Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 8
missense 2462
nonsense 449
start codon destroyed 24
start gained 2
synonymous 0
splice acceptor site 17
splice donor site 30
critical splice acceptor site 45
critical splice donor site 264
splice site 130
large deletion 2
large insertion 0
rearrangement 0
small deletion 3
small insertion 0
exon 0
frame shift 20
intragenic 0
intron 56
utr 3 prime 6
utr 5 prime 5
Total: 3523
Incidental Mutation Types
Mutation TypeNumber*
makesense 1198
missense 422007
nonsense 21539
start codon destroyed 1660
start gained 1359
synonymous 302
splice acceptor site 0
splice donor site 0
critical splice acceptor site 2881
critical splice donor site 11797
splice site 21199
large deletion 0
large insertion 0
rearrangement 0
small deletion 975
small insertion 1682
exon 2010
frame shift 1979
intragenic 0
intron 7034
utr 3 prime 1420
utr 5 prime 802
unclassified 11678
Total: 511522
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 80
A ⇒ G 638
A ⇒ T 487
C ⇒ A 164
C ⇒ G 15
C ⇒ T 285
G ⇒ A 274
G ⇒ C 11
G ⇒ T 185
T ⇒ A 601
T ⇒ C 697
T ⇒ G 86
Total: 3523
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 12728
A ⇒ G 102759
A ⇒ T 68503
C ⇒ A 24314
C ⇒ G 2827
C ⇒ T 40666
G ⇒ A 40366
G ⇒ C 2861
G ⇒ T 23894
T ⇒ A 69279
T ⇒ C 103674
T ⇒ G 12850
Total: 504721
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 8
Alanine Glutamic Acid 5
Alanine Glycine 1
Alanine Proline 2
Alanine Serine 7
Alanine Threonine 7
Alanine Valine 18
Arginine Cysteine 23
Arginine Glutamine 17
Arginine Glycine 13
Arginine Histidine 26
Arginine Isoleucine 0
Arginine Leucine 19
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 2
Arginine Serine 11
Arginine Threonine 0
Arginine Tryptophan 9
Arginine Stop codon 61
Asparagine Aspartic acid 14
Asparagine Histidine 0
Asparagine Isoleucine 19
Asparagine Lysine 41
Asparagine Serine 33
Asparagine Threonine 3
Asparagine Tyrosine 13
Aspartic acid Alanine 8
Aspartic acid Asparagine 5
Aspartic acid Glutamic Acid 39
Aspartic acid Glycine 115
Aspartic acid Histidine 1
Aspartic acid Tyrosine 4
Aspartic acid Valine 29
Cysteine Arginine 35
Cysteine Glycine 5
Cysteine Phenylalanine 17
Cysteine Serine 35
Cysteine Tryptophan 3
Cysteine Tyrosine 16
Cysteine Stop codon 55
Glutamic Acid Alanine 1
Glutamic Acid Aspartic acid 4
Glutamic Acid Glutamine 1
Glutamic Acid Glycine 78
Glutamic Acid Lysine 8
Glutamic Acid Valine 8
Glutamic Acid Stop codon 31
Glutamine Arginine 8
Glutamine Glutamic Acid 0
Glutamine Histidine 5
Glutamine Leucine 15
Glutamine Lysine 15
Glutamine Proline 3
Glutamine Stop codon 76
Glycine Alanine 1
Glycine Arginine 8
Glycine Aspartic acid 13
Glycine Cysteine 4
Glycine Glutamic Acid 5
Glycine Serine 10
Glycine Tryptophan 7
Glycine Valine 7
Glycine Stop codon 7
Histidine Arginine 29
Histidine Asparagine 12
Histidine Aspartic acid 2
Histidine Glutamine 26
Histidine Leucine 20
Histidine Proline 6
Histidine Tyrosine 4
Isoleucine Arginine 1
Isoleucine Asparagine 66
Isoleucine Leucine 10
Isoleucine Lysine 15
Isoleucine Methionine 5
Isoleucine Phenylalanine 38
Isoleucine Serine 3
