Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 15
missense 4063
nonsense 682
start codon destroyed 33
start gained 4
synonymous 1
splice acceptor site 17
splice donor site 30
critical splice acceptor site 71
critical splice donor site 403
splice site 242
large deletion 2
large insertion 0
rearrangement 0
small deletion 4
small insertion 0
exon 0
frame shift 35
intragenic 0
intron 70
utr 3 prime 7
utr 5 prime 5
Total: 5684
Incidental Mutation Types
Mutation TypeNumber*
makesense 1480
missense 511699
nonsense 25767
start codon destroyed 2024
start gained 2028
synonymous 113
splice acceptor site 0
splice donor site 0
critical splice acceptor site 3477
critical splice donor site 14210
splice site 26830
large deletion 0
large insertion 0
rearrangement 0
small deletion 1346
small insertion 1866
exon 2010
frame shift 2396
intragenic 0
intron 6011
utr 3 prime 1458
utr 5 prime 720
unclassified 10013
Total: 613448
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 127
A ⇒ G 1057
A ⇒ T 780
C ⇒ A 262
C ⇒ G 21
C ⇒ T 444
G ⇒ A 444
G ⇒ C 22
G ⇒ T 279
T ⇒ A 953
T ⇒ C 1131
T ⇒ G 157
Total: 5677
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 15282
A ⇒ G 123099
A ⇒ T 82163
C ⇒ A 28979
C ⇒ G 3524
C ⇒ T 49126
G ⇒ A 48421
G ⇒ C 3570
G ⇒ T 28353
T ⇒ A 83305
T ⇒ C 123875
T ⇒ G 15478
Total: 605175
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 9
Alanine Glutamic Acid 14
Alanine Glycine 4
Alanine Proline 2
Alanine Serine 13
Alanine Threonine 13
Alanine Valine 27
Arginine Cysteine 39
Arginine Glutamine 29
Arginine Glycine 23
Arginine Histidine 37
Arginine Isoleucine 0
Arginine Leucine 39
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 3
Arginine Serine 16
Arginine Threonine 0
Arginine Tryptophan 24
Arginine Stop codon 88
Asparagine Aspartic acid 30
Asparagine Histidine 1
Asparagine Isoleucine 26
Asparagine Lysine 61
Asparagine Serine 58
Asparagine Threonine 7
Asparagine Tyrosine 22
Aspartic acid Alanine 13
Aspartic acid Asparagine 10
Aspartic acid Glutamic Acid 75
Aspartic acid Glycine 195
Aspartic acid Histidine 1
Aspartic acid Tyrosine 6
Aspartic acid Valine 63
Cysteine Arginine 46
Cysteine Glycine 7
Cysteine Phenylalanine 24
Cysteine Serine 47
Cysteine Tryptophan 3
Cysteine Tyrosine 27
Cysteine Stop codon 84
Glutamic Acid Alanine 3
Glutamic Acid Aspartic acid 12
Glutamic Acid Glutamine 1
Glutamic Acid Glycine 122
Glutamic Acid Lysine 18
Glutamic Acid Valine 14
Glutamic Acid Stop codon 44
Glutamine Arginine 14
Glutamine Glutamic Acid 1
Glutamine Histidine 9
Glutamine Leucine 22
Glutamine Lysine 22
Glutamine Proline 4
Glutamine Stop codon 117
Glycine Alanine 2
Glycine Arginine 16
Glycine Aspartic acid 26
Glycine Cysteine 9
Glycine Glutamic Acid 5
Glycine Serine 13
Glycine Tryptophan 8
Glycine Valine 10
Glycine Stop codon 12
Histidine Arginine 43
Histidine Asparagine 15
Histidine Aspartic acid 2
Histidine Glutamine 37
Histidine Leucine 33
Histidine Proline 9
Histidine Tyrosine 8
Isoleucine Arginine 3
Isoleucine Asparagine 107
Isoleucine Leucine 21
Isoleucine Lysine 26
Isoleucine Methionine 9
Isoleucine Phenylalanine 56
Isoleucine Serine 11
