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Phenotypic Mutations
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mutations affecting
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Mutations Mapped and Identified Based on Phenotype
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Gene
E Score
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Chr
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Chr Loc
Coordinate
Mode of Inheritance
Unknown
Autosomal Codominant
Autosomal Dominant
Autosomal Recessive
Autosomal Semidominant
X-linked Recessive
X-linked Dominant
ML Prediction
excellent candidate
good candidate
potential candidate
no damage prob,maybe good
no ML prob,maybe good
no damage prob,maybe not good
no ML prob,maybe not good
not good candidate
failed initial filter
no linkage results
OR is recruited
OR is public
OR is verified
AND is recruited
AND is not recruited
Updated
Phenotypic Category
all of
any of
125-03 Response - decreased
125-03 Response - increased
30 min GTT hyperglycemic (male)
30 min GTT hyperoglycemic (female)
30 min GTT hypoglycemic
30 min GTT hypoglycemic (female)
30 min GTT hypoglycemic (male)
30 Min. Insulin (Female) - decreased
adenovirus infection of macrophages - decreased
adenovirus infection of macrophages - increased
adipose tissue
anemia
autoimmunity
Blood Analysis EO% - decreased
Blood Analysis EO% - increased
Blood Analysis Hb - decreased
Blood Analysis Hb - increased
Blood Analysis HCT - decreased
Blood Analysis HCT - increased
Blood Analysis LY# - decreased
Blood Analysis LY# - increased
Blood Analysis MCH - decreased
Blood Analysis MCH - increased
Blood Analysis MCHC - decreased
Blood Analysis MCHC - increased
Blood Analysis MCV - decreased
Blood Analysis MCV - increased
Blood Analysis MO# - decreased
Blood Analysis MO# - increased
Blood Analysis NE# - decreased
Blood Analysis NE# - increased
Blood Analysis Platelet Count - decreased
Blood Analysis Platelet Count - increased
Blood Analysis RBC - decreased
Blood Analysis RBC - increased
Blood Analysis RDW - decreased
Blood Analysis RDW - increased
Blood Analysis WBC - decreased
Blood Analysis WBC - increased
Blood pressure defect: decrease in SBP day 1
Blood pressure defect: decrease in SBP day 2
Blood pressure defect: increase in SBP day 2
Body Weight - decreased
Body Weight - increased
Body Weight (DSS Female) - decreased
Body Weight (DSS Female) - increased
Body Weight (DSS Male) - decreased
Body Weight (DSS Male) - increased
Body Weight (DSS) - decreased
Body Weight (DSS) - increased
Body Weight (DSS, z-score) - decreased
Body Weight (DSS, z-score) - increased
Body Weight (Female) - decreased
Body Weight (Female) - increased
Body Weight (Male) - decreased
Body Weight (Male) - increased
Body Weight (Z-score) - decreased
Body Weight (Z-score) - increased
cardiovascular system
CD8 response - decreased
cellular phenotype
CTL killing - decreased
CTL killing - increased
CTL killing dominant epitope - decreased
CTL killing dominant epitope - increased
CTL killing subdominant epitope - decreased
CTL killing subdominant epitope - increased
defect in 125-03 response
dsDNA Antibody - decreased
dsDNA Antibody - increased
dsDNA induced type I IFN production - decreased
dsDNA induced type I IFN production - increased
DSS: resistant
DSS: resistant day 10
DSS: resistant day 7
DSS: sensitive
DSS: sensitive day 10
DSS: sensitive day 7
embryogenesis
endocrine/exocrine gland
extracellular cGAMP: high response
extracellular cGAMP: low response
eye: cataract
eye: corneal opacity
eye: retinal vascular anomaly
FACS B cells - decreased
FACS B cells - increased
FACS B:T cells - decreased
FACS B:T cells - increased
FACS B1 cells - decreased
FACS B1 cells - increased
FACS B1a cells - decreased
FACS B1a cells - increased
FACS B1a cells in B1 cells - decreased
FACS B1a cells in B1 cells - increased
FACS B1b cells - decreased
FACS B1b cells - increased
FACS B1b cells in B1 cells - decreased
FACS B1b cells in B1 cells - increased
FACS B2 cells - decreased
FACS B2 cells - increased
FACS B220 MFI - decreased
FACS B220 MFI - increased
FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
FACS CD11b+ DCs (gated in CD11c+ cells) - increased
FACS CD11c+ DCs - decreased
FACS CD11c+ DCs - increased
FACS CD4:CD8 - decreased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells - increased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 MFI - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - decreased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 MFI - decreased
FACS CD44+ CD8 MFI - increased
FACS CD44+ CD8 T cells - decreased
FACS CD44+ CD8 T cells - increased
FACS CD44+ T cells - decreased
FACS CD44+ T cells - increased
FACS CD44+ T MFI - decreased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells - increased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - increased
FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
FACS CD8a+ DCs (gated in CD11c+ cells) - increased
FACS central memory CD4 T cells in CD4 T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - decreased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - decreased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - decreased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS effector T cells - decreased
FACS effector T cells - increased
FACS IgD MFI - decreased
FACS IgD MFI - increased
FACS IgD+ B cell percentage - decreased
FACS IgD+ B cell percentage - increased
FACS IgM MFI - decreased
FACS IgM MFI - increased
FACS IgM+ B cells - decreased
FACS IgM+ B cells - increased
FACS macrophages - decreased
FACS memory T cells - decreased
FACS memory T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD4 T cells in CD4 T cells - increased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - increased
FACS naïve T cells - decreased
FACS naïve T cells - increased
