACS CD4:CD8 - increased
post-MCMV FACS CD4+ T cells - decreased
post-MCMV FACS CD4+ T cells - increased
post-MCMV FACS CD4+ T cells in CD3+ T cells - decreased
post-MCMV FACS CD4+ T cells in CD3+ T cells - increased
post-MCMV FACS CD44+ CD4 MFI - decreased
post-MCMV FACS CD44+ CD4 MFI - increased
post-MCMV FACS CD44+ CD4 T cells - decreased
post-MCMV FACS CD44+ CD4 T cells - increased
post-MCMV FACS CD44+ CD8 MFI - decreased
post-MCMV FACS CD44+ CD8 MFI - increased
post-MCMV FACS CD44+ CD8 T cells - decreased
post-MCMV FACS CD44+ CD8 T cells - increased
post-MCMV FACS CD44+ T cells - decreased
post-MCMV FACS CD44+ T cells - increased
post-MCMV FACS CD44+ T MFI - decreased
post-MCMV FACS CD44+ T MFI - increased
post-MCMV FACS CD8+ T cells - decreased
post-MCMV FACS CD8+ T cells - increased
post-MCMV FACS CD8+ T cells in CD3+ T cells - decreased
post-MCMV FACS CD8+ T cells in CD3+ T cells - increased
post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - increased
post-MCMV FACS central memory CD4 T cells in CD4 T cells - decreased
post-MCMV FACS central memory CD4 T cells in CD4 T cells - increased
post-MCMV FACS central memory CD8 T cells in CD8 T cells - decreased
post-MCMV FACS central memory CD8 T cells in CD8 T cells - increased
post-MCMV FACS effector memory CD4 T cells in CD4 T cells - decreased
post-MCMV FACS effector memory CD4 T cells in CD4 T cells - increased
post-MCMV FACS effector memory CD8 T cells in CD8 T cells - decreased
post-MCMV FACS effector memory CD8 T cells in CD8 T cells - increased
post-MCMV FACS effector T cells - decreased
post-MCMV FACS effector T cells - increased
post-MCMV FACS IgD MFI - decreased
post-MCMV FACS IgD MFI - increased
post-MCMV FACS IgD+ B cell percentage - decreased
post-MCMV FACS IgD+ B cell percentage - increased
post-MCMV FACS IgM MFI - decreased
post-MCMV FACS IgM MFI - increased
post-MCMV FACS IgM+ B cells - decreased
post-MCMV FACS IgM+ B cells - increased
post-MCMV FACS macrophages - decreased
post-MCMV FACS macrophages - increased
post-MCMV FACS memory T cells - decreased
post-MCMV FACS memory T cells - increased
post-MCMV FACS naive CD4 T cells in CD4 T cells - decreased
post-MCMV FACS naive CD4 T cells in CD4 T cells - increased
post-MCMV FACS naive CD8 T cells in CD8 T cells - decreased
post-MCMV FACS naive CD8 T cells in CD8 T cells - increased
post-MCMV FACS naive T cells - decreased
post-MCMV FACS naive T cells - increased
post-MCMV FACS neutrophils - decreased
post-MCMV FACS neutrophils - increased
post-MCMV FACS NK cells - decreased
post-MCMV FACS NK cells - increased
post-MCMV FACS NK T cells - decreased
post-MCMV FACS NK T cells - increased
post-MCMV FACS NKT cells (tet) - decreased
post-MCMV FACS NKT cells (tet) - increased
post-MCMV FACS pDCs - decreased
post-MCMV FACS pDCs - increased
post-MCMV FACS T cells - decreased
post-MCMV FACS T cells - increased
ratio of OVA-specific IgE over the total IgE - decreased
ratio of OVA-specific IgE over the total IgE - increased
renal/urinary system
reproductive system
resistance to B10-F16 melanoma - decreased
resistance to B10-F16 melanoma - increased
respiratory system
response to injected CpG DNA - decreased
RVFV proliferation in macrophages - decreased
RVFV proliferation in macrophages - increased
RVFV susceptibility
secretory SlgA after 2nd OVA/Alum Challenge (day 7) - decreased
secretory SlgA after 2nd OVA/Alum Challenge (day 7) - increased
skeleton phenotype
skin/coat/nails
taste/olfaction
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-dependent humoral response defect- increased antibody response to OVA+ alum immunization
T-dependent humoral response defect- increased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
T-independent B cell response defect- increased TNP-specific IgM to TNP-Ficoll immunization
TLR signaling defect: hypersensitivity to CpG + IFNg
TLR signaling defect: hypersensitivity to LPS
TLR signaling defect: hypersensitivity to MALP2
TLR signaling defect: hypersensitivity to PAM3CSK4
TLR signaling defect: hypersensitivity to poly I:C
TLR signaling defect: hypersensitivity to poly I:C + IFNg
TLR signaling defect: hypersensitivity to R848
TLR signaling defect: hyposensitivity to CpG + IFNg
TLR signaling defect: hyposensitivity to LPS
TLR signaling defect: hyposensitivity to MALP2
TLR signaling defect: hyposensitivity to PAM3CSK4
TLR signaling defect: hyposensitivity to poly I:C
TLR signaling defect: hyposensitivity to poly I:C + IFNg
TLR signaling defect: hyposensitivity to R848
TLR signaling defect: TNF production by macrophages
total IgE after 2nd OVA/Alum - decreased
total IgE after 2nd OVA/Alum - increased
Total IgE After 2nd OVA/Alum Challenge (day 7) - decreased
Total IgE After 2nd OVA/Alum Challenge (day 7) - increased
total IgE level - decreased
total IgE level - increased
touch/vibrissae
tumorigenesis
vision/eye
and
any of
none of
125-03 Response - decreased
125-03 Response - increased
30 min GTT hyperglycemic
30 min GTT hyperglycemic (male)
30 min GTT hyperoglycemic (female)
30 min GTT hypoglycemic
30 min GTT hypoglycemic (female)
30 min GTT hypoglycemic (male)
30 Min. Insulin (Female) - decreased
adenovirus infection of macrophages - decreased
adenovirus infection of macrophages - increased
adipose tissue
anemia
Anophthalmia
Antibody: FACS B cells - decreased
Antibody: FACS B cells - increased
Antibody: FACS B:T cells - decreased
Antibody: FACS B:T cells - increased
Antibody: FACS B1 cells - decreased
Antibody: FACS B1 cells - increased
Antibody: FACS B1a cells - decreased
Antibody: FACS B1a cells - increased
Antibody: FACS B1a cells in B1 cells - decreased
Antibody: FACS B1a cells in B1 cells - increased
Antibody: FACS B1b cells - decreased
Antibody: FACS B1b cells - increased
Antibody: FACS B1b cells in B1 cells - decreased
Antibody: FACS B1b cells in B1 cells - increased
Antibody: FACS B2 cells - decreased
Antibody: FACS B2 cells - increased
Antibody: FACS B220 MFI - decreased
Antibody: FACS B220 MFI - increased
Antibody: FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
Antibody: FACS CD11b+ DCs (gated in CD11c+ cells) - increased
Antibody: FACS CD11c+ DCs - decreased
Antibody: FACS CD11c+ DCs - increased
Antibody: FACS CD4:CD8 - decreased
Antibody: FACS CD4:CD8 - increased
Antibody: FACS CD4+ T cells - decreased
Antibody: FACS CD4+ T cells - increased
Antibody: FACS CD4+ T cells in CD3+ T cells - decreased
Antibody: FACS CD4+ T cells in CD3+ T cells - increased
Antibody: FACS CD44+ CD4 MFI - decreased
Antibody: FACS CD44+ CD4 MFI - increased
Antibody: FACS CD44+ CD4 T cells - decreased
Antibody: FACS CD44+ CD4 T cells - increased
Antibody: FACS CD44+ CD8 MFI - decreased
Antibody: FACS CD44+ CD8 MFI - increased
Antibody: FACS CD44+ CD8 T cells - decreased
Antibody: FACS CD44+ CD8 T cells - increased
Antibody: FACS CD44+ T cells - decreased
Antibody: FACS CD44+ T cells - increased
Antibody: FACS CD44+ T MFI - decreased
Antibody: FACS CD44+ T MFI - increased
Antibody: FACS CD8+ T cells - decreased
Antibody: FACS CD8+ T cells - increased
Antibody: FACS CD8+ T cells in CD3+ T cells - decreased
Antibody: FACS CD8+ T cells in CD3+ T cells - increased
Antibody: FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
Antibody: FACS CD8a+ DCs (gated in CD11c+ cells) - increased
Antibody: FACS central memory CD4 T cells in CD4 T cells - decreased
Antibody: FACS central memory CD4 T cells in CD4 T cells - increased
Antibody: FACS central memory CD8 T cells in CD8 T cells - decreased
Antibody: FACS central memory CD8 T cells in CD8 T cells - increased
Antibody: FACS effector memory CD4 T cells in CD4 T cells - decreased
Antibody: FACS effector memory CD4 T cells in CD4 T cells - increased
Antibody: FACS effector memory CD8 T cells in CD8 T cells - decreased
Antibody: FACS effector memory CD8 T cells in CD8 T cells - increased
Antibody: FACS effector T cells - decreased
Antibody: FACS effector T cells - increased
Antibody: FACS IgD MFI - decreased
