Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 14
missense 3030
nonsense 563
start codon destroyed 28
start gained 3
synonymous 1
splice acceptor site 17
splice donor site 30
critical splice acceptor site 54
critical splice donor site 318
splice site 178
large deletion 2
large insertion 0
rearrangement 0
small deletion 4
small insertion 0
exon 0
frame shift 27
intragenic 0
intron 59
utr 3 prime 7
utr 5 prime 5
Total: 4340
Incidental Mutation Types
Mutation TypeNumber*
makesense 1286
missense 445475
nonsense 22637
start codon destroyed 1764
start gained 1522
synonymous 103
splice acceptor site 0
splice donor site 0
critical splice acceptor site 3006
critical splice donor site 12458
splice site 26294
large deletion 0
large insertion 0
rearrangement 0
small deletion 1051
small insertion 1698
exon 2010
frame shift 2071
intragenic 0
intron 5414
utr 3 prime 1376
utr 5 prime 709
unclassified 9359
Total: 538233
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 94
A ⇒ G 784
A ⇒ T 599
C ⇒ A 209
C ⇒ G 18
C ⇒ T 355
G ⇒ A 344
G ⇒ C 15
G ⇒ T 223
T ⇒ A 743
T ⇒ C 839
T ⇒ G 112
Total: 4335
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 13394
A ⇒ G 108249
A ⇒ T 72015
C ⇒ A 25545
C ⇒ G 2984
C ⇒ T 42856
G ⇒ A 42421
G ⇒ C 3029
G ⇒ T 25129
T ⇒ A 72940
T ⇒ C 109029
T ⇒ G 13537
Total: 531128
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 9
Alanine Glutamic Acid 9
Alanine Glycine 2
Alanine Proline 2
Alanine Serine 8
Alanine Threonine 9
Alanine Valine 22
Arginine Cysteine 28
Arginine Glutamine 19
Arginine Glycine 16
Arginine Histidine 32
Arginine Isoleucine 0
Arginine Leucine 31
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 3
Arginine Serine 13
Arginine Threonine 0
Arginine Tryptophan 19
Arginine Stop codon 75
Asparagine Aspartic acid 20
Asparagine Histidine 0
Asparagine Isoleucine 21
Asparagine Lysine 51
Asparagine Serine 42
Asparagine Threonine 4
Asparagine Tyrosine 18
Aspartic acid Alanine 9
Aspartic acid Asparagine 7
Aspartic acid Glutamic Acid 57
Aspartic acid Glycine 143
Aspartic acid Histidine 1
Aspartic acid Tyrosine 6
Aspartic acid Valine 39
Cysteine Arginine 38
Cysteine Glycine 5
Cysteine Phenylalanine 20
Cysteine Serine 38
Cysteine Tryptophan 3
Cysteine Tyrosine 25
Cysteine Stop codon 71
Glutamic Acid Alanine 1
Glutamic Acid Aspartic acid 7
Glutamic Acid Glutamine 1
Glutamic Acid Glycine 95
Glutamic Acid Lysine 10
Glutamic Acid Valine 9
Glutamic Acid Stop codon 37
Glutamine Arginine 9
Glutamine Glutamic Acid 1
Glutamine Histidine 7
Glutamine Leucine 18
Glutamine Lysine 19
Glutamine Proline 4
Glutamine Stop codon 98
Glycine Alanine 1
Glycine Arginine 11
Glycine Aspartic acid 16
Glycine Cysteine 5
Glycine Glutamic Acid 5
Glycine Serine 11
Glycine Tryptophan 8
Glycine Valine 9
Glycine Stop codon 10
Histidine Arginine 30
Histidine Asparagine 14
Histidine Aspartic acid 2
Histidine Glutamine 28
Histidine Leucine 25
Histidine Proline 8
Histidine Tyrosine 6
Isoleucine Arginine 3
Isoleucine Asparagine 79
Isoleucine Leucine 12
Isoleucine Lysine 18
Isoleucine Methionine 6
Isoleucine Phenylalanine 45
Isoleucine Serine 5
