Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 1
missense 659
nonsense 153
start codon destroyed 3
start gained 1
synonymous 0
splice acceptor site 24
splice donor site 29
critical splice acceptor site 15
critical splice donor site 77
splice site 0
large deletion 4
large insertion 0
rearrangement 0
small deletion 2
small insertion 2
exon 0
frame shift 6
intragenic 0
intron 5
utr 3 prime 1
utr 5 prime 0
Total: 982
Incidental Mutation Types
Mutation TypeNumber*
makesense 1295
missense 325597
nonsense 17122
start codon destroyed 729
start gained 807
synonymous 504
splice acceptor site 14111
splice donor site 14295
critical splice acceptor site 1217
critical splice donor site 5204
splice site 8044
large deletion 0
large insertion 0
rearrangement 0
small deletion 753
small insertion 353
exon 36
frame shift 1244
intragenic 6
intron 1086
utr 3 prime 85
utr 5 prime 96
Total: 392584
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 23
A ⇒ G 171
A ⇒ T 152
C ⇒ A 40
C ⇒ G 5
C ⇒ T 73
G ⇒ A 84
G ⇒ C 3
G ⇒ T 56
T ⇒ A 157
T ⇒ C 181
T ⇒ G 27
Total: 972
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 9735
A ⇒ G 82801
A ⇒ T 52402
C ⇒ A 17756
C ⇒ G 1790
C ⇒ T 32908
G ⇒ A 32532
G ⇒ C 1720
G ⇒ T 17333
T ⇒ A 53192
T ⇒ C 83344
T ⇒ G 9820
Total: 395333
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 2
Alanine Glutamic Acid 1
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 1
Alanine Threonine 0
Alanine Valine 3
Arginine Cysteine 6
Arginine Glutamine 5
Arginine Glycine 6
Arginine Histidine 6
Arginine Isoleucine 0
Arginine Leucine 7
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 4
Arginine Threonine 0
Arginine Tryptophan 1
Arginine Stop codon 24
Asparagine Aspartic acid 5
Asparagine Histidine 0
Asparagine Isoleucine 6
Asparagine Lysine 7
Asparagine Serine 5
Asparagine Threonine 0
Asparagine Tyrosine 3
Aspartic acid Alanine 3
Aspartic acid Asparagine 1
Aspartic acid Glutamic Acid 6
Aspartic acid Glycine 21
Aspartic acid Histidine 0
Aspartic acid Tyrosine 3
Aspartic acid Valine 10
Cysteine Arginine 13
Cysteine Glycine 2
Cysteine Phenylalanine 7
Cysteine Serine 10
Cysteine Tryptophan 3
Cysteine Tyrosine 6
Cysteine Stop codon 19
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 2
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 14
Glutamic Acid Lysine 2
Glutamic Acid Valine 2
Glutamic Acid Stop codon 8
Glutamine Arginine 1
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 4
Glutamine Lysine 2
Glutamine Proline 1
Glutamine Stop codon 27
Glycine Alanine 0
Glycine Arginine 4
Glycine Aspartic acid 7
Glycine Cysteine 2
Glycine Glutamic Acid 0
Glycine Serine 2
Glycine Tryptophan 1
Glycine Valine 3
Glycine Stop codon 1
Histidine Arginine 13
Histidine Asparagine 3
Histidine Aspartic acid 0
Histidine Glutamine 3
Histidine Leucine 8
Histidine Proline 3
Histidine Tyrosine 0
Isoleucine Arginine 1
Isoleucine Asparagine 24
Isoleucine Leucine 4
Isoleucine Lysine 4
Isoleucine Methionine 0
Isoleucine Phenylalanine 11
Isoleucine Serine 0
Isoleucine Threonine 16
Isoleucine Valine 6
Leucine Arginine 4
Leucine Glutamine 12
Leucine Histidine 0
Leucine Isoleucine 3
Leucine Methionine 0
Leucine Phenylalanine 1
Leucine Proline 33
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 1
Leucine Stop codon 10
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 2
Lysine Glutamine 0
Lysine Isoleucine 0
Lysine Methionine 1
Lysine Threonine 0
Lysine Stop codon 18
Methionine Arginine 2
Methionine Isoleucine 1
Methionine Leucine 2
Methionine Lysine 14
Methionine Threonine 5
Methionine Valine 7
Phenylalanine Cysteine 0
Phenylalanine Isoleucine 8
Phenylalanine Leucine 6
Phenylalanine Serine 7
Phenylalanine Tyrosine 1
Phenylalanine Valine 1
Proline Alanine 0
Proline Arginine 1
Proline Glutamine 1
Proline Histidine 0
Proline Leucine 3
Proline Serine 2
Proline Threonine 2
Serine Alanine 0
Serine Arginine 3
Serine Asparagine 1
Serine Cysteine 1
Serine Glycine 1
Serine Isoleucine 1
Serine Leucine 3
Serine Phenylalanine 0
Serine Proline 33
Serine Threonine 5
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 5
Threonine Alanine 14
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 7
Threonine Lysine 5
Threonine Methionine 4
Threonine Proline 2
Threonine Serine 6
Tryptophan Arginine 12
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 6
Tyrosine Asparagine 1
Tyrosine Aspartic acid 4
Tyrosine Cysteine 26
Tyrosine Histidine 10
Tyrosine Phenylalanine 5
Tyrosine Serine 0
Tyrosine Stop codon 34
