Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 3
missense 956
nonsense 252
start codon destroyed 11
start gained 1
synonymous 0
splice acceptor site 17
splice donor site 29
critical splice acceptor site 26
critical splice donor site 128
splice site 37
large deletion 2
large insertion 0
rearrangement 0
small deletion 2
small insertion 0
exon 0
frame shift 9
intragenic 0
intron 20
utr 3 prime 1
utr 5 prime 1
Total: 1495
Incidental Mutation Types
Mutation TypeNumber*
makesense 981
missense 349258
nonsense 17594
start codon destroyed 1348
start gained 804
synonymous 236
splice acceptor site 0
splice donor site 0
critical splice acceptor site 2224
critical splice donor site 9852
splice site 19597
large deletion 0
large insertion 0
rearrangement 0
small deletion 619
small insertion 687
exon 1943
frame shift 1312
intragenic 0
intron 5918
utr 3 prime 1285
utr 5 prime 754
unclassified 10853
Total: 425265
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 32
A ⇒ G 267
A ⇒ T 223
C ⇒ A 73
C ⇒ G 6
C ⇒ T 127
G ⇒ A 117
G ⇒ C 4
G ⇒ T 81
T ⇒ A 246
T ⇒ C 269
T ⇒ G 37
Total: 1482
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 10496
A ⇒ G 87900
A ⇒ T 57007
C ⇒ A 19078
C ⇒ G 1946
C ⇒ T 34534
G ⇒ A 34093
G ⇒ C 1888
G ⇒ T 18756
T ⇒ A 57781
T ⇒ C 88644
T ⇒ G 10582
Total: 422705
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 3
Alanine Glutamic Acid 2
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 2
Alanine Threonine 1
Alanine Valine 6
Arginine Cysteine 11
Arginine Glutamine 8
Arginine Glycine 7
Arginine Histidine 8
Arginine Isoleucine 0
Arginine Leucine 8
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 4
Arginine Threonine 0
Arginine Tryptophan 3
Arginine Stop codon 28
Asparagine Aspartic acid 7
Asparagine Histidine 0
Asparagine Isoleucine 5
Asparagine Lysine 16
Asparagine Serine 11
Asparagine Threonine 0
Asparagine Tyrosine 5
Aspartic acid Alanine 4
Aspartic acid Asparagine 2
Aspartic acid Glutamic Acid 15
Aspartic acid Glycine 36
Aspartic acid Histidine 1
Aspartic acid Tyrosine 2
Aspartic acid Valine 12
Cysteine Arginine 18
Cysteine Glycine 3
Cysteine Phenylalanine 10
Cysteine Serine 10
Cysteine Tryptophan 2
Cysteine Tyrosine 8
Cysteine Stop codon 33
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 1
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 25
Glutamic Acid Lysine 2
Glutamic Acid Valine 4
Glutamic Acid Stop codon 19
Glutamine Arginine 2
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 4
Glutamine Lysine 6
Glutamine Proline 1
Glutamine Stop codon 45
Glycine Alanine 0
Glycine Arginine 4
Glycine Aspartic acid 7
Glycine Cysteine 3
Glycine Glutamic Acid 2
Glycine Serine 3
Glycine Tryptophan 2
Glycine Valine 5
Glycine Stop codon 3
Histidine Arginine 13
Histidine Asparagine 5
Histidine Aspartic acid 1
Histidine Glutamine 7
Histidine Leucine 10
Histidine Proline 3
Histidine Tyrosine 0
Isoleucine Arginine 0
Isoleucine Asparagine 26
Isoleucine Leucine 4
Isoleucine Lysine 7
Isoleucine Methionine 1
Isoleucine Phenylalanine 12
Isoleucine Serine 0
Isoleucine Threonine 25
Isoleucine Valine 6
Leucine Arginine 7
Leucine Glutamine 13
Leucine Histidine 1
Leucine Isoleucine 2
Leucine Methionine 1
Leucine Phenylalanine 2
Leucine Proline 39
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 2
Leucine Stop codon 18
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 7
Lysine Glutamine 1
Lysine Isoleucine 0
Lysine Methionine 2
Lysine Threonine 1
Lysine Stop codon 31
Methionine Arginine 2
Methionine Isoleucine 1
Methionine Leucine 4
Methionine Lysine 28
Methionine Threonine 7
Methionine Valine 11
Phenylalanine Cysteine 1
Phenylalanine Isoleucine 10
Phenylalanine Leucine 14
Phenylalanine Serine 17
Phenylalanine Tyrosine 1
Phenylalanine Valine 2
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 0
Proline Histidine 0
Proline Leucine 4
Proline Serine 3
Proline Threonine 3
Serine Alanine 1
Serine Arginine 5
Serine Asparagine 2
Serine Cysteine 4
Serine Glycine 5
Serine Isoleucine 0
Serine Leucine 2
Serine Phenylalanine 1
Serine Proline 51
Serine Threonine 9
Serine Tryptophan 0
Serine Tyrosine 0
Serine Stop codon 6
Threonine Alanine 22
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 12
Threonine Lysine 8
Threonine Methionine 8
Threonine Proline 2
Threonine Serine 9
Tryptophan Arginine 17
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 7
Tyrosine Asparagine 4
Tyrosine Aspartic acid 2
Tyrosine Cysteine 37
Tyrosine Histidine 22
Tyrosine Phenylalanine 5
Tyrosine Serine 1
