Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 15
missense 3503
nonsense 605
start codon destroyed 29
start gained 3
synonymous 1
splice acceptor site 17
splice donor site 30
critical splice acceptor site 61
critical splice donor site 350
splice site 215
large deletion 2
large insertion 0
rearrangement 0
small deletion 4
small insertion 0
exon 0
frame shift 31
intragenic 0
intron 63
utr 3 prime 7
utr 5 prime 5
Total: 4941
Incidental Mutation Types
Mutation TypeNumber*
makesense 1364
missense 471650
nonsense 23742
start codon destroyed 1869
start gained 1729
synonymous 107
splice acceptor site 0
splice donor site 0
critical splice acceptor site 3207
critical splice donor site 13132
splice site 26474
large deletion 0
large insertion 0
rearrangement 0
small deletion 1194
small insertion 1811
exon 2010
frame shift 2245
intragenic 0
intron 5604
utr 3 prime 1408
utr 5 prime 711
unclassified 9606
Total: 567863
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 106
A ⇒ G 904
A ⇒ T 691
C ⇒ A 231
C ⇒ G 19
C ⇒ T 395
G ⇒ A 389
G ⇒ C 17
G ⇒ T 250
T ⇒ A 838
T ⇒ C 968
T ⇒ G 129
Total: 4937
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 14190
A ⇒ G 113848
A ⇒ T 75901
C ⇒ A 26915
C ⇒ G 3299
C ⇒ T 45433
G ⇒ A 44815
G ⇒ C 3304
G ⇒ T 26393
T ⇒ A 76865
T ⇒ C 114830
T ⇒ G 14359
Total: 560152
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 9
Alanine Glutamic Acid 12
Alanine Glycine 3
Alanine Proline 2
Alanine Serine 11
Alanine Threonine 11
Alanine Valine 26
Arginine Cysteine 34
Arginine Glutamine 22
Arginine Glycine 21
Arginine Histidine 34
Arginine Isoleucine 0
Arginine Leucine 32
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 3
Arginine Serine 15
Arginine Threonine 0
Arginine Tryptophan 22
Arginine Stop codon 78
Asparagine Aspartic acid 24
Asparagine Histidine 0
Asparagine Isoleucine 23
Asparagine Lysine 54
Asparagine Serine 49
Asparagine Threonine 6
Asparagine Tyrosine 21
Aspartic acid Alanine 9
Aspartic acid Asparagine 9
Aspartic acid Glutamic Acid 66
Aspartic acid Glycine 166
Aspartic acid Histidine 1
Aspartic acid Tyrosine 6
Aspartic acid Valine 52
Cysteine Arginine 39
Cysteine Glycine 5
Cysteine Phenylalanine 23
Cysteine Serine 43
Cysteine Tryptophan 3
Cysteine Tyrosine 25
Cysteine Stop codon 73
Glutamic Acid Alanine 1
Glutamic Acid Aspartic acid 10
Glutamic Acid Glutamine 1
Glutamic Acid Glycine 104
Glutamic Acid Lysine 14
Glutamic Acid Valine 12
Glutamic Acid Stop codon 39
Glutamine Arginine 11
Glutamine Glutamic Acid 1
Glutamine Histidine 9
Glutamine Leucine 20
Glutamine Lysine 21
Glutamine Proline 4
Glutamine Stop codon 107
Glycine Alanine 1
Glycine Arginine 13
Glycine Aspartic acid 21
Glycine Cysteine 6
Glycine Glutamic Acid 5
Glycine Serine 11
Glycine Tryptophan 8
Glycine Valine 9
Glycine Stop codon 12
Histidine Arginine 37
Histidine Asparagine 14
Histidine Aspartic acid 2
Histidine Glutamine 33
Histidine Leucine 29
Histidine Proline 9
Histidine Tyrosine 7
Isoleucine Arginine 3
Isoleucine Asparagine 95
Isoleucine Leucine 18
Isoleucine Lysine 21
Isoleucine Methionine 6
Isoleucine Phenylalanine 51
Isoleucine Serine 6