Isoleucine Threonine 59
Isoleucine Valine 30
Leucine Arginine 18
Leucine Glutamine 33
Leucine Histidine 8
Leucine Isoleucine 2
Leucine Methionine 5
Leucine Phenylalanine 12
Leucine Proline 78
Leucine Serine 14
Leucine Tryptophan 0
Leucine Valine 4
Leucine Stop codon 34
Lysine Arginine 7
Lysine Asparagine 8
Lysine Glutamic Acid 20
Lysine Glutamine 2
Lysine Isoleucine 0
Lysine Methionine 4
Lysine Threonine 2
Lysine Stop codon 51
Methionine Arginine 7
Methionine Isoleucine 7
Methionine Leucine 20
Methionine Lysine 55
Methionine Threonine 12
Methionine Valine 20
Phenylalanine Cysteine 1
Phenylalanine Isoleucine 15
Phenylalanine Leucine 48
Phenylalanine Serine 37
Phenylalanine Tyrosine 2
Phenylalanine Valine 8
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 3
Proline Histidine 0
Proline Leucine 12
Proline Serine 13
Proline Threonine 6
Serine Alanine 4
Serine Arginine 14
Serine Asparagine 7
Serine Cysteine 7
Serine Glycine 21
Serine Isoleucine 2
Serine Leucine 7
Serine Phenylalanine 3
Serine Proline 105
Serine Threonine 23
Serine Tryptophan 0
Serine Tyrosine 2
Serine Stop codon 11
Threonine Alanine 58
Threonine Arginine 0
Threonine Asparagine 2
Threonine Isoleucine 38
Threonine Lysine 17
Threonine Methionine 13
Threonine Proline 5
Threonine Serine 22
Tryptophan Arginine 36
Tryptophan Cysteine 1
Tryptophan Glycine 1
Tryptophan Leucine 4
Tryptophan Serine 0
Tryptophan Stop codon 14
Tyrosine Asparagine 13
Tyrosine Aspartic acid 3
Tyrosine Cysteine 74
Tyrosine Histidine 56
Tyrosine Phenylalanine 17
Tyrosine Serine 2
Tyrosine Stop codon 105
Valine Alanine 131
Valine Aspartic acid 29
Valine Glutamic Acid 62
Valine Glycine 9
Valine Isoleucine 26
Valine Leucine 14
Valine Methionine 20
Valine Phenylalanine 12
Stop codon Arginine 1
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 3
Stop codon Glycine 1
Stop codon Leucine 1
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 2
Stop codon Tyrosine 0
2927 changes of 152 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 718
Alanine Glutamic Acid 1415
Alanine Glycine 263
Alanine Proline 350
Alanine Serine 2401
Alanine Threonine 3573
Alanine Valine 3479
Arginine Cysteine 2937
Arginine Glutamine 2875
Arginine Glycine 2907
Arginine Histidine 3493
Arginine Isoleucine 116
Arginine Leucine 3030
Arginine Lysine 458
Arginine Methionine 151
Arginine Proline 284
Arginine Serine 2389
Arginine Threonine 46
Arginine Tryptophan 2132
Arginine Stop codon 2738
Asparagine Aspartic acid 2952
Asparagine Histidine 221
Asparagine Isoleucine 2635
Asparagine Lysine 6764
Asparagine Serine 7930
Asparagine Threonine 612
Asparagine Tyrosine 1448
Aspartic acid Alanine 1554
Aspartic acid Asparagine 2181
Aspartic acid Glutamic Acid 9022
Aspartic acid Glycine 18327
Aspartic acid Histidine 175
Aspartic acid Tyrosine 969
Aspartic acid Valine 5551
Cysteine Arginine 2269
Cysteine Glycine 496
Cysteine Phenylalanine 1516
Cysteine Serine 3840
Cysteine Tryptophan 288
Cysteine Tyrosine 2164
Cysteine Stop codon 2662
Glutamic Acid Alanine 677
Glutamic Acid Aspartic acid 2254
Glutamic Acid Glutamine 211
