Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 8
missense 2224
nonsense 396
start codon destroyed 22
start gained 2
synonymous 0
splice acceptor site 17
splice donor site 29
critical splice acceptor site 40
critical splice donor site 233
splice site 116
large deletion 2
large insertion 0
rearrangement 0
small deletion 2
small insertion 0
exon 0
frame shift 18
intragenic 0
intron 47
utr 3 prime 5
utr 5 prime 4
Total: 3165
Incidental Mutation Types
Mutation TypeNumber*
makesense 1122
missense 395802
nonsense 19982
start codon destroyed 1551
start gained 1128
synonymous 274
splice acceptor site 0
splice donor site 0
critical splice acceptor site 2511
critical splice donor site 11063
splice site 20744
large deletion 0
large insertion 0
rearrangement 0
small deletion 760
small insertion 754
exon 2010
frame shift 1477
intragenic 0
intron 6576
utr 3 prime 1361
utr 5 prime 771
unclassified 11216
Total: 479102
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 73
A ⇒ G 578
A ⇒ T 434
C ⇒ A 147
C ⇒ G 14
C ⇒ T 257
G ⇒ A 252
G ⇒ C 10
G ⇒ T 168
T ⇒ A 532
T ⇒ C 626
T ⇒ G 78
Total: 3169
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 11828
A ⇒ G 98274
A ⇒ T 64605
C ⇒ A 21485
C ⇒ G 2182
C ⇒ T 38535
G ⇒ A 38114
G ⇒ C 2184
G ⇒ T 21014
T ⇒ A 65402
T ⇒ C 99077
T ⇒ G 11973
Total: 474673
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 7
Alanine Glutamic Acid 4
Alanine Glycine 1
Alanine Proline 2
Alanine Serine 6
Alanine Threonine 7
Alanine Valine 16
Arginine Cysteine 19
Arginine Glutamine 14
Arginine Glycine 13
Arginine Histidine 22
Arginine Isoleucine 0
Arginine Leucine 18
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 2
Arginine Serine 9
Arginine Threonine 0
Arginine Tryptophan 9
Arginine Stop codon 55
Asparagine Aspartic acid 11
Asparagine Histidine 0
Asparagine Isoleucine 17
Asparagine Lysine 40
Asparagine Serine 28
Asparagine Threonine 3
Asparagine Tyrosine 12
Aspartic acid Alanine 8
Aspartic acid Asparagine 5
Aspartic acid Glutamic Acid 35
Aspartic acid Glycine 100
Aspartic acid Histidine 1
Aspartic acid Tyrosine 4
Aspartic acid Valine 25
Cysteine Arginine 31
Cysteine Glycine 5
Cysteine Phenylalanine 16
Cysteine Serine 30
Cysteine Tryptophan 3
Cysteine Tyrosine 17
Cysteine Stop codon 47
Glutamic Acid Alanine 1
Glutamic Acid Aspartic acid 5
Glutamic Acid Glutamine 1
Glutamic Acid Glycine 71
Glutamic Acid Lysine 7
Glutamic Acid Valine 6
Glutamic Acid Stop codon 30
Glutamine Arginine 6
Glutamine Glutamic Acid 0
Glutamine Histidine 5
Glutamine Leucine 13
Glutamine Lysine 14
Glutamine Proline 3
Glutamine Stop codon 70
Glycine Alanine 1
Glycine Arginine 7
Glycine Aspartic acid 12
Glycine Cysteine 3
Glycine Glutamic Acid 3
Glycine Serine 10
Glycine Tryptophan 5
Glycine Valine 6
Glycine Stop codon 7
Histidine Arginine 29
Histidine Asparagine 12
Histidine Aspartic acid 2
Histidine Glutamine 22
Histidine Leucine 18
Histidine Proline 5
Histidine Tyrosine 3
Isoleucine Arginine 0
Isoleucine Asparagine 60
Isoleucine Leucine 10
Isoleucine Lysine 13
Isoleucine Methionine 5
Isoleucine Phenylalanine 33
Isoleucine Serine 3