Antibody: FACS IgD MFI - increased
Antibody: FACS IgD+ B cell percentage - decreased
Antibody: FACS IgD+ B cell percentage - increased
Antibody: FACS IgM MFI - decreased
Antibody: FACS IgM MFI - increased
Antibody: FACS IgM+ B cells - decreased
Antibody: FACS IgM+ B cells - increased
Antibody: FACS Macrophages - decreased
Antibody: FACS Macrophages - increased
Antibody: FACS memory T cells - decreased
Antibody: FACS memory T cells - increased
Antibody: FACS naive CD4 T cells in CD4 T cells - decreased
Antibody: FACS naive CD4 T cells in CD4 T cells - increased
Antibody: FACS naive CD8 T cells in CD8 T cells - decreased
Antibody: FACS naive CD8 T cells in CD8 T cells - increased
Antibody: FACS naive T cells - decreased
Antibody: FACS naive T cells - increased
Antibody: FACS Neutrophils - decreased
Antibody: FACS Neutrophils - increased
Antibody: FACS NK cells - decreased
Antibody: FACS NK cells - increased
Antibody: FACS NK1.1+ T cells - decreased
Antibody: FACS NK1.1+ T cells - increased
Antibody: FACS NKT cells (tet) - decreased
Antibody: FACS NKT cells (tet) - increased
Antibody: FACS pDCs - decreased
Antibody: FACS pDCs - increased
Antibody: FACS T cells - decreased
Antibody: FACS T cells - increased
Antibody: MC38 tumor volume (day 13) - decreased
Antibody: MC38 tumor volume (day 13) - increased
Antibody: MC38 tumor volume (day 20) - decreased
Antibody: MC38 tumor volume (day 20) - increased
autoimmunity
behavior/neurological
Blood Analysis EO% - decreased
Blood Analysis EO% - increased
Blood Analysis Hb - decreased
Blood Analysis Hb - increased
Blood Analysis HCT - decreased
Blood Analysis HCT - increased
Blood Analysis LY# - decreased
Blood Analysis LY# - increased
Blood Analysis MCH - decreased
Blood Analysis MCH - increased
Blood Analysis MCHC - decreased
Blood Analysis MCHC - increased
Blood Analysis MCV - decreased
Blood Analysis MCV - increased
Blood Analysis MO# - decreased
Blood Analysis MO# - increased
Blood Analysis NE# - decreased
Blood Analysis NE# - increased
Blood Analysis Platelet Count - decreased
Blood Analysis Platelet Count - increased
Blood Analysis RBC - decreased
Blood Analysis RBC - increased
Blood Analysis RDW - decreased
Blood Analysis RDW - increased
Blood Analysis WBC - decreased
Blood Analysis WBC - increased
Blood Pressure: Pooled HR - decreased
Blood Pressure: Pooled HR - increased
Blood Pressure: Pooled SBP - decreased
Blood Pressure: Pooled SBP - increased
Body Weight - decreased
Body Weight - increased
Body Weight (DSS Female) - decreased
Body Weight (DSS Female) - increased
Body Weight (DSS Male) - decreased
Body Weight (DSS Male) - increased
Body Weight (DSS) - decreased
Body Weight (DSS) - increased
Body Weight (DSS, Day10) - decreased
Body Weight (DSS, Day10) - increased
Body Weight (DSS, Day7) - decreased
Body Weight (DSS, Day7) - increased
Body Weight (DSS, z-score) - decreased
Body Weight (DSS, z-score) - increased
Body Weight (Female) - decreased
Body Weight (Female) - increased
Body Weight (Male) - decreased
Body Weight (Male) - increased
Body Weight (Z-score) - decreased
Body Weight (Z-score) - increased
Bone: Femur Length (AI, residual) - decreased
Bone: Femur Length (AI, residual) - increased
Bone: Femur Length (AI, residual, female) - decreased
Bone: Femur Length (AI, residual, female) - increased
Bone: Femur Length (AI, residual, male) - decreased
Bone: Femur Length (AI, residual, male) - increased
Bone: Pelvis Length (AI, residual) - decreased
Bone: Pelvis Length (AI, residual) - increased
Bone: Pelvis Length (AI, residual, female) - decreased
Bone: Pelvis Length (AI, residual, female) - increased
Bone: Pelvis Length (AI, residual, male) - decreased
Bone: Pelvis Length (AI, residual, male) - increased
Bone: Spine Deformity (female)
Bone: Spine Deformity (male)
Bone: Tibia Length (AI, residual) - decreased
Bone: Tibia Length (AI, residual) - increased
Bone: Tibia Length (AI, residual, female) - decreased
Bone: Tibia Length (AI, residual, female) - increased
Bone: Tibia Length (AI, residual, male) - decreased
Bone: Tibia Length (AI, residual, male) - increased
cardiovascular system
CD8 response - decreased
cellular phenotype
craniofacial
CTL killing - decreased
CTL killing - increased
CTL killing dominant epitope - decreased
CTL killing dominant epitope - increased
CTL killing subdominant epitope - decreased
CTL killing subdominant epitope - increased
digestive/alimentary
dsDNA Antibody - decreased
dsDNA Antibody - increased
dsDNA induced type I IFN production - decreased
dsDNA induced type I IFN production - increased
DSS: resistant
DSS: resistant day 10
DSS: resistant day 7
DSS: sensitive day 10
DSS: sensitive day 7
embryogenesis
endocrine/exocrine gland
extracellular cGAMP: high response
extracellular cGAMP: low response
eye: micro-ophthalmia
Eye: SL-OCT BM to ILM thickness - decreased
Eye: SL-OCT BM to ILM thickness - increased
Eye: SL-OCT INL to ILM thickness - decreased
Eye: SL-OCT INL to ILM thickness - increased
Eye: SL-OCT IPL to ILM thickness - decreased
Eye: SL-OCT IPL to ILM thickness - increased
FACS B cells - decreased
FACS B cells - increased
FACS B:T cells - decreased
FACS B:T cells - increased
FACS B1 cells - decreased
FACS B1 cells - increased
FACS B1a cells - decreased
FACS B1a cells - increased
FACS B1a cells in B1 cells - decreased
FACS B1a cells in B1 cells - increased
FACS B1b cells - decreased
FACS B1b cells - increased
FACS B1b cells in B1 cells - decreased
FACS B1b cells in B1 cells - increased
FACS B2 cells - decreased
FACS B2 cells - increased
FACS B220 MFI - decreased
FACS B220 MFI - increased
FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
FACS CD11b+ DCs (gated in CD11c+ cells) - increased
FACS CD11c+ DCs - decreased
FACS CD11c+ DCs - increased
FACS CD4:CD8 - decreased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells - increased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 MFI - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - decreased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 MFI - decreased
FACS CD44+ CD8 MFI - increased
FACS CD44+ CD8 T cells - decreased
FACS CD44+ CD8 T cells - increased
FACS CD44+ T cells - decreased
FACS CD44+ T cells - increased
FACS CD44+ T MFI - decreased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells - increased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - increased
FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
FACS CD8a+ DCs (gated in CD11c+ cells) - increased
FACS central memory CD4 T cells in CD4 T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - decreased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - decreased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - decreased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS effector T cells - decreased
FACS effector T cells - increased
FACS IgD MFI - decreased
FACS IgD MFI - increased
FACS IgD+ B cell percentage - decreased
FACS IgD+ B cell percentage - increased
FACS IgM MFI - decreased
FACS IgM MFI - increased
FACS IgM+ B cells - decreased
FACS IgM+ B cells - increased
FACS macrophages - decreased
FACS macrophages - increased
FACS memory T cells - decreased
FACS memory T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD4 T cells in CD4 T cells - increased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - increased
FACS naive T cells - decreased
FACS naive T cells - increased
FACS neutrophils - decreased
FACS neutrophils - increased
FACS NK cells - decreased
FACS NK cells - increased
FACS NK1.1+ T cells - decreased
FACS NK1.1+ T cells - increased
FACS NKT cells (tet) - decreased
FACS NKT cells (tet) - increased
FACS pDCs - decreased
FACS pDCs - increased
FACS T cells - decreased
FACS T cells - increased
growth/size
hearing/vestibular/ear
hematopoietic competition - disadvantage
hematopoietic system
homeostasis/metabolism
IgA response to 2nd OVA/Alum Challenge (day 7) - decreased
IgA response to 2nd OVA/Alum Challenge (day 7) - increased
