Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 2
missense 690
nonsense 169
start codon destroyed 9
start gained 1
synonymous 0
splice acceptor site 16
splice donor site 30
critical splice acceptor site 15
critical splice donor site 91
splice site 8
large deletion 2
large insertion 0
rearrangement 0
small deletion 2
small insertion 0
exon 0
frame shift 6
intragenic 0
intron 11
utr 3 prime 1
utr 5 prime 1
Total: 1054
Incidental Mutation Types
Mutation TypeNumber*
makesense 768
missense 329007
nonsense 16226
start codon destroyed 853
start gained 1079
synonymous 3326
splice acceptor site 467
splice donor site 491
critical splice acceptor site 1664
critical splice donor site 6957
splice site 13606
large deletion 0
large insertion 0
rearrangement 0
small deletion 712
small insertion 349
exon 2139
frame shift 1135
intragenic 0
intron 2909
utr 3 prime 952
utr 5 prime 764
Total: 383404
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 26
A ⇒ G 186
A ⇒ T 158
C ⇒ A 49
C ⇒ G 5
C ⇒ T 85
G ⇒ A 86
G ⇒ C 2
G ⇒ T 54
T ⇒ A 179
T ⇒ C 186
T ⇒ G 25
Total: 1041
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 9793
A ⇒ G 82254
A ⇒ T 52950
C ⇒ A 17918
C ⇒ G 1820
C ⇒ T 32692
G ⇒ A 32370
G ⇒ C 1780
G ⇒ T 17489
T ⇒ A 53712
T ⇒ C 82929
T ⇒ G 9827
Total: 395534
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 2
Alanine Glutamic Acid 2
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 1
Alanine Threonine 0
Alanine Valine 2
Arginine Cysteine 7
Arginine Glutamine 9
Arginine Glycine 7
Arginine Histidine 7
Arginine Isoleucine 0
Arginine Leucine 5
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 4
Arginine Threonine 0
Arginine Tryptophan 3
Arginine Stop codon 20
Asparagine Aspartic acid 5
Asparagine Histidine 0
Asparagine Isoleucine 7
Asparagine Lysine 8
Asparagine Serine 7
Asparagine Threonine 0
Asparagine Tyrosine 4
Aspartic acid Alanine 4
Aspartic acid Asparagine 1
Aspartic acid Glutamic Acid 7
Aspartic acid Glycine 29
Aspartic acid Histidine 1
Aspartic acid Tyrosine 3
Aspartic acid Valine 9
Cysteine Arginine 12
Cysteine Glycine 2
Cysteine Phenylalanine 7
Cysteine Serine 7
Cysteine Tryptophan 2
Cysteine Tyrosine 6
Cysteine Stop codon 21
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 1
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 17
Glutamic Acid Lysine 2
Glutamic Acid Valine 1
Glutamic Acid Stop codon 14
Glutamine Arginine 2
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 4
Glutamine Lysine 2
Glutamine Proline 1
Glutamine Stop codon 29
Glycine Alanine 0
Glycine Arginine 4
Glycine Aspartic acid 6
Glycine Cysteine 2
Glycine Glutamic Acid 0
Glycine Serine 3
Glycine Tryptophan 2
Glycine Valine 3
Glycine Stop codon 2
Histidine Arginine 10
Histidine Asparagine 3
Histidine Aspartic acid 0
Histidine Glutamine 5
Histidine Leucine 10
Histidine Proline 2
Histidine Tyrosine 0
Isoleucine Arginine 0
Isoleucine Asparagine 25
Isoleucine Leucine 4
Isoleucine Lysine 5
Isoleucine Methionine 1
Isoleucine Phenylalanine 8
Isoleucine Serine 0
Isoleucine Threonine 17
Isoleucine Valine 5
Leucine Arginine 5
Leucine Glutamine 10
Leucine Histidine 0
Leucine Isoleucine 3
Leucine Methionine 0
Leucine Phenylalanine 1
Leucine Proline 27
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 1
Leucine Stop codon 11
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 4
Lysine Glutamine 0
Lysine Isoleucine 0
Lysine Methionine 1
Lysine Threonine 1
Lysine Stop codon 25
Methionine Arginine 2
Methionine Isoleucine 1
Methionine Leucine 3
Methionine Lysine 19
Methionine Threonine 5
Methionine Valine 8
Phenylalanine Cysteine 0
Phenylalanine Isoleucine 8
Phenylalanine Leucine 9
Phenylalanine Serine 12
Phenylalanine Tyrosine 1
Phenylalanine Valine 1
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 0
Proline Histidine 0
Proline Leucine 3
Proline Serine 2
Proline Threonine 3
Serine Alanine 1
Serine Arginine 4
Serine Asparagine 1
Serine Cysteine 1
Serine Glycine 3
Serine Isoleucine 0
Serine Leucine 3
Serine Phenylalanine 1
Serine Proline 27
Serine Threonine 7
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 2
Threonine Alanine 14
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 9
Threonine Lysine 5
Threonine Methionine 5
Threonine Proline 3
Threonine Serine 7
Tryptophan Arginine 9
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 4
Tyrosine Asparagine 3
Tyrosine Aspartic acid 1
Tyrosine Cysteine 26
Tyrosine Histidine 13
Tyrosine Phenylalanine 5
Tyrosine Serine 0
Tyrosine Stop codon 39
