Incidental Mutation 'IGL00783:Tns4'
| ID |
14541 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tns4
|
| Ensembl Gene |
ENSMUSG00000017607 |
| Gene Name |
tensin 4 |
| Synonyms |
9930017A07Rik |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.362)
|
| Stock # |
IGL00783
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
11 |
| Chromosomal Location |
98956504-98980132 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to G
at 98961221 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000017751
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000017751]
|
| AlphaFold |
Q8BZ33 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000017751
|
| SMART Domains |
Protein: ENSMUSP00000017751
Gene: ENSMUSG00000017607
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
63 |
72 |
N/A |
INTRINSIC |
|
low complexity region
|
271 |
304 |
N/A |
INTRINSIC |
|
SH2
|
427 |
527 |
6.95e-18 |
SMART |
|
Pfam:PTB
|
562 |
695 |
1.6e-31 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000107465
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153351
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 22 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5031410I06Rik |
T |
C |
5: 26,309,153 (GRCm39) |
R50G |
probably damaging |
Het |
| Arhgef33 |
A |
T |
17: 80,675,659 (GRCm39) |
I403L |
probably benign |
Het |
| Cd4 |
A |
G |
6: 124,849,952 (GRCm39) |
V121A |
possibly damaging |
Het |
| Dock10 |
A |
G |
1: 80,550,166 (GRCm39) |
|
probably benign |
Het |
| Faim |
G |
A |
9: 98,874,218 (GRCm39) |
G15R |
probably damaging |
Het |
| Hid1 |
A |
T |
11: 115,239,336 (GRCm39) |
Y776N |
probably damaging |
Het |
| Hnrnpl |
T |
C |
7: 28,520,067 (GRCm39) |
F482L |
probably benign |
Het |
| Ift122 |
T |
A |
6: 115,882,863 (GRCm39) |
H659Q |
probably benign |
Het |
| Igsf3 |
A |
G |
3: 101,338,555 (GRCm39) |
R290G |
probably damaging |
Het |
| Jhy |
T |
C |
9: 40,834,048 (GRCm39) |
T291A |
probably benign |
Het |
| Kmt2e |
A |
G |
5: 23,697,356 (GRCm39) |
I605V |
probably damaging |
Het |
| Nmt2 |
T |
A |
2: 3,315,846 (GRCm39) |
F279I |
probably damaging |
Het |
| Nup93 |
G |
A |
8: 95,035,651 (GRCm39) |
|
probably null |
Het |
| Oas2 |
A |
G |
5: 120,876,428 (GRCm39) |
F15S |
probably damaging |
Het |
| Pecam1 |
T |
C |
11: 106,590,624 (GRCm39) |
D22G |
probably damaging |
Het |
| Pold2 |
T |
C |
11: 5,822,412 (GRCm39) |
E419G |
probably benign |
Het |
| Rassf3 |
T |
C |
10: 121,251,985 (GRCm39) |
H142R |
probably benign |
Het |
| Rp2 |
T |
A |
X: 20,243,408 (GRCm39) |
C128S |
probably damaging |
Het |
| Scn7a |
T |
G |
2: 66,522,908 (GRCm39) |
E932A |
probably damaging |
Het |
| Sis |
T |
C |
3: 72,853,965 (GRCm39) |
H504R |
probably benign |
Het |
| Syce1l |
A |
G |
8: 114,379,494 (GRCm39) |
D120G |
probably benign |
Het |
| Unc80 |
G |
A |
1: 66,647,596 (GRCm39) |
G1512E |
probably benign |
Het |
|
| Other mutations in Tns4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01940:Tns4
|
APN |
11 |
98,959,047 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03130:Tns4
|
APN |
11 |
98,959,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03376:Tns4
|
APN |
11 |
98,969,382 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4486001:Tns4
|
UTSW |
11 |
98,962,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0089:Tns4
|
UTSW |
11 |
98,966,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1598:Tns4
|
UTSW |
11 |
98,961,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1872:Tns4
|
UTSW |
11 |
98,970,926 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1903:Tns4
|
UTSW |
11 |
98,966,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1998:Tns4
|
UTSW |
11 |
98,976,529 (GRCm39) |
missense |
probably benign |
|
|
R2126:Tns4
|
UTSW |
11 |
98,970,904 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4468:Tns4
|
UTSW |
11 |
98,961,241 (GRCm39) |
missense |
probably benign |
0.41 |
|
R4973:Tns4
|
UTSW |
11 |
98,966,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5048:Tns4
|
UTSW |
11 |
98,969,605 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5918:Tns4
|
UTSW |
11 |
98,964,497 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6088:Tns4
|
UTSW |
11 |
98,964,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6151:Tns4
|
UTSW |
11 |
98,966,376 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6586:Tns4
|
UTSW |
11 |
98,971,093 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7543:Tns4
|
UTSW |
11 |
98,963,079 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7667:Tns4
|
UTSW |
11 |
98,962,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7909:Tns4
|
UTSW |
11 |
98,976,849 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8206:Tns4
|
UTSW |
11 |
98,976,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2012-12-06 |
Incidental Mutation