Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 3
missense 909
nonsense 238
start codon destroyed 11
start gained 1
synonymous 0
splice acceptor site 16
splice donor site 29
critical splice acceptor site 27
critical splice donor site 121
splice site 34
large deletion 2
large insertion 0
rearrangement 0
small deletion 2
small insertion 0
exon 0
frame shift 9
intragenic 0
intron 20
utr 3 prime 1
utr 5 prime 1
Total: 1424
Incidental Mutation Types
Mutation TypeNumber*
makesense 801
missense 348297
nonsense 17140
start codon destroyed 1003
start gained 1277
synonymous 282
splice acceptor site 453
splice donor site 484
critical splice acceptor site 1928
critical splice donor site 8367
splice site 14531
large deletion 0
large insertion 0
rearrangement 0
small deletion 893
small insertion 1162
exon 2170
frame shift 1349
intragenic 3
intron 3556
utr 3 prime 974
utr 5 prime 787
unclassified 15845
Total: 421302
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 31
A ⇒ G 255
A ⇒ T 211
C ⇒ A 72
C ⇒ G 5
C ⇒ T 122
G ⇒ A 108
G ⇒ C 3
G ⇒ T 77
T ⇒ A 236
T ⇒ C 253
T ⇒ G 35
Total: 1408
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 10383
A ⇒ G 86754
A ⇒ T 56258
C ⇒ A 18851
C ⇒ G 1914
C ⇒ T 34127
G ⇒ A 33678
G ⇒ C 1848
G ⇒ T 18541
T ⇒ A 57045
T ⇒ C 87566
T ⇒ G 10424
Total: 417389
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 3
Alanine Glutamic Acid 2
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 2
Alanine Threonine 1
Alanine Valine 5
Arginine Cysteine 10
Arginine Glutamine 8
Arginine Glycine 7
Arginine Histidine 8
Arginine Isoleucine 0
Arginine Leucine 7
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 4
Arginine Threonine 0
Arginine Tryptophan 3
Arginine Stop codon 26
Asparagine Aspartic acid 7
Asparagine Histidine 0
Asparagine Isoleucine 5
Asparagine Lysine 16
Asparagine Serine 10
Asparagine Threonine 0
Asparagine Tyrosine 5
Aspartic acid Alanine 4
Aspartic acid Asparagine 2
Aspartic acid Glutamic Acid 14
Aspartic acid Glycine 35
Aspartic acid Histidine 1
Aspartic acid Tyrosine 2
Aspartic acid Valine 12
Cysteine Arginine 18
Cysteine Glycine 3
Cysteine Phenylalanine 9
Cysteine Serine 9
Cysteine Tryptophan 2
Cysteine Tyrosine 8
Cysteine Stop codon 32
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 1
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 22
Glutamic Acid Lysine 2
Glutamic Acid Valine 3
Glutamic Acid Stop codon 17
Glutamine Arginine 2
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 4
Glutamine Lysine 6
Glutamine Proline 1
Glutamine Stop codon 44
Glycine Alanine 0
Glycine Arginine 4
Glycine Aspartic acid 7
Glycine Cysteine 3
Glycine Glutamic Acid 2
Glycine Serine 3
Glycine Tryptophan 2
Glycine Valine 5
Glycine Stop codon 2
Histidine Arginine 13
Histidine Asparagine 5
Histidine Aspartic acid 0
Histidine Glutamine 6
Histidine Leucine 10
Histidine Proline 3
Histidine Tyrosine 0
Isoleucine Arginine 0
Isoleucine Asparagine 25
Isoleucine Leucine 4
Isoleucine Lysine 7
Isoleucine Methionine 1
Isoleucine Phenylalanine 12
Isoleucine Serine 0
Isoleucine Threonine 22
Isoleucine Valine 6
Leucine Arginine 7
Leucine Glutamine 12
Leucine Histidine 1
Leucine Isoleucine 2
Leucine Methionine 1
Leucine Phenylalanine 2
Leucine Proline 37
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 1
Leucine Stop codon 17
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 7
Lysine Glutamine 0
Lysine Isoleucine 0
Lysine Methionine 2
Lysine Threonine 1
Lysine Stop codon 29
Methionine Arginine 2
Methionine Isoleucine 1
Methionine Leucine 3
Methionine Lysine 27
Methionine Threonine 7
Methionine Valine 11
Phenylalanine Cysteine 1
Phenylalanine Isoleucine 9
Phenylalanine Leucine 13
Phenylalanine Serine 17
Phenylalanine Tyrosine 1
Phenylalanine Valine 2
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 0
Proline Histidine 0
Proline Leucine 3
Proline Serine 2
Proline Threonine 3
Serine Alanine 1
Serine Arginine 5
Serine Asparagine 2
Serine Cysteine 3
Serine Glycine 5
Serine Isoleucine 0
Serine Leucine 2
Serine Phenylalanine 1
Serine Proline 46
Serine Threonine 9
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 6
Threonine Alanine 21
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 12
Threonine Lysine 8
Threonine Methionine 8
Threonine Proline 2
Threonine Serine 9
Tryptophan Arginine 15
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 6
Tyrosine Asparagine 4
Tyrosine Aspartic acid 2
Tyrosine Cysteine 36
Tyrosine Histidine 20
Tyrosine Phenylalanine 5
Tyrosine Serine 1