FACS neutrophils - decreased
FACS NK cells - decreased
FACS NK cells - increased
FACS NK T cells - decreased
FACS NK T cells - increased
FACS NKT cells (tet) - decreased
FACS NKT cells (tet) - increased
FACS pDCs - decreased
FACS pDCs - increased
FACS T cells - decreased
FACS T cells - increased
hematopoietic competition - disadvantage
homeostasis/metabolism
hypersensitivity to TLR CpGODN + IFNg
hyposensitivity to TLR CpGODN + IFNg
IgA response to 2nd OVA/Alum Challenge (day 7) - decreased
IgA response to 2nd OVA/Alum Challenge (day 7) - increased
IgE response to a Cysteine Protease (Papain) - decreased
IgE response to a Cysteine Protease (Papain) - increased
IgG1 response to a Cysteine Protease (Papain) - decreased
IgG1 response to a Cysteine Protease (Papain) - increased
immune system
impaired response to dsDNA- type I IFN production by macrophages
inflammatory bowel disease phenotype
influenza proliferation in macrophages - decreased
influenza proliferation in macrophages - increased
influenza resistance
iron deficiency
iron excess
LCMV clone 13 resistance
lethality-embryonic/perinatal
LPS Cachexia: Body Weight (day 0) - decreased
LPS Cachexia: Body Weight (day 0) - increased
LPS Cachexia: Body Weight (day 0, z-score) - decreased
LPS Cachexia: Body Weight (day 0, z-score) - increased
LPS Cachexia: Body Weight (day 1) - decreased
LPS Cachexia: Body Weight (day 1) - increased
LPS Cachexia: Body Weight (day 14) - decreased
LPS Cachexia: Body Weight (day 14) - increased
LPS Cachexia: Body Weight (day 2) - decreased
LPS Cachexia: Body Weight (day 2) - increased
LPS Cachexia: Body Weight Change (day 1, g) - decreased
LPS Cachexia: Body Weight Change (day 1, g) - increased
LPS Cachexia: Body Weight Change (day 1, ratio) - decreased
LPS Cachexia: Body Weight Change (day 1, ratio) - increased
LPS Cachexia: Body Weight Change (day 14, g) - decreased
LPS Cachexia: Body Weight Change (day 14, g) - increased
LPS Cachexia: Body Weight Change (day 14, ratio) - decreased
LPS Cachexia: Body Weight Change (day 14, ratio) - increased
LPS Cachexia: Body Weight Change (day 2, g) - decreased
LPS Cachexia: Body Weight Change (day 2, g) - increased
LPS Cachexia: Body Weight Change (day 2, ratio) - decreased
LPS Cachexia: Body Weight Change (day 2, ratio) - increased
LPS Hypersensitivity - decreased
LPS Hypersensitivity - increased
LPS-induced Necroptosis - decreased
LPS-induced Necroptosis - increased
Macrophage necroptosis: high
Macrophage necroptosis: low
MCMV proliferation in macrophages - decreased
MCMV proliferation in macrophages - increased
MCMV resistance
MCMV susceptibility
Motor: rotarod weight
MTT dsDNA PECs - decreased
MTT dsDNA PECs - increased
MTT Value of PECs - decreased
MTT Value of PECs - increased
naive T cells - increased
NALP3 inflammasome signaling defect
NK cell response - decreased
NK killing - decreased
NK killing - increased
Nlrc4 inflammasome: high response
Nlrc4 inflammasome: low response
NLRP3 inflammasome: high response
NLRP3 inflammasome: low response
no phenotypic analysis
normal phenotype
OVA-specific IgE - decreased
OVA-specific IgE - increased
OVA-specific IgE after 2nd OVA/Alum - decreased
OVA-specific IgE after 2nd OVA/Alum - increased
Peritoneal exudates B1a cell % - decreased
Peritoneal exudates B1a cell % - increased
Peritoneal exudates B1a cell numbers - decreased
Peritoneal exudates B1a cell numbers - increased
Peritoneal exudates B1b cell % - decreased
Peritoneal exudates B1b cell % - increased
Peritoneal exudates B1b cell numbers - decreased
Peritoneal exudates B1b cell numbers - increased
Peritoneal exudates macrophage % - decreased
Peritoneal exudates macrophage % - increased
Peritoneal exudates macrophage numbers - decreased
Peritoneal exudates macrophage numbers - increased
Peritoneal exudates neutrophil % - decreased
Peritoneal exudates neutrophil % - increased
Peritoneal exudates neutrophil numbers - decreased
Peritoneal exudates neutrophil numbers - increased
phagocytosis in PECs - decreased
phagocytosis in PECs - increased
polycythemia
post-MCMV FACS B cells - decreased
post-MCMV FACS B cells - increased
post-MCMV FACS B:T cells - decreased
post-MCMV FACS B:T cells - increased
post-MCMV FACS B1 cells - decreased
post-MCMV FACS B1 cells - increased
post-MCMV FACS B1a cells - decreased
post-MCMV FACS B1a cells - increased
post-MCMV FACS B1a cells in B1 cells - decreased
post-MCMV FACS B1a cells in B1 cells - increased
post-MCMV FACS B1b cells - decreased
post-MCMV FACS B1b cells - increased
post-MCMV FACS B1b cells in B1 cells - decreased
post-MCMV FACS B1b cells in B1 cells - increased
post-MCMV FACS B2 cells - decreased
post-MCMV FACS B2 cells - increased
post-MCMV FACS B220 MFI - decreased
post-MCMV FACS B220 MFI - increased
post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - increased
post-MCMV FACS CD11c+ DCs - decreased
post-MCMV FACS CD11c+ DCs - increased
post-MCMV FACS CD4:CD8 - decreased
post-MCMV FACS CD4:CD8 - increased
post-MCMV FACS CD4+ T cells - decreased
post-MCMV FACS CD4+ T cells - increased
post-MCMV FACS CD4+ T cells in CD3+ T cells - decreased
post-MCMV FACS CD4+ T cells in CD3+ T cells - increased
post-MCMV FACS CD44+ CD4 MFI - decreased
post-MCMV FACS CD44+ CD4 MFI - increased
post-MCMV FACS CD44+ CD4 T cells - decreased
post-MCMV FACS CD44+ CD4 T cells - increased
post-MCMV FACS CD44+ CD8 MFI - decreased
post-MCMV FACS CD44+ CD8 MFI - increased
post-MCMV FACS CD44+ CD8 T cells - decreased
post-MCMV FACS CD44+ CD8 T cells - increased
post-MCMV FACS CD44+ T cells - decreased
post-MCMV FACS CD44+ T cells - increased
post-MCMV FACS CD44+ T MFI - decreased
post-MCMV FACS CD44+ T MFI - increased
post-MCMV FACS CD8 response - decreased
post-MCMV FACS CD8 response - increased
post-MCMV FACS CD8+ T cells - decreased
post-MCMV FACS CD8+ T cells - increased
post-MCMV FACS CD8+ T cells in CD3+ T cells - decreased