Valine Alanine 36
Valine Aspartic acid 9
Valine Glutamic Acid 16
Valine Glycine 3
Valine Isoleucine 5
Valine Leucine 0
Valine Methionine 8
Valine Phenylalanine 3
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 0
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
805 changes of 125 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 468
Alanine Glutamic Acid 1041
Alanine Glycine 141
Alanine Proline 214
Alanine Serine 1727
Alanine Threonine 2806
Alanine Valine 2732
Arginine Cysteine 2376
Arginine Glutamine 2322
Arginine Glycine 2497
Arginine Histidine 2841
Arginine Isoleucine 76
Arginine Leucine 2161
Arginine Lysine 390
Arginine Methionine 99
Arginine Proline 170
Arginine Serine 1829
Arginine Threonine 33
Arginine Tryptophan 1723
Arginine Stop codon 2366
Asparagine Aspartic acid 2265
Asparagine Histidine 166
Asparagine Isoleucine 1971
Asparagine Lysine 5061
Asparagine Serine 6164
Asparagine Threonine 445
Asparagine Tyrosine 1064
Aspartic acid Alanine 1139
Aspartic acid Asparagine 1632
Aspartic acid Glutamic Acid 6611
Aspartic acid Glycine 13971
Aspartic acid Histidine 97
Aspartic acid Tyrosine 667
Aspartic acid Valine 4105
Cysteine Arginine 1958
Cysteine Glycine 396
Cysteine Phenylalanine 1209
Cysteine Serine 3072
Cysteine Tryptophan 223
Cysteine Tyrosine 1808
Cysteine Stop codon 2231
Glutamic Acid Alanine 514
Glutamic Acid Aspartic acid 1572
Glutamic Acid Glutamine 125
Glutamic Acid Glycine 9825
Glutamic Acid Lysine 2262
Glutamic Acid Valine 1424
Glutamic Acid Stop codon 1124
Glutamine Arginine 1454
Glutamine Glutamic Acid 84
Glutamine Histidine 519
Glutamine Leucine 2496
Glutamine Lysine 1846
Glutamine Proline 423
Glutamine Stop codon 2733
Glycine Alanine 144
Glycine Arginine 1189
Glycine Aspartic acid 1839
Glycine Cysteine 601
Glycine Glutamic Acid 649
Glycine Serine 973
Glycine Tryptophan 410
Glycine Valine 737
Glycine Stop codon 357
Histidine Arginine 3308
Histidine Asparagine 904
Histidine Aspartic acid 71
Histidine Glutamine 3117
Histidine Leucine 3291
Histidine Proline 356
Histidine Tyrosine 1183
Isoleucine Arginine 182
Isoleucine Asparagine 5155
Isoleucine Leucine 2048
Isoleucine Lysine 1294
Isoleucine Methionine 1301
Isoleucine Phenylalanine 5796
Isoleucine Serine 762
Isoleucine Threonine 7470
Isoleucine Valine 6552
Leucine Arginine 1169
Leucine Glutamine 3258
Leucine Histidine 906
Leucine Isoleucine 601
Leucine Methionine 413
Leucine Phenylalanine 2012
Leucine Proline 6983
Leucine Serine 896
Leucine Tryptophan 79
Leucine Valine 396
Leucine Stop codon 1405
Lysine Arginine 2303
Lysine Asparagine 1697
Lysine Glutamic Acid 3658
Lysine Glutamine 250
Lysine Isoleucine 209
Lysine Methionine 430
Lysine Threonine 351
Lysine Stop codon 1686
Methionine Arginine 601
Methionine Isoleucine 1562
Methionine Leucine 3097
Methionine Lysine 5176
Methionine Threonine 2152
Methionine Valine 2352
Phenylalanine Cysteine 233
Phenylalanine Isoleucine 1895
Phenylalanine Leucine 5718
Phenylalanine Serine 3251
Phenylalanine Tyrosine 828
Phenylalanine Valine 546
Proline Alanine 165
Proline Arginine 158
Proline Glutamine 987
Proline Histidine 180
Proline Leucine 2010
Proline Serine 2776
Proline Threonine 683
Serine Alanine 1265
Serine Arginine 2513
Serine Asparagine 1171
Serine Cysteine 891
Serine Glycine 2775
Serine Isoleucine 385
Serine Leucine 1146
Serine Phenylalanine 745
Serine Proline 12954
Serine Threonine 4134
Serine Tryptophan 14
Serine Tyrosine 235
Serine Stop codon 632
Threonine Alanine 14505
Threonine Arginine 83
Threonine Asparagine 663
Threonine Isoleucine 5391
Threonine Lysine 1997
Threonine Methionine 2247
Threonine Proline 849
Threonine Serine 4415
Tryptophan Arginine 2316
Tryptophan Cysteine 131
Tryptophan Glycine 148
Tryptophan Leucine 409
Tryptophan Serine 23
Tryptophan Stop codon 826
Tyrosine Asparagine 2025
Tyrosine Aspartic acid 290
Tyrosine Cysteine 7013
Tyrosine Histidine 5314
Tyrosine Phenylalanine 2450
Tyrosine Serine 316
Tyrosine Stop codon 3809
Valine Alanine 17396
Valine Aspartic acid 2663
Valine Glutamic Acid 4317
Valine Glycine 1515
Valine Isoleucine 4750
Valine Leucine 1836
Valine Methionine 3228
Valine Phenylalanine 1254
Stop codon Arginine 336
Stop codon Cysteine 57
Stop codon Glutamic Acid 25
Stop codon Glutamine 339
Stop codon Glycine 33
Stop codon Leucine 93
Stop codon Lysine 87
Stop codon Serine 8
Stop codon Tryptophan 303
Stop codon Tyrosine 30
345779 changes of 170 types
We have now tabulated 346584 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.