Incidental Mutation 'IGL01660:Or11m3'
ID 103133
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or11m3
Ensembl Gene ENSMUSG00000054036
Gene Name olfactory receptor family 11 subfamily M member 3
Synonyms Olfr234, GA_x6K02T04SN1-554-3, MOR122-1, GA_x6K02T2NBG7-5241885-5241019, Olfr279
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # IGL01660
Quality Score
Status
Chromosome 15
Chromosomal Location 98390281-98397312 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 98396076 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 241 (T241I)
Ref Sequence ENSEMBL: ENSMUSP00000150851 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050451] [ENSMUST00000205772] [ENSMUST00000216822]
AlphaFold Q8VFD8
Predicted Effect probably damaging
Transcript: ENSMUST00000050451
AA Change: T241I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000061693
Gene: ENSMUSG00000054036
AA Change: T241I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.9e-50 PFAM
Pfam:7tm_1 41 291 2.3e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205676
Predicted Effect probably damaging
Transcript: ENSMUST00000205772
AA Change: T241I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000216822
AA Change: T241I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acta2 A G 19: 34,229,191 (GRCm39) I66T probably damaging Het
Actl11 T C 9: 107,806,247 (GRCm39) V190A probably benign Het
Ankub1 T A 3: 57,597,817 (GRCm39) Y51F possibly damaging Het
Armh3 A T 19: 45,928,915 (GRCm39) L393H probably damaging Het
Ccdc63 G A 5: 122,249,027 (GRCm39) S434L possibly damaging Het
Cdan1 T A 2: 120,556,134 (GRCm39) I711F possibly damaging Het
Cep170b C A 12: 112,710,594 (GRCm39) N1474K probably damaging Het
Cyp2c40 A G 19: 39,775,254 (GRCm39) S333P probably damaging Het
Dars1 A G 1: 128,343,081 (GRCm39) probably benign Het
Dock3 T A 9: 106,909,563 (GRCm39) probably benign Het
Dsp A G 13: 38,360,471 (GRCm39) I359V possibly damaging Het
Fut8 T G 12: 77,497,032 (GRCm39) L414* probably null Het
Gja1 A G 10: 56,264,544 (GRCm39) Y301C probably damaging Het
Glipr1l1 T C 10: 111,908,184 (GRCm39) S161P probably damaging Het
Gpat4 A T 8: 23,665,354 (GRCm39) probably null Het
Grhl1 T A 12: 24,658,577 (GRCm39) probably null Het
Hectd3 T C 4: 116,853,569 (GRCm39) V181A possibly damaging Het
Htr2a T A 14: 74,943,194 (GRCm39) I258N probably damaging Het
Hyou1 T A 9: 44,292,414 (GRCm39) D83E possibly damaging Het
Myh10 T A 11: 68,676,715 (GRCm39) L862Q probably benign Het
Nkx2-2 T C 2: 147,027,833 (GRCm39) S36G probably benign Het
Nsun2 T A 13: 69,771,368 (GRCm39) V326E probably benign Het
Nuak2 T C 1: 132,259,308 (GRCm39) V362A probably benign Het
Nyap2 G A 1: 81,169,642 (GRCm39) C133Y probably damaging Het
Oas2 T C 5: 120,879,288 (GRCm39) T351A probably benign Het
Or5m13 T C 2: 85,748,908 (GRCm39) I213T probably benign Het
Pde4d A T 13: 110,074,606 (GRCm39) I404F probably damaging Het
Pga5 A G 19: 10,652,456 (GRCm39) S95P probably damaging Het
Pitpnm2 A T 5: 124,261,257 (GRCm39) D947E probably damaging Het
Pla2g10 C T 16: 13,545,950 (GRCm39) R28H probably damaging Het
Prlr A G 15: 10,317,676 (GRCm39) D84G probably damaging Het
Rbm15b C T 9: 106,762,908 (GRCm39) G420D probably damaging Het
Tbcd A G 11: 121,496,153 (GRCm39) T1063A probably benign Het
Tmc2 C T 2: 130,102,144 (GRCm39) Q770* probably null Het
Tpo T C 12: 30,169,399 (GRCm39) probably benign Het
Vim A G 2: 13,579,624 (GRCm39) N128D probably damaging Het
Vmn1r21 A T 6: 57,821,222 (GRCm39) I74N probably damaging Het
Vmn2r52 A C 7: 9,893,107 (GRCm39) I677M probably damaging Het
Other mutations in Or11m3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0944:Or11m3 UTSW 15 98,395,565 (GRCm39) missense probably benign 0.39
R1341:Or11m3 UTSW 15 98,396,135 (GRCm39) missense possibly damaging 0.65
R1785:Or11m3 UTSW 15 98,395,716 (GRCm39) missense probably damaging 1.00
R4504:Or11m3 UTSW 15 98,396,015 (GRCm39) missense probably benign 0.00
R8099:Or11m3 UTSW 15 98,395,694 (GRCm39) missense probably benign 0.00
R9439:Or11m3 UTSW 15 98,396,247 (GRCm39) missense possibly damaging 0.89
Z1177:Or11m3 UTSW 15 98,396,159 (GRCm39) missense probably benign 0.00
Posted On 2014-01-21