post-MCMV FACS CD8+ T cells in CD3+ T cells - increased
post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - increased
post-MCMV FACS central memory CD4 T cells in CD4 T cells - decreased
post-MCMV FACS central memory CD4 T cells in CD4 T cells - increased
post-MCMV FACS central memory CD8 T cells in CD8 T cells - decreased
post-MCMV FACS central memory CD8 T cells in CD8 T cells - increased
post-MCMV FACS effector memory CD4 T cells in CD4 T cells - decreased
post-MCMV FACS effector memory CD4 T cells in CD4 T cells - increased
post-MCMV FACS effector memory CD8 T cells in CD8 T cells - decreased
post-MCMV FACS effector memory CD8 T cells in CD8 T cells - increased
post-MCMV FACS effector T cells - decreased
post-MCMV FACS effector T cells - increased
post-MCMV FACS IgD MFI - decreased
post-MCMV FACS IgD MFI - increased
post-MCMV FACS IgD+ B cell percentage - decreased
post-MCMV FACS IgD+ B cell percentage - increased
post-MCMV FACS IgM MFI - decreased
post-MCMV FACS IgM MFI - increased
post-MCMV FACS IgM+ B cells - decreased
post-MCMV FACS IgM+ B cells - increased
post-MCMV FACS macrophages - decreased
post-MCMV FACS macrophages - increased
post-MCMV FACS memory T cells - decreased
post-MCMV FACS memory T cells - increased
post-MCMV FACS naive CD4 T cells in CD4 T cells - decreased
post-MCMV FACS naive CD4 T cells in CD4 T cells - increased
post-MCMV FACS naive CD8 T cells in CD8 T cells - decreased
post-MCMV FACS naive CD8 T cells in CD8 T cells - increased
post-MCMV FACS naïve T cells - decreased
post-MCMV FACS naïve T cells - increased
post-MCMV FACS neutrophils - decreased
post-MCMV FACS neutrophils - increased
post-MCMV FACS NK cell response - decreased
post-MCMV FACS NK cell response - increased
post-MCMV FACS NK cells - decreased
post-MCMV FACS NK cells - increased
post-MCMV FACS NK T cells - decreased
post-MCMV FACS NK T cells - increased
post-MCMV FACS NKT cells (tet) - decreased
post-MCMV FACS NKT cells (tet) - increased
post-MCMV FACS pDCs - decreased
post-MCMV FACS pDCs - increased
post-MCMV FACS T cells - decreased
post-MCMV FACS T cells - increased
ratio of OVA-specific IgE over the total IgE - decreased
ratio of OVA-specific IgE over the total IgE - increased
resistance to B10-F16 melanoma - decreased
resistance to B10-F16 melanoma - increased
respiratory system
response to injected CpG DNA - decreased
RVFV proliferation in macrophages - decreased
RVFV proliferation in macrophages - increased
RVFV susceptibility
secretory SlgA after 2nd OVA/Alum Challenge (day 7) - decreased
secretory SlgA after 2nd OVA/Alum Challenge (day 7) - increased
taste/olfaction
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-dependent humoral response defect- increased antibody response to OVA+ alum immunization
T-dependent humoral response defect- increased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
T-independent B cell response defect- increased TNP-specific IgM to TNP-Ficoll immunization
TLR signaling defect: hypersensitivity to CpG
TLR signaling defect: hypersensitivity to CpG + IFNg
TLR signaling defect: hypersensitivity to LPS
TLR signaling defect: hypersensitivity to MALP2
TLR signaling defect: hypersensitivity to PAM3CSK4
TLR signaling defect: hypersensitivity to poly I:C
TLR signaling defect: hypersensitivity to poly I:C + IFNg
TLR signaling defect: hypersensitivity to R848
TLR signaling defect: hyposensitivity to CpG
TLR signaling defect: hyposensitivity to CpG + IFNg
TLR signaling defect: hyposensitivity to LPS
TLR signaling defect: hyposensitivity to MALP2
TLR signaling defect: hyposensitivity to PAM3CSK4
TLR signaling defect: hyposensitivity to poly I:C
TLR signaling defect: hyposensitivity to poly I:C + IFNg
TLR signaling defect: hyposensitivity to R848
TLR signaling defect: TNF production by macrophages
TLR signaling defect: type I IFN production by macrophages
TLR signaling defect: type I IFN production by pDC
total IgE after 2nd OVA/Alum - decreased
total IgE after 2nd OVA/Alum - increased
Total IgE After 2nd OVA/Alum Challenge (day 7) - decreased
Total IgE After 2nd OVA/Alum Challenge (day 7) - increased
total IgE level - decreased
total IgE level - increased
tumorigenesis
any of
and
any of
none of
125-03 Response - decreased
125-03 Response - increased
30 min GTT hyperglycemic (male)
30 min GTT hyperoglycemic (female)
30 min GTT hypoglycemic
30 min GTT hypoglycemic (female)
30 min GTT hypoglycemic (male)
30 Min. Insulin (Female) - decreased
adenovirus infection of macrophages - decreased
adenovirus infection of macrophages - increased
adipose tissue
anemia
autoimmunity
Blood Analysis EO% - decreased
Blood Analysis EO% - increased
Blood Analysis Hb - decreased
Blood Analysis Hb - increased
Blood Analysis HCT - decreased
Blood Analysis HCT - increased
Blood Analysis LY# - decreased
Blood Analysis LY# - increased
Blood Analysis MCH - decreased
Blood Analysis MCH - increased
Blood Analysis MCHC - decreased
Blood Analysis MCHC - increased
Blood Analysis MCV - decreased
Blood Analysis MCV - increased
Blood Analysis MO# - decreased
Blood Analysis MO# - increased
Blood Analysis NE# - decreased
Blood Analysis NE# - increased
Blood Analysis Platelet Count - decreased
Blood Analysis Platelet Count - increased
Blood Analysis RBC - decreased
Blood Analysis RBC - increased
Blood Analysis RDW - decreased
Blood Analysis RDW - increased
Blood Analysis WBC - decreased
Blood Analysis WBC - increased
Blood pressure defect: decrease in SBP day 1
Blood pressure defect: decrease in SBP day 2
Blood pressure defect: increase in SBP day 2
Body Weight - decreased
Body Weight - increased
Body Weight (DSS Female) - decreased
Body Weight (DSS Female) - increased
Body Weight (DSS Male) - decreased
Body Weight (DSS Male) - increased
Body Weight (DSS) - decreased
Body Weight (DSS) - increased
Body Weight (DSS, z-score) - decreased
Body Weight (DSS, z-score) - increased
