Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 2
missense 719
nonsense 186
start codon destroyed 9
start gained 1
synonymous 0
splice acceptor site 16
splice donor site 30
critical splice acceptor site 18
critical splice donor site 98
splice site 13
large deletion 2
large insertion 0
rearrangement 0
small deletion 2
small insertion 0
exon 0
frame shift 7
intragenic 0
intron 13
utr 3 prime 1
utr 5 prime 1
Total: 1118
Incidental Mutation Types
Mutation TypeNumber*
makesense 771
missense 328290
nonsense 16186
start codon destroyed 861
start gained 1137
synonymous 3453
splice acceptor site 467
splice donor site 491
critical splice acceptor site 1679
critical splice donor site 7003
splice site 13767
large deletion 0
large insertion 0
rearrangement 0
small deletion 847
small insertion 1086
exon 2174
frame shift 1250
intragenic 0
intron 3077
utr 3 prime 969
utr 5 prime 781
Total: 384289
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 26
A ⇒ G 197
A ⇒ T 166
C ⇒ A 54
C ⇒ G 5
C ⇒ T 95
G ⇒ A 89
G ⇒ C 3
G ⇒ T 58
T ⇒ A 193
T ⇒ C 190
T ⇒ G 27
Total: 1103
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 9824
A ⇒ G 82284
A ⇒ T 53081
C ⇒ A 17892
C ⇒ G 1786
C ⇒ T 32543
G ⇒ A 32200
G ⇒ C 1725
G ⇒ T 17515
T ⇒ A 53798
T ⇒ C 82912
T ⇒ G 9818
Total: 395378
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 2
Alanine Glutamic Acid 2
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 1
Alanine Threonine 0
Alanine Valine 3
Arginine Cysteine 8
Arginine Glutamine 9
Arginine Glycine 7
Arginine Histidine 7
Arginine Isoleucine 0
Arginine Leucine 5
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 4
Arginine Threonine 0
Arginine Tryptophan 3
Arginine Stop codon 20
Asparagine Aspartic acid 5
Asparagine Histidine 0
Asparagine Isoleucine 7
Asparagine Lysine 9
Asparagine Serine 7
Asparagine Threonine 0
Asparagine Tyrosine 5
Aspartic acid Alanine 4
Aspartic acid Asparagine 1
Aspartic acid Glutamic Acid 8
Aspartic acid Glycine 29
Aspartic acid Histidine 1
Aspartic acid Tyrosine 3
Aspartic acid Valine 9
Cysteine Arginine 13
Cysteine Glycine 2
Cysteine Phenylalanine 7
Cysteine Serine 8
Cysteine Tryptophan 2
Cysteine Tyrosine 6
Cysteine Stop codon 25
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 1
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 18
Glutamic Acid Lysine 2
Glutamic Acid Valine 1
Glutamic Acid Stop codon 15
Glutamine Arginine 2
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 4
Glutamine Lysine 2
Glutamine Proline 1
Glutamine Stop codon 33
Glycine Alanine 0
Glycine Arginine 4
Glycine Aspartic acid 6
Glycine Cysteine 2
Glycine Glutamic Acid 1
Glycine Serine 3
Glycine Tryptophan 2
Glycine Valine 3
Glycine Stop codon 2
Histidine Arginine 11
Histidine Asparagine 3
Histidine Aspartic acid 0
Histidine Glutamine 5
Histidine Leucine 10
Histidine Proline 2
Histidine Tyrosine 0
Isoleucine Arginine 0
Isoleucine Asparagine 25
Isoleucine Leucine 4
Isoleucine Lysine 5
Isoleucine Methionine 1
Isoleucine Phenylalanine 8
Isoleucine Serine 0
Isoleucine Threonine 18
Isoleucine Valine 5
Leucine Arginine 5
Leucine Glutamine 10
Leucine Histidine 1
Leucine Isoleucine 2
Leucine Methionine 0
Leucine Phenylalanine 1
Leucine Proline 28
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 1
Leucine Stop codon 12
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 5
Lysine Glutamine 0
Lysine Isoleucine 0
Lysine Methionine 1
Lysine Threonine 1
Lysine Stop codon 26
Methionine Arginine 2
Methionine Isoleucine 1
Methionine Leucine 3
Methionine Lysine 20
Methionine Threonine 7
Methionine Valine 8
Phenylalanine Cysteine 0
Phenylalanine Isoleucine 9
Phenylalanine Leucine 10
Phenylalanine Serine 12
Phenylalanine Tyrosine 1
Phenylalanine Valine 2
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 0
Proline Histidine 0
Proline Leucine 3
Proline Serine 2
Proline Threonine 4
Serine Alanine 1
Serine Arginine 4
Serine Asparagine 1
Serine Cysteine 2
Serine Glycine 3
Serine Isoleucine 0
Serine Leucine 3
Serine Phenylalanine 1
Serine Proline 27
Serine Threonine 7
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 3
Threonine Alanine 13
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 10
Threonine Lysine 5
Threonine Methionine 5
Threonine Proline 3
Threonine Serine 7
Tryptophan Arginine 10
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 4
Tyrosine Asparagine 3
Tyrosine Aspartic acid 1
Tyrosine Cysteine 30
Tyrosine Histidine 15
Tyrosine Phenylalanine 5
Tyrosine Serine 0
Tyrosine Stop codon 43