Tyrosine Stop codon 57
Valine Alanine 41
Valine Aspartic acid 16
Valine Glutamic Acid 21
Valine Glycine 5
Valine Isoleucine 8
Valine Leucine 2
Valine Methionine 13
Valine Phenylalanine 2
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 1
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
1153 changes of 134 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 570
Alanine Glutamic Acid 1133
Alanine Glycine 158
Alanine Proline 218
Alanine Serine 1883
Alanine Threonine 3066
Alanine Valine 2939
Arginine Cysteine 2497
Arginine Glutamine 2461
Arginine Glycine 2479
Arginine Histidine 2977
Arginine Isoleucine 83
Arginine Leucine 2384
Arginine Lysine 386
Arginine Methionine 104
Arginine Proline 188
Arginine Serine 1930
Arginine Threonine 29
Arginine Tryptophan 1811
Arginine Stop codon 2302
Asparagine Aspartic acid 2487
Asparagine Histidine 188
Asparagine Isoleucine 2166
Asparagine Lysine 5630
Asparagine Serine 6742
Asparagine Threonine 502
Asparagine Tyrosine 1206
Aspartic acid Alanine 1270
Aspartic acid Asparagine 1777
Aspartic acid Glutamic Acid 7457
Aspartic acid Glycine 15564
Aspartic acid Histidine 125
Aspartic acid Tyrosine 748
Aspartic acid Valine 4590
Cysteine Arginine 1916
Cysteine Glycine 397
Cysteine Phenylalanine 1240
Cysteine Serine 3181
Cysteine Tryptophan 230
Cysteine Tyrosine 1806
Cysteine Stop codon 2137
Glutamic Acid Alanine 560
Glutamic Acid Aspartic acid 1771
Glutamic Acid Glutamine 140
Glutamic Acid Glycine 10847
Glutamic Acid Lysine 2468
Glutamic Acid Valine 1584
Glutamic Acid Stop codon 1175
Glutamine Arginine 1567
Glutamine Glutamic Acid 100
Glutamine Histidine 566
Glutamine Leucine 2744
Glutamine Lysine 2003
Glutamine Proline 440
Glutamine Stop codon 2732
Glycine Alanine 157
Glycine Arginine 1324
Glycine Aspartic acid 1971
Glycine Cysteine 630
Glycine Glutamic Acid 668
Glycine Serine 1102
Glycine Tryptophan 430
Glycine Valine 824
Glycine Stop codon 339
Histidine Arginine 3455
Histidine Asparagine 989
Histidine Aspartic acid 59
Histidine Glutamine 3356
Histidine Leucine 3358
Histidine Proline 368
Histidine Tyrosine 1227
Isoleucine Arginine 203
Isoleucine Asparagine 5884
Isoleucine Leucine 2241
Isoleucine Lysine 1403
Isoleucine Methionine 1373
Isoleucine Phenylalanine 6369
Isoleucine Serine 847
Isoleucine Threonine 8187
Isoleucine Valine 7122
Leucine Arginine 1231
Leucine Glutamine 3494
Leucine Histidine 992
Leucine Isoleucine 626
Leucine Methionine 451
Leucine Phenylalanine 2160
Leucine Proline 7444
Leucine Serine 922
Leucine Tryptophan 88
Leucine Valine 418
Leucine Stop codon 1419
Lysine Arginine 2503
Lysine Asparagine 1849
Lysine Glutamic Acid 3969
Lysine Glutamine 286
Lysine Isoleucine 223
Lysine Methionine 500
Lysine Threonine 400
Lysine Stop codon 1808
Methionine Arginine 663
Methionine Isoleucine 1693
Methionine Leucine 3389
Methionine Lysine 5703
Methionine Threonine 2300
Methionine Valine 2572
Phenylalanine Cysteine 242
Phenylalanine Isoleucine 2077
Phenylalanine Leucine 6212
Phenylalanine Serine 3462
Phenylalanine Tyrosine 906
Phenylalanine Valine 594
Proline Alanine 161
Proline Arginine 158
Proline Glutamine 1011
Proline Histidine 181
Proline Leucine 2123
Proline Serine 2807
Proline Threonine 724
Serine Alanine 1394
Serine Arginine 2730
Serine Asparagine 1198
Serine Cysteine 956
Serine Glycine 2872
Serine Isoleucine 412
Serine Leucine 1148
Serine Phenylalanine 763
Serine Proline 13626
Serine Threonine 4367
Serine Tryptophan 17
Serine Tyrosine 259
Serine Stop codon 604
Threonine Alanine 15336
Threonine Arginine 97
Threonine Asparagine 712
Threonine Isoleucine 5690
Threonine Lysine 2171
Threonine Methionine 2447
Threonine Proline 908
Threonine Serine 4793
Tryptophan Arginine 2280
Tryptophan Cysteine 133
Tryptophan Glycine 153
Tryptophan Leucine 393
Tryptophan Serine 27
Tryptophan Stop codon 765
Tyrosine Asparagine 2294
Tyrosine Aspartic acid 332
Tyrosine Cysteine 7773
Tyrosine Histidine 5910
Tyrosine Phenylalanine 2673
Tyrosine Serine 334
Tyrosine Stop codon 4026
Valine Alanine 18667
Valine Aspartic acid 2878
Valine Glutamic Acid 4805
Valine Glycine 1646
Valine Isoleucine 5113
Valine Leucine 2009
Valine Methionine 3600
Valine Phenylalanine 1357
Stop codon Arginine 171
Stop codon Cysteine 48
Stop codon Glutamic Acid 18
Stop codon Glutamine 191
Stop codon Glycine 29
Stop codon Leucine 44
Stop codon Lysine 55
Stop codon Serine 4
Stop codon Tryptophan 228
Stop codon Tyrosine 17
371774 changes of 170 types
We have now tabulated 372927 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.