Isoleucine Threonine 55
Isoleucine Valine 24
Leucine Arginine 16
Leucine Glutamine 28
Leucine Histidine 7
Leucine Isoleucine 2
Leucine Methionine 5
Leucine Phenylalanine 10
Leucine Proline 74
Leucine Serine 12
Leucine Tryptophan 0
Leucine Valine 4
Leucine Stop codon 28
Lysine Arginine 7
Lysine Asparagine 8
Lysine Glutamic Acid 20
Lysine Glutamine 2
Lysine Isoleucine 0
Lysine Methionine 4
Lysine Threonine 2
Lysine Stop codon 44
Methionine Arginine 7
Methionine Isoleucine 6
Methionine Leucine 19
Methionine Lysine 48
Methionine Threonine 12
Methionine Valine 18
Phenylalanine Cysteine 1
Phenylalanine Isoleucine 13
Phenylalanine Leucine 39
Phenylalanine Serine 32
Phenylalanine Tyrosine 2
Phenylalanine Valine 5
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 3
Proline Histidine 0
Proline Leucine 10
Proline Serine 13
Proline Threonine 6
Serine Alanine 4
Serine Arginine 13
Serine Asparagine 7
Serine Cysteine 7
Serine Glycine 19
Serine Isoleucine 1
Serine Leucine 6
Serine Phenylalanine 3
Serine Proline 94
Serine Threonine 22
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 10
Threonine Alanine 53
Threonine Arginine 0
Threonine Asparagine 2
Threonine Isoleucine 36
Threonine Lysine 16
Threonine Methionine 13
Threonine Proline 5
Threonine Serine 20
Tryptophan Arginine 34
Tryptophan Cysteine 1
Tryptophan Glycine 1
Tryptophan Leucine 4
Tryptophan Serine 0
Tryptophan Stop codon 10
Tyrosine Asparagine 10
Tyrosine Aspartic acid 3
Tyrosine Cysteine 66
Tyrosine Histidine 52
Tyrosine Phenylalanine 14
Tyrosine Serine 2
Tyrosine Stop codon 92
Valine Alanine 120
Valine Aspartic acid 25
Valine Glutamic Acid 55
Valine Glycine 9
Valine Isoleucine 24
Valine Leucine 13
Valine Methionine 19
Valine Phenylalanine 11
Stop codon Arginine 1
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 3
Stop codon Glycine 1
Stop codon Leucine 1
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 2
Stop codon Tyrosine 0
2635 changes of 151 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 631
Alanine Glutamic Acid 1280
Alanine Glycine 182
Alanine Proline 241
Alanine Serine 2089
Alanine Threonine 3347
Alanine Valine 3264
Arginine Cysteine 2780
Arginine Glutamine 2737
Arginine Glycine 2705
Arginine Histidine 3267
Arginine Isoleucine 95
Arginine Leucine 2651
Arginine Lysine 421
Arginine Methionine 105
Arginine Proline 198
Arginine Serine 2151
Arginine Threonine 35
Arginine Tryptophan 1988
Arginine Stop codon 2599
Asparagine Aspartic acid 2812
Asparagine Histidine 208
Asparagine Isoleucine 2473
Asparagine Lysine 6402
Asparagine Serine 7593
Asparagine Threonine 564
Asparagine Tyrosine 1364
Aspartic acid Alanine 1459
Aspartic acid Asparagine 2018
Aspartic acid Glutamic Acid 8519
Aspartic acid Glycine 17498
Aspartic acid Histidine 137
Aspartic acid Tyrosine 811
Aspartic acid Valine 5234
Cysteine Arginine 2179
Cysteine Glycine 451
Cysteine Phenylalanine 1392
Cysteine Serine 3578
Cysteine Tryptophan 260
Cysteine Tyrosine 2023
Cysteine Stop codon 2499
Glutamic Acid Alanine 628
Glutamic Acid Aspartic acid 1995
Glutamic Acid Glutamine 162
