Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 15
missense 3737
nonsense 633
start codon destroyed 32
start gained 3
synonymous 1
splice acceptor site 17
splice donor site 30
critical splice acceptor site 67
critical splice donor site 370
splice site 232
large deletion 2
large insertion 0
rearrangement 0
small deletion 4
small insertion 0
exon 0
frame shift 32
intragenic 0
intron 64
utr 3 prime 7
utr 5 prime 5
Total: 5251
Incidental Mutation Types
Mutation TypeNumber*
makesense 1430
missense 494134
nonsense 24888
start codon destroyed 1954
start gained 1905
synonymous 111
splice acceptor site 0
splice donor site 0
critical splice acceptor site 3361
critical splice donor site 13762
splice site 26656
large deletion 0
large insertion 0
rearrangement 0
small deletion 1290
small insertion 1846
exon 2010
frame shift 2339
intragenic 0
intron 5823
utr 3 prime 1448
utr 5 prime 717
unclassified 9849
Total: 593523
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 116
A ⇒ G 966
A ⇒ T 733
C ⇒ A 246
C ⇒ G 20
C ⇒ T 407
G ⇒ A 409
G ⇒ C 18
G ⇒ T 260
T ⇒ A 887
T ⇒ C 1041
T ⇒ G 143
Total: 5246
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 14821
A ⇒ G 119010
A ⇒ T 79442
C ⇒ A 28065
C ⇒ G 3430
C ⇒ T 47511
G ⇒ A 46780
G ⇒ C 3463
G ⇒ T 27486
T ⇒ A 80461
T ⇒ C 119979
T ⇒ G 15000
Total: 585448
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 9
Alanine Glutamic Acid 13
Alanine Glycine 3
Alanine Proline 2
Alanine Serine 13
Alanine Threonine 11
Alanine Valine 26
Arginine Cysteine 37
Arginine Glutamine 24
Arginine Glycine 22
Arginine Histidine 35
Arginine Isoleucine 0
Arginine Leucine 35
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 3
Arginine Serine 16
Arginine Threonine 0
Arginine Tryptophan 22
Arginine Stop codon 83
Asparagine Aspartic acid 27
Asparagine Histidine 1
Asparagine Isoleucine 24
Asparagine Lysine 57
Asparagine Serine 53
Asparagine Threonine 6
Asparagine Tyrosine 21
Aspartic acid Alanine 11
Aspartic acid Asparagine 10
Aspartic acid Glutamic Acid 69
Aspartic acid Glycine 178
Aspartic acid Histidine 1
Aspartic acid Tyrosine 6
Aspartic acid Valine 62
Cysteine Arginine 43
Cysteine Glycine 6
Cysteine Phenylalanine 24
Cysteine Serine 47
Cysteine Tryptophan 3
Cysteine Tyrosine 26
Cysteine Stop codon 75
Glutamic Acid Alanine 3
Glutamic Acid Aspartic acid 10
Glutamic Acid Glutamine 1
Glutamic Acid Glycine 111
Glutamic Acid Lysine 16
Glutamic Acid Valine 13
Glutamic Acid Stop codon 40
Glutamine Arginine 11
Glutamine Glutamic Acid 1
Glutamine Histidine 9
Glutamine Leucine 20
Glutamine Lysine 22
Glutamine Proline 4
Glutamine Stop codon 109
Glycine Alanine 1
Glycine Arginine 14
Glycine Aspartic acid 22
Glycine Cysteine 7
Glycine Glutamic Acid 5
Glycine Serine 11
Glycine Tryptophan 8
Glycine Valine 9
Glycine Stop codon 12
Histidine Arginine 39
Histidine Asparagine 14
Histidine Aspartic acid 2
Histidine Glutamine 34
Histidine Leucine 30
Histidine Proline 9
Histidine Tyrosine 8
Isoleucine Arginine 3
Isoleucine Asparagine 99
Isoleucine Leucine 20
Isoleucine Lysine 22
Isoleucine Methionine 6
Isoleucine Phenylalanine 55
Isoleucine Serine 8