Body Weight (Female) - decreased
Body Weight (Female) - increased
Body Weight (Male) - decreased
Body Weight (Male) - increased
Body Weight (Z-score) - decreased
Body Weight (Z-score) - increased
cardiovascular system
CD8 response - decreased
cellular phenotype
CTL killing - decreased
CTL killing - increased
CTL killing dominant epitope - decreased
CTL killing dominant epitope - increased
CTL killing subdominant epitope - decreased
CTL killing subdominant epitope - increased
defect in 125-03 response
dsDNA Antibody - decreased
dsDNA Antibody - increased
dsDNA induced type I IFN production - decreased
dsDNA induced type I IFN production - increased
DSS: resistant
DSS: resistant day 10
DSS: resistant day 7
DSS: sensitive
DSS: sensitive day 10
DSS: sensitive day 7
embryogenesis
endocrine/exocrine gland
extracellular cGAMP: high response
extracellular cGAMP: low response
eye: cataract
eye: corneal opacity
eye: retinal vascular anomaly
FACS B cells - decreased
FACS B cells - increased
FACS B:T cells - decreased
FACS B:T cells - increased
FACS B1 cells - decreased
FACS B1 cells - increased
FACS B1a cells - decreased
FACS B1a cells - increased
FACS B1a cells in B1 cells - decreased
FACS B1a cells in B1 cells - increased
FACS B1b cells - decreased
FACS B1b cells - increased
FACS B1b cells in B1 cells - decreased
FACS B1b cells in B1 cells - increased
FACS B2 cells - decreased
FACS B2 cells - increased
FACS B220 MFI - decreased
FACS B220 MFI - increased
FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
FACS CD11b+ DCs (gated in CD11c+ cells) - increased
FACS CD11c+ DCs - decreased
FACS CD11c+ DCs - increased
FACS CD4:CD8 - decreased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells - increased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 MFI - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - decreased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 MFI - decreased
FACS CD44+ CD8 MFI - increased
FACS CD44+ CD8 T cells - decreased
FACS CD44+ CD8 T cells - increased
FACS CD44+ T cells - decreased
FACS CD44+ T cells - increased
FACS CD44+ T MFI - decreased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells - increased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - increased
FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
FACS CD8a+ DCs (gated in CD11c+ cells) - increased
FACS central memory CD4 T cells in CD4 T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - decreased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - decreased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - decreased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS effector T cells - decreased
FACS effector T cells - increased
FACS IgD MFI - decreased
FACS IgD MFI - increased
FACS IgD+ B cell percentage - decreased
FACS IgD+ B cell percentage - increased
FACS IgM MFI - decreased
FACS IgM MFI - increased
FACS IgM+ B cells - decreased
FACS IgM+ B cells - increased
FACS macrophages - decreased
FACS memory T cells - decreased
FACS memory T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD4 T cells in CD4 T cells - increased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - increased
FACS naïve T cells - decreased
FACS naïve T cells - increased
FACS neutrophils - decreased
FACS NK cells - decreased
FACS NK cells - increased
FACS NK T cells - decreased
FACS NK T cells - increased
FACS NKT cells (tet) - decreased
FACS NKT cells (tet) - increased
FACS pDCs - decreased
FACS pDCs - increased
FACS T cells - decreased
FACS T cells - increased
hematopoietic competition - disadvantage
homeostasis/metabolism
hypersensitivity to TLR CpGODN + IFNg
hyposensitivity to TLR CpGODN + IFNg
IgA response to 2nd OVA/Alum Challenge (day 7) - decreased
IgA response to 2nd OVA/Alum Challenge (day 7) - increased
IgE response to a Cysteine Protease (Papain) - decreased
IgE response to a Cysteine Protease (Papain) - increased
IgG1 response to a Cysteine Protease (Papain) - decreased
IgG1 response to a Cysteine Protease (Papain) - increased
immune system
impaired response to dsDNA- type I IFN production by macrophages
inflammatory bowel disease phenotype
influenza proliferation in macrophages - decreased
influenza proliferation in macrophages - increased
influenza resistance
iron deficiency
iron excess
LCMV clone 13 resistance
lethality-embryonic/perinatal
LPS Cachexia: Body Weight (day 0) - decreased
LPS Cachexia: Body Weight (day 0) - increased
LPS Cachexia: Body Weight (day 0, z-score) - decreased
LPS Cachexia: Body Weight (day 0, z-score) - increased
LPS Cachexia: Body Weight (day 1) - decreased
LPS Cachexia: Body Weight (day 1) - increased
LPS Cachexia: Body Weight (day 14) - decreased
LPS Cachexia: Body Weight (day 14) - increased
LPS Cachexia: Body Weight (day 2) - decreased
LPS Cachexia: Body Weight (day 2) - increased
LPS Cachexia: Body Weight Change (day 1, g) - decreased
LPS Cachexia: Body Weight Change (day 1, g) - increased
LPS Cachexia: Body Weight Change (day 1, ratio) - decreased
LPS Cachexia: Body Weight Change (day 1, ratio) - increased
LPS Cachexia: Body Weight Change (day 14, g) - decreased
LPS Cachexia: Body Weight Change (day 14, g) - increased
LPS Cachexia: Body Weight Change (day 14, ratio) - decreased
LPS Cachexia: Body Weight Change (day 14, ratio) - increased
LPS Cachexia: Body Weight Change (day 2, g) - decreased
LPS Cachexia: Body Weight Change (day 2, g) - increased
LPS Cachexia: Body Weight Change (day 2, ratio) - decreased
LPS Cachexia: Body Weight Change (day 2, ratio) - increased
LPS Hypersensitivity - decreased
LPS Hypersensitivity - increased
LPS-induced Necroptosis - decreased
LPS-induced Necroptosis - increased
Macrophage necroptosis: high
Macrophage necroptosis: low
MCMV proliferation in macrophages - decreased
MCMV proliferation in macrophages - increased
MCMV resistance
MCMV susceptibility
Motor: rotarod weight