IgE response to a Cysteine Protease (Papain) - decreased
IgE response to a Cysteine Protease (Papain) - increased
IgG1 response to a Cysteine Protease (Papain) - decreased
IgG1 response to a Cysteine Protease (Papain) - increased
immune system
impaired response to dsDNA- type I IFN production by macrophages
inflammatory bowel disease phenotype
influenza proliferation in macrophages - decreased
influenza proliferation in macrophages - increased
influenza resistance
iron deficiency
iron excess
LCMV clone 13 resistance
lethality-embryonic/perinatal
lethality-postnatal
life span-post-weaning/aging
limbs/digits/tail phenotype
liver/biliary system
LPS Cachexia: Body Weight (day 0) - decreased
LPS Cachexia: Body Weight (day 0) - increased
LPS Cachexia: Body Weight (day 0, z-score) - decreased
LPS Cachexia: Body Weight (day 0, z-score) - increased
LPS Cachexia: Body Weight (day 1) - decreased
LPS Cachexia: Body Weight (day 1) - increased
LPS Cachexia: Body Weight (day 14) - decreased
LPS Cachexia: Body Weight (day 14) - increased
LPS Cachexia: Body Weight (day 2) - decreased
LPS Cachexia: Body Weight (day 2) - increased
LPS Cachexia: Body Weight Change (day 1, g) - decreased
LPS Cachexia: Body Weight Change (day 1, g) - increased
LPS Cachexia: Body Weight Change (day 1, ratio) - decreased
LPS Cachexia: Body Weight Change (day 1, ratio) - increased
LPS Cachexia: Body Weight Change (day 14, g) - decreased
LPS Cachexia: Body Weight Change (day 14, g) - increased
LPS Cachexia: Body Weight Change (day 14, ratio) - decreased
LPS Cachexia: Body Weight Change (day 14, ratio) - increased
LPS Cachexia: Body Weight Change (day 2, g) - decreased
LPS Cachexia: Body Weight Change (day 2, g) - increased
LPS Cachexia: Body Weight Change (day 2, ratio) - decreased
LPS Cachexia: Body Weight Change (day 2, ratio) - increased
LPS Hypersensitivity - decreased
LPS Hypersensitivity - increased
LPS-induced Necroptosis - decreased
LPS-induced Necroptosis - increased
Macrophage necroptosis: high
Macrophage necroptosis: low
MC38 tumor volume (day 22) - decreased
MC38 tumor volume (day 22) - increased
MC38 tumor volume (day 22, early sac sick or found dead, IM injection, dermatitis, trimmed) - decreased
MC38 tumor volume (day 22, early sac sick or found dead, IM injection, dermatitis, trimmed) - increased
MC38 tumor volume (day 22, early sac sick or found dead, trimmed) - decreased
MC38 tumor volume (day 22, early sac sick or found dead, trimmed) - increased
MC38 tumor volume (day 22, IM injection, dermatitis, trimmed) - decreased
MC38 tumor volume (day 22, IM injection, dermatitis, trimmed) - increased
MCMV proliferation in macrophages - decreased
MCMV proliferation in macrophages - increased
MCMV resistance
MCMV susceptibility
MTT dsDNA PECs - decreased
MTT dsDNA PECs - increased
MTT Value of PECs - decreased
MTT Value of PECs - increased
muscle
NALP3 inflammasome signaling defect
nervous system
NK cell response - decreased
NK killing - decreased
NK killing - increased
Nlrc4 inflammasome: high response
Nlrc4 inflammasome: low response
NLRP3 inflammasome: high response
NLRP3 inflammasome: low response
no phenotypic analysis
normal phenotype
other phenotype
OVA-specific IgE - decreased
OVA-specific IgE - increased
OVA-specific IgE after 2nd OVA/Alum - decreased
OVA-specific IgE after 2nd OVA/Alum - increased
Peritoneal exudates B1a cell % - decreased
Peritoneal exudates B1a cell % - increased
Peritoneal exudates B1a cell numbers - decreased
Peritoneal exudates B1a cell numbers - increased
Peritoneal exudates B1b cell % - decreased
Peritoneal exudates B1b cell % - increased
Peritoneal exudates B1b cell numbers - decreased
Peritoneal exudates B1b cell numbers - increased
Peritoneal exudates macrophage % - decreased
Peritoneal exudates macrophage % - increased
Peritoneal exudates macrophage numbers - decreased
Peritoneal exudates macrophage numbers - increased
Peritoneal exudates neutrophil % - decreased
Peritoneal exudates neutrophil % - increased
Peritoneal exudates neutrophil numbers - decreased
Peritoneal exudates neutrophil numbers - increased
phagocytosis in PECs - decreased
phagocytosis in PECs - increased
pigmentation
polycythemia
post-MCMV FACS B cells - decreased
post-MCMV FACS B cells - increased
post-MCMV FACS B:T cells - decreased
post-MCMV FACS B:T cells - increased
post-MCMV FACS B1 cells - decreased
post-MCMV FACS B1 cells - increased
post-MCMV FACS B1a cells - decreased
post-MCMV FACS B1a cells - increased
post-MCMV FACS B1a cells in B1 cells - decreased
post-MCMV FACS B1a cells in B1 cells - increased
post-MCMV FACS B1b cells - decreased
post-MCMV FACS B1b cells - increased
post-MCMV FACS B1b cells in B1 cells - decreased
post-MCMV FACS B1b cells in B1 cells - increased
post-MCMV FACS B2 cells - decreased
post-MCMV FACS B2 cells - increased
post-MCMV FACS B220 MFI - decreased
post-MCMV FACS B220 MFI - increased
post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - increased
post-MCMV FACS CD11c+ DCs - decreased
post-MCMV FACS CD11c+ DCs - increased
post-MCMV FACS CD4:CD8 - decreased
post-MCMV FACS CD4:CD8 - increased
post-MCMV FACS CD4+ T cells - decreased
post-MCMV FACS CD4+ T cells - increased
post-MCMV FACS CD4+ T cells in CD3+ T cells - decreased
post-MCMV FACS CD4+ T cells in CD3+ T cells - increased
post-MCMV FACS CD44+ CD4 MFI - decreased
post-MCMV FACS CD44+ CD4 MFI - increased
post-MCMV FACS CD44+ CD4 T cells - decreased
post-MCMV FACS CD44+ CD4 T cells - increased
post-MCMV FACS CD44+ CD8 MFI - decreased
post-MCMV FACS CD44+ CD8 MFI - increased
post-MCMV FACS CD44+ CD8 T cells - decreased
post-MCMV FACS CD44+ CD8 T cells - increased
post-MCMV FACS CD44+ T cells - decreased
post-MCMV FACS CD44+ T cells - increased
post-MCMV FACS CD44+ T MFI - decreased
post-MCMV FACS CD44+ T MFI - increased
post-MCMV FACS CD8+ T cells - decreased
post-MCMV FACS CD8+ T cells - increased
post-MCMV FACS CD8+ T cells in CD3+ T cells - decreased
post-MCMV FACS CD8+ T cells in CD3+ T cells - increased
post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - increased
post-MCMV FACS central memory CD4 T cells in CD4 T cells - decreased
post-MCMV FACS central memory CD4 T cells in CD4 T cells - increased
post-MCMV FACS central memory CD8 T cells in CD8 T cells - decreased
post-MCMV FACS central memory CD8 T cells in CD8 T cells - increased
post-MCMV FACS effector memory CD4 T cells in CD4 T cells - decreased
post-MCMV FACS effector memory CD4 T cells in CD4 T cells - increased
post-MCMV FACS effector memory CD8 T cells in CD8 T cells - decreased
post-MCMV FACS effector memory CD8 T cells in CD8 T cells - increased
post-MCMV FACS effector T cells - decreased
post-MCMV FACS effector T cells - increased
post-MCMV FACS IgD MFI - decreased
post-MCMV FACS IgD MFI - increased
post-MCMV FACS IgD+ B cell percentage - decreased
post-MCMV FACS IgD+ B cell percentage - increased
post-MCMV FACS IgM MFI - decreased
post-MCMV FACS IgM MFI - increased
post-MCMV FACS IgM+ B cells - decreased
post-MCMV FACS IgM+ B cells - increased
post-MCMV FACS macrophages - decreased
post-MCMV FACS macrophages - increased
post-MCMV FACS memory T cells - decreased
post-MCMV FACS memory T cells - increased
post-MCMV FACS naive CD4 T cells in CD4 T cells - decreased
post-MCMV FACS naive CD4 T cells in CD4 T cells - increased
post-MCMV FACS naive CD8 T cells in CD8 T cells - decreased
post-MCMV FACS naive CD8 T cells in CD8 T cells - increased
post-MCMV FACS naive T cells - decreased
post-MCMV FACS naive T cells - increased
post-MCMV FACS neutrophils - decreased
post-MCMV FACS neutrophils - increased
post-MCMV FACS NK cells - decreased
post-MCMV FACS NK cells - increased
post-MCMV FACS NK T cells - decreased
post-MCMV FACS NK T cells - increased
post-MCMV FACS NKT cells (tet) - decreased
post-MCMV FACS NKT cells (tet) - increased
post-MCMV FACS pDCs - decreased
post-MCMV FACS pDCs - increased
post-MCMV FACS T cells - decreased
post-MCMV FACS T cells - increased