Isoleucine Threonine 93
Isoleucine Valine 40
Leucine Arginine 23
Leucine Glutamine 54
Leucine Histidine 9
Leucine Isoleucine 3
Leucine Methionine 6
Leucine Phenylalanine 13
Leucine Proline 138
Leucine Serine 15
Leucine Tryptophan 1
Leucine Valine 5
Leucine Stop codon 46
Lysine Arginine 13
Lysine Asparagine 13
Lysine Glutamic Acid 44
Lysine Glutamine 3
Lysine Isoleucine 0
Lysine Methionine 4
Lysine Threonine 4
Lysine Stop codon 69
Methionine Arginine 14
Methionine Isoleucine 14
Methionine Leucine 27
Methionine Lysine 81
Methionine Threonine 24
Methionine Valine 29
Phenylalanine Cysteine 3
Phenylalanine Isoleucine 24
Phenylalanine Leucine 67
Phenylalanine Serine 54
Phenylalanine Tyrosine 6
Phenylalanine Valine 9
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 5
Proline Histidine 0
Proline Leucine 18
Proline Serine 16
Proline Threonine 7
Serine Alanine 7
Serine Arginine 21
Serine Asparagine 10
Serine Cysteine 10
Serine Glycine 26
Serine Isoleucine 3
Serine Leucine 9
Serine Phenylalanine 3
Serine Proline 156
Serine Threonine 33
Serine Tryptophan 0
Serine Tyrosine 3
Serine Stop codon 19
Threonine Alanine 95
Threonine Arginine 1
Threonine Asparagine 4
Threonine Isoleucine 56
Threonine Lysine 24
Threonine Methionine 15
Threonine Proline 8
Threonine Serine 32
Tryptophan Arginine 53
Tryptophan Cysteine 1
Tryptophan Glycine 1
Tryptophan Leucine 4
Tryptophan Serine 0
Tryptophan Stop codon 22
Tyrosine Asparagine 33
Tyrosine Aspartic acid 6
Tyrosine Cysteine 108
Tyrosine Histidine 83
Tyrosine Phenylalanine 20
Tyrosine Serine 3
Tyrosine Stop codon 153
Valine Alanine 192
Valine Aspartic acid 46
Valine Glutamic Acid 91
Valine Glycine 19
Valine Isoleucine 39
Valine Leucine 18
Valine Methionine 36
Valine Phenylalanine 16
Stop codon Arginine 1
Stop codon Cysteine 2
Stop codon Glutamic Acid 0
Stop codon Glutamine 5
Stop codon Glycine 1
Stop codon Leucine 3
Stop codon Lysine 1
Stop codon Serine 0
Stop codon Tryptophan 2
Stop codon Tyrosine 0
4401 changes of 158 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 874
Alanine Glutamic Acid 1652
Alanine Glycine 325
Alanine Proline 413
Alanine Serine 2842
Alanine Threonine 4179
Alanine Valine 4169
Arginine Cysteine 3535
Arginine Glutamine 3427
Arginine Glycine 3398
Arginine Histidine 4118
Arginine Isoleucine 130
Arginine Leucine 3577
Arginine Lysine 537
Arginine Methionine 159
Arginine Proline 358
Arginine Serine 2815
Arginine Threonine 64
Arginine Tryptophan 2472
Arginine Stop codon 3188
Asparagine Aspartic acid 3462
Asparagine Histidine 277
Asparagine Isoleucine 3070
Asparagine Lysine 7931
Asparagine Serine 9239
Asparagine Threonine 706
Asparagine Tyrosine 1713
Aspartic acid Alanine 1787
Aspartic acid Asparagine 2552
Aspartic acid Glutamic Acid 10583
Aspartic acid Glycine 21367
Aspartic acid Histidine 195
Aspartic acid Tyrosine 1111
Aspartic acid Valine 6489
Cysteine Arginine 2686
Cysteine Glycine 590
Cysteine Phenylalanine 1747
Cysteine Serine 4534
Cysteine Tryptophan 340
Cysteine Tyrosine 2510
Cysteine Stop codon 3126
Glutamic Acid Alanine 797
Glutamic Acid Aspartic acid 2649
Glutamic Acid Glutamine 247