Isoleucine Threonine 106
Isoleucine Valine 43
Leucine Arginine 23
Leucine Glutamine 58
Leucine Histidine 11
Leucine Isoleucine 4
Leucine Methionine 6
Leucine Phenylalanine 14
Leucine Proline 149
Leucine Serine 19
Leucine Tryptophan 2
Leucine Valine 5
Leucine Stop codon 48
Lysine Arginine 13
Lysine Asparagine 15
Lysine Glutamic Acid 49
Lysine Glutamine 3
Lysine Isoleucine 0
Lysine Methionine 4
Lysine Threonine 4
Lysine Stop codon 72
Methionine Arginine 16
Methionine Isoleucine 16
Methionine Leucine 27
Methionine Lysine 88
Methionine Threonine 27
Methionine Valine 30
Phenylalanine Cysteine 4
Phenylalanine Isoleucine 27
Phenylalanine Leucine 72
Phenylalanine Serine 57
Phenylalanine Tyrosine 6
Phenylalanine Valine 11
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 6
Proline Histidine 0
Proline Leucine 19
Proline Serine 18
Proline Threonine 7
Serine Alanine 8
Serine Arginine 23
Serine Asparagine 10
Serine Cysteine 10
Serine Glycine 29
Serine Isoleucine 3
Serine Leucine 9
Serine Phenylalanine 3
Serine Proline 176
Serine Threonine 40
Serine Tryptophan 0
Serine Tyrosine 3
Serine Stop codon 21
Threonine Alanine 108
Threonine Arginine 1
Threonine Asparagine 4
Threonine Isoleucine 60
Threonine Lysine 26
Threonine Methionine 16
Threonine Proline 9
Threonine Serine 37
Tryptophan Arginine 55
Tryptophan Cysteine 1
Tryptophan Glycine 1
Tryptophan Leucine 4
Tryptophan Serine 0
Tryptophan Stop codon 26
Tyrosine Asparagine 39
Tyrosine Aspartic acid 6
Tyrosine Cysteine 116
Tyrosine Histidine 88
Tyrosine Phenylalanine 21
Tyrosine Serine 3
Tyrosine Stop codon 165
Valine Alanine 204
Valine Aspartic acid 50
Valine Glutamic Acid 95
Valine Glycine 21
Valine Isoleucine 42
Valine Leucine 19
Valine Methionine 42
Valine Phenylalanine 18
Stop codon Arginine 1
Stop codon Cysteine 2
Stop codon Glutamic Acid 0
Stop codon Glutamine 5
Stop codon Glycine 1
Stop codon Leucine 3
Stop codon Lysine 1
Stop codon Serine 0
Stop codon Tryptophan 2
Stop codon Tyrosine 0
4777 changes of 158 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 901
Alanine Glutamic Acid 1713
Alanine Glycine 332
Alanine Proline 429
Alanine Serine 2959
Alanine Threonine 4296
Alanine Valine 4302
Arginine Cysteine 3655
Arginine Glutamine 3541
Arginine Glycine 3503
Arginine Histidine 4265
Arginine Isoleucine 134
Arginine Leucine 3699
Arginine Lysine 553
Arginine Methionine 167
Arginine Proline 370
Arginine Serine 2898
Arginine Threonine 65
Arginine Tryptophan 2571
Arginine Stop codon 3304
Asparagine Aspartic acid 3576
Asparagine Histidine 287
Asparagine Isoleucine 3207
Asparagine Lysine 8200
Asparagine Serine 9581
Asparagine Threonine 727
Asparagine Tyrosine 1769
Aspartic acid Alanine 1857
Aspartic acid Asparagine 2638
Aspartic acid Glutamic Acid 10996
Aspartic acid Glycine 22148
Aspartic acid Histidine 198
Aspartic acid Tyrosine 1139
Aspartic acid Valine 6742
Cysteine Arginine 2775
Cysteine Glycine 608
Cysteine Phenylalanine 1804
Cysteine Serine 4684
Cysteine Tryptophan 352
Cysteine Tyrosine 2593
Cysteine Stop codon 3240
Glutamic Acid Alanine 827
Glutamic Acid Aspartic acid 2736
Glutamic Acid Glutamine 260