ratio of OVA-specific IgE over the total IgE - decreased
ratio of OVA-specific IgE over the total IgE - increased
renal/urinary system
reproductive system
resistance to B10-F16 melanoma - decreased
resistance to B10-F16 melanoma - increased
respiratory system
response to injected CpG DNA - decreased
RVFV proliferation in macrophages - decreased
RVFV proliferation in macrophages - increased
RVFV susceptibility
secretory SlgA after 2nd OVA/Alum Challenge (day 7) - decreased
secretory SlgA after 2nd OVA/Alum Challenge (day 7) - increased
skeleton phenotype
skin/coat/nails
taste/olfaction
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-dependent humoral response defect- increased antibody response to OVA+ alum immunization
T-dependent humoral response defect- increased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
T-independent B cell response defect- increased TNP-specific IgM to TNP-Ficoll immunization
TLR signaling defect: hypersensitivity to CpG + IFNg
TLR signaling defect: hypersensitivity to LPS
TLR signaling defect: hypersensitivity to MALP2
TLR signaling defect: hypersensitivity to PAM3CSK4
TLR signaling defect: hypersensitivity to poly I:C
TLR signaling defect: hypersensitivity to poly I:C + IFNg
TLR signaling defect: hypersensitivity to R848
TLR signaling defect: hyposensitivity to CpG + IFNg
TLR signaling defect: hyposensitivity to LPS
TLR signaling defect: hyposensitivity to MALP2
TLR signaling defect: hyposensitivity to PAM3CSK4
TLR signaling defect: hyposensitivity to poly I:C
TLR signaling defect: hyposensitivity to poly I:C + IFNg
TLR signaling defect: hyposensitivity to R848
TLR signaling defect: TNF production by macrophages
total IgE after 2nd OVA/Alum - decreased
total IgE after 2nd OVA/Alum - increased
Total IgE After 2nd OVA/Alum Challenge (day 7) - decreased
Total IgE After 2nd OVA/Alum Challenge (day 7) - increased
total IgE level - decreased
total IgE level - increased
touch/vibrissae
tumorigenesis
vision/eye
and
none of
any of
125-03 Response - decreased
125-03 Response - increased
30 min GTT hyperglycemic
30 min GTT hyperglycemic (male)
30 min GTT hyperoglycemic (female)
30 min GTT hypoglycemic
30 min GTT hypoglycemic (female)
30 min GTT hypoglycemic (male)
30 Min. Insulin (Female) - decreased
adenovirus infection of macrophages - decreased
adenovirus infection of macrophages - increased
adipose tissue
anemia
Anophthalmia
Antibody: FACS B cells - decreased
Antibody: FACS B cells - increased
Antibody: FACS B:T cells - decreased
Antibody: FACS B:T cells - increased
Antibody: FACS B1 cells - decreased
Antibody: FACS B1 cells - increased
Antibody: FACS B1a cells - decreased
Antibody: FACS B1a cells - increased
Antibody: FACS B1a cells in B1 cells - decreased
Antibody: FACS B1a cells in B1 cells - increased
Antibody: FACS B1b cells - decreased
Antibody: FACS B1b cells - increased
Antibody: FACS B1b cells in B1 cells - decreased
Antibody: FACS B1b cells in B1 cells - increased
Antibody: FACS B2 cells - decreased
Antibody: FACS B2 cells - increased
Antibody: FACS B220 MFI - decreased
Antibody: FACS B220 MFI - increased
Antibody: FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
Antibody: FACS CD11b+ DCs (gated in CD11c+ cells) - increased
Antibody: FACS CD11c+ DCs - decreased
Antibody: FACS CD11c+ DCs - increased
Antibody: FACS CD4:CD8 - decreased
Antibody: FACS CD4:CD8 - increased
Antibody: FACS CD4+ T cells - decreased
Antibody: FACS CD4+ T cells - increased
Antibody: FACS CD4+ T cells in CD3+ T cells - decreased
Antibody: FACS CD4+ T cells in CD3+ T cells - increased
Antibody: FACS CD44+ CD4 MFI - decreased
Antibody: FACS CD44+ CD4 MFI - increased
Antibody: FACS CD44+ CD4 T cells - decreased
Antibody: FACS CD44+ CD4 T cells - increased
Antibody: FACS CD44+ CD8 MFI - decreased
Antibody: FACS CD44+ CD8 MFI - increased
Antibody: FACS CD44+ CD8 T cells - decreased
Antibody: FACS CD44+ CD8 T cells - increased
Antibody: FACS CD44+ T cells - decreased
Antibody: FACS CD44+ T cells - increased
Antibody: FACS CD44+ T MFI - decreased
Antibody: FACS CD44+ T MFI - increased
Antibody: FACS CD8+ T cells - decreased
Antibody: FACS CD8+ T cells - increased
Antibody: FACS CD8+ T cells in CD3+ T cells - decreased
Antibody: FACS CD8+ T cells in CD3+ T cells - increased
Antibody: FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
Antibody: FACS CD8a+ DCs (gated in CD11c+ cells) - increased
Antibody: FACS central memory CD4 T cells in CD4 T cells - decreased
Antibody: FACS central memory CD4 T cells in CD4 T cells - increased
Antibody: FACS central memory CD8 T cells in CD8 T cells - decreased
Antibody: FACS central memory CD8 T cells in CD8 T cells - increased
Antibody: FACS effector memory CD4 T cells in CD4 T cells - decreased
Antibody: FACS effector memory CD4 T cells in CD4 T cells - increased
Antibody: FACS effector memory CD8 T cells in CD8 T cells - decreased
Antibody: FACS effector memory CD8 T cells in CD8 T cells - increased
Antibody: FACS effector T cells - decreased
Antibody: FACS effector T cells - increased
Antibody: FACS IgD MFI - decreased
Antibody: FACS IgD MFI - increased
Antibody: FACS IgD+ B cell percentage - decreased
Antibody: FACS IgD+ B cell percentage - increased
Antibody: FACS IgM MFI - decreased
Antibody: FACS IgM MFI - increased
Antibody: FACS IgM+ B cells - decreased
Antibody: FACS IgM+ B cells - increased
Antibody: FACS Macrophages - decreased
Antibody: FACS Macrophages - increased
Antibody: FACS memory T cells - decreased
Antibody: FACS memory T cells - increased
Antibody: FACS naive CD4 T cells in CD4 T cells - decreased
Antibody: FACS naive CD4 T cells in CD4 T cells - increased
Antibody: FACS naive CD8 T cells in CD8 T cells - decreased
Antibody: FACS naive CD8 T cells in CD8 T cells - increased
Antibody: FACS naive T cells - decreased
Antibody: FACS naive T cells - increased
Antibody: FACS Neutrophils - decreased
Antibody: FACS Neutrophils - increased
Antibody: FACS NK cells - decreased
Antibody: FACS NK cells - increased
Antibody: FACS NK1.1+ T cells - decreased
Antibody: FACS NK1.1+ T cells - increased
Antibody: FACS NKT cells (tet) - decreased
Antibody: FACS NKT cells (tet) - increased
Antibody: FACS pDCs - decreased
Antibody: FACS pDCs - increased
Antibody: FACS T cells - decreased
Antibody: FACS T cells - increased
Antibody: MC38 tumor volume (day 13) - decreased
Antibody: MC38 tumor volume (day 13) - increased
Antibody: MC38 tumor volume (day 20) - decreased
Antibody: MC38 tumor volume (day 20) - increased
autoimmunity
behavior/neurological
Blood Analysis EO% - decreased
Blood Analysis EO% - increased
Blood Analysis Hb - decreased
Blood Analysis Hb - increased
Blood Analysis HCT - decreased
Blood Analysis HCT - increased
Blood Analysis LY# - decreased
Blood Analysis LY# - increased
Blood Analysis MCH - decreased
Blood Analysis MCH - increased
Blood Analysis MCHC - decreased
Blood Analysis MCHC - increased
Blood Analysis MCV - decreased
Blood Analysis MCV - increased
Blood Analysis MO# - decreased
Blood Analysis MO# - increased
Blood Analysis NE# - decreased
Blood Analysis NE# - increased
Blood Analysis Platelet Count - decreased
Blood Analysis Platelet Count - increased
Blood Analysis RBC - decreased
Blood Analysis RBC - increased
Blood Analysis RDW - decreased
Blood Analysis RDW - increased
Blood Analysis WBC - decreased
Blood Analysis WBC - increased
Blood Pressure: Pooled HR - decreased
Blood Pressure: Pooled HR - increased
Blood Pressure: Pooled SBP - decreased
Blood Pressure: Pooled SBP - increased
Body Weight - decreased
Body Weight - increased
Body Weight (DSS Female) - decreased
Body Weight (DSS Female) - increased
Body Weight (DSS Male) - decreased
Body Weight (DSS Male) - increased
Body Weight (DSS) - decreased
Body Weight (DSS) - increased
Body Weight (DSS, Day10) - decreased
Body Weight (DSS, Day10) - increased
Body Weight (DSS, Day7) - decreased
Body Weight (DSS, Day7) - increased
Body Weight (DSS, z-score) - decreased
Body Weight (DSS, z-score) - increased
