Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 3
missense 860
nonsense 224
start codon destroyed 10
start gained 1
synonymous 0
splice acceptor site 16
splice donor site 29
critical splice acceptor site 24
critical splice donor site 106
splice site 28
large deletion 2
large insertion 0
rearrangement 0
small deletion 2
small insertion 0
exon 0
frame shift 9
intragenic 0
intron 18
utr 3 prime 1
utr 5 prime 1
Total: 1334
Incidental Mutation Types
Mutation TypeNumber*
makesense 812
missense 344755
nonsense 16988
start codon destroyed 917
start gained 1278
synonymous 277
splice acceptor site 467
splice donor site 504
critical splice acceptor site 1769
critical splice donor site 7479
splice site 13921
large deletion 0
large insertion 0
rearrangement 0
small deletion 888
small insertion 1149
exon 2180
frame shift 1324
intragenic 3
intron 3270
utr 3 prime 981
utr 5 prime 794
Total: 399756
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 29
A ⇒ G 235
A ⇒ T 197
C ⇒ A 65
C ⇒ G 5
C ⇒ T 109
G ⇒ A 105
G ⇒ C 3
G ⇒ T 73
T ⇒ A 228
T ⇒ C 236
T ⇒ G 32
Total: 1317
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 10211
A ⇒ G 85381
A ⇒ T 55354
C ⇒ A 18569
C ⇒ G 1879
C ⇒ T 33622
G ⇒ A 33171
G ⇒ C 1804
G ⇒ T 18223
T ⇒ A 56107
T ⇒ C 86088
T ⇒ G 10252
Total: 410661
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 2
Alanine Glutamic Acid 2
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 2
Alanine Threonine 1
Alanine Valine 4
Arginine Cysteine 8
Arginine Glutamine 9
Arginine Glycine 7
Arginine Histidine 8
Arginine Isoleucine 0
Arginine Leucine 6
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 4
Arginine Threonine 0
Arginine Tryptophan 3
Arginine Stop codon 22
Asparagine Aspartic acid 7
Asparagine Histidine 0
Asparagine Isoleucine 7
Asparagine Lysine 15
Asparagine Serine 10
Asparagine Threonine 0
Asparagine Tyrosine 5
Aspartic acid Alanine 4
Aspartic acid Asparagine 2
Aspartic acid Glutamic Acid 14
Aspartic acid Glycine 36
Aspartic acid Histidine 1
Aspartic acid Tyrosine 2
Aspartic acid Valine 11
Cysteine Arginine 17
Cysteine Glycine 3
Cysteine Phenylalanine 8
Cysteine Serine 9
Cysteine Tryptophan 2
Cysteine Tyrosine 8
Cysteine Stop codon 30
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 1
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 22
Glutamic Acid Lysine 2
Glutamic Acid Valine 3
Glutamic Acid Stop codon 16
Glutamine Arginine 2
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 4
Glutamine Lysine 5
Glutamine Proline 1
Glutamine Stop codon 41
Glycine Alanine 0
Glycine Arginine 4
Glycine Aspartic acid 7
Glycine Cysteine 3
Glycine Glutamic Acid 2
Glycine Serine 3
Glycine Tryptophan 2
Glycine Valine 5
Glycine Stop codon 2
Histidine Arginine 13
Histidine Asparagine 3
Histidine Aspartic acid 0
Histidine Glutamine 5
Histidine Leucine 10
Histidine Proline 2
Histidine Tyrosine 0
Isoleucine Arginine 0
Isoleucine Asparagine 25
Isoleucine Leucine 4
Isoleucine Lysine 7
Isoleucine Methionine 1
Isoleucine Phenylalanine 12
Isoleucine Serine 0
Isoleucine Threonine 19
Isoleucine Valine 6
Leucine Arginine 6
Leucine Glutamine 10
Leucine Histidine 1
Leucine Isoleucine 2
Leucine Methionine 0
Leucine Phenylalanine 2
Leucine Proline 37
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 1
Leucine Stop codon 17
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 5
Lysine Glutamine 0
Lysine Isoleucine 0
Lysine Methionine 2
Lysine Threonine 1
Lysine Stop codon 29
Methionine Arginine 2
Methionine Isoleucine 1
Methionine Leucine 3
Methionine Lysine 24
Methionine Threonine 7
Methionine Valine 11
Phenylalanine Cysteine 0
Phenylalanine Isoleucine 9
Phenylalanine Leucine 12
Phenylalanine Serine 15
Phenylalanine Tyrosine 1
Phenylalanine Valine 2
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 0
Proline Histidine 0
Proline Leucine 3
Proline Serine 1
Proline Threonine 4
Serine Alanine 1
Serine Arginine 5
Serine Asparagine 2
Serine Cysteine 3
Serine Glycine 3
Serine Isoleucine 0
Serine Leucine 2
Serine Phenylalanine 1
Serine Proline 39
Serine Threonine 9
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 6
Threonine Alanine 19
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 12
Threonine Lysine 7
Threonine Methionine 7
Threonine Proline 3
Threonine Serine 7
Tryptophan Arginine 14
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 5
Tyrosine Asparagine 3
Tyrosine Aspartic acid 2
Tyrosine Cysteine 34
Tyrosine Histidine 20
Tyrosine Phenylalanine 5
Tyrosine Serine 1
Tyrosine Stop codon 53