Tyrosine Stop codon 60
Valine Alanine 42
Valine Aspartic acid 17
Valine Glutamic Acid 22
Valine Glycine 6
Valine Isoleucine 8
Valine Leucine 3
Valine Methionine 14
Valine Phenylalanine 2
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 1
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
1213 changes of 135 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 542
Alanine Glutamic Acid 1132
Alanine Glycine 156
Alanine Proline 218
Alanine Serine 1857
Alanine Threonine 2993
Alanine Valine 2862
Arginine Cysteine 2482
Arginine Glutamine 2425
Arginine Glycine 2415
Arginine Histidine 2888
Arginine Isoleucine 85
Arginine Leucine 2321
Arginine Lysine 376
Arginine Methionine 98
Arginine Proline 179
Arginine Serine 1876
Arginine Threonine 31
Arginine Tryptophan 1766
Arginine Stop codon 2305
Asparagine Aspartic acid 2480
Asparagine Histidine 188
Asparagine Isoleucine 2174
Asparagine Lysine 5635
Asparagine Serine 6666
Asparagine Threonine 498
Asparagine Tyrosine 1196
Aspartic acid Alanine 1264
Aspartic acid Asparagine 1773
Aspartic acid Glutamic Acid 7455
Aspartic acid Glycine 15416
Aspartic acid Histidine 121
Aspartic acid Tyrosine 728
Aspartic acid Valine 4555
Cysteine Arginine 1911
Cysteine Glycine 383
Cysteine Phenylalanine 1226
Cysteine Serine 3117
Cysteine Tryptophan 230
Cysteine Tyrosine 1789
Cysteine Stop codon 2184
Glutamic Acid Alanine 555
Glutamic Acid Aspartic acid 1752
Glutamic Acid Glutamine 136
Glutamic Acid Glycine 10759
Glutamic Acid Lysine 2470
Glutamic Acid Valine 1527
Glutamic Acid Stop codon 1177
Glutamine Arginine 1556
Glutamine Glutamic Acid 99
Glutamine Histidine 555
Glutamine Leucine 2700
Glutamine Lysine 1981
Glutamine Proline 434
Glutamine Stop codon 2762
Glycine Alanine 152
Glycine Arginine 1312
Glycine Aspartic acid 1943
Glycine Cysteine 622
Glycine Glutamic Acid 670
Glycine Serine 1084
Glycine Tryptophan 435
Glycine Valine 805
Glycine Stop codon 346
Histidine Arginine 3418
Histidine Asparagine 980
Histidine Aspartic acid 61
Histidine Glutamine 3330
Histidine Leucine 3336
Histidine Proline 368
Histidine Tyrosine 1206
Isoleucine Arginine 201
Isoleucine Asparagine 5905
Isoleucine Leucine 2234
Isoleucine Lysine 1396
Isoleucine Methionine 1362
Isoleucine Phenylalanine 6399
Isoleucine Serine 836
Isoleucine Threonine 8104
Isoleucine Valine 7087
Leucine Arginine 1206
Leucine Glutamine 3381
Leucine Histidine 985
Leucine Isoleucine 630
Leucine Methionine 453
Leucine Phenylalanine 2145
Leucine Proline 7378
Leucine Serine 923
Leucine Tryptophan 89
Leucine Valine 405
Leucine Stop codon 1427
Lysine Arginine 2463
Lysine Asparagine 1850
Lysine Glutamic Acid 3956
Lysine Glutamine 285
Lysine Isoleucine 217
Lysine Methionine 500
Lysine Threonine 397
Lysine Stop codon 1811
Methionine Arginine 655
Methionine Isoleucine 1689
Methionine Leucine 3394
Methionine Lysine 5700
Methionine Threonine 2291
Methionine Valine 2537
Phenylalanine Cysteine 240
Phenylalanine Isoleucine 2082
Phenylalanine Leucine 6190
Phenylalanine Serine 3475
Phenylalanine Tyrosine 895
Phenylalanine Valine 603
Proline Alanine 158
Proline Arginine 154
Proline Glutamine 983
Proline Histidine 183
Proline Leucine 2033
Proline Serine 2761
Proline Threonine 706
Serine Alanine 1390
Serine Arginine 2691
Serine Asparagine 1182
Serine Cysteine 940
Serine Glycine 2821
Serine Isoleucine 399
Serine Leucine 1133
Serine Phenylalanine 757
Serine Proline 13445
Serine Threonine 4300
Serine Tryptophan 17
Serine Tyrosine 253
Serine Stop codon 616
Threonine Alanine 15209
Threonine Arginine 96
Threonine Asparagine 694
Threonine Isoleucine 5675
Threonine Lysine 2155
Threonine Methionine 2443
Threonine Proline 902
Threonine Serine 4715
Tryptophan Arginine 2245
Tryptophan Cysteine 132
Tryptophan Glycine 149
Tryptophan Leucine 390
Tryptophan Serine 27
Tryptophan Stop codon 775
Tyrosine Asparagine 2295
Tyrosine Aspartic acid 329
Tyrosine Cysteine 7737
Tyrosine Histidine 5898
Tyrosine Phenylalanine 2693
Tyrosine Serine 341
Tyrosine Stop codon 4083
Valine Alanine 18550
Valine Aspartic acid 2872
Valine Glutamic Acid 4765
Valine Glycine 1643
Valine Isoleucine 5111
Valine Leucine 2019
Valine Methionine 3567
Valine Phenylalanine 1359
Stop codon Arginine 199
Stop codon Cysteine 60
Stop codon Glutamic Acid 18
Stop codon Glutamine 198
Stop codon Glycine 34
Stop codon Leucine 49
Stop codon Lysine 67
Stop codon Serine 6
Stop codon Tryptophan 289
Stop codon Tyrosine 17
369031 changes of 170 types
We have now tabulated 370244 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.