Incidental Mutation 'IGL01771:Or1ad8'
| ID |
153847 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Or1ad8
|
| Ensembl Gene |
ENSMUSG00000060918 |
| Gene Name |
olfactory receptor family 1 subfamily AD member 8 |
| Synonyms |
Olfr51, ID7, GA_x6K02T2QP88-4431129-4430206, MOR129-3 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.060)
|
| Stock # |
IGL01771
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
11 |
| Chromosomal Location |
50897801-50898724 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 50898593 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 265
(T265A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000151005
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076514]
[ENSMUST00000213415]
|
| AlphaFold |
Q8VGG9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000076514
AA Change: T265A
PolyPhen 2
Score 0.152 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000075832
Gene: ENSMUSG00000060918
AA Change: T265A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
31 |
307 |
3.4e-50 |
PFAM |
|
Pfam:7tm_1
|
41 |
289 |
8.7e-26 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000213415
AA Change: T265A
PolyPhen 2
Score 0.152 (Sensitivity: 0.92; Specificity: 0.87)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 20 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Capn10 |
T |
A |
1: 92,868,087 (GRCm39) |
W185R |
probably damaging |
Het |
| Frmd8 |
A |
G |
19: 5,919,603 (GRCm39) |
L148P |
probably damaging |
Het |
| Gk5 |
T |
C |
9: 96,059,488 (GRCm39) |
C447R |
probably damaging |
Het |
| Hip1r |
T |
A |
5: 124,137,606 (GRCm39) |
V704D |
possibly damaging |
Het |
| Kcnj10 |
C |
A |
1: 172,197,150 (GRCm39) |
H221Q |
probably benign |
Het |
| Klk1b8 |
A |
T |
7: 43,604,290 (GRCm39) |
I253L |
probably damaging |
Het |
| Or10aa4-ps1 |
T |
C |
1: 173,878,887 (GRCm39) |
|
probably benign |
Het |
| Or1e29 |
A |
T |
11: 73,667,490 (GRCm39) |
I221N |
probably damaging |
Het |
| Or5ac22 |
T |
C |
16: 59,134,891 (GRCm39) |
N293S |
probably damaging |
Het |
| Or8k40 |
C |
T |
2: 86,584,626 (GRCm39) |
C152Y |
probably benign |
Het |
| Pdp2 |
A |
T |
8: 105,320,754 (GRCm39) |
Y201F |
probably benign |
Het |
| Ppfia1 |
A |
T |
7: 144,036,094 (GRCm39) |
I1112K |
probably benign |
Het |
| Ppwd1 |
A |
G |
13: 104,353,624 (GRCm39) |
I378T |
probably damaging |
Het |
| Rhbdd1 |
T |
A |
1: 82,355,313 (GRCm39) |
D248E |
probably benign |
Het |
| Sec14l5 |
T |
C |
16: 4,996,494 (GRCm39) |
|
probably null |
Het |
| Sel1l3 |
T |
G |
5: 53,279,183 (GRCm39) |
D960A |
probably damaging |
Het |
| Slc35f3 |
T |
C |
8: 127,115,951 (GRCm39) |
Y293H |
probably benign |
Het |
| Wwc1 |
A |
G |
11: 35,744,185 (GRCm39) |
|
probably null |
Het |
| Zan |
T |
C |
5: 137,391,330 (GRCm39) |
N4718S |
unknown |
Het |
| Zfyve16 |
T |
C |
13: 92,658,680 (GRCm39) |
I410M |
probably benign |
Het |
|
| Other mutations in Or1ad8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02729:Or1ad8
|
APN |
11 |
50,897,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0367:Or1ad8
|
UTSW |
11 |
50,897,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1675:Or1ad8
|
UTSW |
11 |
50,898,464 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1716:Or1ad8
|
UTSW |
11 |
50,898,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1943:Or1ad8
|
UTSW |
11 |
50,898,502 (GRCm39) |
missense |
probably benign |
0.42 |
|
R3027:Or1ad8
|
UTSW |
11 |
50,897,879 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R4569:Or1ad8
|
UTSW |
11 |
50,898,381 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5190:Or1ad8
|
UTSW |
11 |
50,898,381 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5447:Or1ad8
|
UTSW |
11 |
50,898,170 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5560:Or1ad8
|
UTSW |
11 |
50,898,350 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6396:Or1ad8
|
UTSW |
11 |
50,898,312 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6943:Or1ad8
|
UTSW |
11 |
50,898,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7199:Or1ad8
|
UTSW |
11 |
50,898,223 (GRCm39) |
nonsense |
probably null |
|
|
R7991:Or1ad8
|
UTSW |
11 |
50,898,071 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8118:Or1ad8
|
UTSW |
11 |
50,898,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8178:Or1ad8
|
UTSW |
11 |
50,898,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8496:Or1ad8
|
UTSW |
11 |
50,897,877 (GRCm39) |
missense |
probably benign |
|
|
R9006:Or1ad8
|
UTSW |
11 |
50,897,975 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9246:Or1ad8
|
UTSW |
11 |
50,897,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2014-02-04 |
Incidental Mutation