Body Weight (Female) - decreased
Body Weight (Female) - increased
Body Weight (Male) - decreased
Body Weight (Male) - increased
Body Weight (Z-score) - decreased
Body Weight (Z-score) - increased
Bone: Femur Length (AI, residual) - decreased
Bone: Femur Length (AI, residual) - increased
Bone: Femur Length (AI, residual, female) - decreased
Bone: Femur Length (AI, residual, female) - increased
Bone: Femur Length (AI, residual, male) - decreased
Bone: Femur Length (AI, residual, male) - increased
Bone: Pelvis Length (AI, residual) - decreased
Bone: Pelvis Length (AI, residual) - increased
Bone: Pelvis Length (AI, residual, female) - decreased
Bone: Pelvis Length (AI, residual, female) - increased
Bone: Pelvis Length (AI, residual, male) - decreased
Bone: Pelvis Length (AI, residual, male) - increased
Bone: Spine Deformity (female)
Bone: Spine Deformity (male)
Bone: Tibia Length (AI, residual) - decreased
Bone: Tibia Length (AI, residual) - increased
Bone: Tibia Length (AI, residual, female) - decreased
Bone: Tibia Length (AI, residual, female) - increased
Bone: Tibia Length (AI, residual, male) - decreased
Bone: Tibia Length (AI, residual, male) - increased
cardiovascular system
CD8 response - decreased
cellular phenotype
craniofacial
CTL killing - decreased
CTL killing - increased
CTL killing dominant epitope - decreased
CTL killing dominant epitope - increased
CTL killing subdominant epitope - decreased
CTL killing subdominant epitope - increased
digestive/alimentary
dsDNA Antibody - decreased
dsDNA Antibody - increased
dsDNA induced type I IFN production - decreased
dsDNA induced type I IFN production - increased
DSS: resistant
DSS: resistant day 10
DSS: resistant day 7
DSS: sensitive day 10
DSS: sensitive day 7
embryogenesis
endocrine/exocrine gland
extracellular cGAMP: high response
extracellular cGAMP: low response
eye: micro-ophthalmia
Eye: SL-OCT BM to ILM thickness - decreased
Eye: SL-OCT BM to ILM thickness - increased
Eye: SL-OCT INL to ILM thickness - decreased
Eye: SL-OCT INL to ILM thickness - increased
Eye: SL-OCT IPL to ILM thickness - decreased
Eye: SL-OCT IPL to ILM thickness - increased
FACS B cells - decreased
FACS B cells - increased
FACS B:T cells - decreased
FACS B:T cells - increased
FACS B1 cells - decreased
FACS B1 cells - increased
FACS B1a cells - decreased
FACS B1a cells - increased
FACS B1a cells in B1 cells - decreased
FACS B1a cells in B1 cells - increased
FACS B1b cells - decreased
FACS B1b cells - increased
FACS B1b cells in B1 cells - decreased
FACS B1b cells in B1 cells - increased
FACS B2 cells - decreased
FACS B2 cells - increased
FACS B220 MFI - decreased
FACS B220 MFI - increased
FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
FACS CD11b+ DCs (gated in CD11c+ cells) - increased
FACS CD11c+ DCs - decreased
FACS CD11c+ DCs - increased
FACS CD4:CD8 - decreased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells - increased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 MFI - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - decreased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 MFI - decreased
FACS CD44+ CD8 MFI - increased
FACS CD44+ CD8 T cells - decreased
FACS CD44+ CD8 T cells - increased
FACS CD44+ T cells - decreased
FACS CD44+ T cells - increased
FACS CD44+ T MFI - decreased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells - increased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - increased
FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
FACS CD8a+ DCs (gated in CD11c+ cells) - increased
FACS central memory CD4 T cells in CD4 T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - decreased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - decreased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - decreased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS effector T cells - decreased
FACS effector T cells - increased
FACS IgD MFI - decreased
FACS IgD MFI - increased
FACS IgD+ B cell percentage - decreased
FACS IgD+ B cell percentage - increased
FACS IgM MFI - decreased
FACS IgM MFI - increased
FACS IgM+ B cells - decreased
FACS IgM+ B cells - increased
FACS macrophages - decreased
FACS macrophages - increased
FACS memory T cells - decreased
FACS memory T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD4 T cells in CD4 T cells - increased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - increased
FACS naive T cells - decreased
FACS naive T cells - increased
FACS neutrophils - decreased
FACS neutrophils - increased
FACS NK cells - decreased
FACS NK cells - increased
FACS NK1.1+ T cells - decreased
FACS NK1.1+ T cells - increased
FACS NKT cells (tet) - decreased
FACS NKT cells (tet) - increased
FACS pDCs - decreased
FACS pDCs - increased
FACS T cells - decreased
FACS T cells - increased
growth/size
hearing/vestibular/ear
hematopoietic competition - disadvantage
hematopoietic system
homeostasis/metabolism
IgA response to 2nd OVA/Alum Challenge (day 7) - decreased
IgA response to 2nd OVA/Alum Challenge (day 7) - increased
IgE response to a Cysteine Protease (Papain) - decreased
IgE response to a Cysteine Protease (Papain) - increased
IgG1 response to a Cysteine Protease (Papain) - decreased
IgG1 response to a Cysteine Protease (Papain) - increased
immune system
impaired response to dsDNA- type I IFN production by macrophages
inflammatory bowel disease phenotype
influenza proliferation in macrophages - decreased
influenza proliferation in macrophages - increased
influenza resistance
iron deficiency
iron excess
LCMV clone 13 resistance
lethality-embryonic/perinatal
lethality-postnatal
life span-post-weaning/aging
limbs/digits/tail phenotype
liver/biliary system
LPS Cachexia: Body Weight (day 0) - decreased
LPS Cachexia: Body Weight (day 0) - increased
LPS Cachexia: Body Weight (day 0, z-score) - decreased
LPS Cachexia: Body Weight (day 0, z-score) - increased
LPS Cachexia: Body Weight (day 1) - decreased
LPS Cachexia: Body Weight (day 1) - increased
LPS Cachexia: Body Weight (day 14) - decreased
LPS Cachexia: Body Weight (day 14) - increased
LPS Cachexia: Body Weight (day 2) - decreased
LPS Cachexia: Body Weight (day 2) - increased
LPS Cachexia: Body Weight Change (day 1, g) - decreased
LPS Cachexia: Body Weight Change (day 1, g) - increased
LPS Cachexia: Body Weight Change (day 1, ratio) - decreased
LPS Cachexia: Body Weight Change (day 1, ratio) - increased
LPS Cachexia: Body Weight Change (day 14, g) - decreased
LPS Cachexia: Body Weight Change (day 14, g) - increased
LPS Cachexia: Body Weight Change (day 14, ratio) - decreased
LPS Cachexia: Body Weight Change (day 14, ratio) - increased
LPS Cachexia: Body Weight Change (day 2, g) - decreased
LPS Cachexia: Body Weight Change (day 2, g) - increased
LPS Cachexia: Body Weight Change (day 2, ratio) - decreased
LPS Cachexia: Body Weight Change (day 2, ratio) - increased
LPS Hypersensitivity - decreased
LPS Hypersensitivity - increased
LPS-induced Necroptosis - decreased
LPS-induced Necroptosis - increased
Macrophage necroptosis: high
Macrophage necroptosis: low
MC38 tumor volume (day 22) - decreased
MC38 tumor volume (day 22) - increased
MC38 tumor volume (day 22, early sac sick or found dead, IM injection, dermatitis, trimmed) - decreased
MC38 tumor volume (day 22, early sac sick or found dead, IM injection, dermatitis, trimmed) - increased
MC38 tumor volume (day 22, early sac sick or found dead, trimmed) - decreased
MC38 tumor volume (day 22, early sac sick or found dead, trimmed) - increased
MC38 tumor volume (day 22, IM injection, dermatitis, trimmed) - decreased
MC38 tumor volume (day 22, IM injection, dermatitis, trimmed) - increased
MCMV proliferation in macrophages - decreased
MCMV proliferation in macrophages - increased
MCMV resistance
MCMV susceptibility
MTT dsDNA PECs - decreased
MTT dsDNA PECs - increased
MTT Value of PECs - decreased
MTT Value of PECs - increased
muscle
NALP3 inflammasome signaling defect
nervous system