Isoleucine Threonine 86
Isoleucine Valine 37
Leucine Arginine 20
Leucine Glutamine 49
Leucine Histidine 9
Leucine Isoleucine 3
Leucine Methionine 6
Leucine Phenylalanine 13
Leucine Proline 125
Leucine Serine 15
Leucine Tryptophan 0
Leucine Valine 4
Leucine Stop codon 44
Lysine Arginine 11
Lysine Asparagine 12
Lysine Glutamic Acid 42
Lysine Glutamine 3
Lysine Isoleucine 0
Lysine Methionine 4
Lysine Threonine 3
Lysine Stop codon 65
Methionine Arginine 12
Methionine Isoleucine 12
Methionine Leucine 25
Methionine Lysine 78
Methionine Threonine 20
Methionine Valine 27
Phenylalanine Cysteine 3
Phenylalanine Isoleucine 21
Phenylalanine Leucine 65
Phenylalanine Serine 49
Phenylalanine Tyrosine 5
Phenylalanine Valine 9
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 5
Proline Histidine 0
Proline Leucine 17
Proline Serine 16
Proline Threonine 7
Serine Alanine 7
Serine Arginine 20
Serine Asparagine 9
Serine Cysteine 9
Serine Glycine 26
Serine Isoleucine 2
Serine Leucine 9
Serine Phenylalanine 3
Serine Proline 145
Serine Threonine 33
Serine Tryptophan 0
Serine Tyrosine 3
Serine Stop codon 17
Threonine Alanine 86
Threonine Arginine 1
Threonine Asparagine 3
Threonine Isoleucine 54
Threonine Lysine 24
Threonine Methionine 14
Threonine Proline 8
Threonine Serine 29
Tryptophan Arginine 48
Tryptophan Cysteine 1
Tryptophan Glycine 1
Tryptophan Leucine 4
Tryptophan Serine 0
Tryptophan Stop codon 22
Tyrosine Asparagine 31
Tyrosine Aspartic acid 6
Tyrosine Cysteine 102
Tyrosine Histidine 76
Tyrosine Phenylalanine 18
Tyrosine Serine 3
Tyrosine Stop codon 143
Valine Alanine 187
Valine Aspartic acid 44
Valine Glutamic Acid 86
Valine Glycine 16
Valine Isoleucine 36
Valine Leucine 18
Valine Methionine 35
Valine Phenylalanine 16
Stop codon Arginine 1
Stop codon Cysteine 2
Stop codon Glutamic Acid 0
Stop codon Glutamine 5
Stop codon Glycine 1
Stop codon Leucine 3
Stop codon Lysine 1
Stop codon Serine 0
Stop codon Tryptophan 2
Stop codon Tyrosine 0
4136 changes of 156 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 838
Alanine Glutamic Acid 1585
Alanine Glycine 307
Alanine Proline 407
Alanine Serine 2712
Alanine Threonine 4012
Alanine Valine 3984
Arginine Cysteine 3363
Arginine Glutamine 3268
Arginine Glycine 3251
Arginine Histidine 3942
Arginine Isoleucine 125
Arginine Leucine 3391
Arginine Lysine 515
Arginine Methionine 157
Arginine Proline 321
Arginine Serine 2695
Arginine Threonine 64
Arginine Tryptophan 2364
Arginine Stop codon 3058
Asparagine Aspartic acid 3324
Asparagine Histidine 262
Asparagine Isoleucine 2919
Asparagine Lysine 7563
Asparagine Serine 8818
Asparagine Threonine 681
Asparagine Tyrosine 1628
Aspartic acid Alanine 1709
Aspartic acid Asparagine 2429
Aspartic acid Glutamic Acid 10098
Aspartic acid Glycine 20398
Aspartic acid Histidine 188
Aspartic acid Tyrosine 1063
Aspartic acid Valine 6189
Cysteine Arginine 2564
Cysteine Glycine 557
Cysteine Phenylalanine 1684
Cysteine Serine 4310
Cysteine Tryptophan 322
Cysteine Tyrosine 2377
Cysteine Stop codon 2967
Glutamic Acid Alanine 765
Glutamic Acid Aspartic acid 2537
Glutamic Acid Glutamine 240