Valine Alanine 35
Valine Aspartic acid 13
Valine Glutamic Acid 19
Valine Glycine 4
Valine Isoleucine 5
Valine Leucine 0
Valine Methionine 11
Valine Phenylalanine 2
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 0
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
906 changes of 128 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 515
Alanine Glutamic Acid 1062
Alanine Glycine 143
Alanine Proline 200
Alanine Serine 1749
Alanine Threonine 2882
Alanine Valine 2761
Arginine Cysteine 2349
Arginine Glutamine 2308
Arginine Glycine 2327
Arginine Histidine 2809
Arginine Isoleucine 75
Arginine Leucine 2201
Arginine Lysine 372
Arginine Methionine 97
Arginine Proline 172
Arginine Serine 1824
Arginine Threonine 28
Arginine Tryptophan 1714
Arginine Stop codon 2154
Asparagine Aspartic acid 2310
Asparagine Histidine 175
Asparagine Isoleucine 2026
Asparagine Lysine 5256
Asparagine Serine 6266
Asparagine Threonine 473
Asparagine Tyrosine 1093
Aspartic acid Alanine 1187
Aspartic acid Asparagine 1656
Aspartic acid Glutamic Acid 6994
Aspartic acid Glycine 14544
Aspartic acid Histidine 120
Aspartic acid Tyrosine 696
Aspartic acid Valine 4319
Cysteine Arginine 1805
Cysteine Glycine 380
Cysteine Phenylalanine 1169
Cysteine Serine 2993
Cysteine Tryptophan 217
Cysteine Tyrosine 1684
Cysteine Stop codon 2014
Glutamic Acid Alanine 524
Glutamic Acid Aspartic acid 1656
Glutamic Acid Glutamine 130
Glutamic Acid Glycine 10150
Glutamic Acid Lysine 2315
Glutamic Acid Valine 1501
Glutamic Acid Stop codon 1102
Glutamine Arginine 1472
Glutamine Glutamic Acid 89
Glutamine Histidine 518
Glutamine Leucine 2562
Glutamine Lysine 1869
Glutamine Proline 411
Glutamine Stop codon 2555
Glycine Alanine 150
Glycine Arginine 1205
Glycine Aspartic acid 1839
Glycine Cysteine 590
Glycine Glutamic Acid 630
Glycine Serine 1015
Glycine Tryptophan 403
Glycine Valine 776
Glycine Stop codon 313
Histidine Arginine 3247
Histidine Asparagine 924
Histidine Aspartic acid 54
Histidine Glutamine 3137
Histidine Leucine 3157
Histidine Proline 340
Histidine Tyrosine 1145
Isoleucine Arginine 192
Isoleucine Asparagine 5492
Isoleucine Leucine 2103
Isoleucine Lysine 1308
Isoleucine Methionine 1288
Isoleucine Phenylalanine 5961
Isoleucine Serine 803
Isoleucine Threonine 7606
Isoleucine Valine 6676
Leucine Arginine 1152
Leucine Glutamine 3289
Leucine Histidine 934
Leucine Isoleucine 590
Leucine Methionine 432
Leucine Phenylalanine 2010
Leucine Proline 6952
Leucine Serine 866
Leucine Tryptophan 79
Leucine Valine 396
Leucine Stop codon 1331
Lysine Arginine 2356
Lysine Asparagine 1720
Lysine Glutamic Acid 3738
Lysine Glutamine 264
Lysine Isoleucine 211
Lysine Methionine 475
Lysine Threonine 372
Lysine Stop codon 1685
Methionine Arginine 612
Methionine Isoleucine 1605
Methionine Leucine 3172
Methionine Lysine 5336
Methionine Threonine 2161
Methionine Valine 2408
Phenylalanine Cysteine 231
Phenylalanine Isoleucine 1935
Phenylalanine Leucine 5829
Phenylalanine Serine 3240
Phenylalanine Tyrosine 853
Phenylalanine Valine 556
Proline Alanine 147
Proline Arginine 151
Proline Glutamine 962
Proline Histidine 172
Proline Leucine 2004
Proline Serine 2651
Proline Threonine 681
Serine Alanine 1290
Serine Arginine 2577
Serine Asparagine 1131
Serine Cysteine 895
Serine Glycine 2674
Serine Isoleucine 389
Serine Leucine 1096
Serine Phenylalanine 728
Serine Proline 12754
Serine Threonine 4089
Serine Tryptophan 15
Serine Tyrosine 246
Serine Stop codon 569
Threonine Alanine 14342
Threonine Arginine 91
Threonine Asparagine 680
Threonine Isoleucine 5334
Threonine Lysine 2057
Threonine Methionine 2307
Threonine Proline 853
Threonine Serine 4478
Tryptophan Arginine 2147
Tryptophan Cysteine 125
Tryptophan Glycine 142
Tryptophan Leucine 366
Tryptophan Serine 22
Tryptophan Stop codon 725
Tyrosine Asparagine 2161
Tyrosine Aspartic acid 313
Tyrosine Cysteine 7248
Tyrosine Histidine 5533
Tyrosine Phenylalanine 2514
Tyrosine Serine 321
Tyrosine Stop codon 3779
Valine Alanine 17450
Valine Aspartic acid 2715
Valine Glutamic Acid 4506
Valine Glycine 1562
Valine Isoleucine 4796
Valine Leucine 1897
Valine Methionine 3372
Valine Phenylalanine 1270
Stop codon Arginine 159
Stop codon Cysteine 45
Stop codon Glutamic Acid 17
Stop codon Glutamine 178
Stop codon Glycine 27
Stop codon Leucine 42
Stop codon Lysine 51
Stop codon Serine 4
Stop codon Tryptophan 218
Stop codon Tyrosine 15
348200 changes of 170 types
We have now tabulated 349106 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.