NK cell response - decreased
NK killing - decreased
NK killing - increased
Nlrc4 inflammasome: high response
Nlrc4 inflammasome: low response
NLRP3 inflammasome: high response
NLRP3 inflammasome: low response
no phenotypic analysis
normal phenotype
other phenotype
OVA-specific IgE - decreased
OVA-specific IgE - increased
OVA-specific IgE after 2nd OVA/Alum - decreased
OVA-specific IgE after 2nd OVA/Alum - increased
Peritoneal exudates B1a cell % - decreased
Peritoneal exudates B1a cell % - increased
Peritoneal exudates B1a cell numbers - decreased
Peritoneal exudates B1a cell numbers - increased
Peritoneal exudates B1b cell % - decreased
Peritoneal exudates B1b cell % - increased
Peritoneal exudates B1b cell numbers - decreased
Peritoneal exudates B1b cell numbers - increased
Peritoneal exudates macrophage % - decreased
Peritoneal exudates macrophage % - increased
Peritoneal exudates macrophage numbers - decreased
Peritoneal exudates macrophage numbers - increased
Peritoneal exudates neutrophil % - decreased
Peritoneal exudates neutrophil % - increased
Peritoneal exudates neutrophil numbers - decreased
Peritoneal exudates neutrophil numbers - increased
phagocytosis in PECs - decreased
phagocytosis in PECs - increased
pigmentation
polycythemia
post-MCMV FACS B cells - decreased
post-MCMV FACS B cells - increased
post-MCMV FACS B:T cells - decreased
post-MCMV FACS B:T cells - increased
post-MCMV FACS B1 cells - decreased
post-MCMV FACS B1 cells - increased
post-MCMV FACS B1a cells - decreased
post-MCMV FACS B1a cells - increased
post-MCMV FACS B1a cells in B1 cells - decreased
post-MCMV FACS B1a cells in B1 cells - increased
post-MCMV FACS B1b cells - decreased
post-MCMV FACS B1b cells - increased
post-MCMV FACS B1b cells in B1 cells - decreased
post-MCMV FACS B1b cells in B1 cells - increased
post-MCMV FACS B2 cells - decreased
post-MCMV FACS B2 cells - increased
post-MCMV FACS B220 MFI - decreased
post-MCMV FACS B220 MFI - increased
post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - increased
post-MCMV FACS CD11c+ DCs - decreased
post-MCMV FACS CD11c+ DCs - increased
post-MCMV FACS CD4:CD8 - decreased
post-MCMV FACS CD4:CD8 - increased
post-MCMV FACS CD4+ T cells - decreased
post-MCMV FACS CD4+ T cells - increased
post-MCMV FACS CD4+ T cells in CD3+ T cells - decreased
post-MCMV FACS CD4+ T cells in CD3+ T cells - increased
post-MCMV FACS CD44+ CD4 MFI - decreased
post-MCMV FACS CD44+ CD4 MFI - increased
post-MCMV FACS CD44+ CD4 T cells - decreased
post-MCMV FACS CD44+ CD4 T cells - increased
post-MCMV FACS CD44+ CD8 MFI - decreased
post-MCMV FACS CD44+ CD8 MFI - increased
post-MCMV FACS CD44+ CD8 T cells - decreased
post-MCMV FACS CD44+ CD8 T cells - increased
post-MCMV FACS CD44+ T cells - decreased
post-MCMV FACS CD44+ T cells - increased
post-MCMV FACS CD44+ T MFI - decreased
post-MCMV FACS CD44+ T MFI - increased
post-MCMV FACS CD8+ T cells - decreased
post-MCMV FACS CD8+ T cells - increased
post-MCMV FACS CD8+ T cells in CD3+ T cells - decreased
post-MCMV FACS CD8+ T cells in CD3+ T cells - increased
post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - increased
post-MCMV FACS central memory CD4 T cells in CD4 T cells - decreased
post-MCMV FACS central memory CD4 T cells in CD4 T cells - increased
post-MCMV FACS central memory CD8 T cells in CD8 T cells - decreased
post-MCMV FACS central memory CD8 T cells in CD8 T cells - increased
post-MCMV FACS effector memory CD4 T cells in CD4 T cells - decreased
post-MCMV FACS effector memory CD4 T cells in CD4 T cells - increased
post-MCMV FACS effector memory CD8 T cells in CD8 T cells - decreased
post-MCMV FACS effector memory CD8 T cells in CD8 T cells - increased
post-MCMV FACS effector T cells - decreased
post-MCMV FACS effector T cells - increased
post-MCMV FACS IgD MFI - decreased
post-MCMV FACS IgD MFI - increased
post-MCMV FACS IgD+ B cell percentage - decreased
post-MCMV FACS IgD+ B cell percentage - increased
post-MCMV FACS IgM MFI - decreased
post-MCMV FACS IgM MFI - increased
post-MCMV FACS IgM+ B cells - decreased
post-MCMV FACS IgM+ B cells - increased
post-MCMV FACS macrophages - decreased
post-MCMV FACS macrophages - increased
post-MCMV FACS memory T cells - decreased
post-MCMV FACS memory T cells - increased
post-MCMV FACS naive CD4 T cells in CD4 T cells - decreased
post-MCMV FACS naive CD4 T cells in CD4 T cells - increased
post-MCMV FACS naive CD8 T cells in CD8 T cells - decreased
post-MCMV FACS naive CD8 T cells in CD8 T cells - increased
post-MCMV FACS naive T cells - decreased
post-MCMV FACS naive T cells - increased
post-MCMV FACS neutrophils - decreased
post-MCMV FACS neutrophils - increased
post-MCMV FACS NK cells - decreased
post-MCMV FACS NK cells - increased
post-MCMV FACS NK T cells - decreased
post-MCMV FACS NK T cells - increased
post-MCMV FACS NKT cells (tet) - decreased
post-MCMV FACS NKT cells (tet) - increased
post-MCMV FACS pDCs - decreased
post-MCMV FACS pDCs - increased
post-MCMV FACS T cells - decreased
post-MCMV FACS T cells - increased
ratio of OVA-specific IgE over the total IgE - decreased
ratio of OVA-specific IgE over the total IgE - increased
renal/urinary system
reproductive system
resistance to B10-F16 melanoma - decreased
resistance to B10-F16 melanoma - increased
respiratory system
response to injected CpG DNA - decreased
RVFV proliferation in macrophages - decreased
RVFV proliferation in macrophages - increased
RVFV susceptibility
secretory SlgA after 2nd OVA/Alum Challenge (day 7) - decreased
secretory SlgA after 2nd OVA/Alum Challenge (day 7) - increased
skeleton phenotype
skin/coat/nails
taste/olfaction
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-dependent humoral response defect- increased antibody response to OVA+ alum immunization
T-dependent humoral response defect- increased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
T-independent B cell response defect- increased TNP-specific IgM to TNP-Ficoll immunization
TLR signaling defect: hypersensitivity to CpG + IFNg
TLR signaling defect: hypersensitivity to LPS
TLR signaling defect: hypersensitivity to MALP2
TLR signaling defect: hypersensitivity to PAM3CSK4
TLR signaling defect: hypersensitivity to poly I:C
TLR signaling defect: hypersensitivity to poly I:C + IFNg
TLR signaling defect: hypersensitivity to R848
TLR signaling defect: hyposensitivity to CpG + IFNg
TLR signaling defect: hyposensitivity to LPS
TLR signaling defect: hyposensitivity to MALP2
TLR signaling defect: hyposensitivity to PAM3CSK4
TLR signaling defect: hyposensitivity to poly I:C
TLR signaling defect: hyposensitivity to poly I:C + IFNg
TLR signaling defect: hyposensitivity to R848
TLR signaling defect: TNF production by macrophages
total IgE after 2nd OVA/Alum - decreased
total IgE after 2nd OVA/Alum - increased
Total IgE After 2nd OVA/Alum Challenge (day 7) - decreased
Total IgE After 2nd OVA/Alum Challenge (day 7) - increased
total IgE level - decreased
total IgE level - increased
touch/vibrissae
tumorigenesis
vision/eye
and
validated
validated (with ENU)
validated (without ENU)
excluded
untested (pending)
untested (not pending)
validated
validated (with ENU)
validated (without ENU)
excluded
untested
Base Change
A
C
G
T
⇒
A
C
G
T
Type of Mutation
makesense
missense
nonsense
start codon destroyed
start gained
synonymous
splice acceptor site
splice donor site
critical splice acceptor site
critical splice donor site
splice site
large deletion
large insertion
rearrangement
small deletion
small insertion
exon
frame shift
intragenic
intron
utr 3 prime
utr 5 prime
unclassified
Exon Dist
Predicted Effect
unknown
probably benign
probably null
possibly damaging
probably damaging
noncoding transcript
silent
not run
no transcript
PPH Score
1
Rac2
0.000
Potter
15
78559167-78572783 bp (-)
78570743
Autosomal Recessive (4;19)
Autosomal Semidominant (2;11)
0.880
2020-07-29
External Program
FACS B cells - decreased
FACS B1a cells in B1 cells - decreased