MTT dsDNA PECs - decreased
MTT dsDNA PECs - increased
MTT Value of PECs - decreased
MTT Value of PECs - increased
naive T cells - increased
NALP3 inflammasome signaling defect
NK cell response - decreased
NK killing - decreased
NK killing - increased
Nlrc4 inflammasome: high response
Nlrc4 inflammasome: low response
NLRP3 inflammasome: high response
NLRP3 inflammasome: low response
no phenotypic analysis
normal phenotype
OVA-specific IgE - decreased
OVA-specific IgE - increased
OVA-specific IgE after 2nd OVA/Alum - decreased
OVA-specific IgE after 2nd OVA/Alum - increased
Peritoneal exudates B1a cell % - decreased
Peritoneal exudates B1a cell % - increased
Peritoneal exudates B1a cell numbers - decreased
Peritoneal exudates B1a cell numbers - increased
Peritoneal exudates B1b cell % - decreased
Peritoneal exudates B1b cell % - increased
Peritoneal exudates B1b cell numbers - decreased
Peritoneal exudates B1b cell numbers - increased
Peritoneal exudates macrophage % - decreased
Peritoneal exudates macrophage % - increased
Peritoneal exudates macrophage numbers - decreased
Peritoneal exudates macrophage numbers - increased
Peritoneal exudates neutrophil % - decreased
Peritoneal exudates neutrophil % - increased
Peritoneal exudates neutrophil numbers - decreased
Peritoneal exudates neutrophil numbers - increased
phagocytosis in PECs - decreased
phagocytosis in PECs - increased
polycythemia
post-MCMV FACS B cells - decreased
post-MCMV FACS B cells - increased
post-MCMV FACS B:T cells - decreased
post-MCMV FACS B:T cells - increased
post-MCMV FACS B1 cells - decreased
post-MCMV FACS B1 cells - increased
post-MCMV FACS B1a cells - decreased
post-MCMV FACS B1a cells - increased
post-MCMV FACS B1a cells in B1 cells - decreased
post-MCMV FACS B1a cells in B1 cells - increased
post-MCMV FACS B1b cells - decreased
post-MCMV FACS B1b cells - increased
post-MCMV FACS B1b cells in B1 cells - decreased
post-MCMV FACS B1b cells in B1 cells - increased
post-MCMV FACS B2 cells - decreased
post-MCMV FACS B2 cells - increased
post-MCMV FACS B220 MFI - decreased
post-MCMV FACS B220 MFI - increased
post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - increased
post-MCMV FACS CD11c+ DCs - decreased
post-MCMV FACS CD11c+ DCs - increased
post-MCMV FACS CD4:CD8 - decreased
post-MCMV FACS CD4:CD8 - increased
post-MCMV FACS CD4+ T cells - decreased
post-MCMV FACS CD4+ T cells - increased
post-MCMV FACS CD4+ T cells in CD3+ T cells - decreased
post-MCMV FACS CD4+ T cells in CD3+ T cells - increased
post-MCMV FACS CD44+ CD4 MFI - decreased
post-MCMV FACS CD44+ CD4 MFI - increased
post-MCMV FACS CD44+ CD4 T cells - decreased
post-MCMV FACS CD44+ CD4 T cells - increased
post-MCMV FACS CD44+ CD8 MFI - decreased
post-MCMV FACS CD44+ CD8 MFI - increased
post-MCMV FACS CD44+ CD8 T cells - decreased
post-MCMV FACS CD44+ CD8 T cells - increased
post-MCMV FACS CD44+ T cells - decreased
post-MCMV FACS CD44+ T cells - increased
post-MCMV FACS CD44+ T MFI - decreased
post-MCMV FACS CD44+ T MFI - increased
post-MCMV FACS CD8 response - decreased
post-MCMV FACS CD8 response - increased
post-MCMV FACS CD8+ T cells - decreased
post-MCMV FACS CD8+ T cells - increased
post-MCMV FACS CD8+ T cells in CD3+ T cells - decreased
post-MCMV FACS CD8+ T cells in CD3+ T cells - increased
post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - increased
post-MCMV FACS central memory CD4 T cells in CD4 T cells - decreased
post-MCMV FACS central memory CD4 T cells in CD4 T cells - increased
post-MCMV FACS central memory CD8 T cells in CD8 T cells - decreased
post-MCMV FACS central memory CD8 T cells in CD8 T cells - increased
post-MCMV FACS effector memory CD4 T cells in CD4 T cells - decreased
post-MCMV FACS effector memory CD4 T cells in CD4 T cells - increased
post-MCMV FACS effector memory CD8 T cells in CD8 T cells - decreased
post-MCMV FACS effector memory CD8 T cells in CD8 T cells - increased
post-MCMV FACS effector T cells - decreased
post-MCMV FACS effector T cells - increased
post-MCMV FACS IgD MFI - decreased
post-MCMV FACS IgD MFI - increased
post-MCMV FACS IgD+ B cell percentage - decreased
post-MCMV FACS IgD+ B cell percentage - increased
post-MCMV FACS IgM MFI - decreased
post-MCMV FACS IgM MFI - increased
post-MCMV FACS IgM+ B cells - decreased
post-MCMV FACS IgM+ B cells - increased
post-MCMV FACS macrophages - decreased
post-MCMV FACS macrophages - increased
post-MCMV FACS memory T cells - decreased
post-MCMV FACS memory T cells - increased
post-MCMV FACS naive CD4 T cells in CD4 T cells - decreased
post-MCMV FACS naive CD4 T cells in CD4 T cells - increased
post-MCMV FACS naive CD8 T cells in CD8 T cells - decreased
post-MCMV FACS naive CD8 T cells in CD8 T cells - increased
post-MCMV FACS naïve T cells - decreased
post-MCMV FACS naïve T cells - increased
post-MCMV FACS neutrophils - decreased
post-MCMV FACS neutrophils - increased
post-MCMV FACS NK cell response - decreased
post-MCMV FACS NK cell response - increased
post-MCMV FACS NK cells - decreased
post-MCMV FACS NK cells - increased
post-MCMV FACS NK T cells - decreased
post-MCMV FACS NK T cells - increased
post-MCMV FACS NKT cells (tet) - decreased
post-MCMV FACS NKT cells (tet) - increased
post-MCMV FACS pDCs - decreased
post-MCMV FACS pDCs - increased
post-MCMV FACS T cells - decreased
post-MCMV FACS T cells - increased
ratio of OVA-specific IgE over the total IgE - decreased
ratio of OVA-specific IgE over the total IgE - increased
resistance to B10-F16 melanoma - decreased
resistance to B10-F16 melanoma - increased
respiratory system
response to injected CpG DNA - decreased
RVFV proliferation in macrophages - decreased
RVFV proliferation in macrophages - increased
RVFV susceptibility
secretory SlgA after 2nd OVA/Alum Challenge (day 7) - decreased
secretory SlgA after 2nd OVA/Alum Challenge (day 7) - increased