Valine Alanine 39
Valine Aspartic acid 14
Valine Glutamic Acid 20
Valine Glycine 5
Valine Isoleucine 8
Valine Leucine 1
Valine Methionine 12
Valine Phenylalanine 2
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 1
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
1087 changes of 132 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 560
Alanine Glutamic Acid 1113
Alanine Glycine 157
Alanine Proline 209
Alanine Serine 1847
Alanine Threonine 3030
Alanine Valine 2891
Arginine Cysteine 2458
Arginine Glutamine 2422
Arginine Glycine 2441
Arginine Histidine 2930
Arginine Isoleucine 80
Arginine Leucine 2316
Arginine Lysine 382
Arginine Methionine 101
Arginine Proline 182
Arginine Serine 1906
Arginine Threonine 28
Arginine Tryptophan 1784
Arginine Stop codon 2263
Asparagine Aspartic acid 2442
Asparagine Histidine 186
Asparagine Isoleucine 2131
Asparagine Lysine 5529
Asparagine Serine 6625
Asparagine Threonine 495
Asparagine Tyrosine 1175
Aspartic acid Alanine 1250
Aspartic acid Asparagine 1747
Aspartic acid Glutamic Acid 7330
Aspartic acid Glycine 15287
Aspartic acid Histidine 122
Aspartic acid Tyrosine 738
Aspartic acid Valine 4525
Cysteine Arginine 1885
Cysteine Glycine 393
Cysteine Phenylalanine 1225
Cysteine Serine 3114
Cysteine Tryptophan 224
Cysteine Tyrosine 1778
Cysteine Stop codon 2101
Glutamic Acid Alanine 548
Glutamic Acid Aspartic acid 1743
Glutamic Acid Glutamine 138
Glutamic Acid Glycine 10660
Glutamic Acid Lysine 2428
Glutamic Acid Valine 1567
Glutamic Acid Stop codon 1157
Glutamine Arginine 1541
Glutamine Glutamic Acid 98
Glutamine Histidine 547
Glutamine Leucine 2681
Glutamine Lysine 1974
Glutamine Proline 435
Glutamine Stop codon 2683
Glycine Alanine 155
Glycine Arginine 1293
Glycine Aspartic acid 1935
Glycine Cysteine 615
Glycine Glutamic Acid 656
Glycine Serine 1084
Glycine Tryptophan 419
Glycine Valine 815
Glycine Stop codon 337
Histidine Arginine 3388
Histidine Asparagine 977
Histidine Aspartic acid 58
Histidine Glutamine 3304
Histidine Leucine 3306
Histidine Proline 359
Histidine Tyrosine 1213
Isoleucine Arginine 201
Isoleucine Asparagine 5783
Isoleucine Leucine 2199
Isoleucine Lysine 1382
Isoleucine Methionine 1354
Isoleucine Phenylalanine 6259
Isoleucine Serine 832
Isoleucine Threonine 8013
Isoleucine Valine 7013
Leucine Arginine 1216
Leucine Glutamine 3453
Leucine Histidine 974
Leucine Isoleucine 615
Leucine Methionine 448
Leucine Phenylalanine 2120
Leucine Proline 7315
Leucine Serine 907
Leucine Tryptophan 86
Leucine Valine 415
Leucine Stop codon 1399
Lysine Arginine 2460
Lysine Asparagine 1818
Lysine Glutamic Acid 3901
Lysine Glutamine 277
Lysine Isoleucine 221
Lysine Methionine 495
Lysine Threonine 393
Lysine Stop codon 1770
Methionine Arginine 647
Methionine Isoleucine 1666
Methionine Leucine 3324
Methionine Lysine 5607
Methionine Threonine 2265
Methionine Valine 2532
Phenylalanine Cysteine 238
Phenylalanine Isoleucine 2039
Phenylalanine Leucine 6107
Phenylalanine Serine 3414
Phenylalanine Tyrosine 895
Phenylalanine Valine 581
Proline Alanine 157
Proline Arginine 154
Proline Glutamine 998
Proline Histidine 179
Proline Leucine 2086
Proline Serine 2774
Proline Threonine 715
Serine Alanine 1361
Serine Arginine 2697
Serine Asparagine 1179
Serine Cysteine 944
Serine Glycine 2821
Serine Isoleucine 409
Serine Leucine 1138
Serine Phenylalanine 755
Serine Proline 13400
Serine Threonine 4294
Serine Tryptophan 16
Serine Tyrosine 255
Serine Stop codon 593
Threonine Alanine 15087
Threonine Arginine 94
Threonine Asparagine 703
Threonine Isoleucine 5598
Threonine Lysine 2138
Threonine Methionine 2408
Threonine Proline 896
Threonine Serine 4713
Tryptophan Arginine 2247
Tryptophan Cysteine 131
Tryptophan Glycine 150
Tryptophan Leucine 384
Tryptophan Serine 27
Tryptophan Stop codon 758
Tyrosine Asparagine 2259
Tyrosine Aspartic acid 330
Tyrosine Cysteine 7651
Tyrosine Histidine 5806
Tyrosine Phenylalanine 2623
Tyrosine Serine 330
Tyrosine Stop codon 3962
Valine Alanine 18325
Valine Aspartic acid 2838
Valine Glutamic Acid 4719
Valine Glycine 1619
Valine Isoleucine 5028
Valine Leucine 1975
Valine Methionine 3549
Valine Phenylalanine 1336
Stop codon Arginine 170
Stop codon Cysteine 48
Stop codon Glutamic Acid 18
Stop codon Glutamine 187
Stop codon Glycine 29
Stop codon Leucine 44
Stop codon Lysine 54
Stop codon Serine 4
Stop codon Tryptophan 226
Stop codon Tyrosine 17
365556 changes of 170 types
We have now tabulated 366643 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.