FACS B1b cells in B1 cells - increased
FACS IgD+ B cell percentage - decreased
FACS IgM+ B cells - decreased
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
G ⇒ T
nonsense
probably null
2
Pparg
1.000
Energy
6
115360951-115490399 bp (+)
115451044
Unknown (4;0)
Autosomal Dominant (5;20)
0.273
2019-11-06
Bruce Beutler
Body Weight - decreased
Body Weight (DSS) - decreased
Body Weight (DSS, z-score) - decreased
Body Weight (Z-score) - decreased
growth/size
G ⇒ T
missense
probably damaging
1.000
3
Ryr2
1.000
Arruda2
13
11553102-12106945 bp (-)
11879496
Autosomal Recessive (4;16)
Autosomal Semidominant (3;23)
no linkage result
2019-10-29
Anne Murray
G ⇒ T
missense
probably damaging
0.998
4
Pcdh15
0.000
Tortilla
10
73099342-74649737 bp (+)
74379417
Autosomal Recessive (1;6)
Autosomal Semidominant (2;9)
0.317
2019-10-23
Diantha La Vine
FACS CD44+ CD8 T cells - increased
FACS CD44+ T cells - increased
OVA-specific IgE after 2nd OVA/Alum - increased
G ⇒ T
splice site
probably null
5
Grm1
0.151
donald
10
10686059-11082356 bp (-)
10741508
Autosomal Recessive (1;2)
failed initial filter
2019-09-04
Diantha La Vine
behavior/neurological
growth/size
life span-post-weaning/aging
skeleton phenotype
G ⇒ T
nonsense
probably null
6
Smtn
0.426
runtish
11
3517523-3540612 bp (-)
3531326
Autosomal Recessive (1;6)
0.102
2019-09-04
Anne Murray
Body Weight - decreased
growth/size
G ⇒ T
missense
possibly damaging
0.895
7
Naip5
0.071
inwood2
13
100211739-100246323 bp (-)
100223014
Autosomal Recessive (1;6)
0.871
2019-09-04
Anne Murray
Nlrc4 inflammasome: low response
G ⇒ T
nonsense
probably null
8
Lyn
0.000
Pacific
4
3678115-3813122 bp (+)
3745330
Autosomal Recessive (1;4)
Autosomal Semidominant (4;22)
0.722
2019-09-04
Diantha La Vine
FACS B1 cells - increased
FACS CD8+ T cells - decreased
FACS macrophages - increased
FACS NK cells - decreased
FACS T cells - decreased
G ⇒ T
missense
probably damaging
1.000
9
Bcl3
0.000
sunrise
7
19808462-19822770 bp (-)
19811580
Autosomal Dominant (1;5)
Autosomal Recessive (7;47), Autosomal Semidominant (3;15)
0.766
2019-09-04
Diantha La Vine
FACS B1 cells - increased
FACS B1b cells in B1 cells - decreased
FACS CD44+ CD8 MFI - increased
FACS CD8+ T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS IgD+ B cell percentage - decreased
FACS macrophages - increased
ratio of OVA-specific IgE over the total IgE - increased
T-dependent humoral response defect- decreased antibody response to rSFV
Total IgE After 2nd OVA/Alum Challenge (day 7) - decreased
total IgE level - decreased
G ⇒ T
nonsense
probably null
10
Ly96
0.103
pique
1
16688051-16709611 bp (+)
16691716
Autosomal Recessive (4;25)
0.727
2019-09-04
Anne Murray
LPS-induced Necroptosis - decreased
Macrophage necroptosis: low
NALP3 inflammasome signaling defect
Nlrc4 inflammasome: low response
NLRP3 inflammasome: low response
TLR signaling defect: hyposensitivity to LPS
TLR signaling defect: TNF production by macrophages
G ⇒ T
nonsense
probably null
11
Trp53bp1
0.000
lentil2
2
121193281-121271407 bp (-)
121207887
Autosomal Recessive (7;57)
Autosomal Semidominant (2;9)
0.982
2019-09-04
Diantha La Vine
Body Weight - decreased
Body Weight (Z-score) - decreased
FACS CD44+ CD8 MFI - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS IgD MFI - decreased
FACS IgD+ B cell percentage - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
G ⇒ T
missense
probably damaging
1.000
12
Card11
0.000
unmodulated2
5
140872990-141000582 bp (-)
140883782
Autosomal Dominant (2;10)
Autosomal Recessive (10;112), Autosomal Semidominant (5;51)
0.975
2019-09-04
Diantha La Vine
CD8 response - decreased
CTL killing - decreased
CTL killing dominant epitope - decreased
FACS B cells - decreased
FACS B:T cells - decreased
FACS B1a cells in B1 cells - decreased
FACS B1b cells in B1 cells - increased
FACS B220 MFI - decreased
FACS CD4+ T cells - increased
FACS CD8+ T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - decreased
FACS IgM MFI - increased
FACS IgM+ B cells - decreased
FACS macrophages - decreased
FACS NK1.1+ T cells - increased
FACS T cells - increased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
G ⇒ T
splice site
probably null
13
Themis
0.129
cloudies
10
28668360-28883818 bp (+)
28761199
Autosomal Recessive (19;252)
0.941
2019-09-04
Diantha La Vine
CD8 response - decreased
CTL killing - decreased
CTL killing dominant epitope - decreased
FACS B:T cells - increased
FACS CD4:CD8 - decreased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ CD8 T cells - increased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - increased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS T cells - decreased
T-dependent humoral response defect- decreased antibody response to rSFV
G ⇒ T
nonsense
probably null
14
Cd79a
0.108
elementary
7
24897381-24902197 bp (+)
24899262
Autosomal Recessive (2;13)
Autosomal Semidominant (1;5)
0.862
2019-09-04
Anne Murray
FACS B1 cells - decreased
FACS B1b cells - decreased
FACS IgD MFI - decreased
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
G ⇒ T
missense
probably damaging
0.999
15
Ppp3cb
0.000
eden_express
14
20499364-20546573 bp (-)
20528195
Autosomal Dominant (1;6)
Autosomal Recessive (4;39), Autosomal Semidominant (4;18)
0.954
2019-09-04
Diantha La Vine
FACS B:T cells - increased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS macrophages - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS neutrophils - increased
FACS NK cells - increased
FACS T cells - decreased
IgG1 response to a Cysteine Protease (Papain) - decreased
OVA-specific IgE - increased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
Total IgE After 2nd OVA/Alum Challenge (day 7) - increased
total IgE level - increased
G ⇒ T
nonsense
probably null
16
Bbs9
0.727
corpulent
9
22475715-22888280 bp (+)
22575196
Unknown (3;0)
Autosomal Recessive (16;182)
0.642
2019-09-04
Anne Murray
Body Weight - increased
Body Weight (Female) - increased
Body Weight (Male) - increased
Body Weight (Z-score) - increased
FACS naive CD4 T cells in CD4 T cells - decreased
G ⇒ T
critical splice donor site
probably null
17
Elmo1
0.000
Edinburg
13
20090596-20608353 bp (+)
20290383
Autosomal Recessive (4;26)
Autosomal Semidominant (4;27)
0.976
2019-09-04
Diantha La Vine
FACS B cells - decreased
FACS B1 cells - increased
FACS B220 MFI - decreased
FACS CD4:CD8 - decreased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD8+ T cells - increased
FACS CD8+ T cells in CD3+ T cells - increased
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
G ⇒ T
nonsense
probably null
18
Fnip1
0.684
hamel2
11
54438199-54518235 bp (+)
54502271
Autosomal Recessive (7;116)
0.706
2019-09-04
Diantha La Vine
FACS B cells - decreased
FACS B:T cells - decreased
FACS B1 cells - increased
FACS B220 MFI - decreased
FACS CD4+ T cells - increased
FACS CD8+ T cells - increased
FACS T cells - increased
G ⇒ T
missense
probably damaging
1.000
19
Postn
0.000
sticklike
3
54361109-54391037 bp (+)
54372106
Autosomal Recessive (3;24)
no linkage result
2019-09-04
Anne Murray
G ⇒ T
missense
probably damaging
1.000
20
Hcn2
0.000
curveball2
10
79716634-79736108 bp (+)
79733773
Autosomal Recessive (17;111)
0.970
2019-09-04
Diantha La Vine
Body Weight - decreased
Body Weight (Male) - decreased
Body Weight (Z-score) - decreased
FACS B cells - decreased
FACS B:T cells - decreased
FACS CD4:CD8 - increased
FACS CD4+ T cells - increased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 T cells - increased
FACS CD44+ T cells - increased
FACS T cells - increased
G ⇒ T
nonsense
probably null
21
Itgb2
0.360
barely
10
77530252-77565708 bp (+)
77548536
Unknown
no linkage result
2019-09-04
Anne Murray
G ⇒ T
splice site
probably benign
22
Elmo1
0.000
Dollie
13
20090596-20608353 bp (+)
20572446
Autosomal Dominant (3;18)
Autosomal Semidominant (4;21)
0.869
2019-09-04
Anne Murray
FACS B cells - decreased
FACS B:T cells - decreased
FACS B1 cells - increased
FACS CD4:CD8 - decreased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD8+ T cells - increased