Glutamic Acid Glycine 15156
Glutamic Acid Lysine 3521
Glutamic Acid Valine 2274
Glutamic Acid Stop codon 1884
Glutamine Arginine 2352
Glutamine Glutamic Acid 195
Glutamine Histidine 937
Glutamine Leucine 4057
Glutamine Lysine 2968
Glutamine Proline 666
Glutamine Stop codon 3943
Glycine Alanine 330
Glycine Arginine 2024
Glycine Aspartic acid 2844
Glycine Cysteine 1097
Glycine Glutamic Acid 1001
Glycine Serine 1628
Glycine Tryptophan 765
Glycine Valine 1410
Glycine Stop codon 511
Histidine Arginine 4986
Histidine Asparagine 1410
Histidine Aspartic acid 111
Histidine Glutamine 4994
Histidine Leucine 4959
Histidine Proline 599
Histidine Tyrosine 1808
Isoleucine Arginine 302
Isoleucine Asparagine 8480
Isoleucine Leucine 3298
Isoleucine Lysine 2052
Isoleucine Methionine 1980
Isoleucine Phenylalanine 9279
Isoleucine Serine 1272
Isoleucine Threonine 11590
Isoleucine Valine 10187
Leucine Arginine 1789
Leucine Glutamine 5057
Leucine Histidine 1399
Leucine Isoleucine 967
Leucine Methionine 752
Leucine Phenylalanine 3127
Leucine Proline 10760
Leucine Serine 1317
Leucine Tryptophan 146
Leucine Valine 649
Leucine Stop codon 2062
Lysine Arginine 3555
Lysine Asparagine 2781
Lysine Glutamic Acid 5556
Lysine Glutamine 437
Lysine Isoleucine 325
Lysine Methionine 725
Lysine Threonine 625
Lysine Stop codon 2604
Methionine Arginine 960
Methionine Isoleucine 2448
Methionine Leucine 5003
Methionine Lysine 8489
Methionine Threonine 3320
Methionine Valine 3656
Phenylalanine Cysteine 351
Phenylalanine Isoleucine 3045
Phenylalanine Leucine 8995
Phenylalanine Serine 4980
Phenylalanine Tyrosine 1297
Phenylalanine Valine 896
Proline Alanine 312
Proline Arginine 279
Proline Glutamine 1510
Proline Histidine 382
Proline Leucine 3118
Proline Serine 3921
Proline Threonine 1188
Serine Alanine 2048
Serine Arginine 4058
Serine Asparagine 1735
Serine Cysteine 1437
Serine Glycine 4114
Serine Isoleucine 628
Serine Leucine 1642
Serine Phenylalanine 1082
Serine Proline 19300
Serine Threonine 6458
Serine Tryptophan 34
Serine Tyrosine 365
Serine Stop codon 922
Threonine Alanine 21880
Threonine Arginine 161
Threonine Asparagine 1076
Threonine Isoleucine 8107
Threonine Lysine 3132
Threonine Methionine 3531
Threonine Proline 1345
Threonine Serine 7054
Tryptophan Arginine 3319
Tryptophan Cysteine 254
Tryptophan Glycine 225
Tryptophan Leucine 641
Tryptophan Serine 47
Tryptophan Stop codon 1152
Tyrosine Asparagine 3395
Tyrosine Aspartic acid 469
Tyrosine Cysteine 10897
Tyrosine Histidine 8314
Tyrosine Phenylalanine 3938
Tyrosine Serine 485
Tyrosine Stop codon 5896
Valine Alanine 26459
Valine Aspartic acid 4169
Valine Glutamic Acid 7032
Valine Glycine 2449
Valine Isoleucine 7342
Valine Leucine 3229
Valine Methionine 5135
Valine Phenylalanine 2013
Stop codon Arginine 316
Stop codon Cysteine 87
Stop codon Glutamic Acid 22
Stop codon Glutamine 301
Stop codon Glycine 48
Stop codon Leucine 77
Stop codon Lysine 98
Stop codon Serine 13
Stop codon Tryptophan 415
Stop codon Tyrosine 26
540626 changes of 170 types
We have now tabulated 545403 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.