Valine Alanine 37
Valine Aspartic acid 12
Valine Glutamic Acid 19
Valine Glycine 4
Valine Isoleucine 5
Valine Leucine 0
Valine Methionine 9
Valine Phenylalanine 2
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 0
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
861 changes of 126 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 501
Alanine Glutamic Acid 1070
Alanine Glycine 147
Alanine Proline 204
Alanine Serine 1748
Alanine Threonine 2890
Alanine Valine 2752
Arginine Cysteine 2375
Arginine Glutamine 2351
Arginine Glycine 2342
Arginine Histidine 2830
Arginine Isoleucine 73
Arginine Leucine 2217
Arginine Lysine 384
Arginine Methionine 99
Arginine Proline 177
Arginine Serine 1841
Arginine Threonine 32
Arginine Tryptophan 1738
Arginine Stop codon 2158
Asparagine Aspartic acid 2296
Asparagine Histidine 174
Asparagine Isoleucine 2032
Asparagine Lysine 5259
Asparagine Serine 6281
Asparagine Threonine 469
Asparagine Tyrosine 1095
Aspartic acid Alanine 1188
Aspartic acid Asparagine 1687
Aspartic acid Glutamic Acid 7015
Aspartic acid Glycine 14554
Aspartic acid Histidine 127
Aspartic acid Tyrosine 701
Aspartic acid Valine 4296
Cysteine Arginine 1824
Cysteine Glycine 383
Cysteine Phenylalanine 1166
Cysteine Serine 2995
Cysteine Tryptophan 217
Cysteine Tyrosine 1698
Cysteine Stop codon 2025
Glutamic Acid Alanine 521
Glutamic Acid Aspartic acid 1668
Glutamic Acid Glutamine 135
Glutamic Acid Glycine 10157
Glutamic Acid Lysine 2350
Glutamic Acid Valine 1475
Glutamic Acid Stop codon 1109
Glutamine Arginine 1462
Glutamine Glutamic Acid 89
Glutamine Histidine 531
Glutamine Leucine 2560
Glutamine Lysine 1861
Glutamine Proline 413
Glutamine Stop codon 2579
Glycine Alanine 148
Glycine Arginine 1208
Glycine Aspartic acid 1834
Glycine Cysteine 597
Glycine Glutamic Acid 624
Glycine Serine 1020
Glycine Tryptophan 405
Glycine Valine 763
Glycine Stop codon 317
Histidine Arginine 3254
Histidine Asparagine 923
Histidine Aspartic acid 53
Histidine Glutamine 3140
Histidine Leucine 3139
Histidine Proline 342
Histidine Tyrosine 1159
Isoleucine Arginine 188
Isoleucine Asparagine 5479
Isoleucine Leucine 2108
Isoleucine Lysine 1314
Isoleucine Methionine 1307
Isoleucine Phenylalanine 5976
Isoleucine Serine 804
Isoleucine Threonine 7614
Isoleucine Valine 6693
Leucine Arginine 1153
Leucine Glutamine 3257
Leucine Histidine 935
Leucine Isoleucine 598
Leucine Methionine 435
Leucine Phenylalanine 2023
Leucine Proline 6961
Leucine Serine 867
Leucine Tryptophan 81
Leucine Valine 401
Leucine Stop codon 1332
Lysine Arginine 2355
Lysine Asparagine 1720
Lysine Glutamic Acid 3770
Lysine Glutamine 264
Lysine Isoleucine 213
Lysine Methionine 470
Lysine Threonine 377
Lysine Stop codon 1679
Methionine Arginine 604
Methionine Isoleucine 1607
Methionine Leucine 3177
Methionine Lysine 5353
Methionine Threonine 2141
Methionine Valine 2413
Phenylalanine Cysteine 236
Phenylalanine Isoleucine 1927
Phenylalanine Leucine 5832
Phenylalanine Serine 3266
Phenylalanine Tyrosine 852
Phenylalanine Valine 554
Proline Alanine 148
Proline Arginine 163
Proline Glutamine 962
Proline Histidine 169
Proline Leucine 2042
Proline Serine 2671
Proline Threonine 682
Serine Alanine 1295
Serine Arginine 2589
Serine Asparagine 1139
Serine Cysteine 896
Serine Glycine 2673
Serine Isoleucine 377
Serine Leucine 1111
Serine Phenylalanine 741
Serine Proline 12763
Serine Threonine 4101
Serine Tryptophan 15
Serine Tyrosine 251
Serine Stop codon 577
Threonine Alanine 14406
Threonine Arginine 97
Threonine Asparagine 683
Threonine Isoleucine 5350
Threonine Lysine 2065
Threonine Methionine 2293
Threonine Proline 852
Threonine Serine 4464
Tryptophan Arginine 2150
Tryptophan Cysteine 125
Tryptophan Glycine 148
Tryptophan Leucine 370
Tryptophan Serine 22
Tryptophan Stop codon 735
Tyrosine Asparagine 2157
Tyrosine Aspartic acid 311
Tyrosine Cysteine 7254
Tyrosine Histidine 5530
Tyrosine Phenylalanine 2501
Tyrosine Serine 322
Tyrosine Stop codon 3790
Valine Alanine 17511
Valine Aspartic acid 2715
Valine Glutamic Acid 4488
Valine Glycine 1553
Valine Isoleucine 4827
Valine Leucine 1906
Valine Methionine 3395
Valine Phenylalanine 1260
Stop codon Arginine 155
Stop codon Cysteine 43
Stop codon Glutamic Acid 17
Stop codon Glutamine 178
Stop codon Glycine 27
Stop codon Leucine 43
Stop codon Lysine 53
Stop codon Serine 4
Stop codon Tryptophan 222
Stop codon Tyrosine 14
348984 changes of 170 types
We have now tabulated 349845 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.