Isoleucine Threonine 70
Isoleucine Valine 30
Leucine Arginine 19
Leucine Glutamine 40
Leucine Histidine 9
Leucine Isoleucine 2
Leucine Methionine 6
Leucine Phenylalanine 12
Leucine Proline 104
Leucine Serine 14
Leucine Tryptophan 0
Leucine Valine 4
Leucine Stop codon 39
Lysine Arginine 9
Lysine Asparagine 10
Lysine Glutamic Acid 32
Lysine Glutamine 3
Lysine Isoleucine 0
Lysine Methionine 3
Lysine Threonine 2
Lysine Stop codon 62
Methionine Arginine 8
Methionine Isoleucine 10
Methionine Leucine 22
Methionine Lysine 69
Methionine Threonine 16
Methionine Valine 23
Phenylalanine Cysteine 3
Phenylalanine Isoleucine 19
Phenylalanine Leucine 56
Phenylalanine Serine 46
Phenylalanine Tyrosine 4
Phenylalanine Valine 9
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 4
Proline Histidine 0
Proline Leucine 15
Proline Serine 14
Proline Threonine 7
Serine Alanine 5
Serine Arginine 18
Serine Asparagine 8
Serine Cysteine 7
Serine Glycine 24
Serine Isoleucine 2
Serine Leucine 9
Serine Phenylalanine 3
Serine Proline 129
Serine Threonine 29
Serine Tryptophan 0
Serine Tyrosine 3
Serine Stop codon 15
Threonine Alanine 64
Threonine Arginine 1
Threonine Asparagine 2
Threonine Isoleucine 48
Threonine Lysine 19
Threonine Methionine 14
Threonine Proline 7
Threonine Serine 26
Tryptophan Arginine 46
Tryptophan Cysteine 1
Tryptophan Glycine 1
Tryptophan Leucine 4
Tryptophan Serine 0
Tryptophan Stop codon 19
Tyrosine Asparagine 25
Tyrosine Aspartic acid 5
Tyrosine Cysteine 92
Tyrosine Histidine 67
Tyrosine Phenylalanine 17
Tyrosine Serine 2
Tyrosine Stop codon 132
Valine Alanine 156
Valine Aspartic acid 37
Valine Glutamic Acid 79
Valine Glycine 13
Valine Isoleucine 31
Valine Leucine 15
Valine Methionine 31
Valine Phenylalanine 14
Stop codon Arginine 1
Stop codon Cysteine 2
Stop codon Glutamic Acid 0
Stop codon Glutamine 4
Stop codon Glycine 1
Stop codon Leucine 3
Stop codon Lysine 1
Stop codon Serine 0
Stop codon Tryptophan 2
Stop codon Tyrosine 0
3618 changes of 156 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 788
Alanine Glutamic Acid 1485
Alanine Glycine 288
Alanine Proline 363
Alanine Serine 2539
Alanine Threonine 3747
Alanine Valine 3683
Arginine Cysteine 3136
Arginine Glutamine 3038
Arginine Glycine 3087
Arginine Histidine 3674
Arginine Isoleucine 118
Arginine Leucine 3209
Arginine Lysine 478
Arginine Methionine 155
Arginine Proline 300
Arginine Serine 2525
Arginine Threonine 53
Arginine Tryptophan 2257
Arginine Stop codon 2914
Asparagine Aspartic acid 3115
Asparagine Histidine 239
Asparagine Isoleucine 2750
Asparagine Lysine 7130
Asparagine Serine 8353
Asparagine Threonine 649
Asparagine Tyrosine 1543
Aspartic acid Alanine 1609
Aspartic acid Asparagine 2295
Aspartic acid Glutamic Acid 9531
Aspartic acid Glycine 19388
Aspartic acid Histidine 181
Aspartic acid Tyrosine 1009
Aspartic acid Valine 5863
Cysteine Arginine 2394
Cysteine Glycine 524
Cysteine Phenylalanine 1601
Cysteine Serine 4043
Cysteine Tryptophan 298
Cysteine Tyrosine 2265
Cysteine Stop codon 2827
Glutamic Acid Alanine 721
Glutamic Acid Aspartic acid 2391
Glutamic Acid Glutamine 221