FACS CD8+ T cells in CD3+ T cells - increased
G ⇒ T
missense
possibly damaging
0.912
23
Ebf1
0.916
ebby
11
44617317-45008091 bp (+)
44883814
Autosomal Dominant (2;8)
Autosomal Recessive (14;134), Autosomal Semidominant (1;9)
0.945
2019-09-04
Anne Murray
FACS B cells - decreased
FACS B:T cells - decreased
FACS B1 cells - decreased
FACS B220 MFI - increased
FACS CD4+ T cells - increased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 T cells - increased
FACS CD44+ T cells - increased
FACS CD8+ T cells - increased
FACS CD8+ T cells in CD3+ T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - decreased
FACS IgD MFI - decreased
FACS IgD+ B cell percentage - decreased
FACS IgM+ B cells - decreased
FACS naive CD4 T cells in CD4 T cells - increased
FACS T cells - increased
G ⇒ T
missense
probably damaging
1.000
24
Prkdc
0.953
anhimid
16
15637866-15842235 bp (+)
15725461
Autosomal Recessive (20;182)
0.883
2019-09-04
Diantha La Vine
FACS B cells - decreased
FACS B:T cells - decreased
FACS B1 cells - decreased
FACS B220 MFI - decreased
FACS CD4:CD8 - decreased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ CD8 T cells - increased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS T cells - decreased
G ⇒ T
critical splice donor site
1 bp
probably null
25
Prkdc
0.953
screamer
16
15637866-15842235 bp (+)
15831282
Autosomal Recessive (24;276)
0.902
2019-07-17
Diantha La Vine
Body Weight - decreased
Body Weight (Z-score) - decreased
FACS B cells - decreased
FACS B1 cells - increased
FACS B1a cells - decreased
FACS B1b cells - increased
FACS B2 cells - decreased
FACS B220 MFI - decreased
FACS CD11c+ DCs - increased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS IgD MFI - decreased
FACS IgD+ B cell percentage - decreased
FACS IgM+ B cells - decreased
FACS macrophages - increased
FACS neutrophils - increased
FACS T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
G ⇒ T
nonsense
probably null
26
Lmbr1l
0.000
strawberry
15
98903917-98918231 bp (-)
98909263
Autosomal Dominant (1;4)
Autosomal Recessive (24;220)
0.990
2019-05-14
Anne Murray
CD8 response - decreased
CTL killing - decreased
CTL killing dominant epitope - decreased
FACS B cells - increased
FACS B:T cells - increased
FACS B1 cells - increased
FACS B1a cells in B1 cells - decreased
FACS B220 MFI - decreased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ T cells - decreased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS IgD MFI - decreased
FACS IgD+ B cell percentage - increased
FACS IgM MFI - increased
FACS IgM+ B cells - increased
FACS macrophages - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS neutrophils - increased
FACS NK cells - decreased
FACS NK1.1+ T cells - decreased
FACS T cells - decreased
MCMV susceptibility
NK cell response - decreased
NK killing - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
total IgE after 2nd OVA/Alum - decreased
Total IgE After 2nd OVA/Alum Challenge (day 7) - decreased
G ⇒ T
nonsense
probably null
27
Tlr9
0.092
cpg7
9
106222598-106226883 bp (+)
106225349
Unknown (2;0)
no linkage results
2019-04-01
Stephen Lyon
immune system
TLR signaling defect: TNF production by macrophages
G ⇒ T
missense
probably benign
0.002
28
Lepr
0.000
odd
4
101717404-101815352 bp (+)
101728075
Unknown
no linkage results
2019-03-30
Diantha La Vine
adipose tissue
behavior/neurological
Body Weight - increased
growth/size
homeostasis/metabolism
G ⇒ T
splice site
5 bp
probably benign
29
Rag1
0.502
maladaptive
2
101638282-101649501 bp (-)
101645647
Unknown (1;0)
no linkage results
2019-03-21
Diantha La Vine
FACS B cells - decreased
FACS CD4+ T cells - decreased
FACS CD8+ T cells - decreased
hematopoietic system
immune system
RVFV susceptibility
G ⇒ T
intron
probably benign
30
Gimap1
0.067
vonnegut
6
48739054-48743795 bp (+)
48743098
Autosomal Recessive (6;58)
0.171
2018-12-12
Anne Murray
FACS B220 MFI - decreased
FACS CD4:CD8 - increased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS IgD MFI - decreased
FACS IgM MFI - increased
G ⇒ T
missense
probably damaging
0.999
31
Cd3e
0.000
tumormouse
9
44998740-45009627 bp (-)
45006150
Unknown (1;0)
no linkage results
2018-11-30
Diantha La Vine
hematopoietic system
immune system
G ⇒ T
intron
probably benign
32
Cdh23
0.568
dee_dee
10
60302748-60696490 bp (-)
60308056
Unknown
no linkage result
2018-10-11
Diantha La Vine
G ⇒ T
nonsense
probably null
33
Adamts20
0.169
panda
15
94270163-94465418 bp (-)
94326699
Unknown
no linkage results
2018-10-05
Diantha La Vine
pigmentation
skin/coat/nails
G ⇒ T
intron
probably benign
34
Slc45a2
0.107
zuckerkuss
15
11000721-11029233 bp (+)
11025935
Unknown
no linkage results
2018-08-01
Diantha La Vine
pigmentation
skin/coat/nails
G ⇒ T
critical splice donor site
1 bp
probably benign
35
Scn8a
0.797
Tremord
15
100869858-101045938 bp (+)
101013504
Unknown
no linkage results
2018-05-22
Anne Murray
behavior/neurological
G ⇒ T
missense
probably damaging
1.000
36
Edar
0.249
achtung2
10
58600789-58675654 bp (-)
58603163
Unknown
no linkage results
2018-04-24
Diantha La Vine
craniofacial
limbs/digits/tail phenotype
skin/coat/nails
G ⇒ T
missense
probably damaging
1.000
37
Ap3b1
0.572
bullet_gray
13
94358960-94566317 bp (+)
94451087
Unknown (2;0)
no linkage results
2018-01-15
Diantha La Vine
immune system
MCMV susceptibility
pigmentation
skin/coat/nails
G ⇒ T
critical splice donor site
1 bp
probably benign
38
Gimap5
0.000
sphinx
6
48746197-48754210 bp (+)
48752609
Unknown (2;0)
no linkage results
2018-01-05
Eva Marie Y. Moresco
CTL killing - decreased
FACS B cells - decreased
FACS CD4+ T cells - decreased
FACS CD8+ T cells - decreased
FACS NK cells - decreased
FACS NK1.1+ T cells - decreased
hematopoietic system
immune system
inflammatory bowel disease phenotype
lethality-postnatal
life span-post-weaning/aging
liver/biliary system
MCMV susceptibility
NK cell response - decreased
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
G ⇒ T
missense
probably damaging
1.000
39
Fgf5
0.153
porcupine
5
98254184-98277030 bp (+)
98254746
Unknown
no linkage results
2017-10-13
Anne Murray
skin/coat/nails
G ⇒ T
missense
probably damaging
1.000
40
Muc2
0.093
Schlendrian
7
141690340-141754693 bp (+)
141695682
Unknown (1;0)
no linkage results
2017-09-13
Diantha La Vine
immune system
G ⇒ T
missense
probably damaging
1.000
41
Tnf
0.000
Panr1
17
35199381-35202007 bp (-)
35200204
Unknown (1;0)
no linkage results
2017-04-18
Katherine Timer
immune system
TLR signaling defect: TNF production by macrophages
G ⇒ T
missense
probably damaging
1.000
42
Unc13d
0.158
jinx
11
116062095-116077961 bp (-)
116073423
Unknown (1;0)
no linkage results
2016-10-11
Bruce Beutler
DSS: sensitive day 7
hematopoietic system
immune system
MCMV susceptibility
NK cell response - decreased
G ⇒ T
unclassified
57 bp
probably benign
43
Atp7a
0.712
Tigrou
X
106027276-106124926 bp (+)
106088407
Unknown
no linkage results
2016-05-13
Stephen Lyon
growth/size
lethality-embryonic/perinatal
lethality-postnatal
pigmentation
skin/coat/nails
G ⇒ T
missense
probably benign
0.041
44
Cd4
0.000
thoth
6
124864692-124888221 bp (-)
124873140
Unknown
no linkage results
2016-05-13
Peter Jurek
FACS CD4+ T cells - decreased
immune system
G ⇒ T
splice site
10 bp
probably benign
45
Myo5a
0.957
silver_decerebrate
9
75071015-75223688 bp (+)
75164195
Unknown
no linkage results
2016-05-13
Stephen Lyon
behavior/neurological
lethality-postnatal
life span-post-weaning/aging
nervous system
pigmentation
skin/coat/nails
G ⇒ T
missense
probably damaging
1.000
46
Scd1
0.952
flake
19
44394451-44407709 bp (-)
44400330
Unknown
no linkage results
2016-05-13
Stephen Lyon
endocrine/exocrine gland
immune system
skin/coat/nails
G ⇒ T
missense
probably damaging
0.998
47
Ap3d1
0.937
christian
10
80706956-80742264 bp (-)
80730042
Autosomal Semidominant (1;0)
failed initial filter
2016-05-13
Anne Murray
pigmentation
skin/coat/nails
G ⇒ T
missense
probably damaging
1.000
[records 1 to 47 of 47]