Glutamic Acid Glycine 13991
Glutamic Acid Lysine 3231
Glutamic Acid Valine 2090
Glutamic Acid Stop codon 1746
Glutamine Arginine 2150
Glutamine Glutamic Acid 179
Glutamine Histidine 884
Glutamine Leucine 3758
Glutamine Lysine 2747
Glutamine Proline 622
Glutamine Stop codon 3627
Glycine Alanine 316
Glycine Arginine 1911
Glycine Aspartic acid 2606
Glycine Cysteine 1036
Glycine Glutamic Acid 906
Glycine Serine 1528
Glycine Tryptophan 726
Glycine Valine 1337
Glycine Stop codon 480
Histidine Arginine 4575
Histidine Asparagine 1297
Histidine Aspartic acid 106
Histidine Glutamine 4572
Histidine Leucine 4570
Histidine Proline 545
Histidine Tyrosine 1643
Isoleucine Arginine 279
Isoleucine Asparagine 7806
Isoleucine Leucine 3045
Isoleucine Lysine 1889
Isoleucine Methionine 1808
Isoleucine Phenylalanine 8501
Isoleucine Serine 1152
Isoleucine Threonine 10653
Isoleucine Valine 9430
Leucine Arginine 1659
Leucine Glutamine 4642
Leucine Histidine 1305
Leucine Isoleucine 893
Leucine Methionine 700
Leucine Phenylalanine 2890
Leucine Proline 9896
Leucine Serine 1220
Leucine Tryptophan 136
Leucine Valine 616
Leucine Stop codon 1912
Lysine Arginine 3275
Lysine Asparagine 2566
Lysine Glutamic Acid 5146
Lysine Glutamine 407
Lysine Isoleucine 298
Lysine Methionine 676
Lysine Threonine 599
Lysine Stop codon 2392
Methionine Arginine 887
Methionine Isoleucine 2290
Methionine Leucine 4623
Methionine Lysine 7781
Methionine Threonine 3026
Methionine Valine 3395
Phenylalanine Cysteine 321
Phenylalanine Isoleucine 2834
Phenylalanine Leucine 8304
Phenylalanine Serine 4580
Phenylalanine Tyrosine 1217
Phenylalanine Valine 834
Proline Alanine 291
Proline Arginine 258
Proline Glutamine 1393
Proline Histidine 350
Proline Leucine 2781
Proline Serine 3656
Proline Threonine 1102
Serine Alanine 1886
Serine Arginine 3752
Serine Asparagine 1578
Serine Cysteine 1347
Serine Glycine 3801
Serine Isoleucine 597
Serine Leucine 1520
Serine Phenylalanine 980
Serine Proline 17741
Serine Threonine 5921
Serine Tryptophan 32
Serine Tyrosine 347
Serine Stop codon 842
Threonine Alanine 20114
Threonine Arginine 154
Threonine Asparagine 987
Threonine Isoleucine 7451
Threonine Lysine 2890
Threonine Methionine 3215
Threonine Proline 1232
Threonine Serine 6448
Tryptophan Arginine 3037
Tryptophan Cysteine 241
Tryptophan Glycine 203
Tryptophan Leucine 585
Tryptophan Serine 46
Tryptophan Stop codon 1061
Tyrosine Asparagine 3112
Tyrosine Aspartic acid 444
Tyrosine Cysteine 10057
Tyrosine Histidine 7719
Tyrosine Phenylalanine 3621
Tyrosine Serine 447
Tyrosine Stop codon 5417
Valine Alanine 24378
Valine Aspartic acid 3853
Valine Glutamic Acid 6425
Valine Glycine 2262
Valine Isoleucine 6826
Valine Leucine 2980
Valine Methionine 4754
Valine Phenylalanine 1857
Stop codon Arginine 287
Stop codon Cysteine 80
Stop codon Glutamic Acid 21
Stop codon Glutamine 285
Stop codon Glycine 48
Stop codon Leucine 74
Stop codon Lysine 88
Stop codon Serine 11
Stop codon Tryptophan 374
Stop codon Tyrosine 24
498296 changes of 170 types
We have now tabulated 502432 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.