taste/olfaction
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-dependent humoral response defect- increased antibody response to OVA+ alum immunization
T-dependent humoral response defect- increased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
T-independent B cell response defect- increased TNP-specific IgM to TNP-Ficoll immunization
TLR signaling defect: hypersensitivity to CpG
TLR signaling defect: hypersensitivity to CpG + IFNg
TLR signaling defect: hypersensitivity to LPS
TLR signaling defect: hypersensitivity to MALP2
TLR signaling defect: hypersensitivity to PAM3CSK4
TLR signaling defect: hypersensitivity to poly I:C
TLR signaling defect: hypersensitivity to poly I:C + IFNg
TLR signaling defect: hypersensitivity to R848
TLR signaling defect: hyposensitivity to CpG
TLR signaling defect: hyposensitivity to CpG + IFNg
TLR signaling defect: hyposensitivity to LPS
TLR signaling defect: hyposensitivity to MALP2
TLR signaling defect: hyposensitivity to PAM3CSK4
TLR signaling defect: hyposensitivity to poly I:C
TLR signaling defect: hyposensitivity to poly I:C + IFNg
TLR signaling defect: hyposensitivity to R848
TLR signaling defect: TNF production by macrophages
TLR signaling defect: type I IFN production by macrophages
TLR signaling defect: type I IFN production by pDC
total IgE after 2nd OVA/Alum - decreased
total IgE after 2nd OVA/Alum - increased
Total IgE After 2nd OVA/Alum Challenge (day 7) - decreased
Total IgE After 2nd OVA/Alum Challenge (day 7) - increased
total IgE level - decreased
total IgE level - increased
tumorigenesis
and none of
and
none of
any of
125-03 Response - decreased
125-03 Response - increased
30 min GTT hyperglycemic (male)
30 min GTT hyperoglycemic (female)
30 min GTT hypoglycemic
30 min GTT hypoglycemic (female)
30 min GTT hypoglycemic (male)
30 Min. Insulin (Female) - decreased
adenovirus infection of macrophages - decreased
adenovirus infection of macrophages - increased
adipose tissue
anemia
autoimmunity
Blood Analysis EO% - decreased
Blood Analysis EO% - increased
Blood Analysis Hb - decreased
Blood Analysis Hb - increased
Blood Analysis HCT - decreased
Blood Analysis HCT - increased
Blood Analysis LY# - decreased
Blood Analysis LY# - increased
Blood Analysis MCH - decreased
Blood Analysis MCH - increased
Blood Analysis MCHC - decreased
Blood Analysis MCHC - increased
Blood Analysis MCV - decreased
Blood Analysis MCV - increased
Blood Analysis MO# - decreased
Blood Analysis MO# - increased
Blood Analysis NE# - decreased
Blood Analysis NE# - increased
Blood Analysis Platelet Count - decreased
Blood Analysis Platelet Count - increased
Blood Analysis RBC - decreased
Blood Analysis RBC - increased
Blood Analysis RDW - decreased
Blood Analysis RDW - increased
Blood Analysis WBC - decreased
Blood Analysis WBC - increased
Blood pressure defect: decrease in SBP day 1
Blood pressure defect: decrease in SBP day 2
Blood pressure defect: increase in SBP day 2
Body Weight - decreased
Body Weight - increased
Body Weight (DSS Female) - decreased
Body Weight (DSS Female) - increased
Body Weight (DSS Male) - decreased
Body Weight (DSS Male) - increased
Body Weight (DSS) - decreased
Body Weight (DSS) - increased
Body Weight (DSS, z-score) - decreased
Body Weight (DSS, z-score) - increased
Body Weight (Female) - decreased
Body Weight (Female) - increased
Body Weight (Male) - decreased
Body Weight (Male) - increased
Body Weight (Z-score) - decreased
Body Weight (Z-score) - increased
cardiovascular system
CD8 response - decreased
cellular phenotype
CTL killing - decreased
CTL killing - increased
CTL killing dominant epitope - decreased
CTL killing dominant epitope - increased
CTL killing subdominant epitope - decreased
CTL killing subdominant epitope - increased
defect in 125-03 response
dsDNA Antibody - decreased
dsDNA Antibody - increased
dsDNA induced type I IFN production - decreased
dsDNA induced type I IFN production - increased
DSS: resistant
DSS: resistant day 10
DSS: resistant day 7
DSS: sensitive
DSS: sensitive day 10
DSS: sensitive day 7
embryogenesis
endocrine/exocrine gland
extracellular cGAMP: high response
extracellular cGAMP: low response
eye: cataract
eye: corneal opacity
eye: retinal vascular anomaly
FACS B cells - decreased
FACS B cells - increased
FACS B:T cells - decreased
FACS B:T cells - increased
FACS B1 cells - decreased
FACS B1 cells - increased
FACS B1a cells - decreased
FACS B1a cells - increased
FACS B1a cells in B1 cells - decreased
FACS B1a cells in B1 cells - increased
FACS B1b cells - decreased
FACS B1b cells - increased
FACS B1b cells in B1 cells - decreased
FACS B1b cells in B1 cells - increased
FACS B2 cells - decreased
FACS B2 cells - increased
FACS B220 MFI - decreased
FACS B220 MFI - increased
FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
FACS CD11b+ DCs (gated in CD11c+ cells) - increased
FACS CD11c+ DCs - decreased
FACS CD11c+ DCs - increased
FACS CD4:CD8 - decreased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells - increased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 MFI - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - decreased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 MFI - decreased
FACS CD44+ CD8 MFI - increased
FACS CD44+ CD8 T cells - decreased
FACS CD44+ CD8 T cells - increased
FACS CD44+ T cells - decreased
FACS CD44+ T cells - increased
FACS CD44+ T MFI - decreased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells - increased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - increased
FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
FACS CD8a+ DCs (gated in CD11c+ cells) - increased
FACS central memory CD4 T cells in CD4 T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - decreased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - decreased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - decreased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS effector T cells - decreased
