Incidental Mutation 'IGL01658:Gpr26'
| ID |
103085 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Gpr26
|
| Ensembl Gene |
ENSMUSG00000040125 |
| Gene Name |
G protein-coupled receptor 26 |
| Synonyms |
9630036A11Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.062)
|
| Stock # |
IGL01658
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
131567891-131587362 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 131585834 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 268
(T268I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000041664
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045840]
[ENSMUST00000124096]
|
| AlphaFold |
Q8BZA7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000045840
AA Change: T268I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000041664
Gene: ENSMUSG00000040125
AA Change: T268I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srsx
|
15 |
309 |
1.9e-7 |
PFAM |
|
Pfam:7tm_1
|
22 |
294 |
1.4e-33 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124096
|
| SMART Domains |
Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
1 |
118 |
4.8e-19 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1 |
118 |
1.7e-50 |
PFAM |
|
low complexity region
|
146 |
160 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]
PHENOTYPE: Mice homozygous for one null allele exhibit increased anxiety- and depression-related behaviors and alcohol preference. Female mice homozygous for another allele display increased susceptibility to diet-induced obesity with increased food intake. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Blm |
A |
G |
7: 80,113,689 (GRCm39) |
S1203P |
probably damaging |
Het |
| Cdc25a |
C |
A |
9: 109,705,194 (GRCm39) |
|
probably null |
Het |
| Cstf1 |
T |
A |
2: 172,214,993 (GRCm39) |
I38N |
probably benign |
Het |
| Fam168a |
C |
A |
7: 100,462,180 (GRCm39) |
P42T |
possibly damaging |
Het |
| Fstl5 |
A |
G |
3: 76,389,562 (GRCm39) |
Q253R |
possibly damaging |
Het |
| Herc2 |
T |
A |
7: 55,809,200 (GRCm39) |
Y2567N |
probably damaging |
Het |
| Hspg2 |
C |
T |
4: 137,292,237 (GRCm39) |
T4035I |
probably damaging |
Het |
| Iqgap3 |
G |
A |
3: 88,023,278 (GRCm39) |
R523Q |
possibly damaging |
Het |
| Mad2l1 |
T |
A |
6: 66,514,586 (GRCm39) |
V85E |
possibly damaging |
Het |
| Mical2 |
T |
C |
7: 111,914,205 (GRCm39) |
Y292H |
probably damaging |
Het |
| Myom2 |
T |
C |
8: 15,127,880 (GRCm39) |
S239P |
probably damaging |
Het |
| Ncoa3 |
T |
C |
2: 165,893,222 (GRCm39) |
|
probably benign |
Het |
| Nthl1 |
A |
G |
17: 24,853,819 (GRCm39) |
T155A |
probably benign |
Het |
| Or2a14 |
T |
A |
6: 43,130,784 (GRCm39) |
S182T |
probably damaging |
Het |
| Plcxd2 |
T |
G |
16: 45,785,424 (GRCm39) |
E327A |
probably benign |
Het |
| Prr36 |
G |
A |
8: 4,265,243 (GRCm39) |
P169L |
probably damaging |
Het |
| Satb1 |
C |
A |
17: 52,082,279 (GRCm39) |
M458I |
probably benign |
Het |
| Smarcal1 |
T |
C |
1: 72,625,290 (GRCm39) |
S146P |
probably benign |
Het |
| Taf4b |
T |
C |
18: 14,977,477 (GRCm39) |
S750P |
probably damaging |
Het |
| Tha1 |
A |
G |
11: 117,762,438 (GRCm39) |
L102P |
probably damaging |
Het |
| Trf |
A |
G |
9: 103,104,055 (GRCm39) |
F103L |
probably benign |
Het |
| Trim2 |
T |
C |
3: 84,117,592 (GRCm39) |
I8V |
probably benign |
Het |
| Usf1 |
C |
T |
1: 171,244,867 (GRCm39) |
S177L |
possibly damaging |
Het |
| Usp12 |
T |
C |
5: 146,688,739 (GRCm39) |
D205G |
probably damaging |
Het |
| Vps13b |
A |
G |
15: 35,671,479 (GRCm39) |
T1661A |
probably damaging |
Het |
|
| Other mutations in Gpr26 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01065:Gpr26
|
APN |
7 |
131,569,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01345:Gpr26
|
APN |
7 |
131,569,161 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL02724:Gpr26
|
APN |
7 |
131,576,121 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0408:Gpr26
|
UTSW |
7 |
131,576,001 (GRCm39) |
splice site |
probably null |
|
|
R0408:Gpr26
|
UTSW |
7 |
131,569,249 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R0547:Gpr26
|
UTSW |
7 |
131,586,026 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2508:Gpr26
|
UTSW |
7 |
131,568,823 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4088:Gpr26
|
UTSW |
7 |
131,568,805 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4630:Gpr26
|
UTSW |
7 |
131,568,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4680:Gpr26
|
UTSW |
7 |
131,576,082 (GRCm39) |
missense |
probably benign |
0.34 |
|
R4756:Gpr26
|
UTSW |
7 |
131,569,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5229:Gpr26
|
UTSW |
7 |
131,585,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5610:Gpr26
|
UTSW |
7 |
131,568,694 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6605:Gpr26
|
UTSW |
7 |
131,585,893 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6653:Gpr26
|
UTSW |
7 |
131,585,830 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7213:Gpr26
|
UTSW |
7 |
131,569,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7351:Gpr26
|
UTSW |
7 |
131,576,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7768:Gpr26
|
UTSW |
7 |
131,576,077 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7887:Gpr26
|
UTSW |
7 |
131,568,702 (GRCm39) |
missense |
probably benign |
|
|
R8822:Gpr26
|
UTSW |
7 |
131,568,997 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9382:Gpr26
|
UTSW |
7 |
131,568,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9508:Gpr26
|
UTSW |
7 |
131,585,830 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1088:Gpr26
|
UTSW |
7 |
131,585,823 (GRCm39) |
frame shift |
probably null |
|
|
Z1176:Gpr26
|
UTSW |
7 |
131,568,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Gpr26
|
UTSW |
7 |
131,568,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2014-01-21 |
Incidental Mutation