Glutamic Acid Glycine 13311
Glutamic Acid Lysine 3056
Glutamic Acid Valine 1980
Glutamic Acid Stop codon 1648
Glutamine Arginine 1997
Glutamine Glutamic Acid 163
Glutamine Histidine 839
Glutamine Leucine 3549
Glutamine Lysine 2621
Glutamine Proline 595
Glutamine Stop codon 3469
Glycine Alanine 277
Glycine Arginine 1784
Glycine Aspartic acid 2484
Glycine Cysteine 993
Glycine Glutamic Acid 855
Glycine Serine 1429
Glycine Tryptophan 688
Glycine Valine 1274
Glycine Stop codon 462
Histidine Arginine 4309
Histidine Asparagine 1241
Histidine Aspartic acid 101
Histidine Glutamine 4310
Histidine Leucine 4326
Histidine Proline 507
Histidine Tyrosine 1544
Isoleucine Arginine 259
Isoleucine Asparagine 7420
Isoleucine Leucine 2871
Isoleucine Lysine 1796
Isoleucine Methionine 1712
Isoleucine Phenylalanine 8042
Isoleucine Serine 1097
Isoleucine Threonine 10118
Isoleucine Valine 8918
Leucine Arginine 1566
Leucine Glutamine 4389
Leucine Histidine 1244
Leucine Isoleucine 836
Leucine Methionine 643
Leucine Phenylalanine 2709
Leucine Proline 9323
Leucine Serine 1150
Leucine Tryptophan 123
Leucine Valine 560
Leucine Stop codon 1822
Lysine Arginine 3079
Lysine Asparagine 2443
Lysine Glutamic Acid 4837
Lysine Glutamine 373
Lysine Isoleucine 279
Lysine Methionine 635
Lysine Threonine 569
Lysine Stop codon 2294
Methionine Arginine 835
Methionine Isoleucine 2140
Methionine Leucine 4367
Methionine Lysine 7355
Methionine Threonine 2850
Methionine Valine 3195
Phenylalanine Cysteine 305
Phenylalanine Isoleucine 2673
Phenylalanine Leucine 7844
Phenylalanine Serine 4334
Phenylalanine Tyrosine 1146
Phenylalanine Valine 788
Proline Alanine 260
Proline Arginine 235
Proline Glutamine 1331
Proline Histidine 327
Proline Leucine 2633
Proline Serine 3465
Proline Threonine 1050
Serine Alanine 1751
Serine Arginine 3542
Serine Asparagine 1492
Serine Cysteine 1259
Serine Glycine 3561
Serine Isoleucine 567
Serine Leucine 1436
Serine Phenylalanine 921
Serine Proline 16862
Serine Threonine 5550
Serine Tryptophan 24
Serine Tyrosine 330
Serine Stop codon 799
Threonine Alanine 19023
Threonine Arginine 138
Threonine Asparagine 946
Threonine Isoleucine 7062
Threonine Lysine 2762
Threonine Methionine 3028
Threonine Proline 1175
Threonine Serine 6091
Tryptophan Arginine 2842
Tryptophan Cysteine 235
Tryptophan Glycine 198
Tryptophan Leucine 541
Tryptophan Serine 46
Tryptophan Stop codon 1009
Tyrosine Asparagine 2937
Tyrosine Aspartic acid 419
Tyrosine Cysteine 9569
Tyrosine Histidine 7344
Tyrosine Phenylalanine 3410
Tyrosine Serine 425
Tyrosine Stop codon 5157
Valine Alanine 23069
Valine Aspartic acid 3636
Valine Glutamic Acid 6071
Valine Glycine 2108
Valine Isoleucine 6413
Valine Leucine 2815
Valine Methionine 4478
Valine Phenylalanine 1755
Stop codon Arginine 268
Stop codon Cysteine 78
Stop codon Glutamic Acid 21
Stop codon Glutamine 263
Stop codon Glycine 43
Stop codon Leucine 67
Stop codon Lysine 83
Stop codon Serine 11
Stop codon Tryptophan 361
Stop codon Tyrosine 21
470841 changes of 170 types
We have now tabulated 474459 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.