FACS effector T cells - increased
FACS IgD MFI - decreased
FACS IgD MFI - increased
FACS IgD+ B cell percentage - decreased
FACS IgD+ B cell percentage - increased
FACS IgM MFI - decreased
FACS IgM MFI - increased
FACS IgM+ B cells - decreased
FACS IgM+ B cells - increased
FACS macrophages - decreased
FACS memory T cells - decreased
FACS memory T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD4 T cells in CD4 T cells - increased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - increased
FACS naïve T cells - decreased
FACS naïve T cells - increased
FACS neutrophils - decreased
FACS NK cells - decreased
FACS NK cells - increased
FACS NK T cells - decreased
FACS NK T cells - increased
FACS NKT cells (tet) - decreased
FACS NKT cells (tet) - increased
FACS pDCs - decreased
FACS pDCs - increased
FACS T cells - decreased
FACS T cells - increased
hematopoietic competition - disadvantage
homeostasis/metabolism
hypersensitivity to TLR CpGODN + IFNg
hyposensitivity to TLR CpGODN + IFNg
IgA response to 2nd OVA/Alum Challenge (day 7) - decreased
IgA response to 2nd OVA/Alum Challenge (day 7) - increased
IgE response to a Cysteine Protease (Papain) - decreased
IgE response to a Cysteine Protease (Papain) - increased
IgG1 response to a Cysteine Protease (Papain) - decreased
IgG1 response to a Cysteine Protease (Papain) - increased
immune system
impaired response to dsDNA- type I IFN production by macrophages
inflammatory bowel disease phenotype
influenza proliferation in macrophages - decreased
influenza proliferation in macrophages - increased
influenza resistance
iron deficiency
iron excess
LCMV clone 13 resistance
lethality-embryonic/perinatal
LPS Cachexia: Body Weight (day 0) - decreased
LPS Cachexia: Body Weight (day 0) - increased
LPS Cachexia: Body Weight (day 0, z-score) - decreased
LPS Cachexia: Body Weight (day 0, z-score) - increased
LPS Cachexia: Body Weight (day 1) - decreased
LPS Cachexia: Body Weight (day 1) - increased
LPS Cachexia: Body Weight (day 14) - decreased
LPS Cachexia: Body Weight (day 14) - increased
LPS Cachexia: Body Weight (day 2) - decreased
LPS Cachexia: Body Weight (day 2) - increased
LPS Cachexia: Body Weight Change (day 1, g) - decreased
LPS Cachexia: Body Weight Change (day 1, g) - increased
LPS Cachexia: Body Weight Change (day 1, ratio) - decreased
LPS Cachexia: Body Weight Change (day 1, ratio) - increased
LPS Cachexia: Body Weight Change (day 14, g) - decreased
LPS Cachexia: Body Weight Change (day 14, g) - increased
LPS Cachexia: Body Weight Change (day 14, ratio) - decreased
LPS Cachexia: Body Weight Change (day 14, ratio) - increased
LPS Cachexia: Body Weight Change (day 2, g) - decreased
LPS Cachexia: Body Weight Change (day 2, g) - increased
LPS Cachexia: Body Weight Change (day 2, ratio) - decreased
LPS Cachexia: Body Weight Change (day 2, ratio) - increased
LPS Hypersensitivity - decreased
LPS Hypersensitivity - increased
LPS-induced Necroptosis - decreased
LPS-induced Necroptosis - increased
Macrophage necroptosis: high
Macrophage necroptosis: low
MCMV proliferation in macrophages - decreased
MCMV proliferation in macrophages - increased
MCMV resistance
MCMV susceptibility
Motor: rotarod weight
MTT dsDNA PECs - decreased
MTT dsDNA PECs - increased
MTT Value of PECs - decreased
MTT Value of PECs - increased
naive T cells - increased
NALP3 inflammasome signaling defect
NK cell response - decreased
NK killing - decreased
NK killing - increased
Nlrc4 inflammasome: high response
Nlrc4 inflammasome: low response
NLRP3 inflammasome: high response
NLRP3 inflammasome: low response
no phenotypic analysis
normal phenotype
OVA-specific IgE - decreased
OVA-specific IgE - increased
OVA-specific IgE after 2nd OVA/Alum - decreased
OVA-specific IgE after 2nd OVA/Alum - increased
Peritoneal exudates B1a cell % - decreased
Peritoneal exudates B1a cell % - increased
Peritoneal exudates B1a cell numbers - decreased
Peritoneal exudates B1a cell numbers - increased
Peritoneal exudates B1b cell % - decreased
Peritoneal exudates B1b cell % - increased
Peritoneal exudates B1b cell numbers - decreased
Peritoneal exudates B1b cell numbers - increased
Peritoneal exudates macrophage % - decreased
Peritoneal exudates macrophage % - increased
Peritoneal exudates macrophage numbers - decreased
Peritoneal exudates macrophage numbers - increased
Peritoneal exudates neutrophil % - decreased
Peritoneal exudates neutrophil % - increased
Peritoneal exudates neutrophil numbers - decreased
Peritoneal exudates neutrophil numbers - increased
phagocytosis in PECs - decreased
phagocytosis in PECs - increased
polycythemia
post-MCMV FACS B cells - decreased
post-MCMV FACS B cells - increased
post-MCMV FACS B:T cells - decreased
post-MCMV FACS B:T cells - increased
post-MCMV FACS B1 cells - decreased
post-MCMV FACS B1 cells - increased
post-MCMV FACS B1a cells - decreased
post-MCMV FACS B1a cells - increased
post-MCMV FACS B1a cells in B1 cells - decreased
post-MCMV FACS B1a cells in B1 cells - increased
post-MCMV FACS B1b cells - decreased
post-MCMV FACS B1b cells - increased
post-MCMV FACS B1b cells in B1 cells - decreased
post-MCMV FACS B1b cells in B1 cells - increased
post-MCMV FACS B2 cells - decreased
post-MCMV FACS B2 cells - increased
post-MCMV FACS B220 MFI - decreased
post-MCMV FACS B220 MFI - increased
post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - decreased
post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - increased
post-MCMV FACS CD11c+ DCs - decreased
post-MCMV FACS CD11c+ DCs - increased
post-MCMV FACS CD4:CD8 - decreased
post-MCMV FACS CD4:CD8 - increased
post-MCMV FACS CD4+ T cells - decreased
post-MCMV FACS CD4+ T cells - increased
post-MCMV FACS CD4+ T cells in CD3+ T cells - decreased
post-MCMV FACS CD4+ T cells in CD3+ T cells - increased
