Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00591:Iqce'

13557

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Iqce

Ensembl Gene

ENSMUSG00000036555

Gene Name

IQ motif containing E

Synonyms

1700028P05Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00591

Quality Score

Status

Chromosome

Chromosomal Location

140648308-140688158 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 140663883 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Stop codon at position 132 (L132*)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041783] [ENSMUST00000077890]

AlphaFold

Q6PCQ0

Predicted Effect

probably null
Transcript: ENSMUST00000041783
AA Change: L442*

SMART Domains

Protein: ENSMUSP00000045913
Gene: ENSMUSG00000036555
AA Change: L442*

Domain	Start	End	E-Value	Type
low complexity region	33	53	N/A	INTRINSIC
low complexity region	128	139	N/A	INTRINSIC
coiled coil region	157	190	N/A	INTRINSIC
coiled coil region	212	266	N/A	INTRINSIC
coiled coil region	287	323	N/A	INTRINSIC
low complexity region	345	362	N/A	INTRINSIC
coiled coil region	398	491	N/A	INTRINSIC
IQ	552	574	1.36e-3	SMART
low complexity region	579	598	N/A	INTRINSIC
IQ	614	636	1.63e-1	SMART
low complexity region	734	753	N/A	INTRINSIC
low complexity region	754	766	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000077890
AA Change: L397*

SMART Domains

Protein: ENSMUSP00000077050
Gene: ENSMUSG00000036555
AA Change: L397*

Domain	Start	End	E-Value	Type
low complexity region	33	53	N/A	INTRINSIC
coiled coil region	112	145	N/A	INTRINSIC
coiled coil region	167	221	N/A	INTRINSIC
coiled coil region	242	278	N/A	INTRINSIC
low complexity region	300	317	N/A	INTRINSIC
coiled coil region	353	446	N/A	INTRINSIC
IQ	507	529	1.36e-3	SMART
low complexity region	534	553	N/A	INTRINSIC
IQ	569	591	1.63e-1	SMART
low complexity region	628	647	N/A	INTRINSIC
low complexity region	717	736	N/A	INTRINSIC
low complexity region	737	749	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124005

Predicted Effect

probably null
Transcript: ENSMUST00000129704
AA Change: L132*

SMART Domains

Protein: ENSMUSP00000121457
Gene: ENSMUSG00000036555
AA Change: L132*

Domain	Start	End	E-Value	Type
coiled coil region	1	33	N/A	INTRINSIC
low complexity region	42	52	N/A	INTRINSIC
coiled coil region	88	181	N/A	INTRINSIC
IQ	186	208	1.36e-3	SMART
low complexity region	213	232	N/A	INTRINSIC
IQ	248	270	1.63e-1	SMART
low complexity region	312	331	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136385

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 15 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Csmd3	C	T	15: 47,868,279 (GRCm39)	C747Y	probably damaging	Het
Elk3	T	C	10: 93,120,689 (GRCm39)	N50S	probably damaging	Het
Esyt2	T	A	12: 116,327,064 (GRCm39)	L544H	probably damaging	Het
Faap20	A	G	4: 155,335,067 (GRCm39)	N56S	probably benign	Het
Fnd3c2	T	A	X: 105,279,597 (GRCm39)	Y845F	probably damaging	Het
Gm1110	C	A	9: 26,792,170 (GRCm39)	E617*	probably null	Het
Gpbp1	T	C	13: 111,577,284 (GRCm39)	D202G	probably damaging	Het
Hecw1	C	T	13: 14,440,565 (GRCm39)	G1242R	possibly damaging	Het
Mthfd1	C	A	12: 76,347,213 (GRCm39)	P550Q	possibly damaging	Het
Pabpc6	C	T	17: 9,887,427 (GRCm39)	V375I	possibly damaging	Het
Sh2d4b	G	T	14: 40,594,490 (GRCm39)	F163L	probably benign	Het
Sp140	G	A	1: 85,549,393 (GRCm39)	R208K	probably benign	Het
Vps13d	T	C	4: 144,917,129 (GRCm39)	T12A	possibly damaging	Het
Xkr8	A	T	4: 132,455,357 (GRCm39)	Y339N	probably damaging	Het
Zfp108	A	G	7: 23,960,911 (GRCm39)	K501E	possibly damaging	Het

Other mutations in Iqce

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01862:Iqce	APN	5	140,685,480 (GRCm39)	missense	possibly damaging	0.93
R0255:Iqce	UTSW	5	140,651,957 (GRCm39)	missense	possibly damaging	0.62
R0492:Iqce	UTSW	5	140,660,990 (GRCm39)	missense	probably damaging	0.99
R0580:Iqce	UTSW	5	140,651,156 (GRCm39)	missense	possibly damaging	0.85
R0592:Iqce	UTSW	5	140,671,862 (GRCm39)	splice site	probably null
R2177:Iqce	UTSW	5	140,677,348 (GRCm39)	splice site	probably benign
R4849:Iqce	UTSW	5	140,679,214 (GRCm39)	missense	possibly damaging	0.84
R4979:Iqce	UTSW	5	140,677,376 (GRCm39)	missense	probably damaging	1.00
R5007:Iqce	UTSW	5	140,661,003 (GRCm39)	missense	possibly damaging	0.48
R5341:Iqce	UTSW	5	140,675,814 (GRCm39)	missense	possibly damaging	0.95
R5558:Iqce	UTSW	5	140,657,560 (GRCm39)	critical splice donor site	probably null
R5765:Iqce	UTSW	5	140,651,895 (GRCm39)	missense	probably damaging	0.99
R5910:Iqce	UTSW	5	140,687,973 (GRCm39)	unclassified	probably benign
R6354:Iqce	UTSW	5	140,662,090 (GRCm39)	splice site	probably null
R6732:Iqce	UTSW	5	140,660,990 (GRCm39)	missense	probably benign
R7050:Iqce	UTSW	5	140,651,846 (GRCm39)	missense	possibly damaging	0.76
R7238:Iqce	UTSW	5	140,675,713 (GRCm39)	nonsense	probably null
R7567:Iqce	UTSW	5	140,671,830 (GRCm39)	missense	probably damaging	1.00
R7735:Iqce	UTSW	5	140,663,839 (GRCm39)	missense	probably benign	0.00
R8339:Iqce	UTSW	5	140,660,093 (GRCm39)	missense	probably damaging	0.97
R8951:Iqce	UTSW	5	140,675,578 (GRCm39)	missense	probably damaging	1.00
R9043:Iqce	UTSW	5	140,651,810 (GRCm39)	missense	probably benign	0.01
R9348:Iqce	UTSW	5	140,677,380 (GRCm39)	missense	probably damaging	1.00
R9571:Iqce	UTSW	5	140,651,862 (GRCm39)	missense	possibly damaging	0.65
R9630:Iqce	UTSW	5	140,666,591 (GRCm39)	missense	possibly damaging	0.63
R9734:Iqce	UTSW	5	140,678,564 (GRCm39)	missense	probably damaging	0.96

Posted On

2012-12-06