Glutamic Acid Glycine 14631
Glutamic Acid Lysine 3381
Glutamic Acid Valine 2194
Glutamic Acid Stop codon 1813
Glutamine Arginine 2271
Glutamine Glutamic Acid 189
Glutamine Histidine 913
Glutamine Leucine 3921
Glutamine Lysine 2868
Glutamine Proline 653
Glutamine Stop codon 3792
Glycine Alanine 326
Glycine Arginine 1967
Glycine Aspartic acid 2733
Glycine Cysteine 1071
Glycine Glutamic Acid 964
Glycine Serine 1584
Glycine Tryptophan 753
Glycine Valine 1383
Glycine Stop codon 499
Histidine Arginine 4815
Histidine Asparagine 1356
Histidine Aspartic acid 108
Histidine Glutamine 4800
Histidine Leucine 4775
Histidine Proline 572
Histidine Tyrosine 1732
Isoleucine Arginine 294
Isoleucine Asparagine 8181
Isoleucine Leucine 3194
Isoleucine Lysine 1973
Isoleucine Methionine 1902
Isoleucine Phenylalanine 8934
Isoleucine Serine 1216
Isoleucine Threonine 11190
Isoleucine Valine 9860
Leucine Arginine 1738
Leucine Glutamine 4864
Leucine Histidine 1363
Leucine Isoleucine 940
Leucine Methionine 724
Leucine Phenylalanine 3028
Leucine Proline 10403
Leucine Serine 1274
Leucine Tryptophan 144
Leucine Valine 638
Leucine Stop codon 1995
Lysine Arginine 3436
Lysine Asparagine 2680
Lysine Glutamic Acid 5383
Lysine Glutamine 428
Lysine Isoleucine 311
Lysine Methionine 701
Lysine Threonine 612
Lysine Stop codon 2529
Methionine Arginine 935
Methionine Isoleucine 2377
Methionine Leucine 4854
Methionine Lysine 8199
Methionine Threonine 3201
Methionine Valine 3534
Phenylalanine Cysteine 339
Phenylalanine Isoleucine 2944
Phenylalanine Leucine 8696
Phenylalanine Serine 4796
Phenylalanine Tyrosine 1272
Phenylalanine Valine 868
Proline Alanine 302
Proline Arginine 266
Proline Glutamine 1463
Proline Histidine 369
Proline Leucine 2949
Proline Serine 3796
Proline Threonine 1144
Serine Alanine 1976
Serine Arginine 3917
Serine Asparagine 1662
Serine Cysteine 1398
Serine Glycine 3978
Serine Isoleucine 621
Serine Leucine 1595
Serine Phenylalanine 1021
Serine Proline 18617
Serine Threonine 6207
Serine Tryptophan 34
Serine Tyrosine 357
Serine Stop codon 894
Threonine Alanine 21120
Threonine Arginine 161
Threonine Asparagine 1035
Threonine Isoleucine 7829
Threonine Lysine 3030
Threonine Methionine 3399
Threonine Proline 1296
Threonine Serine 6772
Tryptophan Arginine 3196
Tryptophan Cysteine 247
Tryptophan Glycine 211
Tryptophan Leucine 618
Tryptophan Serine 47
Tryptophan Stop codon 1109
Tyrosine Asparagine 3272
Tyrosine Aspartic acid 455
Tyrosine Cysteine 10517
Tyrosine Histidine 8041
Tyrosine Phenylalanine 3807
Tyrosine Serine 469
Tyrosine Stop codon 5694
Valine Alanine 25564
Valine Aspartic acid 4030
Valine Glutamic Acid 6773
Valine Glycine 2376
Valine Isoleucine 7111
Valine Leucine 3112
Valine Methionine 4954
Valine Phenylalanine 1944
Stop codon Arginine 304
Stop codon Cysteine 86
Stop codon Glutamic Acid 22
Stop codon Glutamine 295
Stop codon Glycine 48
Stop codon Leucine 75
Stop codon Lysine 94
Stop codon Serine 13
Stop codon Tryptophan 393
Stop codon Tyrosine 26
522065 changes of 170 types
We have now tabulated 526466 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.