post-MCMV FACS CD44+ CD4 MFI - decreased
post-MCMV FACS CD44+ CD4 MFI - increased
post-MCMV FACS CD44+ CD4 T cells - decreased
post-MCMV FACS CD44+ CD4 T cells - increased
post-MCMV FACS CD44+ CD8 MFI - decreased
post-MCMV FACS CD44+ CD8 MFI - increased
post-MCMV FACS CD44+ CD8 T cells - decreased
post-MCMV FACS CD44+ CD8 T cells - increased
post-MCMV FACS CD44+ T cells - decreased
post-MCMV FACS CD44+ T cells - increased
post-MCMV FACS CD44+ T MFI - decreased
post-MCMV FACS CD44+ T MFI - increased
post-MCMV FACS CD8 response - decreased
post-MCMV FACS CD8 response - increased
post-MCMV FACS CD8+ T cells - decreased
post-MCMV FACS CD8+ T cells - increased
post-MCMV FACS CD8+ T cells in CD3+ T cells - decreased
post-MCMV FACS CD8+ T cells in CD3+ T cells - increased
post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - decreased
post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - increased
post-MCMV FACS central memory CD4 T cells in CD4 T cells - decreased
post-MCMV FACS central memory CD4 T cells in CD4 T cells - increased
post-MCMV FACS central memory CD8 T cells in CD8 T cells - decreased
post-MCMV FACS central memory CD8 T cells in CD8 T cells - increased
post-MCMV FACS effector memory CD4 T cells in CD4 T cells - decreased
post-MCMV FACS effector memory CD4 T cells in CD4 T cells - increased
post-MCMV FACS effector memory CD8 T cells in CD8 T cells - decreased
post-MCMV FACS effector memory CD8 T cells in CD8 T cells - increased
post-MCMV FACS effector T cells - decreased
post-MCMV FACS effector T cells - increased
post-MCMV FACS IgD MFI - decreased
post-MCMV FACS IgD MFI - increased
post-MCMV FACS IgD+ B cell percentage - decreased
post-MCMV FACS IgD+ B cell percentage - increased
post-MCMV FACS IgM MFI - decreased
post-MCMV FACS IgM MFI - increased
post-MCMV FACS IgM+ B cells - decreased
post-MCMV FACS IgM+ B cells - increased
post-MCMV FACS macrophages - decreased
post-MCMV FACS macrophages - increased
post-MCMV FACS memory T cells - decreased
post-MCMV FACS memory T cells - increased
post-MCMV FACS naive CD4 T cells in CD4 T cells - decreased
post-MCMV FACS naive CD4 T cells in CD4 T cells - increased
post-MCMV FACS naive CD8 T cells in CD8 T cells - decreased
post-MCMV FACS naive CD8 T cells in CD8 T cells - increased
post-MCMV FACS naïve T cells - decreased
post-MCMV FACS naïve T cells - increased
post-MCMV FACS neutrophils - decreased
post-MCMV FACS neutrophils - increased
post-MCMV FACS NK cell response - decreased
post-MCMV FACS NK cell response - increased
post-MCMV FACS NK cells - decreased
post-MCMV FACS NK cells - increased
post-MCMV FACS NK T cells - decreased
post-MCMV FACS NK T cells - increased
post-MCMV FACS NKT cells (tet) - decreased
post-MCMV FACS NKT cells (tet) - increased
post-MCMV FACS pDCs - decreased
post-MCMV FACS pDCs - increased
post-MCMV FACS T cells - decreased
post-MCMV FACS T cells - increased
ratio of OVA-specific IgE over the total IgE - decreased
ratio of OVA-specific IgE over the total IgE - increased
resistance to B10-F16 melanoma - decreased
resistance to B10-F16 melanoma - increased
respiratory system
response to injected CpG DNA - decreased
RVFV proliferation in macrophages - decreased
RVFV proliferation in macrophages - increased
RVFV susceptibility
secretory SlgA after 2nd OVA/Alum Challenge (day 7) - decreased
secretory SlgA after 2nd OVA/Alum Challenge (day 7) - increased
taste/olfaction
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-dependent humoral response defect- increased antibody response to OVA+ alum immunization
T-dependent humoral response defect- increased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
T-independent B cell response defect- increased TNP-specific IgM to TNP-Ficoll immunization
TLR signaling defect: hypersensitivity to CpG
TLR signaling defect: hypersensitivity to CpG + IFNg
TLR signaling defect: hypersensitivity to LPS
TLR signaling defect: hypersensitivity to MALP2
TLR signaling defect: hypersensitivity to PAM3CSK4
TLR signaling defect: hypersensitivity to poly I:C
TLR signaling defect: hypersensitivity to poly I:C + IFNg
TLR signaling defect: hypersensitivity to R848
TLR signaling defect: hyposensitivity to CpG
TLR signaling defect: hyposensitivity to CpG + IFNg
TLR signaling defect: hyposensitivity to LPS
TLR signaling defect: hyposensitivity to MALP2
TLR signaling defect: hyposensitivity to PAM3CSK4
TLR signaling defect: hyposensitivity to poly I:C
TLR signaling defect: hyposensitivity to poly I:C + IFNg
TLR signaling defect: hyposensitivity to R848
TLR signaling defect: TNF production by macrophages
TLR signaling defect: type I IFN production by macrophages
TLR signaling defect: type I IFN production by pDC
total IgE after 2nd OVA/Alum - decreased
total IgE after 2nd OVA/Alum - increased
Total IgE After 2nd OVA/Alum Challenge (day 7) - decreased
Total IgE After 2nd OVA/Alum Challenge (day 7) - increased
total IgE level - decreased
total IgE level - increased
tumorigenesis
and
validated
validated (with ENU)
validated (without ENU)
excluded
untested (pending)
untested (not pending)
validated
validated (with ENU)
validated (without ENU)
excluded
untested
Base Change
A
C
G
T
⇒
A
C
G
T
Type of Mutation
makesense
missense
nonsense
start codon destroyed
start gained
synonymous
splice acceptor site
splice donor site
critical splice acceptor site
critical splice donor site
splice site
large deletion
large insertion
rearrangement
small deletion
small insertion
exon
frame shift
intragenic
intron
utr 3 prime
utr 5 prime
unclassified
Exon Dist
Predicted Effect
unknown
probably benign
probably null
possibly damaging
probably damaging
noncoding transcript
silent
not run
no transcript
PPH Score
1
Irs2
0.613
Dum_dum
8
10984681-11008458 bp (-)
10987012
Autosomal Semidominant (5;27)
no Linkage result
2019-09-04
Anne Murray
A ⇒ C
makesense
probably null
[records 1 to 1 of 1]