Glutamic Acid Glycine 12033
Glutamic Acid Lysine 2717
Glutamic Acid Valine 1745
Glutamic Acid Stop codon 1327
Glutamine Arginine 1785
Glutamine Glutamic Acid 125
Glutamine Histidine 621
Glutamine Leucine 3108
Glutamine Lysine 2281
Glutamine Proline 498
Glutamine Stop codon 3130
Glycine Alanine 172
Glycine Arginine 1489
Glycine Aspartic acid 2212
Glycine Cysteine 698
Glycine Glutamic Acid 735
Glycine Serine 1256
Glycine Tryptophan 502
Glycine Valine 890
Glycine Stop codon 385
Histidine Arginine 3888
Histidine Asparagine 1087
Histidine Aspartic acid 73
Histidine Glutamine 3846
Histidine Leucine 3824
Histidine Proline 425
Histidine Tyrosine 1362
Isoleucine Arginine 236
Isoleucine Asparagine 6684
Isoleucine Leucine 2543
Isoleucine Lysine 1605
Isoleucine Methionine 1520
Isoleucine Phenylalanine 7227
Isoleucine Serine 955
Isoleucine Threonine 9165
Isoleucine Valine 7965
Leucine Arginine 1358
Leucine Glutamine 3882
Leucine Histidine 1103
Leucine Isoleucine 710
Leucine Methionine 513
Leucine Phenylalanine 2393
Leucine Proline 8372
Leucine Serine 1032
Leucine Tryptophan 104
Leucine Valine 454
Leucine Stop codon 1639
Lysine Arginine 2747
Lysine Asparagine 2116
Lysine Glutamic Acid 4399
Lysine Glutamine 330
Lysine Isoleucine 247
Lysine Methionine 550
Lysine Threonine 438
Lysine Stop codon 2046
Methionine Arginine 749
Methionine Isoleucine 1870
Methionine Leucine 3909
Methionine Lysine 6552
Methionine Threonine 2578
Methionine Valine 2880
Phenylalanine Cysteine 261
Phenylalanine Isoleucine 2405
Phenylalanine Leucine 7010
Phenylalanine Serine 3891
Phenylalanine Tyrosine 1007
Phenylalanine Valine 690
Proline Alanine 178
Proline Arginine 179
Proline Glutamine 1131
Proline Histidine 206
Proline Leucine 2347
Proline Serine 3130
Proline Threonine 798
Serine Alanine 1564
Serine Arginine 3069
Serine Asparagine 1325
Serine Cysteine 1079
Serine Glycine 3215
Serine Isoleucine 451
Serine Leucine 1280
Serine Phenylalanine 826
Serine Proline 15174
Serine Threonine 4919
Serine Tryptophan 20
Serine Tyrosine 272
Serine Stop codon 703
Threonine Alanine 17229
Threonine Arginine 113
Threonine Asparagine 777
Threonine Isoleucine 6405
Threonine Lysine 2442
Threonine Methionine 2736
Threonine Proline 1037
Threonine Serine 5452
Tryptophan Arginine 2535
Tryptophan Cysteine 149
Tryptophan Glycine 176
Tryptophan Leucine 442
Tryptophan Serine 32
Tryptophan Stop codon 898
Tyrosine Asparagine 2619
Tyrosine Aspartic acid 365
Tyrosine Cysteine 8670
Tyrosine Histidine 6697
Tyrosine Phenylalanine 3066
Tyrosine Serine 388
Tyrosine Stop codon 4649
Valine Alanine 20871
Valine Aspartic acid 3277
Valine Glutamic Acid 5455
Valine Glycine 1875
Valine Isoleucine 5774
Valine Leucine 2328
Valine Methionine 3995
Valine Phenylalanine 1536
Stop codon Arginine 237
Stop codon Cysteine 68
Stop codon Glutamic Acid 19
Stop codon Glutamine 233
Stop codon Glycine 36
Stop codon Leucine 51
Stop codon Lysine 76
Stop codon Serine 6
Stop codon Tryptophan 322
Stop codon Tyrosine 20
418296 changes of 170 types
We have now tabulated 420931 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.