Glutamic Acid Glycine 12659
Glutamic Acid Lysine 2912
Glutamic Acid Valine 1877
Glutamic Acid Stop codon 1558
Glutamine Arginine 1902
Glutamine Glutamic Acid 153
Glutamine Histidine 795
Glutamine Leucine 3384
Glutamine Lysine 2488
Glutamine Proline 562
Glutamine Stop codon 3302
Glycine Alanine 269
Glycine Arginine 1669
Glycine Aspartic acid 2353
Glycine Cysteine 950
Glycine Glutamic Acid 794
Glycine Serine 1357
Glycine Tryptophan 644
Glycine Valine 1214
Glycine Stop codon 459
Histidine Arginine 4096
Histidine Asparagine 1206
Histidine Aspartic acid 96
Histidine Glutamine 4075
Histidine Leucine 4066
Histidine Proline 472
Histidine Tyrosine 1454
Isoleucine Arginine 245
Isoleucine Asparagine 7080
Isoleucine Leucine 2689
Isoleucine Lysine 1703
Isoleucine Methionine 1608
Isoleucine Phenylalanine 7669
Isoleucine Serine 1031
Isoleucine Threonine 9584
Isoleucine Valine 8373
Leucine Arginine 1468
Leucine Glutamine 4145
Leucine Histidine 1186
Leucine Isoleucine 800
Leucine Methionine 603
Leucine Phenylalanine 2551
Leucine Proline 8803
Leucine Serine 1106
Leucine Tryptophan 115
Leucine Valine 539
Leucine Stop codon 1734
Lysine Arginine 2915
Lysine Asparagine 2330
Lysine Glutamic Acid 4579
Lysine Glutamine 354
Lysine Isoleucine 267
Lysine Methionine 617
Lysine Threonine 525
Lysine Stop codon 2187
Methionine Arginine 800
Methionine Isoleucine 2035
Methionine Leucine 4108
Methionine Lysine 6922
Methionine Threonine 2702
Methionine Valine 3019
Phenylalanine Cysteine 285
Phenylalanine Isoleucine 2540
Phenylalanine Leucine 7402
Phenylalanine Serine 4099
Phenylalanine Tyrosine 1071
Phenylalanine Valine 752
Proline Alanine 246
Proline Arginine 222
Proline Glutamine 1261
Proline Histidine 319
Proline Leucine 2490
Proline Serine 3287
Proline Threonine 983
Serine Alanine 1664
Serine Arginine 3358
Serine Asparagine 1412
Serine Cysteine 1189
Serine Glycine 3395
Serine Isoleucine 529
Serine Leucine 1347
Serine Phenylalanine 878
Serine Proline 15855
Serine Threonine 5249
Serine Tryptophan 26
Serine Tyrosine 326
Serine Stop codon 765
Threonine Alanine 18053
Threonine Arginine 131
Threonine Asparagine 893
Threonine Isoleucine 6708
Threonine Lysine 2594
Threonine Methionine 2876
Threonine Proline 1111
Threonine Serine 5796
Tryptophan Arginine 2694
Tryptophan Cysteine 238
Tryptophan Glycine 183
Tryptophan Leucine 519
Tryptophan Serine 45
Tryptophan Stop codon 966
Tyrosine Asparagine 2786
Tyrosine Aspartic acid 380
Tyrosine Cysteine 9069
Tyrosine Histidine 6979
Tyrosine Phenylalanine 3245
Tyrosine Serine 411
Tyrosine Stop codon 4934
Valine Alanine 21887
Valine Aspartic acid 3440
Valine Glutamic Acid 5783
Valine Glycine 2016
Valine Isoleucine 6092
Valine Leucine 2645
Valine Methionine 4228
Valine Phenylalanine 1674
Stop codon Arginine 246
Stop codon Cysteine 69
Stop codon Glutamic Acid 20
Stop codon Glutamine 248
Stop codon Glycine 39
Stop codon Leucine 58
Stop codon Lysine 80
Stop codon Serine 10
Stop codon Tryptophan 340
Stop codon Tyrosine 21
446088 changes of 170 types
We have now tabulated 449015 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.